Association of 20 potential ATP2B1‐interacting genes with blood pressure in Koreans

Kyung‐Won Hong,Hyun‐Seok Jin,Ji‐Eun Lim,Bermseok Oh 한국유전학회 2011 Genes & Genomics Vol.33 No.3

Plasma membrane calcium‐transporting ATPase 1 (ATP2B1)is associated significantly with blood pressure in Caucasians and Asians. ATP2B1 regulates calcium homeostasis and belongs to the P‐type calcium pump family; several studies have identified diverse proteins that bind to ATP2B1. We hypothesized that ATP2B1 regulates blood pressure through ATP2B1‐interacting genes. To this end, 20 potential ATP2B1‐interacting genes were selected, 197 SNPs of which were analyzed for their association of systolic and diastolic blood pressure. These 20 genes were categorized into 2 groups: ATP2B1‐binding genes and ATP2B1‐cleaving calpain family members. Three ATP2B1‐binding genes (CALM1, NOS1, and PDLIM1)were associated with blood pressure, and a SNP in CALM1(rs2401887) generated the strongest association signal (beta=‐3.60±0.92, p=8.9×10^(‐5) for systolic blood pressure and beta=‐1.40±0.62, p=0.02 for diastolic blood pressure). Of the calpain family members, 3 genes (CAPN6, CAPN9, and CAPN10)were associated with blood pressure, and the CAPN10 SNP rs4676348 yielded the strongest association signal (beta=‐0.88±0.27, p=0.001 for systolic blood pressure and beta=‐0.58±0.18, p=0.015 for diastolic blood pressure). Further, the interaction of CALM1 to ATP2B1 was examined using the blood pressure of individuals who carried both variants of CALM1and ATP2B1 genes. Similarly the interaction of CAPN10 to ATP2B1 was also examined. The CALM1 variant (rs2401887)and CAPN10 variants (rs4676348) appear to decrease blood pressure further in addition to the decrease by the variant (rs17249754) of ATP2B1, which suggests that ATP2B1 might regulate blood pressure through the ATP2B1‐interacting genes CALM1 and CAPN10.

장애학생 관련 변인에 따른 비장애 학생의 통합태도 연구

오원석 ( Won Seok Oh ),남경숙 ( Kyung Sook Nam ),허명진 ( Myung Jin Huh ) 대구대학교 한국특수교육문제연구소 2006 특수교육저널 : 이론과 실천 Vol.7 No.3

The purpose of this study is to determine the attitudes for integration education and the intimacy with disabled students of Nondisabled students influenced by disabled students. For such purpose, 477 students of 15 classes from 5 elementary schools located in Daegu Metropolitan City were selected as the object of this study. Integrated Attitudes was measured through an investigation equipment by Oh Won-Seok and Seo-Yeong Ran which adapted and modified a testing document called Inclusion of Students who are Deaf or Hard of Hearing Inventory (ISDHH) invented by Hsin-Ling Hung(2005). The result indicated that the factors which influence the Attitudes of nondisabled students regarding integration with disabled students are the type of injury, the gender and the cleanness of the disabled student. The factors which do not influence the above are interests of the disabled student``s parents, economic level of the family and the learning ability of the disabled student.

난소 및 난소 종양 염전의 초음파 소견

오연희,이현경,이원재,이성우,박수성,윤혜원,임문환,심재철,김용탁,김성숙,김정란 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Acute torsion of the ovary and ovarian mass is a recognized surgical emergency, but rarely has the diagnosis been made preoperatively on the basis of imaging studies. The sonographic findings in 14 cases of surgically proven torsion of the ovary and ovarian mass are described. Mostly cystic ovarian mass, engorged vessel, dilated uterine tube, beak-like echo(torsion site), smooth mass wall thickening an free-fluid collection in cul-de-sac are described. More significant in terms of specificity were the demonstration in 6 cases(42.9%) of the smooth mass wall thickening and in 8 cases(57.1%) of a free fluid in the cul-de-sac. We report the sonographic findings of ovary and ovarian mass torsion that may suggest the preoperative diagnosis of this condition.

HRTF(머리저달함수)의 샘플링률 변환에 따른 입체음향 플레이어

오재경,이동재,임철수,최범석,이원돈 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 논문에서는 3D사운드 생성 기술 중 대표적인 방법인 원음에 HRTF(머리전달함수)를 콘볼루션(convolution하는 방식으로 음상정위 모듈을 구현하였으며 음장감을 부여하기 위하여 잔향(reverberation)효과를 추가하고 크로스토크 현상을 제거하기 위하여 트랜스오럴 필터를 추가하였다.본 논문에서는 sampling rate conversion을 사용하여 decimation과 interpolation을 수행하여 44.1KHz의 sampling rate로된 coefficient를 downsample하거나 upsample한 HRTR(머리전달함수)를 사용하여 콘볼루션(convolution)을 수행했다.본 논문에서는 3D사운드 생성과정에서 필요한 연산과정을 최소화하여 일반 PC의 computing power로도 sampling rate conversion된 데이터를 처리하여 줄 수 있는 알고리즘을 제시하고 구현하였다.

전계자격에 따른 Arac.acid박막의 전류특성

오재한,송진원,이경섭 東新大學校 1999 論文集 Vol.11 No.-

We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is 30[mN/m]. In processing of a device manufacture, we can see the process is good from the change of a surface pressure for organic thin films and transfer ratio of area per molecule. The structure of manufactured device is Au/arachidic acid/Al; the number of accumulated layers is 17, 19 and 21. Also, we then examined of the MIM device by means of Ⅰ-Ⅴ. Then Ⅰ-Ⅴcharacteristic of the device is measured from 0 to +2[V]. In the cyclicvoltammetry, stable up to 0.9[V] vs. Ag/AgCl. The insulation property of a thin film Is better as the distance between electrodes is larger.

한국인 성장기 아동에서 Angle씨 2급 1류 부정교합자의 골격 특징

경희문,권오원,김유경,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.3

This study was designed to investigate the difference of teeth and craniofacial complex between normal occlusion and Angle's Class II, div. 1 malocclusion in korean childern. The sample was divided into 2 groups, the 66 subjects with normal occlusion and 96 subjects with Angle's Class II, div.1 malocclusion in both sexes. The results obtained were as follows: 1. No significant differences were observed in ant. cranial base length & flexure(saddle angle) between normal occlusion & cranial Angle's Class II, div. 1 malocclusion group, but posterior cranial base length of Class II, div. 1 malocclusion group was larger than that of normal occlusion group. 2. No significant difference was observed in the anteroposterior position of Maxilla to cranial base between two groups, but mandibular position in Class II. div. 1 malocclusion was posterior and interior to that of normal occlusion. 3. The length of maxilla (ANS-PSN) was larger in Class II, div. 1 malocclusion than normal occlusion. The length of mandibular body(Go-Me) was nor differnet between Class II, div. 1 malocclusion and normal occlusion. 4. Maxillary incisor position of Class II, div. 1 malocclusion to cranial base was more protrusive than that of normal occlusion, but there was no difference in mandibular incisor position between two groups.

재구성 가능한 구조를 위한 HW/SW 분할 및 스케쥴링 알고리즘

오세준,김남섭,김진상,조원경 경희-다반 ASIC 설계교육센터 2002 경희-다반 ASIC센터 논문집 Vol.3 No.-

동적 재구성 가능한 하드웨어 구조를 포함하는 시스템은 실시간으로 알고리즘을 처리할 수 있도록 하드웨어 자원을 효과적으로 이용할 수 있어야 한다. 이런 시스템의 수행 성능은 기본적으로 HW/SW 분할 문제에 의존한다. 이 논문은 동적 재구성 가능한 하드웨어를 위한 새로운 HW/SW 분할 알고리즘을 제안했다. 알고리즘은 초기해 얻기 후 그 해를 다시 최적화하는 단계적인 접근방법이다. 알고리즘은 분할 과정에서 FPGA를 재구성하는 과정을 고려했고 이를 최적화하기 위해서 부분적인 재구성(partial reconfiguration) 방법과 prefetching 재구성 방법을 사용했다. 이 휴리스틱(heuristic) 알고리즘을 통하여 JPEG 부호화기가 다른 접근 방법에 비하여 최적의 수행 성능을 얻음을 보였다.

비장경색이 동반된 쯔쯔가무시병 1예

오종찬,이범주,장재현,원경준,박경희,김동민,박치영,정춘해 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Tsutsugamushi disease is an acute febrile illness caused by Orientie. tsutsugsmushi. It is characterized by fever, myalgia, lymphadenopathy, and rash. And it can be easily diagnosed by characteristic eschar and serologic testing. Nearly all of the patients with tsutsugamushi disease improve with antibiotics such as doxycycline. However, the fatality rate of untreated cases is seven to ten percent. Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, splenic torsion and septicemia. We experienced one case of tsutsugamushi disease with splenic infarction, which was improved after doxycycline treatment finished.

정보기술의 특성이 조직구성원의 저항에 미치는 영향에 관한 연구 : 사용자의 IT인지정도와 개인성향을 중심으로

오종석,김경원 釜山 大學校 經營 經濟 硏究所 2002 經營 經濟 硏究 Vol.21 No.1

정보기술 도입과 관련된 연구에 있어서 초기의 시스템설계나 시스템관리와 같은 기술적 측면에서 접근하였으나 최근 연구에서는 조직구조나 조직 행동적인 측면에서 접근하려는 시도가 많아지고 있다. 정보기술의 도입은 조직의 변화를 유발하며 조직구조의 변화는 조직구성원의 반발과 저항을 초래할 수 있기 때문에 본 연구를 통하여 정보기술의 도입과 저항과의 관계를 조직행동적 측면에서 고찰하고자 한다.

계장화충격시험에 의한 복합조직강의 파괴인성에 관한 연구

오세욱,유재환,박원조,이경봉 동아대학교 공과대학 부설 한국자원개발연구소 1989 硏究報告 Vol.13 No.1

The dynamic fracture toughness (K_(Id)) is measured using the precracked standard Charpy specimen with an instrumented impact machine. The value of K_(Id) is determined as a function of yield strength and microstructure, and correlations are established between K_(Id) and both energy of initial fracture and total energy of fracture. Since the K_(Id) values of the precracted impact specimens are in accordance with their theoretical ones, this test method is sufficiently practical.