정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

기판 부근의 자기장이 RF 스퍼터링법으로 증착된 ITO 박막의 특성에 미치는 영향

김현수,장호원,강종윤,김진상,윤석진,김창교,Kim, Hyun-Soo,Jang, Ho-Won,Kang, Jong-Yoon,Kim, Jin-Sang,Yoon, Suk-Jin,Kim, Chang-Kyo 한국전기전자재료학회 2012 전기전자재료학회논문지 Vol.25 No.7

Indium tin oxide (ITO) films were prepared using radio frequency (RF) magnetron sputtering method, magnets were equipped near the target in the sputter to bring the plasma near the target. The effect of magnetic field that brings the plasma near the substrate was compared with that of substrate heating. The effect of substrate heating on the grain size of the ITO thin film was larger than that of the magnetic field. However, the grain size of the ITO thin film was larger when the magnetic field was applied near the substrate during the sputtering process than when the substrate was not heated and the magnetic field was not applied. If stronger magnetic field is applied near the substrate during sputtering, it can be expected that the ITO thin film with good electrical conductivity and high transparency is obtained at low substrate temperature. When magnetic field of 90 Gauss was applied near the substrate during sputtering, the mobility of the ITO thin film increased from 15.2 $cm^2/V.s$ to 23.3 $cm^2/V.s$, whereas the sheet resistivity decreased from 7.68 ${\Omega}{\cdot}cm$ to 5.11 ${\Omega}{\cdot}cm$.

리튬2차전지용 LiCoO₂/LiNi_1/3Mn_1/3Co_1/3O₂계 복합정극의 전기화학적 특성 연구

김현수,김성일,엄승욱,김우성,Kim Hyun-Soo,Kim Sung-Il,Eom Seung-Wook,Kim Woo-Seong 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.1

In this study, the $LiCoO_2/LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ mixed cathode electrodes were prepared and their electrochemical performances were measured in a high cut-off voltage. As the content of $LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ increased in a mixed cathode, the reversible specific capacity and cycleability of the electrode enhanced, but the rate capability was deteriorated. On the contrary the rate capability of the cathode enhanced, but the reversible specific capacity and cycleability were deteriorated, increasing the content of $LiCoO_2$ in the mixed cathode. The cell of $LiCoO_2/LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ ($50:50 wt\%$) mixed cathode delivered a discharge capacity of ca. 168 mAh/g at a 0.2 C rate. The capacity of the cell decreased with the current rate and a useful capacity of ca. 152 mAh/g was obtained at a 2.0 C rate. However, the cell showed very stable cycleability: the discharge capacity of the cell after 20th charge/discharge cycling maintains ca. 163 mAh/g.

자동변속기 이너레이스 스플라인 치형의 정밀열간단조 공정에 관한 연구

김현수,이정환,김현필,김용조,강성훈,Kim, Hyun-Soo,Lee, Jung-Hwan,Kim, Hyun-Pil,Kim, Yong-Jo,Kang, Seong-Hoon 한국금형공학회 2012 한국금형공학회지 Vol.6 No.2

In this study, the hot forging technology for precision forming of spline teeth of the inner race in the auto-transmission was developed in order to minimize its finishing allowance. Several blocker and finisher shapes for the precision hot forging process of the inner race were proposed and the forging processes were analyzed using the three-dimensional finite element method. The optimum hot forging process was obtained considering some parameters such as metal flow patterns, forging defects and forming load. Blocker and finisher dies for the hot forging process were designed by selecting the most suitable shapes obtained from the finite element analysis. Experimental works were also performed in order to verify the optimum design of hot forging process.

Rat periodontal ligament cell에서의 RANKL mRNA의 발현

김현수,정현주,김영준,김옥수,Kim, Hyun-Soo,Chung, Hyun-Ju,Kim, Young-Joon,Kim, Ok-Su 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.2

As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor $^{\kappa}B$ ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease. This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1 ${\beta}in$ the concentration of $0.01{\sim}10$ ng/ml. The results are as follows; 1. Periodontal ligament cells which stimulated by 1L-1 ${\beta}$ increased soluble RANKL synthesis by dose-dependent pattern in the concentration of $0.01{\sim}10$ ng/ml. 2. 1L-1 ${\beta}$ induced mRANKL expression in dose-dependent manner in the concentration of $0.01{\sim}5$ ng/ml. 3. mOPG expression was not to be influenced by 1L-1 ${\beta}$. These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.

Poly-TPD/PVK 이중 박막 정공수송층 구조의 양자점발광다이오드

김현수,이도형,김바다,황보람,김창교,Kim, Hyun Soo,Lee, Do Hyung,Kim, Bada,Hwang, Bo Ram,Kim, Chang Kyo 한국전기전자재료학회 2019 전기전자재료학회논문지 Vol.32 No.5

A poly[bis(4-butypheny)-bis(phenyl)benzidine] (poly-TPD) and poly(9-vinylcarbazole) (PVK) bilayer was employed as a hole transport layer (HTL) in solution-processed CdSe/ZnS quantum dot light-emitting diodes (QLEDs). The thickness of the PVK layer spin-coated onto the poly-TPD layer, whose thickness was fixed to 40 nm, was varied, with PVK layer thicknesses of 0 nm, 35 nm, 45 nm, and 55 nm. Because the thickness of the PVK can determine the hole transport properties of the HTL, a PVK thickness that maximizes the performance of the HTL for the QLEDs was investigated. By employing the optimized PVK thickness of 45 nm, the current efficiency of the QLED exhibited a 1.74 times improvement when compared with that of the QLED with poly-TPD based HTL without PVK. This was mainly attributed to the decrease in the energy barrier between the HTL and the quantum dot (QD) emitting layer (EML).

CVT의 변속제어

김현수,김광원,김성호,성덕환,은탁,박성현,양진승,권혁빈,Kim, Hyun-Soo,Kim, Kwang-Won,Kim, Sung-Ho,Sung, Duk-Hwan,Eun, Tak,Park, Seong-Hyon,Yang, Jin-Seung,Kwon, Hyuk-Bin 대한기계학회 1993 大韓機械學會誌 Vol.33 No.10

환경오염과 차량 성능향상에 따라서 날로 강화되는 연비규제는 차량용 변속기로서 CVT 양상 보급에 대한 필요를 앞당기고 있다. CVT는 소형차를 중심으로 일부 자동차 에이커에 의해 이미 실용화되어 있으며 일본 및 구미 자동차 각 사는 CVT에 대한 자체기술을 보유하고 경쟁성 있 는 완성품 개발을 위하여 총력을 기울이고 있는 실정이다. CVT에 대한 연구개발의 추세는 동 력전달 구동요소의 특성에 따라 벨트식과 토로이달 (Torodial)식으로 구분할 수 있으며 대부분의 경우 현재 일부 실용화 개발된 벨트식 CVT가 기술완성도가 높은 반면 토로이달롤러의 각도를 연속적으로 변환시킴으로써 무단변속을 이루는 토로이달 방식은 2000년대 이후에 양산을 목표로 일본 및 영국 등에서 개발 진행주이나 새로운 재질과 제어기술개발 등의 숙제를 안고 있다. 벨 트식의 경우 금속벨트는 지난 십 수년이상 시행착오를 겪으며 CVT용으로 개발된 전문업체의 제품이 이미 특허화되어 있기 때문에 자동차 각사는 벨트와 같은 구동요소보다는 CVT 메카니즘 설계 및 제어시스템 개발에 기술력을 투입하고 있다. 따라서 국내 CVT 개발도 이와 같은 추세를 따를 것으로 기대되고 있으나 AT와 같은 완성품으로서의 상품가치를 갖기 위하여는 CVT에 대한 보다 많은 연구개발이 필요하다고 생각된다.

頭蓋骨骨幹端不全形成症

김현수(Kim Hyung Soo),강신혁(Kang Shin Hyuk),이석현(Lee Suck Hyun),유명철(Yoo Myung Chul) 대한정형외과학회 1976 대한정형외과학회지 Vol.11 No.4

한국인 구강암 환자에서 인유두종 바이러스의 발현율 분석

김현수,서미현,김성민,조영아,이석근,이종호,명훈,Kim, Hyun Soo,Seo, Mi Hyun,Kim, Soung Min,Cho, Young Ah,Lee, Suk Keun,Lee, Jong Ho,Myoung, Hoon 대한악안면성형재건외과학회 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.4

Purpose: High risk human papillomavirus (HPV) is the main source of cervical cancer, nearly up to 100%. Because there are no affordable data regarding the incidence of HPV in different sites of oral cavity, the purpose of this study is to review the previous article and to find out about the incidence and types of HPV in specific areas of oral cavity. Methods: We examined a total of 106 patients with oral cavity cancer for HPV detection. Available DNA chip (MY-HPV chip kit$^{(R)}$, Mygene Co., Korea) was used for the detection of low risk HPV types (6, 11, 34, 40, 42, 43, 44) and high risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 54, 56, 58). Patients were previously diagnosed as invasive cancer of oral cavity. Specimen used for HPV detection was extracted from the main mass during resection and were tested for HPV type, performed by a DNA chip method. Results: Histologic results showed that there were squamous cell carcinomas, mucoepidermoid carcinomas, cystadenocarcinomas, leiomyosarcoma and etc. Among HPV positive cancer, 2 patients showed positive for high risk HPV type 16, 3 patients showed positive for low risk HPV type 6 and the other 2 patients were positive for other types of HPV. Of the 7 patients with HPV positive, 4 patients were on the tongue, 3 on the lower gingiva. Conclusion: Most of the HPV positive cancers were on the tongue in our study. Cervical cancer of HPV infection is reported to be increasing in our society and because HPV infection largely spreads by sexual contact, the incidence of oral cancer with HPV infection is greatly assumed to be on the increase, simultaneously. Because the incidence of HPV on specific areas of oral cavity among oral cancer patients is not identified, more studies are ongoing.

Giant Cell Tumor of the Rib: A Case Report and Review of the Literature

김현수,김대현,임성직,박용구,Kim, Hyun-Soo,Kim, Dae-Hyun,Lim, Sung-Jig,Park, Yong-Koo The Korean Musculoskeletal Tumor Society 2009 대한골관절종양학회지 Vol.15 No.1

거대세포종은 늑골에서 드물게 발생할 수 있으며, 후중격에서 발생한 종괴로 나타난 늑골의 거대세포종은 지금까지 4 예가 보고되었다. 38세 남자의 늑골에서 발생하여 후중격 종괴로 보인 거대세포종 1 예를 문헌 고찰과 함께 보고한다. 흉부 전산화 단층 촬영에서 우측 후상부 중격의 대부분을 차지하는, 경계가 명확한 다분엽성의 종괴가 우측 3번 늑골과 흉추를 침범하고 있었다. 임상적으로는 후중격에서 발생한 신경절신경종 혹은 그와 동반된 악성 변화를 의심하였다. 그러나 육안적으로 종괴는 우측 3번 늑골에서 발생하여 늑골 바깥쪽으로 성장하는 모습을 보였고, 현미경적으로 균일하게 산재된 다핵 거대 세포와 단핵 기질 세포로 구성되어 있어 늑골에서 발생한 거대세포종에 합당하였다. 거대세포종의 치료를 위해서는 재발과 전이의 가능성을 고려하여 광범위한 수술적 절제와 술후 방사선 치료를 고려해야 한다. 후중격 신경절신경종은 수술적 절제만으로 치료가 가능한 종양이므로, 거대세포종과 반드시 감별해야 한다. Giant cell tumor (GCT) of the rib may present as a posterior mediastinal mass when it involves the posterior arc. Only 4 cases of GCT of the rib presenting as a posterior mediastinal mass have been reported. We report a case of a 38-year-old man with GCT of the rib. Computed tomography revealed a well-defined, multi-lobulated, heterogeneous mass in the right superoposterior mediastinum, which appeared to invade the right third rib and thoracic vertebra. It was thought to be a posterior mediastinal ganglioneuroma or its malignant transformation. Grossly, the tumor mass arose in the posterior arc and showed substantial growth out of the rib. Microscopically, the tumor consisted of interspersed multi-nucleated giant cells and stromal mononuclear cells, compatible with GCT. For GCT, a wide excision with elective radiotherapy should be considered. GCT must be differentiated from posterior mediastinal ganglioneuroma that can be treated by surgical excision alone.