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이석근,권영수 한국부동산경영학회 2012 부동산경영 Vol.6 No.-
According to the fifth clause of Article 91 of Civil Execution Act, although it practically takes on abernahmeprinzip that forces a purchaser of real estate auctions (successful bidder) to reimburse receivables collateralized as a lien with respect to a real estate lien, a rightful person is not legally obliged to report a lien in auction procedures and the auction court is not responsible for definite title examination, solely notifying a purchase candidate of legal relationships such as whether or not a lien is valid by record with ambiguous not indisputable expression. The responsibility on this is completely imposed on a purchaser. Further, different from other rights over real estate that take registration as a method of public notice, a lien is valid with lawful occupation (Civil Law the second clause of Article 320) without registration, which is subject to conflict with a lien and other rights. In Civil Execution Act, if a false or exaggerated lien is reported by abusing the problem in a real estate auction with a collusion of debtor, owner, and lien holder, a rightful person in a prior-order security right is subject to infringement by a lowered winning bid and a status of a purchaser of real estate auctions (successful bidder) noticeably is not secured. For this, along with genuine protection of lien holder and prevention of false, exaggerated report of a lien, auction participants should be able to check in advance whether or not a lien is true. To achieve this, required is to introduce a lien registration order system similar to the lease registration order system of housing (shop) leaseholder in Special Civil Law. Required is also to secure a status of a rightful person such as a person holding a security right and a purchaser by enabling a lien holder to access to material, along with making public the court's screening, when a lien holder applies for his or her right. If a valid part on a lien can be definitized and also title examination on the sale property can be settled in concrete through an enhanced lien holder legal status on real estate and relevant improvement schemes, a transparent real estate auction market will be set up which prevents delayed real estate procedures and possible disputes later on in advance.
사람의 침샘에서 발현하는 새로운 유전자의 분리 및 동정
이석근,김연숙 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.4
In order to unravel unidentified genes from human salivary gland, a cDNA library of human submandibular gland was constructed in the Uni‐ZAP XR vector by use of mRNA from human submandibular gland and ZAP‐cDNA® Gigapack® III Gold Cloning Kit. cDNA of salivary gland was subtracted with cDNA of immortalized human keratinocyte cell line, Rhim Human Epithelial Keratinocyte cell line. The phage cDNA library was converted into a pBluescript phagemid cDNA library, which was subsequently plated on LB plates with ampicillin, IPTG, and X‐gal, and white colonies were selected for sequencing. Among 200 clones analyzed, four clones containing C77‐091, C75‐014, C76‐022, and C76‐012 designated orphan genes that are intensely expressed in the interlobular ductal and serous acinar cells of human submandibular gland. Particularly C77‐091 gene expresses 46 amino acids peptide (pI=9.45). C75‐014 and C76‐022 genes were characterized as those expressing excretory basic proteins primarily consist of alanine, proline, and leucine residues, mimicking a basic proline‐rich protein (bPRP) showing helical structures and having multiple consensus sequences of phosphorylation sites. The strong expression of C76‐012 mRNA in the nuclei of salivary ductal and acinar cells suggests a role of C76‐012 gene as a DNA binding RNA/protein. These data suggest that the identification of four orphan genes from the human salivary glands may add further understanding of greater role of salivary proteins providing innate immunity by protecting and stabilizing the mucosal epithelium in the maintaining homeostasis of oral mucosa.
이석근,김연숙 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.3
Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke’s pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.
소석회를 채움재로서 사용한 배수성 혼합물의 박리저항성에 관한 연구
이석근,이철희 경희대학교 산학협력기술연구원 2005 산학협력기술연구논문집 Vol.11 No.4
This study which using the hydrated lime as mineral filler in the porous asphalt mixtures is performed to prevent the stripping which is a big problem in porous asphalt mixtures. For this study, the modified asphalt binder{PMA) which has high viscosity with SBS was compared with conventional porous asphalt mixtures. Then the moisture susceptibility of the porous asphalt mixtures. Was evaluated. Marshall stability test, indirect tensile test, and creep test are performed to evaluate the mechanical characteristics of the porous asphalt mixtures using hydrated lime as a mineral filler.
Pathological Findings for Mucous Retention Cyst in Maxillary Sinus
이석근,김연숙,안기용 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.1
Mucous retention cyst (MRC) is not uncommon in the pathology of maxillary sinus, which should be differentially diagnosed from chronic maxillary sinusitis. The main stream of diagnosis usually depends on the clinical symptoms and radiological findings. Thus it was sometimes puzzling to confirm the histological features of mucous retention phenomenon in the antral mucosa, when the specimen was from a limited portion or much degenerated by inflammatory reaction. This study aims to define the histopathological features of MRC through reevaluation of MRCs (n=19) and maxillary sinusitis (n=65) diagnosed previously. The present study classified three types of MRC, i.e., an extravasation type, a luminal retention type, and a mixed type of MRC. The extravasation type MRC showed clear pseudocyst cavity under sinus mucosa with infiltration of foamy macrophage, and the luminal retention type MRC showed mucous retention in the luminal cavity of maxillary sinus accompanied with inflammatory reaction, and the mixed type MRC showed the both features of extravasation and luminal retention type MRCs. Resultantly, among nineteen cases of MRC only three cases belonged to the extravasation type MRC, eleven cases belonged to luminal retention type MRC, and three cases belonged to mixed type MRC, while two cases were turned out to be postoperative residual cysts of maxillary sinus. The MRCs examined in this study showed different pathological features from ordinary maxillary sinusitis, exhibiting the typical mucin retention phenomenon of extravasation type or luminal retention type with relatively mild inflammatory reaction with infiltration of mucin-pooled macrophages. However, the luminal retention type MRC was predominant among the MRCs (11/17, 64.7%) and each of the extravasation and mixed type MRCs was only three cases out of 17 MRCs (17.6%). The extravasation type MRC characteristically produces a pseudocyst by the overexpressions of matrix metalloprotease-3 (MMP-3) and connective tissue growth factor (CTGF). Because not only the pathogenetic mechanism but also the prognosis of MRC is different from chronic maxillary sinusitis, we suggest that the MRC of maxillary sinus should be classified into extravasation, luminal retention, and mixed types in the histological observations in addition to the clinical and radiological informations.