정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

교정의사가 선호하는 측모의 유형에 따른 특징적 양상에 관한 연구

김영진,김정환 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.5

교정 치료의 목표를 설정하는 데에 있어서 여성의 아름다운 측모에 관한 정확한 이해는 필수적인 요소이다. 본 연구에서는 치과교정의사 간에 심미안의 차이가 있는지를 조사하고, 치과교정의사에 의해 선호되는 여성의 심미적인 측모를 선정하여, 이들이 facial convexity의 정도에 따라 심미적인 측모를 구성하기 위한 특징적인 양상을 보이는지를 조사하고자 하였다. 먼저 교육적 배경이 다른 5명의 치과교정의사로 하여금 133명의 20대 여성의 측모 사진을 이용하여 선호도에 따라 심미적인 측모를 채점하도록 하였다. 심미적인 측모를 가졌다고 판정된 35명의 측모 두부 방사선 사진의 투사도를 작성하여 연조직 분석을 시행하였고, 이를 facial convexity의 정도에 따라 convex군(G-Sn-Pg≥9˚)과 straight 군(G-Sn-Pg<9˚)의 두 subgroup으로 세분화하였다. 심미적인 측모를 선정하는 데에 있어서의 객관성 여부를 조사하기 위하여 5명의 치과교정의사 간의 심미안의 차이에 대한 동질성 검정을 시행하였는데 미의 기준이 주관적임에도 불구하고 치과교정의사간에 측모 선호 양상은 통계적으로 유의한 차이가 없었다(p<0.05). 안모 형태의 차이에 따라 세분된 두 subgroup간의 코의 전후 관계를 나타내는 N-Pg-Sn, N-Pg-Pn에서 통계적으로 유의한 차이를 보였고(p<0.05), nasolabial angle, labiomental angle, 그리고 수직적 분석 항목에서 통계적으로 유의한 차이가 없었으며(p<0.05), 상하순 돌출도를 분석한 결과에서 H-angle, Ls to E line, Li to E line, Pg to Sn perp.에서 통계적으로 유의한 차이를 보였으나 Sn-Pg line와 Sn perp. 에서부터의 거리에는 차이가 없었다(p<0.05). 이상의 결과에서 안모 형태(facial pattern)에 따라 심미적인 측모를 구성하기 위한 특징적인 양상의 차이가 존재하며, 이는 특히 코와 상하순, 그리고 턱의 전후방적인 위치에 따라 크게 좌우됨을 알 수 있었다. The perception of facial esthetics is critically important to orthodontists. A viewpoint to facial esthetics is influenced by various factors and dependent on the perception of observer. The purpose of this study was to examine the differences regarding esthetic viewpoints among orthodontists, to identify attractive profiles preferred to orthodontists and to present the characteristic aspects of attractive profiles upon the degree of facial convexity. 35 Persons whose faces were judged as attractive one by 5 orthodontists were selected out of 133 young Korean women. Soft tissue profiles identified as a good-profile group were measured and analyzed. And then according to the facial convexity, good-profile group was subdivided to convex (G-Sn-Pg9˚) and straight (G-Sn-Pg<9˚) groups for the purpose of this study. There were statistically no significant differences regarding esthetic viewpoints among 5 orthodontists(p<0.05), even if there exists prevailing concept that the standard for facial esthetics is substantially subjective. N-Pg-Sn and N-Pg-Pn, measured for determining anteroposterior relationship of midfacial convexity, showed significant differences statistically between 2 subgroups (p<0.05) while nasolabial angle, labiomental angle, and vertical measurements didnt show statistically significant difference between 2 subgroups (p<0.05). And all the measurements related to lip position, H-angle, Ls to E line, Li to E line and Pg to Sn perp., had statistically significant differences between 2 subgroups (p<0.05). The results indicate that the attractive facial profile has different characteristics to be recognized as a good facial pattern, which depend strongly on anteroposterior position of nose, upper and lower lips, and chin.

Preparation and Characterization of Surface Energy of BPDA-BAPP Polyimide

Kim, Kyung-Hoe,Kim, Yong-Gwon,Kwon, Young-Hwan The Polymer Society of Korea 2009 Macromolecular Research Vol.17 No.6

The surface properties (water sorption and repellency, adhesion) are closely related to the surface tension of polymer solids. The critical surface tension (${\gamma}_c$) and surface tension (${\gamma}_s$) of a polymer solid were estimated by the contact angle method by our quantitative imaging system. BPDA (3,3',4,4'-biphenyl tetracarboxylic dianhydride)-BAPP (1,3-Bis(4-aminophenoxy) propane) polyimide was successfully synthesized. The ${\gamma}_c$ values were analyzed by a Zisman plot, a Young-$Dupr\acute{e}$-Good-Girifalco plot, and a log ($1+cos{\theta}$) vs log ${\gamma}_L$ plot. The ${\gamma}_s$ value of BPDA-BAPE polyimide was evaluated using the geometric mean equation and our multiple regression analysis. The calculated values of ${{\gamma}_s^d$ (a dispersion component), ${{\gamma}_s^p$ (a polar component), ${{\gamma}_s^h$ (a hydrogen bonding component), and ${\gamma}_s$ were 30.79, 9.32, 0.20, and 40.31 $mN{\cdot}m^{-1}$, respectively. The ${\gamma}_s$ of BPDA-BAPP polyimide containing both a methylene group and an ether group was larger than that of the polyimide containing only a methylene group.

초임계 이산화탄소로 추출한 유자껍질의 향기성분

김영언,김인환,김흥만,이영철 한국식품영양학회 1996 韓國食品營養學會誌 Vol.9 No.4

초임계 이산화탄소를 이용하여 유자(Citrus junos)껍질의 향기성분을 추출하기 위해 동결건조한 유자과피분말을 4,000psi와 40 에서 운전하면서 이산화탄소의 소비량에 따라 4단계로 분획하여 분획별 향기성분의 특성을 조사하였다. 초임계 이산화탄소에 대한 유자의 향기 성분의 수율은 0.011g/CO_2(L)였으며, 최대추출수율은 8.812g/kg이었다. 초임계 이산화탄소로 추출한 유자과피의 주요향기성분은 dl-limonene, γ-terpinene, linaollo, sabinene, β-myrcene, α-pinene, β-farnesene, α-terpineol 과 terpinolene 등 9종이었다. 분획별 향기성분은 휘발성이 높은 α-pinene, β-myrcene과 dl-limonene은 추출시간이 길어짐에 따라 함량이 감소하였으며, 이와 반대로 휘발성이 낮은 α-terpineol과 β-farnesene은 추출시간이 길어짐에 따라 함량이 증가하였다. 따라서 초임계 이산화탄소로 유자의 향기성분을 추출할 경우 추출시간에 따라 얻어지는 분획의 향기 성분 조성이 서로 다른 것으로 나타났다. Volatile compounds were extracted from freeze-dried citron peel(Citrus junos) using supercritical CO_2 under 4,000psi at 40℃. Four fractions were obtained with consumption of CO_2. Volatile compounds of extracts were analyzed by GC-MSD. Yield of volatile compounds from citron peel was 0.11g/CO_2(l) and maximum yield was 8.812g/kg. Major volatile compounds of extracts were dl-limonene, γ-terpinene, linalool, sabinene, β-myrcene, α-pinene, β-farnesene, α-terpineol and terpinolene. α-Pinene, β-myrcene and dl-limonene in the fractions decereased gradually, while α-terpineol and β-farnesene increased as the consumption of CO_2 increased.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

페디그리 사료 섭취에 의한 급성신부전증의 치료 1례

김영실,신영지,박정희,김명철,신상태,조종기,김덕환 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

A 4 years old male poodle dog with gastro-intestinal distress was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. The patient was presented with history of vomiting, hemorrhagic diarrhea and inappetence. Laboratory evaluation revealed that WBC (23.8 x 10^(3)/㎕). BUN (87.9 ㎎/㎗), creatinine (7.3 ㎎/㎗) and phosphate (9.6 ㎎/㎗) was elevated, and proteinuria, hematuria and bilirubinuria were detected on urinalysis. Increased renal cortical echogenicity and parenchymal calcification of kidney were observed by ultrasonography. Based on the findings of history, clinical signs, laboratory assessment and ultrasonography, it was diagnosed as acute renal failure. The present patient showed favorable therapeutic response by fluid therapy. diuretics, peritoneal dialysis and blood transfusion.

개에서 발생한 폐수종의 치료 증례

김유수,심재현,김건우,김지용,이병희,송근호,이영원,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A 9 months intact male American bull dog with chief complaints of dry cough, dyspnea and fever was referred to the Veterinary Teaching Hospital, Chungnam National University. Based on the findings of physical examination, radiological examination, and blood and blood chemical examinations, the present patient was diagnosed into pulmonary edema secondary to primary bacterial and aspiration pneumonia. The patient was hospitalized and treated with buscopan, cephazolin and furosemide for 1 week. His activity and appetite was returned to normal and thoracic radiographs revealed that Jung was recovered to the normal condition after treatment for 7 days. The present patient was a case with pulmonary edema showed favorable therapeutic responses to proper medication.

기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

Gelation에 의한 방사성 금속염화물의 안정화/고정화 : Part2: 알칼리 금속염화물과 이성분계(Si-P)와의 겔화반응 Part2: Gelation with alkali metal chloride in binary system(SiO2/P2O5)

김인태,박환서,김환영,유재형,김준형 한국공업화학회 2002 응용화학 Vol.6 No.2

By gelation with sodium silicate and phosphorous oxide in binary system, we investigated the possibility to fix the volatile alkali metal chlorides in a highly stable matrix at high temperature if the product gel is further solidified to form glass or ceramic waste form. The binary system with different metal chloride(MCl) loadings underwent gelation reaction at 70℃ for 1 day and dried at 110℃ for 1 day. XRD analysis showed that all the dried gel contained NaCl and some unknown crystalline phase. From the experimental results, the reaction mechanism can be proposed as follows. Also, the possibility of Cs vaporization could be lowered by the application of the new gel-route stabilization/solidification to treat waste salt. (G,Na)+MCl→(G,M)+NaCl, (G.H)+MCI→(G,M)+HCl.

급성신부전을 동반한 알콜성 횡문근융해증 2례

김영민,오동렬,이원재,김형국,황두영,이환,최경호,정시경,김세경,김영옥 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Rhabdomyolysis is a biochemical and clinical syndrome caused by lysis of skeletal muscle cell and release of muscle cell contents into the circulation. In addition to traumatic cause, various nontraumatic causes have been reported. Rhabdomyolysis has frequently been associated with seamy aspects of life and society: alcoholic abuse, drug addiction, sadistic drill exercise, war events and attempted suicide. The abuse of alcohol causes many hazards in many organs. One of these is acute alcoholic myopathy that may present as a fulminent syndrome of muscle pain and tenderness associated with rhabdomyolysis and acute renal failure. Because the prognosis of adequately treated rhabdomyolysis is excellent, early recognition and prompt management are essential in emergency situation. We experienced two typical cases of alcohol-induced rhabdomyolysis with acute renal failure and report these cases with literature review.