원발성 알도스테론증과 본태성 고혈압에서의 표적장기 손상 빈도 비교

박주리,김동진,양세정,김혜숙,박수연,류혜진,이윤정,김희영,류옥현,이계원,서지아,김신곤,최경묵,백세현,최동섭 대한내분비학회 2007 Endocrinology and metabolism Vol.22 No.1

Background: A number of recent clinical studies have reported marked target organ damages in patients with primary aldosteronism. The aim of this study was to compare the incidence of target organ damages in patients with primary aldosteronism (PA) and essential hypertension (EHT). Methods: The clinical records of 41 PA patients, over a 20-year period, were retrospectively analyzed. The clinical characteristics and incidence of target organ damages of 33 of the patients in this group were compared with those of 66 patients with essential hypertension, directly matched for age, gender and mean blood pressure. 8 of the PA patients could not be matched with EHT patients for age, gender and mean blood pressure, so were excluded from the comparison. The patients with essential hypertension were sampled from patients who visited for the evaluation of hypertension. Results: Ischemic heart diseases were found in 18.2 and 10.6% of patients with PA and EHT, respectively (P = 0.22). From echocardiograms, left ventricular hypertrophy was found in 93.3% and 61.4% of patients with PA and EHT, respectively (P = 0.017). The degrees of left ventricular hypertrophy were correlated with the levels of serum aldosterone, with an r value of 0.490 (P < 0.005). Cerebrovascular attack was found in 18.2% and 1.5% of patients with PA and EHT, respectively (P = 0.005). Hypertensive retinopathy was found in 50% and 33.3% of patients with PA and EHT (P = 0.255), and nephropathy was found in 42.4% and 25.8% of patients with PA and EHT, respectively (P = 0.074). Conclusion: Patients with primary aldosteronism had target organ damages more frequently than with those with essential hypertension, which was independent of blood pressure. (J Kor Endocrinol Soc 22:11~18, 2007) 배경: 최근 원발성 알도스테론증은 전체 고혈압의 5~13%를 차지하며 표적 장기 손상 빈도도 적지 않게 나타나는 것으로 보고되고 있다. 이번 연구에서는 원발성 알도스테론증의 표적 장기 손상 빈도를 조사하고 이것을 원발성 고혈압 환자와 비교해 보고자 하였다. 방법: 1986년부터 2005년까지 고려대학교 병원을 방문하여 원발성 알도스테론증을 진단받은 41명의 환자를 의무기록을 통해 후향적으로 분석하였다. 이들 중 33명의 환자와 나이, 성별, 평균 혈압을 짝짓기한 원발성 고혈압 환자 66명을 임상적 특성 및 표적 장기 손상 빈도에 대해 비교하였다. 나이, 성별, 평균 혈압을 짝짓기한 원발성 고혈압 환자를 찾을 수 없는 8명의 원발성 알도스테론증 환자는 비교대상에서 제외되었다. 결과: 허혈성 심질환의 과거력을 가진 환자는 원발성 알도스테론증 환자군에서는 6명, 본태성 고혈압 환자군에서는 7명이었다(18.2% 대 10.6%; odds ratio 1.8; 95% CI 0.6 ~6.1, P = 0.22). 심초음파로 진단된 좌심실비대는 원발성 알도스테론증 환자군에서는 14명, 본태성 고혈압 환자군에서는 27명이었다(93.3% 대 61.4%; OR 8.8; 95% CI 1.06 ~73.2). 좌심실비대의 정도는 혈장 알도스테론 수치와 통계적으로 유의한 양의 상관관계를 보였다(r = 0.490). 뇌경색의 과거력을 가진 사람은 원발성 알도스테론증 환자군에서는 6명, 본태성 고혈압 환자군에서는 1명으로 원발성 알도스테론증 환자군에서 통계적으로 유의하게 더 높은 빈도를 나타내었다(18.2% 대 1.5%; odds ratio 14.4; 95% CI 1.65~127.5). 고혈압성 망막질환이나 신질환도 통계적으로 유의하지는 않았으나 각각의 위험도가 2.0, 2.1로 원발성 알도스테론증 환자군에서 더 높은 빈도를 나타내는 경향성을 보였다.

상향비교가 SNS 중독경향성에 미치는 영향과 소외에 대한 두려움(FoMO)의 매개효과: 개방형 SNS와 폐쇄형 SNS의 차이를 중심으로

박주리,이주영 한국정서행동장애학회 2022 정서ㆍ행동장애연구 Vol.38 No.4

본 연구는 SNS를 사용하는 성인을 대상으로 개방형 SNS 집단과 폐쇄형 SNS 집단을 구분한 후 상향비교가 SNS 중독경향성에 미치는 영향을 확인하고 둘 간의 관계에서 소외에 대한 두려움(FoMO)의 매개효과를 검증하고자 하였다. 이를 위해 SNS를 가장 많이 사용하는 계층인 20대와 30대 322명(남 117명, 여 205명)에게 상향비교, FoMO, SNS 중독경향성 척도를 사용하여 온라인 설문조사를 실시하였다. 분석 결과는 다음과 같다. 첫째, 개방형 SNS 집단과 폐쇄형 SNS 집단에서 상향비교, FoMO, SNS 중독경향성 간에 유의한 정적 상관이 나타났다. 둘째, 개방형 SNS 집단과 폐쇄형 SNS 집단을 비교했을 때, 개방형 집단이 SNS 중독경향성에서 유의하게 높은 수준을 보였다. 셋째, 상향비교, FoMO, SNS 중독경향성에서 여성이 남성에 비해 유의하게 높은 수준을 보였다. 넷째, 구조방정식 모형 검증에서 두 집단 모두에서 상향비교가 SNS 중독경향성에 미치는 영향이 유의함을 확인하였고, 이 관계에서 FoMO가 완전 매개함을 확인하였다. 본 연구결과는 상향비교 경향이 소외에 대한 두려움(FoMO)을 강화시켜 SNS 중독경향성을 높인다는 것을 보여준다. 이러한 결과는 SNS 중독으로 인한 문제에서 상향비교와 FoMO에 대한 개입이 필요함을 시사하며, 특히 개방형 SNS 집단과 여성이 SNS 중독경향성 문제에 취약함을 보여준다.

아동 실행 기능(executive function) 결함에 대한 연구 현황 및 향후 방향 제시

박주리,송현주 서울여자대학교 특수치료전문대학원 2009 심리치료: 다학제적 접근 Vol.9 No.2

Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

박주리,이민정,안국영,윤태훈,최인성,이은성,이현숙,최성욱 한국고분자학회 2019 Macromolecular Research Vol.27 No.9

This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing.

포스터발표 : 근시안에서 안경과 소프트콘택트렌즈 착용 시 입체시력의 변화

박주리,이병용,최진영,김현정 한국안광학회 2008 논문집 Vol.2008 No.1

학령기부터 성인기에 이르기까지 장애인 문화예술교육 운영 실태와 방법 및 요구

박주리,정진숙,김두영 한국예술교육학회 2024 예술교육연구 Vol.22 No.2

이 연구는 학령기부터 성인기에 이르기까지 장애인 문화예술교육 프로그램 운영 실태와 방법, 운영을 방해하는 요인, 그리고 지원 요구를 파악하는 데 목적이 있다. 연구를 위해 특수학교(급) 교사 48명과 장애인복지관 문화예술교육 담당자 92명의 설문조사 응답 자료를 분석하였으며, 연구의 주요 결과는 다음과 같다. 첫째, 장애인복지관과 비교해 특수학교(급)에서 운영한 문화예술교육은 음악과 미술 프로그램 편중 현상이 매우 두드러졌다. 둘째, 특수학교(급) 교사와 장애인복지관 문화예술교육 담당자 모두 이용인 요구조사를 근거로 프로그램을 자체 기획했고, 기관 이용인을 대상으로 내부 홍보하여 학습자를 모집했으며, 프로그램 운영 전문성을 고려하여 강사를 섭외했고, 평가 결과를 주로 내부 보고 자료로 활용했다. 하지만 특수학교(급) 교사는 기관의경영방침을 수행하기 위하여 프로그램을 운영한 반면, 장애인복지관 담당자는 기관 이용인의 요구가 있어서프로그램을 운영했고, 특수학교(급) 교사는 학생의 장애 정도나 유형을 고려하여 참여자를 모집한 반면, 장애인복지관 담당자는 학습자의 참여 의지와 욕구를 고려하여 참여자를 모집하는 등 항목에 따라 차이를 보였다. 셋째, 특수학교(급) 교사와 장애인복지관 담당자 모두 강사 모집이나 프로그램 운영 지원 부족으로 인해 문화예술교육 프로그램을 운영하는 데 어려움을 겪고 있었고, 향후 장애인 문화예술교육 발전을 위해 프로그램 운영비 지원, 문화예술 강사 관련 정보 제공, 강사의 장애 이해 및 장애인식 개선 연수 제공, 학습자의 프로그램참여 비용 지원과 미참여 학습자를 위한 프로그램 홍보를 강하게 요구했다. The objective of this study lies in identifying operation statues and ways to run culture and art ed ucational programs for people with disabilities spanning teenage students to adults, factors hindering the implementation of programs, and support requests. For this research, this study analyzed survey response sheets collected from 48 teachers in special schools or classes and 92 workers handling cul ture and art education at welfare centers for people with disabilities. Key findings found in this study are shown as follows. First, it was markedly seen that culture and arts education programs run by spe cial schools or classes were more heavily focused on music and arts programs in comparison with those provided by welfare centers for people with disabilities. Second, both groups of participants de signed their own programs based on investigations requested by users, invited learners by informing programs to center users, hired instructors based on professional capabilities of operating programs, and used evaluation results as internal reporting data. One difference is that teachers launched pro grams with an aim to carry out management guidances issued by centers, while welfare center workers ran programs as center users made requests. Another difference is that teachers attracted participants in consideration of degree of type of disability students have, while workers selected participants ac cording to learner’s will to join and desire. The difference was noted according to categories. Third, both groups are experiencing challenges in operating culture and art educational programs due to lack of assistance for hiring instructore or running programs. In this respect, they strongly demanded fund ing support for educational programs, providing information on culture and art instructore, offering training sessions for helping instructors to understand and know disabilities, funding support to help learners to make available programs, and make programs widely known to non-participating learners.

항Ro/SSA, 항La/SSB 항체 양성인 Cogan’s Syndrome 1예

박주리,노영희,최성재,임기정,장학현,이영호,지종대,송관규 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1

Cogan's syndrome is a rare chronic inflammatory disease of unknown origin, characterized by nonsyphilitic interstitial keratitis, vestibuloauditory dysfunction and vasculitis. Cogan's syndrome is uncommon and few cases have been published. A case of Cogan's syndrome in a patient with anti-Ro and anti-La positivity is described. A 24-year-old woman visited to department of rheumatology with dry mouth, dry eye, and vertigo on August 2004, and interstitial keratitis had developed on October 2004. She was admitted to the otolaryngology department with rapidly progressive hearing loss on December 2004. The patient's audiogram revealed severe sensorineural deafness. The patient was treated with systemic corticosteroid and methotrexate. This case is the first to report a case of Cogan's syndrome associated with anti-Ro and anti-La positivity.

아동용 실행 기능(Executive Function) 결함 질문지 개발 및 타당화 연구

박주리,송현주 한국임상심리학회 2012 Korean Journal of Clinical Psychology Vol.31 No.1

The purpose of this study was to develop a Children's Executive Function Deficits Inventory(CEFDI), and examine its reliability and validity. In the first part of the study, the factors of CEFDI were categorized based on a review of both the literature and a number of existing inventories, and then CEFDI was developed through content and face validity. The CEFDI was then conducted for 1022 students in fourth, fifth, and sixth grades at four elementary schools in Seoul and Gyeonggi-do, Republic of Korea, the inventories of 931 of these children were subsequently analyzed. The item validity of CEFDI was proved by exploratory and confirmatory factor analyses. In the second part of the study, the internal consistency reliability and concurrent validity were analyzed. In order to verify convergent validity, self-report scales, such as ‘Self Regulation Scale, Barratt Impulsiveness Scale Ⅱ, and ADHD Children's Scale’, and neuropsychological tests, such as ‘Tower of Hanoi Test, Stroop Color and Word Test, Children's Color Trails Test, and Digit Span’, were executed. Subjects for the second part of the study included 159 students in fourth, fifth, and sixth grades in elementary school in Seoul. The CEFDI consisted of 29 questions and was confirmed to be a reliable and valid assessment tool to measure executive function deficits in children.

Core-Shell Microcapsules Using Coacervation in a Fluidic Device

박주리,최성욱 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

2-Octyldodecanol(ODD) has been encapsulated using complex coacervation of biopolymers, gelatin and gum arabic. Gelatin-gum arabic microcapsules have been formed through direct homogenization which generally have a non-uniform size, low encapsulation efficiency. These drawbacks led to controlling the structure of microcapsules difficult, which remains unsolved. Herein, we introduce fluidic device process with triple nozzles. Uniform sized gelatin-gum arabic capsules with one core-one shell were fabricated in oil-in-water-in-oil (O-W-O) double emulsion system. With presented system, size of O-W-O emulsion, diameter of core, and thickness of shell can be controlled with adjusting middle phase flowrate.

Communicating with Study Abroad Generation

박주리(Park Joori),전지현(Jeon Jihyeon) 한국사회언어학회 2013 사회언어학 Vol.21 No.2

As the yearning for global competence including English communication ability increases, more and more school aged Korean kids have sojourned to overseas to pursue education. Yet, despite the growing number of study abroad students, little research has been conducted on Korean study abroad returnees. Some Korean people think the Korean returnees from oversea stays are different from domestic Korean people in the way they act and communicate. On the other hand, many Korean returnees find adjusting back to Korea more difficult than adjusting to the host culture abroad. In fact, due to lack of understanding on the returnees, returnees are often not fully valued and utilized at Korean organizations. The goal of this study is to learn about the Korean returnees' reentry experiences using critical incident technique. The study also seeks for reentry adjustment strategies and companies' supports to relieve reentry shock. Twenty-five participants who currently work for various organizations in Korea and have studied abroad in English speaking countries for more than five years shared their experiences through face-to-face or online chatting interviews. The findings show the challenges of coming home and underscore the importance of developing and implementing reentry preparation and support programs to facilitate returnees' readjustment to the Korean living and professional environment. Understanding returnees' reentry shock and transition will promote better communication with study abroad generation. (244)