교정치료와 관련된 치조골 높이 변화에 대한 연구

강경화,이흥수,태기출,김상철 원광대학교 생체재료·매식연구소 1997 원광생체재료·매식 Vol.6 No.2

급성 심근경색증을 동반한 혈전성 혈소판 감소성 자반증 1예

이태희,김진혁,김완중,박지영,강흥선,조정휘,김권삼,송정상,배종화 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

연세대학교 치과병원에 내원한 어린이에서의 영구치 맹출 시기 및 순서

강태성,최병재,권호근,손홍규,최형준 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

치아의 정확한 맹출 시기와 그 순서는 어린이의 발육 성숙도의 지표로서 소아치과 임상 및 예방 교정치료에 있어서 매우 중요하다. 이에 2001~2003년에 연세대학교 치과대학병원 소아치과에 내원한 어린이중 만 5세부터 만 14세까지의 남자 654명, 여자 542명, 총 1,196명의 자료를 수집하여 영구치의 맹출 시기 및 순서에 대한 연구 결과 다음과 같은 결론을 얻었다. 1. 상악 영구치의 맹출 시기는 중절치 남 만6.81세, 여 만6.78세, 측절치 남 만8.30세, 여 만7.98세, 견치 남 만10.28세, 여 만10.04세, 제1소구치 남 만9.74세, 여 만9.90세, 제2소구치 남 만10.87세, 여 만10.41세, 제1대구치 남 만6.25세, 여 만6.54세, 제2대구치 남 만12.21세, 여 만12.03세, 여 만12.03세였다. 2. 하악 영구치의 맹출 시기는 중절치 남 만6.00세, 여 만6.06세, 측절치 남 만6.99세, 여 만6.74세, 견치 남 만9.83세, 여 만9.17세, 제1소구치 남 만9.92세, 여 만9.75세, 제2소구치 남 만10.66세, 여 만10.39세, 제1대구치 남 만5.99세, 여 만5.75세, 제2대구치 남 만11.92세, 여 만12.17세였다. 3. 영구치의 맹출 순서는 상악에서 제1대구치, 중절치, 측절치, 제1소구치, 견치, 제2소구치, 제2대구치의 순이었고, 하악에서 제1대구치, 중절치, 측절치, 견치, 제1소구치, 제2소구치, 제2대구치의 순이었다. Accurate timing and sequence of eruption of permanent teeth are indicies of growth and essential for pediatric dentistry and pediatric clinical orthodontics. From the children brought to the Yonsei Dental Hospital during 2001 to 2003, 654 boys and 542 girls, ranging in age from five to fourteen years, were selected and analysed. The following was concluded. 1. Eruption time of maxillary teeth is 6.81 years in boys, 6.78 years in girls for central incisor, 8.30 years in boys, 7.98 years in girls for lateral incisor, 10.28 years in boys, 10.04years in girls for canine, 9.74 years in boys, 9.90 years in girls for first premolar, 10.87 years in boys, 10.41 years in girls for second premolar, 6.25 years in boys, 6.54 years in girls for first permanent molar, 12.21 years in boys, 12.03 years in girls for second permanent molar. 2. Eruption time of mandibular teeth is 6.00 years in boys, 6.06 years in girls for central incisor, 6.99 years in boys, 6.74 years in girls for lateral incisor, 9.83 years in boys, 9.17 years in girls for canine, 9.92 years in boys, 9.75 years in girls for first premolar, 10.66 years in boys, 10.39 years in girls for second premolar, 5.99 years in boys, 5.75 years in girls for first permanent molar, 11.92 years in boys, 12.17 years in girls for second permanent molar. 3. The following eruption sequence was observed: the first permanent molar erupted first, followed by the central incisor, the lateral incisor, the first premolar, the canine, the second premolar and the second permanent molar in the maxilla. The first permanent molar erupted first, followed by the central incisor, the lateral incisor, the canine, the first premolar, the second premolar and the second permanent molar in the mandible.

YAG LASER에 의한 공구강의 표면개질에 관한 연구

옥철호,강형식,박흥식,전태옥 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.2

Laser induced surface hardening of Tool steel(STC5) can be achieved either with or without surface melting. In trans-formation hardening, as the surface is heated to a temperature below its melting point and is rapidly cooled, solidified microstructures are usually much finer and stronger than those of the base matals. For this reason, surface modification of tool steel by YAG laser irradiation has been studied as a fuction of processing parameters such as, power density, pulse width, defocusing distance, and molten depth. The high energy density changes and refines the microstructure of the near surface layer. In the case of beam passes, martensite formed in the melt zone exhibited very high vickers hardness values. Molten depth and width depend on defocusing distance, and energy of black color painting is more absorptive than other color painting.

융모성 질환의 임상적 연구

남상륜,손영선,이영일,노흥태,강길전 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Seventy nine cases of trophoblastic disease were analyzed at the Department of Obstetrics and Gynecology, Chungnam National University from January, 1985 to October, 1989. The results are as follows: 1. Incidence of trophoblastic disease was one per 31.8 deliveries(3.15%), and it was pathologically consisted with partial mole(27.8%), complete mole(45.6%), invasive mole (17.7%), choriocarcinoma(8.9%). 2. Age group of 26 to 30 was found most frequent(40.5%) and primipara was the most frequent group(43.0%). There was no increase for the persistent disease according to age and para. 3. Clinical manifestations were vaginal bleeding(91.1%), the most common, nausea and vomiting(20.3%), abdominal pain(10.1%) and etc. 4. Molar pregnancies with excessive uterine enlargement were found in 35.6% and were at increased risk for the persistent disease. 5. Antecedant pregnancies prior to trophoblastic disease were abortion(43.0%), term pregnancy(16.5%) and molar pregnancy(16.5%). 6.β-hCG concentration before November, 1986 was significantly lower than after ten. And the first postevacuation β-hCG level was increased in cases of the persistent disease. 7. The treatment regimens in molar pregnancies were suction curettage with prophylactic Act-D(41.4%) and without Act-D(43.1%), hysterectomy with Act-D(13.8%), and hysterotomy(1.7%). There was no difference in complication persistent disease between with and without prophylactic chemotherapy. 8. Non-metastatic and metastatic low risk patients were treated with hysterectomy with or without MTX-CF(66.7%), curettage with MTX-CF, Act-D or MAC(33.3%) to attain remission without failure. All metastatic high risk patients were treated with hysterectomy with 1-6 courses of MAC triple chemotherapy except 1 case of death from respiratory failure and 1 lost case. 9. Side effects after chemotherapy include gastrointestinal symptoms(91.1%), fever(57.8%), leukopenia(49.0%), hepatotoxicity(46.9%), stomatitis(40%), alopecia(28.9%), thrombocytopenia(15.3%) and etc, in order of frequency.

혈액투석중인 만성신부전 환자에서 골대사 지표로써의 Osteocalcin치

송치운,이진홍,안미애,윤환중,윤상임,성기양,이강현,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Background : Serum osteocalcin is synthesized by osteoblast and has been shown to be sensitive indicator of bone turnover inpatients with various metabolic bone disease. In renal osteodystrophy, serum osteocalcin is elevated due to decreased renal clearance and elevated level of PTH. This study was done to evaluate the usefulness of serum osteocalcin as a marker of bone metabolism and the correlation with other biochemical markers of bone metabolism. Methods : We measured serum osteocalcin, calcium, phosphorus, ALP(alkaline phosphatase) and PTH(parathyroid hormone) in 37 patients with end stage renal disease on hemodialysis. Osteocalcin was determined by radioimmunoassay and PTH was determined by radioimmunometric assay. Results : 1) The mean level of serum osteocalcin in ESRD patients was 233.8± 218.2ng/ml which was significantly higher than that of controls(p<0.0001). 2) The mean level of serum PTH in ESRD patients was 40.5± 43.8pg/ml was significantly higher than that of controls(p<0.005). 3) There was a significant positive correlation between the level of serum PTH, ALP and the level of serum osteocalcin in ESRD patients. 4) By using multiple regression, PTH is most reliable factor that affect to elevated level of serum osteocalcin ( beta coefficient = 0.687, Sig T<0.05). Conclusion : Serum osteocalcin as a marker of bone metabolism in ESRD patients is more useful than other biochemical marker such as serum calcium, phosphorus, ALP and PTH is a most reliable factor that affect to elevated level of serum osteocalin.

간장 ( 肝腸 ) 및 담도 ( 膽道 ) : I - 131 - Lipiodol의 간동맥주입과 간동맥 색전술에 의한 원발성 간암 치료 효과

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),이상인(Sang In Lee),한광협(Kwang Hyub Han),전재윤(Chae Yoon Chon),이종태(Jong Tae lee),유형식(Hyung Sik Yoo),한승희(Seung Hee Han),노재경(Jae Kyung Roh) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3

N/A Lipiodol (iodized oil) is known to be selectively retained for an extended duration in hepatocellular carcinoma (HCC), so a number of therapeutic trials using Lipiodol in patients with HCC have been performed. Hepatic arterial infusion of radiolabelled iodized oil (I-131-Lipiodol) has potential as a radiotherapeutic agent in patiens with HCC. This study was undertaken to assess the therapeutic efficacy of hepatic arterial infusion of I-131-Lipiodol alone or I-131-Lipiodol combined with transcath- eter arterial embolization (TAE) in comparison with conventional TAE in patients with HCC. From March 1985 to December 1988, 136 patients with HCC were given eithep an hepatic arterial infusion of I-131-Lipiodol alone (Group 1, n=83), TAE with Ivalon or GelfoaO (Group 2, n=23) or infusion of I-131-Lipiodol combined with TAE (Group 3, n=30). There was no significant difference in sex, age, tumor size and type, biochemical tests, and Child classification among the 3 groups. We analyzed the response rate and survival rate according to the therapeutic modality and tumor size. 1) The response rates were 32.5, 43.5, and 73.3% in groups 1,2, and 3 respectively and the response rate in group 3 was significantly higher than group 1 (p<0.05). (response was defined as a decrease more than 2.5% in tumor size 3 months after treatment). 2) There was no significant difference in response rate among the 3 groups in tumors smaller than 5 cm, but the response rate of group 3 (71.4%) was significantly higher than group 1 (27.9%) in tumors larger than 5 cm (p<0.05). 3) The survival rate among tumors smaller than 5 cm was significantly highter than among tumors larger than 5 cm (p<0.05).

Statistic consideration on the detection frequency of the invasive likelihood hitchhiker insect pests through foreign vessels

Tae Hwa KANG,Sangwook PARK,Ki Jeong HONG,Tae Won HONG,Deuk Soo CHOI,Heung Sik LEE,Jung Hoon HWANG 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04

DNA 바코드를 기반으로 하여 외국발 국내 입항 선박에서 검출되는 편승자 해충(hitchhiker insect pests)에 대한 모니터링을 수행하였다. 국내 입항 선박 조사는 2018년 6월 1일부터 2018년 9월 17일까지 약 109일간 111개 선박에 대해 실시하였다. 모니터링 대상 해충은 ‘보고잡기법(simply collecting method by hands)’으로 확보하였으며, 총 336개체에 대해 종동정을 실시하였으며, 이를 통해 확보된 정보들은 선박정보(선박명, 선박번호, 출항지, 입항지), 조사정보(조 사일, 채집시 표본 상태, 조사자), 유전자 분석 정보(프라이머 정보, 서열판독 결과), 분자생물학적 종동정 정보(NCBI GenBank Accession No., NCBI Blast Searching Results, BOLD Identification Request), 분류학적 통합종 확증 정보(목명, 과명, 종명, 동정자, 비고) 등으로 구분하였으며, MS-Excel을 이용하여 각 필드값에 맞게 기초정보를 입력하였다. 이를 기반으로 하여 편승자 해충에 대한 선박 경로에 따른 편승 양상뿐만 아니라, 월별, 분류군별, 미서식종별로 편승 양상을 분석하였다. 그 결과, 편승사례는 선박 경로에 따라서는 중국에서 출항하거나 중국을 거쳐 편승하는 사례가 207건, 월별로는 9월이 134건, 분류군별로는 나비목이 208건으로 가장 많았다. 특히, 미서식종별 편승 양상에서 는 총 3목 9과 13종 21개체가 국내 입항 선박에서 검출된 것으로 나타났으며, 이 중 2목 6과 9종 15개체는 살아있는 상태로 채집된 것을 확인되었다. 이와 같은 결과로 볼 때, 앞으로 더욱 많은 정보가 확보된다면, 현재의 통계 분석 방법은 편승자 해충의 모니터링뿐만 아니라 대상 해충의 위험성 평가 및 검역검사에 매우 효율적인 정보를 제공할 수 있을 것으로 사료된다.

Enhancement of DNA vaccine potency by antigen linkage to IFN‐γ‐inducible protein‐10

Kang, Tae Heung,Kim, Keon Woo,Bae, Hyun Cheol,Seong, Seung‐,Yong,Kim, Tae Woo Wiley Subscription Services, Inc., A Wiley Company 2011 International journal of cancer: Journal internati Vol.128 No.3

<P><B>Abstract</B></P><P>DNA vaccines have emerged as an attractive approach to generate antigen‐specific T‐cell immune response. Nevertheless, the potency of DNA vaccines still needs to be improved for cancer immunotherapy. In this study, we explored whether functional linkage of a Th1‐polarizing chemokine, IP‐10, to a model tumor antigen, human papillomavirus type 16 (HPV‐16) E7, enhanced DNA vaccine potency. IP‐10 linkage changed the location of E7 from the nucleus to the endoplasmic reticulum and led to the secretion of functionally chemoattractive chimeric IP‐10/E7 protein. In addition, this linkage drastically enhanced the endogenous processing of E7 antigen through MHC class I. More importantly, we found that C57BL/6 mice intradermally vaccinated with IP‐10/E7 DNA exhibited a dramatic increase in the number of E7‐specific CD4<SUP>+</SUP> Th1 T‐cells and CD8<SUP>+</SUP> T‐cells and, consequently, were strongly resistant over the long term to E7‐expressing tumors compared to mice vaccinated with wild‐type E7 DNA. Thus, because of the increase in tumor antigen‐specific T‐cell immune responses obtained through both enhanced antigen presentation and chemoattraction, vaccination with DNA encoding IP‐10 linked to a tumor antigen holds great promise for treating tumors.</P>

Characteristic Evaluation Method of Massive Sandwich Composite-Structure under Transfer Vibration

Heung-Tae Kim(김흥태),Sung-Hwan Yim(임성환),Dong-Hoon Son(손동훈),Kwang-Hee Kang(강광희),Young-Sik Kang(강영식) 한국소음진동공학회 2016 한국소음진동공학회 학술대회논문집 Vol.2016 No.10