동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)

DEN Tip에서의 피로균열 발생 및 진전거동에 대한 파괴역학적 해석

최용식,석창성,조용근,임창현,박종주 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

In order to predict the behaviour of a crack growth with accuracy, the SIF K values for the double edge notched specimen have been determined by finite element method. With considering the root radius of notch and the crack length which increase step by step, the availability of the modified K values have been evaluated by comparing with the experimental results from fatigue test.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

동종 조혈모세포이식 후 발생한 크립토콕쿠스 척추염 1예

고윤호,임동준,이성수,조유경,이동건,최정현,김유진,민창기,김동욱,박정미,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

Skeletal cryptococcosis is an uncommon infection. Cryptococcus is a common cause of meningitis and infects 7∼10% of patients with AIDS. As well as AIDS, the infection may be seen in association with leukemia, lymphoma, Hodgkin's disease, sarcoidosis, tuberculosis and diabetes, also in patients on steroid medication. But there is no case report of skeletal cryptococcosis following allogeneic hematopoietic stem cell transplantation. A 40-year-old woman was admitted to the hospital because of low back pain. She had chronic myelogenous leukemia for 2 years and underwent allogeneic hematopoietic stem cell transplantation 8 months ago. She have been treated with steroid and cyclosporine orally because of chronic graft versus host disease. On examination she was afebrile and had posterior lower lumbar tenderness. But, she had no reduced strength of low extremities. Open biopsy was underwent. Histology demonstrated budding, round-to-oval, refractile yeast-like organisms within debris. The results of a lumbar puncture were unremarkable and cerebrospinal fluid culture failed to grow bacteria and yeast. The patient was treated with amphotericin B (1 gram) and AmBisome□ (2.8 gram) over 6 weeks. Three months after cessation of therapy, the patient was doing well.(Korean J Infect Dis 33:298∼301, 2001)

일 농촌지역의 우울 증상에 관한 역학연구 -위험요인 및 요인구조분석

하양숙,홍진표,김한규,이군희,한경자,조맹제,김용익,송미순,박성애,김창윤 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 세계적으로 널리 사용되는 우울증 척도인 the Center for Epidemiologic Studies Depression Scale(CES-D)을 이용하여 지역사회 주민의 우울증상의 정도를 평가하고, 우울증상의 위험요인을 분석하고, 한국인에서 우울증상의 요인구조를 알기 위해 본 연구를 실시하였다. 방 법 : 경기도 일 농촌 지역의 30세 이상 주민에 대해 무작위 군집 집락 추출을 실시하였고, 훈련된 면담원들이 가정 방문을 통하여 면접 및 자기보고 검사인 CES-D를 실시하였다. 총 1,315명에서 응답을 하였고 응답율은 59.3%이었다. 결 과 : CES-D에 의한 우울증 점수는 0∼5점이 57%정도를 차지하였고, 평균 점수는 남자 7.8점 여자 9.5점으로 비교적 낮은 편이었다. ANCOVA 분석 결과 비결혼, 저학력, 여성이라는 위험요인은 독립적으로 우울증상을 악화시키는 요인이었으나 연령은 통계적으로 유의하지 않았다. CES-D 결과를 요인분석을 시행한 결과 4가지 요인이 추출되었는데 우울증상 및 신체증상이 한 개의 요인으로, 다른 나라에서 보고되지 않는 정서적 고통이 별도의 요인으로 추출되었다. 결 론 : 국내 역학 조사에서도 외국과 유사한 우울점수 및 위험요인이 확인되었으나 우울증의 요인에서는 특이한 요인이 추출되었다. 한국인에 독특한 우울 반응에 관한 추가 연구가 필요하다. Objectives :The rates, correlates, and factor structure of depressive symptoms in a Korean rural sample were examined using Korean version of the Center for Epidemiologic Studies Depression Scale(CES-D). Methods : Door to door visiting survey was conducted by trained interviewers. A random cluster sample of 1,315 respondents, aged 30 and over completed the CES-D scale along with additional sociodemographic questionnaire. Results : In this sample, mean CES-D score of male and female were 7.8 and 9.5, respectively which were lower than those reported previously. Symptoms of depression were most common among the less educated, non-married and female according to ANCOVA. Age was not a significant risk factor for depressive symptoms. Different factor structures emerged from this sample as compared to other studies using this approach. Somatic symptoms and affective symptoms were combined as one factor and emotional hardship emerged as a separate factor. Conclusion : Symptoms scores and risk factors were similar to the results reported in other countries but unique factor structures were found in this study. Further research is needed about the Korean depressive symptomatology and related areas.

상변화 물질을 사용한 축열조에서의 열전달 - 수직원관내에서의 내향용융실험 및 수치해석 -

임장순(Chang-Soon Yim),최국광(Guk-Gwang Choi),이채문(Cha-Moon Lee),김준근(Jun-Gun Kim),송하진(Ha-Jin Shong),조남철(Nam-Cheol Cho) 한국태양에너지학회 1990 한국태양에너지학회 논문집 Vol.10 No.1

온도가 일정한 외벽을 열원으로 하는 수직원통형 축열조 내에 채워진 상변화물질의 내향용융 과정에서 자연대류에 의한 열전달현상을 유한차분법을 이용하여 수치해석하였고, 그 결과를 실험을 통하여 검증하였다.<br/> 상변화물질로는 용융점온도가 42.5℃인 n-docosane paraffin(C₂₂H_(46))을 사용하였다.<br/> 본 연구 결과에서 상변화물질의 용융속도는 액상영역의 자연대류로 인하여 축열조상부로 갈수록 빠른 것으로 나타났다. 그리고 상변화물질의 초기온도는 액상영역의 속도분포에 큰 영향을 주지 않으며, 상변화물질의 초기온도가 낮을수록 용융속도는 늦어지고 축열조의 형상비(H/r_w)가 커질수록 자연대류는 활발해지는 것으로 나타났다.<br/> 이러한 수치해석의 결과는 실험 결과와 잘 일치하였으나, 수치해석시 상변화물질의 용융에 따르는 체적팽창을 고려하지 않았기 때문에 용융이 진행됨에 따라 오차가 발생 하였다. In the present investigation, experiments and numerical analysis during melting process of a phase change material were performed to research heat transfer phenomena generated by means of conduction and natural convection in the vertical tube at inward melting.<br/> The phase change material used in the experiments is 99 percent pure n-Docosane paraffin(C₂₂H_(46)).<br/> In the results, it is found that the velocity of phase change interface at the top of tube is faster than at the bottom of tube because of the effect of natural convection, and the distribution of velocity at the liquid region is little affected by the initial temperature of phase change material.<br/> The velocity of phase change interface is slower as the initial temperature of phase change material is lower, and the effect of natural convection is larger as the aspect ratio of tube is larger.<br/> In tendency of heat transfer phenomena, the experimental results were well corresponded with numerical results.<br/> But there were a little disagrements between the results of experiment and numerical analysis because of the assumption of the constant volumetric expansion coefficient in numerical analysis.

Quality Characteristics of Processed Mushroom Products Using Pleurotus ostreatus, Agaricus bisporus and Flammulina velutipes

Chang, Min-Sun,Kim, Myoung-Sook,Cho, Sun-Duk,Jhune, Chang-Sung,Cho, Weon-Dae,Yoo, Young-Bok,Kim, Gun-Hee Korean Society of Food Culture 2009 Food Quality and Culture Vol.3 No.1

This study examined the effects of adding Pleurotus ostreatus, Agaricus bisporus and Flammulina velutipes on the quality characteristics of cookies and multiple purposes of wheat powders. The water content, crude protein content, mineral content, color value and sensory evaluation of mushroom cookies and multiple purposes of wheat powders were measured. In the case of cookies, the water content was 1.10-1.24% and crude protein content was 8.20-9.80%. General preferences, such as appearance, color, taste and texture, increased when mushroom was added to the cookies, especially flavor, which showed a much higher preference. In the studies where mushroom was added to wheat powders, the water content was 0.57-0.92% and crude protein content was 11.90-12.80%. The addition of mushroom to both of the cookies and multiple purposes of wheat powders resulted in a remarkable increase in the mineral content, especially Fe, K. In addition, an increase in the amount of added mushrooms resulted in an increase in the hunter L and a values; however, this also resulted in a decrease in the b value.

세척조건에 따른 신선편이 결구상추의 잔류 염소량 발생 변화

조순덕(Sun-Duk Cho),장민선(Min-Sun Chang),이유시(Yu-Si Lee),하상도(Sang-Do Ha),김건희(Gun-Hee Kim) 한국원예학회 2010 원예과학기술지 Vol.28 No.1

본 연구에서는 샐러드 등 신선편이 식품의 기본 재료로 가장 많이 사용되고 있는 결구상추를 대상으로 염소수(차아염소산나트륨) 농도, 침지시간, 헹굼 횟수 및 염소수 침지온도에 따른 신선편이 식품의 잔류염소량 분석을 통해 위해정도를 확인하였다. 염소수 농도에 따른 실험 결과 200㎎ · L?¹ 이하에서는 유리잔류염소량이 1.0-7.0㎎ · L?¹으로 농도 의존적 증가를 보였으나 차이는 크지 않았고, 300㎎ · L?¹ 이상에서 30.0-45.0㎎ · L?¹로 급격히 증가하였다. 침지시간에 따른 유리잔류염소량은 비슷한 수준이었으나, 총잔류염소량은 시간이 증가함에 따라 소폭 증가하다가 유지되는 경향을 보였다. 헹굼 횟수별로는 1회 세척 시 총잔류염소량 16.0㎎ · L?¹이었으나, 2회 이상 세척 시 잔류염소는 검출되지 않았다. 염소수 침지온도에 따른 실험 결과 200㎎ · L?¹ 처리시, 5-20℃에서 총잔류염소량이 22.0-28.0㎎ · L?¹이었고, 30-50℃에서 5.0-12.0㎎ · L?¹으로 온도가 높아질수록 잔류량은 감소하였다. This study analyzes the residual chlorine content of fresh-cut lettuce (Lactuca sativa L.) according to changes the concentration of sodium hypochlorite, dipping time, number of washes, and the temperature of wash water to verify the level of toxicity. When the concentration of sodium hypochlorite was under 200 ㎎ · L?¹, the residual amount of free chlorine was 1.0-7.0 ㎎ · L?¹. However, when the concentration of sodium hypochlorite exceeded 300 ㎎ · L?¹, the residual amount dramatically increased to 30.0-45.0 ㎎ · L?¹. The amount of free chlorine did not change much by the time of dipping. In contrast, the total residual chlorine content rose slightly as the dipping time increased. When the subject was washed once after chlorine treatment, the total residual chlorine content stood at 16.0 ㎎ · L?¹. Residual chlorine was not detected when the subject was washed for more than two times. Between the chlorinated water (200 ㎎ · L?¹) temperature of 5-20℃, the total residual chlorine content was 22.0-28.0 ㎎ · L?¹. When the temperature of washing water was raised to 30-50℃, the content decreased to 5.0-12.0 ㎎ · L?¹.

Changes in the Residual Chlorine Content of Fresh-cut Lettuce during Storage

Cho, Sun-Duk,Chang, Min-Sun,Lee, Yu-Si,Ha, Ji-Hyoung,Kim, Gun-Hee,Bae, Dong-Ho,Kim, Yong-Soo,Chung, Myung-Sub,Kim, Yong-Mu,Lee, Dong-Ho,Park, Sun-Hee,Ha, Sang-Do The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.3

Efficacies of the amounts and methods for chlorinated water to use in disinfection of lettuce were investigated. Concentrations of total and free chlorine in lettuce samples were measured using a colorimetric reaction with diethyl-p-phenylenediamine (DPD). For measurement of the total amount of residual chlorine remaining on samples of lettuce during storage, 100 mg/L DPD samples were used. The residual chlorine content decreased an initial amount of 14 mg/L and further decreased by 42.9% after three minutes, by 92.9% after ten minutes, and diminished to 4 mg/L after seven hours of storage. Measurements made while applying 200 mg/L chlorinated water showed a similar trend. The change in the amount of free available chlorine in the washing water was determined based on storage period and frequency. While washing, the amount of free available chlorine decreased proportionally with time.

Application of Interpolation Method to Magnetic Resonance Imaging for Removal of Radio-Frequency Noise

Cho, Jung-Hun,Ahn, Sang-Doo,Oh, Chang-Hyun,Cho, Jang-Gun,Ryu, Eun-Kyoung,Cho, Jee-Hyun,Lee, Chul-Hyun Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.10