반응성 산소 대사물에 의한 지질과산화에 Harmaline과 Harmalol의 효과

신용규,강호만,이무훈 공군본부 의무감실 1992 항공의학 Vol.40 No.1-2

감압증과 과폐압 사고

신용규,이상준,박영민,이인기 공군본부 의무감실 1991 항공의학 Vol.39 No.1-2

물리화학적 영향에 의한 백서 대뇌피질 Mitochondria Monoamine Oxidase활성도의 변경

김영준,신용규,이정수 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.3

Various factors influencing monoamine oxidase activities of mitochondria obtained from rat cerebral cortex were investigated. These factors included pH and temperature of incubation media, anions, divalent cations, hydrogen peroxide, sulfhydryl inhibitor, compounds containing SH groups and sonication. With kynuramine, the maximum MAO activity was observed at the concentration of 0.1mM and increasing the concentratin beyond 0.1mM was accompained by a decrease in the enzyme activitv. The MAO activity -was considerably altered by change of the pH of the incubation medium and the maximum value was observed at pH 8.0. MAO was resistant to temperature of incubation medium and the activity was not significantly affected at the temperature range of 0˚C -37˚C, but thereafter the activity was decreased with temperature, Among anions and cations tested, sulfite ion, Ag^++, Cu^++ and Cd^++ markedly inhibited MAO activity. Specific inhibitors for SH group such as, HgCl_2, PCMB and PCMBSA significantly inhibited MAO activity. Inhibitory action of Hg^++ was reverse by cysteine, GSH and MPG. Hydrogen peroxide weakly inhibited the MAO activity. MAO activity was decreased by sonication. The results suggest that factors influencing the cellular environment can alter MAO activity.

전십자인대 재건에서 경골측 고정에 대한 생역학적 비교 연구

송은규,이영근,김병수,신상규 全南大醫大 2000 전남의대학술지 Vol.36 No.4

입원한 정신분열병 환자의 가족에 대한 가족교육 단기 프로그램의 효과

이부영,신민섭,하규섭,권준수,손정우 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

정신분열병 환자의 가족은 많은 심리적 스트레스와 부담감을 지니고 생활하게 된다. 또한 환자와 그 가족 사이에 마찰이 생겨 결국 환자의 예후에 좋지 않은 영향을 끼치기도 한다. 이런 것들을 해결하기 위한 여러 정신과적 중재방법들 중 정신교육적 가족치료의 일환으로서 가족 교육 단기 프로그램의 유용성이 점점 부각되고 있다. 이에 우선 가족 교육 연구진을 구성하고 교육자료를 준비한 뒤, 1995년 9월 2일부터 입원한 정신분열병 환자의 가족을 대상으로 가족교육을 시행하였으며 교육적·후에 설문지 평가를 하였다. 이때 평가한 것은 일상생활에서의 가족의 전반적인 불안, 환자와 연관된 걱정, 환자에 대한 가족의 거부감, 정신분열병에 대한 전반적 지식 등이다(N=20). 또 대조군은 1996년 1월부터 5월까지 서울대학병원 신경정신과 폐쇄병동에 입원한 정신분열병 환자 가족을 대상으로 하였으며, 같은 종류의 설문지로 사전·사후평가를 하였다(N=10). 결과는 다음과 같다. 1) 교육군과 대조군의 사전평가 점수를 각 설문지별로 비교하였는데, 불안 설문지, 지식 설문지의 점수에서는 두 군간의 차이가 발견되지 않았으나, 거부감 설문지의 점수는 교육군에서 대조군보다 통계적으로 유의하게 높았다(F=9.50, df=1.28, p<0.01). 2) 교육군과 대조군 각 군 내에서 사전·사후평가 점수를 비교하였을 때, 교육군에서는 지식 설문지에서 사후평가 점수가 사전평가 점수보다 유의하게 높았으며(t=5.43, df=19, p<0.01), 걱정 설문지와 거부감 설문지에서는 사후평가 점수가 사전평가 점수보다 유의하게 낮았다(걱정 설문지의 t=-3.03, df=19, p<0.01 ; 거부감 설문지의 t=-2.34 df=19, p<0.05). 그러나 교육군에서 불안 설문지의 점수에서는 별다른 차이가 나타나지 않았다. 한편 대조군에서도 지식 설문지에서 사후평가 점수가 사전평가 점수보다 유의하게 높았지만 (t=1.86, df=19, p<0.05), 교육군에 비해서 그 차이는 경미하였다. 3) 각 설문지의 사전·사후평가 점수의 차이의 상관관계를 측정한 결과 교육군에서는 우선 불안 점수의 차(r=-0.56, p<0.01)와 걱정 점수의 차(r=-0.57, p<0.01)가 지식 점수의 차와 유의한 부적 상관관계를 보였으며, 불안 점수의 차와 걱정 점수의 차 사이에는 유의한 정적 상관관계(r=0.55, p<0.01)가 보였다. 대조군에서는 걱정 점수의 차와 지식 점수의 차 사이에 유의한 부적 상관관계가 존재하였다(r=-0.60, p<0.05). 4) 각 설문지의 사전·사후평가 점수의 차와 사회인구학적 특성 사이의 상관관계를 조사한 결과 교육군에서는 불안 점수의 차와 환자의 유병기간(r=0.39, p<0.05), 불안 점수의 차와 참가 가족의 교육 수준(rs=0.43, p<0.05), 걱정 점수의 차와 환자의 유병기간(r=0.45, p<0.05), 걱정 점수의 차와 참가 가족의 교육 수준(rs=0.49, p<0.05) 사이에 통계적으로 유의한 정적 상관관계가 존재하였으며, 대조군에서는 걱정 점수의 차와 참가 가족의 나이 사이에 정적 상관관계(r=0.64, p<0.05)를, 그리고 걱정 점수의 차와 참가 가족의 교육 수준 사이에 부적 상관관계가 존재하였다(rs=-0.74, p<0.01). Objects : The purpose of this study was to investigate the effectiveness of the brief program of family education in helping families of inpatients with schizophrenia. Methods : The education group consisted of twenty people who were families of inpatients with schizophrenia and who attended the brief program of family education. Ten people who were families of inpatients with schizophrenia and who didn't attend the brief program of family education comprised the comparison group. Four self=report questionnaires assessing global anxiety(Anxiety Questionnaire), worry related to patient(Worry Questionnaire), rejection feeling to patient(Rejection Questionnaire), and knowledge about schizophrenia(Knowledge Questionnaire) were administered to the education group and to the comparison group, twice at the pre-test and post-test. Results : 1) In the education group, scores of Knowledge Questionnaire(t=5.43, df=19, p<0.01) at the post-test were significantly higher than those at the pre-test. Scores of Worry Questionnaire(t=-3.03, df=19, p<0.01) and Rejection Questionnaire t=-2.34 df=19, p<0.05) at the post-test were significantly lower than those at the pre-test. In comparison group, scores of Knowledge Questionnaire were significantly higher at the post-test compared to those at the pre-test(t=1.86, df=19, p<0.05). However, the change in comparison group was not as divergent as in the education group. 2) Differences between the pre-test scores and the post-test scores in each questionnaire were sought. In the education group, significant negative correlation existed between calculated differences of Knowledge Questionnaire and Anxiety Questionnaire(r=-0.56, p<0.01), between Knowledge Questionnaire and Worry Questionnaire(r=-0.57, p<0.01), and significant positive correlation existed between Anxiety Questionnaire and Worry Questionnaire(r=0.55, p<0.01). In the comparison group, significant negative correlation existed between Knowledge Questionnaire and Worry Questionnaire(r=-0.60, p<0.05). 3) The author also assessed the relationship between calculated differences of the pre-test scores from the post-test scores in each questionnaire and demographic characteristics. In the education group, significant positive correlation existed between calculated difference of Anxiety Questionnaire nd duration of illness(r=0.39, p<0.05), between Anxiety Questionnaire and educational level of family(rs=0.43, p<0.05), between Worry Questionnaire and duration of illness(r=0.49, p<0.05) and between Worry Questionnaire and educational level of family(rs=0.45, p<0.05). In control group, significant positive correlation existed between Worry Questionnaire and age of family(r=0.64, p<0.05) and significant negative correlation existed between Worry Questionnaire and educational level of family(rs=-0.74, p<0.01). Conclusion : The brief program of family education was effective in increasing knowledge about schizophrenia, decreasing of worry related to the patients and rejection feeling about the patients in families of inpatienis with schizophrenia.

중증 재생불량성 빈혈 환자의 동종골수이식 후에 병발한 간정맥폐색질환(Hepatic Veno-Occlusive Disease)의 임상 경과 및 혈액응고 인자들의 변화

이제환,이규형,최성준,민영주,김신,이정신,김상희,박찬정,지현숙,김우건 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

연구배경: 재생불량성 빈혈 경우에는 조혈모세포 이식 후 VOD의 발생에 관한 보고가 거의 없는 실정이다. 저자 등은 cyclophosphamide와 antithymocyte globulin으로 전처치 후에 동종골수이식을 시행한 재생불량성 빈혈 환자들을 대상으로 하여 VOD의 발생과 임상 양상, 혈액응고 인자들의 변화에 관하여 분석하여 보았다. 방법: 재생불량성 빈혈로 동종골수이식을 시행 받은 13예 환자를 대상으로 하였다. 임상적 기준에 따라 VOD를 진단하였으며 임상 경과에 따라서 경중을 분류하였다. Protein C, protein S, antithrombin Ⅲ, tPA, PAI-1 등의 혈액응고 인자들을 전처치 투여전, 골수 주입당일, 이식 후 제7, 14, 21일에 측정하였다. 결과: 7예(53.8%)에서 VOD가 발생하였으며, 경증 5예, 중등도 2예였다. VOD군에서 혈소판치가 20.000/㎕ 이상을 유지하는 데까지 걸리는 시간이 더 길었다(p=0.026). 또한 VOD군에서 적혈구 및 혈소판의 수혈 요구량이 각각 유의하게 많았다(p=0.025, 0.015). 혈액응고 인자들의 변화를 보면, 제 0일에 VOD군에서 PAI-1의 혈중 농도가 유의하게 더 높았다.(p=0.034). 결론: 재생불량성 빈혈환자에서도 조혈모세포 이식 후에 VOD의 높은 발생률을 관찰하였으며, 대부분이 경증이었다. VOD 환자에서의 혈액응고 인자들의 변화는 PAL-1이 VOD의 감별 진단을 위하여 이용될 수 있음을 시사하고 있다. Background: There are few reports about the occurrence of hepatic veno-occlusive disease(VOD) after bone marrow transplantation (BMT) for severe aplastic anemia (SAA). We analyzed the incidence and clinical outcomes of VOD and changes of coagulation factors in patients with SAA who were conditioned with cyclophosphamide plus ATG and underwent allogeneic BMT. Methods: Thirteen patients with SAA who underwent allogeneic BMT were included. A diagnosis of VOD was made according to clinical criteria, and severity of VOD was classified according to clinical course. Plasma levels of protein C, protein S, antithrombin Ⅲ, t-PA, and PAI-1 were determined before preparative chemotherapy, in the day of marrow infusion, and days 7, 14, and 21. Results: VOD occurred in 7/13(53.8%). Five were mild VOD and two were moderate VOD. Time to platelet ≥20,000/L was slower (p=0.026) and red cell and platelet transfusion requirements were higher (p=0.025,0.015) in patients with VOD . The mean plasma level of PAI-1 at 0 were higher in patients with VOD (p=0.034). Conclusion: We observed the high incidence of VOD after allogeneic BMT in patients with SAA. A majority of cases of VOD were mild. The changes of PAI-1 after BMT may be useful marker of hepatic VOD

Callus distraction method를 이용한 하악골 신장술 : 계단골절단술식의 적용

김명진,윤필영,신동준,김수경,김종원,김규식 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Since callus distraction technique was applied clinically for the correction of dentofacial deformity to the patients with hemifacial dysplasia by McCarthy in 1992, many surgeons have tried to apply this method to the maxillofacial region. But this technique has some drawbacks. One of the disadvantages of this technique is extensive scar formation in the facial area, which is a sequelae of extraoral approach for supraperiosteal dissection of the periosteum overlying the mandible. Recently, we have made an effort to perform this technique through intraoral approaches to prevent scar formation on the submandibular area and modified the design of the osteotomy, that is step osteotomy technique, to increase the raw bone surface on both osteotomized segments. The rationale for the application of this step osteotomy technique is to increase the amount of regeneracted bone and the length of distraction, to avoid damage of inferior alveolar neurovascular bundle, and to increase initial stability of the splitted segments. Step osteotomy procedure can be done with fine micro-osteotomy saw through subperiosteal tunneling. Extraoral pins should be inserted before making the osteotomy. Since 1974 we have applied this technique at 8 sites In 5 patients with mandibular deficiencies: 2 cases of hemifacial microsomia, 1 case of developmental facial asymmetry and 2 cases of mandibular bony defect. Mandibular elongation have been achieved from 12 to 20mm in length. 1 out of 8 site, we experienced non-union in the case of mandibular body defect. Some skeletal relapse and growth retardation phenomenon have been observed in some cases with the longest follow-up of 48 months.

傳門大學 海洋土木科 敎育課情 開發硏究

林秉龍,鄭營采,申文燮,李東周,張仁奎,金榮燮 군산대학교 1982 群山水産專門大學 硏究報告 Vol.16 No.1

To carry out the study on the curriculum development for the ocean civil department in junior college, we collected and analyzed data which are on the curriculum development or improvement of the inside and outside of the country. We also gathered the opinion through the inquiring paper investigation and the consultation to the industrial organization, concerned school and authorities during 6 months from May, 1981. In addition, we analyzed and compared the present curriculum of special civil and ocean civil department in junior college. On the basis of above methods, a result we made a model curriculum shown in Table 10. Under current trend and circumstances of the industrial society, the best way for the curriculum development is to make like the course curriculum. But, it is is difficult to make the course curriculums of the ocean cavil department at present. Because the ocean civil is a branch of general civil engineering, furthermore the oceanic industry of our country is not developed well. So, dividing the major subjects in four fields for operating the model curriculum flexibly with the characteristics of the community and college, we developed the suitable curriculum in junior college course, such as general basic field, special basic field related to the ocean, special basic field related to the general civil and application field. We also tried to entensify the subjects of general basic field, special basic field related to the ocean, and to simplify the number of subjects in the model curriculum. Of course we can't say this model curriculum is perfect. But we believe firmly that the results of this paper will be a help to another curriculum development or improvement study for the ocean civil department in junior college.

專門大學海洋土木科模型敎育課程 修正開發硏究

李東周,林秉龍,張仁奎,申文燮,金榮燮,朴昌圭,金康洙 군산대학교 1988 群山水産專門大學 硏究報告 Vol.22 No.1

This is a study to modify the curriculum of the ocean civil engineering department in junior college. We collected and analyzed data which are concerned on the curriculum development or improvement, the marine techniques and the ocean policy. And then we also gathered the opinions of the professors serving at the ocean civil engineering department by holding several conferences and investigated the opinions of the ocean civil engineers serving at the industrial organization by way of the inquring papers. In addition we collected the advices of educational specialists and ocean civil specialists by visiting personally. On the basis of above opinions we developed the jobs of graduates and made a model curriculum shown in Table 6. We tried to intensify the subjects of special basic field related to the ocean & civil engineering and the subjects of basic experiment & practise. The ocean observation practise was newly formed and the E. D. P.S was reinforced.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.