[인터뷰] 건설기계부품연구원 신뢰성평가센터 조용근 센터장

조용근,신승원,양회관 대한기계학회 2019 기계저널 Vol.59 No.4

미국 공군의 독립과정 연구: 역사적 신제도주의 관점으로

조용근 (재)한국군사문제연구원 2022 한국군사 Vol.11 No.-

The US Air Force has gained independence force from the US Army with the enactment of the National Security Law of 1947 with the right to foster air-based military operations. In the process, the United States Army Air Service (USAAS) was reorganized into the United States Army Air Corps (USAAC) has functionally emerged to the USAF. Since then the Chief of USAF has exercised its authority for implementation of its own acquirement of independent and robust air force platforms, operating integrated air power within the USCON and exercising global-reaching strategic air power capabilities Many experts has codenamed the establishment of the USAF as independent military service as notion of the historical and newinstitutionalism. There are two factors on it: First three pre-conditions have been met in the context of military-industry market, institutionalization of four military services and impact of introducing new-domain of air operation. Accordingly, a concept of the air power, including land-power as well as sea-power includes new doctrine, concept of operation in the air domain, allocation of budget for USAF, interaction between USAF and defense industries to produce new-generation air force platforms and weapons systems, etc. Many concludes that leadership of the chief of USAF has influenced US national defense authority for development of USAF independently as single-service military capability. This has provided some robust sessions for US itself as well as US Space Force, newly establishing its independent miliary service separating from USAF in 2019 and US allies and other like-minded countries.

Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome

조용근,이상국,지선하,김정호 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.6

Background: We aimed to determine the major contributing component of metabolic syndrome (MetS) that results in an elevated small dense LDL cholesterol (sdLDL-C) concentration and sdLDL-C/LDL-C ratio. Methods: Four hundred and forty-seven subjects (225 men; 222 women) with MetS were randomly selected from the Korean Metabolic Syndrome Research Initiatives-Seoul cohort study. Age- and sex-matched healthy controls (181 men; 179 women) were also randomly selected from the same cohort. Results: A comparison of the median values of the sdLDL-C concentration between subgroups, divided according to whether subjects met or did not meet the criteria for each MetS component in patients with MetS, revealed a significant difference in the sdLDL-C concentration only between subgroups divided according to whether subjects met or did not meet the triglyceride (TG) criteria (P<0.05 for each gender). The TG level showed a good correlation with sdLDL-C concentration (correlation coefficients [r]=0.543 for men; 0.653 for women) and the sdLDL-C/LDL-C ratio (r=0.789 for men; 0.745 for women). Multiple linear regression analyses conducted for the MetS group concordantly identified TG as one of the most significant contributors to sdLDL-C concentration (β=0.1747±0.0105, P<0.0001) and the sdLDL-C/LDL-C ratio (β=6.9518±0.3011, P<0.0001). Conclusions: Among five MetS components, only the abnormal TG level was a differentiating factor for sdLDL-C concentration and sdLDL-C/LDL-C ratio. These results were reproducible in both genders, with or without MetS.

A Case of Late-Onset Li-Fraumeni–like Syndrome with Unilateral Breast Cancer

조용근,김주원,김윤정,이경아,정준 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.3

Li-Fraumeni syndrome (LFS) is a rare, inherited syndrome associated with increased risk of various early-onset tumors. Since the introduction of classic LFS criteria, various criteria have been proposed to include patients with incomplete LFS features, which make up Li-Fraumeni-like syndromes (LFL). Germline missense mutations of TP53 are the primary cause of LFS and LFL. Mutations mostly reside in the DNA-binding domain of the gene and have a dominant-negative effect (DNE) over alternate wild-type alleles. Germline TP53mutation c.566C>T results in the missense mutation GCC (Ala) to GTC (Val) at codon 189(A189V) and has been reported in a case of multiple primary colon tumors. Herein we report a second case of the same mutation in a breast cancer patient, who has familial history of late-onset malignancies. Due to the relatively late onset of malignancies, neither case fulfils previously defined criteria for the syndrome. Mutational analysis for breast tissue in this patient showed a loss of heterozygosity. These clinical features may suggest a relatively weak DNE of A189V compared to other TP53 mutations, and in silico predictions and in vitro findings of the function of A189V mutant protein are conflicting. Considering the increased risk of malignancies and the therapeutic implications for patients who have a TP53 mutation, care must be taken when treating those who are suspected of possessing cancer-prone traits due to TP53 mutation, especially when there is a family history of late-onset cancer with low penetrance.

다목적 최적화 전략을 통한 굴착기 모델의 부정확성을 최소화하는 방법

조용근,Misganaw Abebe,구본용,한승철 한국신뢰성학회 2024 한국신뢰성학회 학술대회논문집 Vol.2024 No.6

특집2 : 투기인가, 투자인가

조용근 기독교대한성결교회 활천사 2021 활천 Vol.813 No.8

유 · 무인 복합 전투기편대와 미래 항공전

조용근 한국방위산업진흥회 2021 國防과 技術 Vol.- No.503

Existence result for heat-conducting viscous incompressible fluids with vacuum

조용근,김현석 대한수학회 2008 대한수학회지 Vol.45 No.3

The Navier-Stokes system for heat-conducting incompressible fluids is studied in a domain Ω ⊂ R³. The viscosity, heat conduction coefficients and specific heat at constant volume are allowed to depend smoothly on density and temperature. We prove local existence of the unique strong solution, provided the initial data satisfy a natural compatibility condition. For the strong regularity, we do not assume the positivity of initial density; it may vanish in an open subset (vacuum) of ­ or decay at infinity when ­Ω is unbounded. The Navier-Stokes system for heat-conducting incompressible fluids is studied in a domain Ω ⊂ R³. The viscosity, heat conduction coefficients and specific heat at constant volume are allowed to depend smoothly on density and temperature. We prove local existence of the unique strong solution, provided the initial data satisfy a natural compatibility condition. For the strong regularity, we do not assume the positivity of initial density; it may vanish in an open subset (vacuum) of ­ or decay at infinity when ­Ω is unbounded.

대장내시경 검사 중 발생한 대장천공의 보존적 치료

조용근,남상우,김현철,고은영,김양호,박승민,이용웅,조진웅 대한소화기내시경학회 2006 Clinical Endoscopy Vol.33 No.1

Background/Aims: Colonoscopic perforation can be treated by both operative or non-operative methods. Non-operative management, and especially conservative management, may be appropriate for selected individuals. We wanted to verify the usefulness of performing conservative management for treating colonoscopic perforations. Methods: We reviewed the medical records of the colonoscopic perforation cases that occurred in the recent 5 yrs. 11 cases of perforation occurred from among 8,536 colonoscopic procedures. Results: Ten cases occurred from a therapeutic procedure (five from polypectomy and another five occurred from an endoscopic (submucosal dissection) and one case occurred from a diagnostic procedure. The perforation sites were the ascending colon (three cases), transverse colon (two cases), descending colon (one case), sigmoid colon (two cases), and rectum (three cases). There were five intraperitoneal perforations and five retroperitoneal perforations. All the cases were detected within 12 hours and all the cases had received good bowel preparation. 10 cases were managed conservatively (nothing by mouth, broad spectrum antibiotics and, Levin tube suction). One case was managed by an operative procedure due to the large size of the defect and the patient's wish. All the patients recovered without complications. The mean hospital stay was 9.5 days. Conclusions: Colonoscopic perforation can managed conservatively in selected cases, such as for those cases that will undergo post-therapeutic colonoscopy and those cases that have undergone good bowel preparation. (Korean J Gastrointest Endosc 2006;33:20-25) 목적: 대장내시경술은 대장질환의 진단과 치료에 매우 유용한 수단으로써 최근 활발하게 시행되고 있다. 이에 따라 여러 가지 합병증의 발생 빈도도 증가하게 되었는데, 이 중 대장천공은 매우 중대하고 심각한 결과를 초래할 수 있는 합병증이다. 대장천공에 대한 치료는 보편적으로 수술적 방법을 선호해 왔으나 최근에는 많은 경우에 보존적 치료로도 효과적이고 안전하게 치료할 수 있다는 보고가 있다. 이에 저자들은 대장내시경 검사 중 발생한 대장천공에 대한 보존적 치료의 효과와 안정성을 평가해 보고자 하였다. 대상 및 방법: 2001년부터 2005년 12월까지 예수병원 소화기병 센터에서 시행된 8,536예의 대장내시경 시술 중 발생한 대장천공 11예에 대하여 임상기록에 의한 임상 양상, 진단, 치료 및 결과를 후향적으로 연구하였다. 결과: 8,536예의 대장내시경술 중 진단내시경술은 총 6,450회였고 치료내시경술은 2,086회였다. 치료내시경술의 종류로는 용종절제술이 2,050회, 내시경 점막하 절개 박리술(endoscopic submucosal dissection, ESD)이 36회였다. 총 11예의 천공이 발생하였고(0.12%), 이 중 진단내시경술에 의한 천공은 1예(0.015%), 치료내시경술에 의해서는 10예(0.48%)가 발생하였다. 천공이 발생한 치료내시경 시술은 용종절제술 5예(0.24%), ESD 5예(13.8%)로 ESD가 유의하게 높았다(p-value<0.001). 천공의 위치는 상행결장 3예, 횡행결장 2예, 하행결장 1예, 에스결장 2예, 직장 3예였고 복막내천공이 6예, 후복막천공이 5예였다. 진단내시경 시술에 의한 천공은 에스결장에서 발생하였다. 4예는 천공 즉시 진단되었고, 5예에서 3시간 이내, 2예에서 12시간 이내에 진단되었다. 모든 예에서 수술을 필요로 하는 대장의 기저질환은 없었다. 천공이 발생한 11예 중 10예에서 보존적 치료를 시행하였다. 보존적 치료로는 금식, 광범위 항생제 투여와 정맥 내 수액공급을 실시하였고, 5예에서 보존적 치료와 함께 대장내시경을 이용한 clipping을 실시하였는데 시술 도중 천공이 확인된 4예 중 3예와 시술 후 천공이 확인되어 추가 대장내시경술을 실시한 3예 중 천공부위가 확인된 2예에서 실시되었다. 1예는 천공의 크기가 비교적 크고 clipping이 불가능하였으며 환자가 원하여 수술을 실행하였다 . 모든 예에서 추가 합병증 없이 평균 10일 후 퇴원하였다. 결론: 대장내시경에 의한 천공의 치료로써 보존적 치료는 많은 환자에서 효과적이고 안전한 치료법이다. 특히 치료내시경술 후 발생, 좋은 장 정결상태, 천공 후 조기발견, 후복막천공, 수술을 요구하는 대장의 기저질환이 없는 경우 우선적으로 고려할 수 있겠다.

음극드럼용 Ti 소재 가속수명시험을 통한 신뢰성 평가

조용근,강명철,정건,한승철,이남규 한국신뢰성학회 2023 한국신뢰성학회 학술대회논문집 Vol.2023 No.11