정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

사후분해 시체에 대한 법의학적 접근

최영식,이상용,김유훈,조갑래,이봉우,양경무,정낙은,서중석,이한영,이원태,강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Disposal of a homicide victim by dismemberment is rare, but individual cases are on record in most major medicolegal departments. Recognition of postmortem mutilation may be of importance in the interpretation of certain murders committed by sexual perverts and other mentally deranged individuals and sometimes performed for the sole reason of easier disposal of the body. Postmortem dismemberment is usually readily recognizable as such; The edges of the injuries are dry and lack evidence of bleeding. The joints may be disarticulated without fracture, or the use of an axe or saw may be evident from examination of bones. Parallel horizontal or oblique furrows in the bone surface are caused by skipping of the saw prior to establishing depth. Such patterns on the bone may assist in identifying the particular saw involved. So we report 25 dismembered corpses that autopsied in National Institute of Scientific Investigation. This paper can help in attempting to establish not only the first criminal investigation steps but also the medicolegal approach methods in unidentified and dismembered deaths.

物質特許導入前後 醫藥品市場의 構造變化에 관한 硏究

이모세,양봉민 서울大學校保健大學院 1995 國民保健硏究所硏究論叢 Vol.5 No.2

This study intended to investigate change in pharmaceutical market structure in relation to the introduction of product patent protection in Korea. The ultimate purpose of this study is to help the government seek the ways of improving pharmaceutical social benefit. The main results of this study is as follows; Concentration ratios decreased in total pharmaceutical market but has increased or decreased in therapeutic markets since the introduction of product patent protection in Korea. The share of multinational and cooperative enterprises had sharply increased 21.1% in 1989 to 29.7% in 1994 in hospital pharmaceutical market. On the contrary it had decreased a little in pharmacy pharmaceutical market, 10.9% in 1989 to 9.4% in 1994. Accordingly the introduction of product patent protection and its impact have resulted in change in pharmaceutical market structure of Korea. They have forced the total pharmaceutical market to be competitive. But it maybe force therapeutic market to be monopolic. The government policies on pharmaceutical products have to be directed to improve pharmaceutical socialbenefits with regard to these aspects.

Insulin의 血球膜과의 結合

李民化,安鳳煥,梁誠烈,朴昞柱 全南大醫大 1983 전남의대학술지 Vol.20 No.4

정상교합자와 골격성 Ⅲ급 부정교합자의 경추골성숙도에 관한 연구

양규호,최남기,최봉선,이영준,류선열,김선미 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.1

정상교합자와 골격성 Ⅲ급 부정교합자간의 성장 정도에 차이가 있는지를 평가하기 위해 8-12세 여자를 대상으로 하여 진단 석고 모형과 측모두부방사선사진을 기준으로 정상교합자 172명 , 골격성 Ⅲ급 부정교합자 191명 총 363명을 분류하여 연구를 시행하였다. 경추의 하연의 만곡도와 수직·수평 길이의 비를 측정해서 연령이 증가함에 따른 변화를 분석하여 다음과 같은 결론을 얻었다. 1. 연령이 증가함에 따라 제2~6경추의 하연의 만곡도는 정상교합자와 골격성 Ⅲ급 부정교합자 모두에서 일정하게 증가하였다. 2. 연령이 증가함에 따라 제3~6경추의 수직·수평 길이의 비도 정상교합자와 골격성 Ⅲ급 부정교합자 모두에서 일정하게 증가하였다. 3. 제2~6경추의 하연의 만곡도와 제3~6경추의 수직·수평 길이의 비에서 정상교합자와 골격성 Ⅲ급 부정교합자간의 경추골성숙도 차이를 조사한 결과 통계적으로 유의한 차이를 보이지 않았다. 이상의 결과에서 정상교합자와 골격성 Ⅲ급 부정교합자간의 경추골성숙도를 비교했을 때 유의한 차이를 보이지 않았으므로 성장에 차이가 없음을 시사하였다. This study was to evaluate and compare differences of the cervical vertebral skeletal maturity of normal occlusion and skeletal Class Ⅲ malocclusion. Normal occlusion (172 girls) and skeletal Class Ⅲ malocclusion(191 girls) were classified according to diagnosis stone model and lateral cephalogram of Korean girls aging from 8 to 12 years. The concavity of inferior border, vertico-horizontal ratio of cervical vertebrae were observed and measured according to age. Differences of the cervical vertebral skeletal maturity were evaluated. The results were as follows : 1. The concavity of inferior border of the 2nd to 6th vertebrae of normal occlusion and skeletal Class Ⅲ had uniformly increased with age. 2. The vertico-horizontal ratio of the 3rd to 6th vertebrae of girls with normal occlusion and skeletal Class Ⅲ had uniformly increased with age. 3. There was no significant difference in cervical vertebral skeletal maturity between normal occlusion and skeletal Class Ⅲ malocclusion in the concavity of inferior border of the 2nd to 6th vertebrae and in the vertico-horizontal ratio of the 3rd to 6th vertebrae. The results in the study indicate that there is no significant difference of cervical vertebral skeletal maturity between girls with normal occlusion and skeletal Class Ⅲ malocclusion.

정상 및 Phenylhydrazine으로 처치한 토끼 적혈구의 Adenosine Deaminase Isozymes의 활성도에 관하여

李鉉國,車鍾希,李奉宰,金良均,李根培 조선의대 1984 The Medical Journal of Chosun University Vol.9 No.1

Phenazine Methosulfate의 Superoxide Radical 生成作用

李民化,安鳳煥,李起榮,朴昞柱,梁誠烈,薛鍾銀 全南大醫大 1984 전남의대학술지 Vol.21 No.2

先電離 窒素레이저에 의하여 펌프된 色素레이저

양준묵,추한태,이봉연 충남대학교 1991 忠南科學硏究誌 Vol.18 No.2

A preionized nitrogen laser with average output power of 3.0 mW in repetition rate of 30 Hz was constructed to be used as a pump for dye lasers such as rhodamine 6G, rhodamine B, coumarin 120 and coumarin 102. Under the optimum dye concentrations and wavelengths, dye laser average output power of rhodamine 6G, rhodamine B, coumarin 120 and coumarin 102 were obtained to be 1.6 mW, 1.1 mW, 1.1 mW respectively. According as nitrogen laser average output power was increased up to 76% by preionization effect, dye laser average output powers of rhodamine 6G, rhodamine B, coumarin 120 and coumarin 102 were increased up to 23%, 38%, 57% and 71% respectively. The nitrogen laser system used for this research can be utilized in dye lasers covering the entire visible spectra and if the nitrogen laser output power is improved, the output power of the coumarin 102 dye laser can be improved higher than that of the rhodamine 6G dye laser.

배추흰나비 食道下神經節의 神經細胞에 관한 形態學的 硏究

梁熙永,李鳳熙,金宇甲 순천향대학교 1985 논문집 Vol.8 No.1

The study on the nerve cells in the subesophageal ganglion of adult cabbage butterfly (Pi-eris rapae L.) was performed to observe their structural characteristics. The subesophageal ganglion which had been associated to rear part of brain in the process of metamorphosis of larva to pupa was consisted of neuropile in the central region and nerve cell bodies in the rind. The nerve cell bodies were divided into three types on basis of their shapes, sizes and presence of neurosecretory granules, etc. In type I nerve cells the sizes of their cell bodies were 9.5 to 14.5μm in diameter and those of their nuclei were 7.0 to 12.0μm. The type I nerve cells which were the most typical neurons of brain nerve cells from cabbage butterflies had round or ellipsoid shapes. The type Ⅱ nerve cells had a variety of shapes, i.e., round, ellipsoid or triangle, and their sizes were 14.5 tp 20.0μm in diameter. The type Ⅱ nerve cells which included a number of neurosecretory granules were considered neurosecretory cells. The type Ⅲ nerve cells had the smallest sizes of approximately 4.5μm in diameter and their nuclei were about 2.5μm. These cells had no secretory granules in their cell bodies.

水素化된 非晶質 게르마늄의 特性調査(Ⅰ)

梁承勳,李原鎭,朴奉斗 慶北大學校 1985 論文集 Vol.39 No.-

Reactive thermal evaporation(RTE) was developed as a new method to deposit hydrogenated amorphous germanium films. RTE was carried out by the evaporation of high purity polycrystalline germanium in an atmosphere of hydrogen plasma produced by high voltage AC discharge of molecular hydrogen. Electrical conductivity and its annealing behavior, electron probe micro-analyzer and scanning electron microscopy were used to characterize the samples. Optimal conditions of sample preparation (from electronic point of view) were determined to be substrate temperature of 200℃ and hydrogen pressure of 1 Torr. Crucible type was proved to have an influence on the sample properties. The sample prepared at the optimum conditions shows the activated type conduction above room temperature.