보건의료 : 약 주고 병 주는 제약업계를 고발한다

이모세 사회평론 1991 월간 사회평론 Vol.91 No.11

Outcomes of Diffuse-Type Pigmented Villonodular Synovitis (PVNS) after Open Total Synovectomy

이모세,이수현,서진석,양우익,신규호,Lee, Mo-Ses,Lee, Soo-Hyun,Suh, Jin-Suck,Yang, Woo-Ik,Shin, Kyoo-Ho The Korean Musculoskeletal Tumor Society 2010 대한골관절종양학회지 Vol.16 No.1

목적: 색소 융모 결절성 활액막염은 슬관절을 비롯한 주요 관절에서 드물게 발생하는 연부 조직 종양으로서 수술 적 치료 후 재발 빈도가 높은 것으로 알려져 있다. 본 연구에서는 주요 관절에 발생한 미만형 색소 융모 결절성 활액막염에 대한 활막 전 절제술 후 임상 경과를 보고하고, 기존에 발표 된 문헌과 비교 분석하고자 한다. 대상 및 방법: 1994년 2월부터 2006년 3월까지 미만형 색소 융모 결절성 활액막염으로 치료 받은 21예의 환자를 대상으로 하였으며, 발생 부위는 슬관절 14예, 족관절 5예, 견주관절 2예가 있었다. 평균 추시 기간은 5년 5개월이었다(36-157개월). 발생 연령은 평균 34세였으며 남자가 7명, 여자가 14명이었다. 후향적 연구 방법으로 관절 운동 범위 측정을 포함한 정기적인 임상 양상 평가를 하였다. 결과: 총 21예의 미만형 환자 중 1예를 제외 한 전례에서 활막 전 절제술 및 전기소작술을 통한 보강 치료를 시행하였으며, 정기적인 외래경과 관찰 상 재발이 의심되었던 2예에서 재수술 후, 1예에서만 조직학적 재발이 확진 되었다. 활막 전 절제술을 시행하지 못한 1예와, 재발로 재수술 받은 1예에서 술 후 방사선 치료를 시행 하였다. 임상 기능 평가상 술전과 비교하여 모든 부분에서 통계적으로 유의한 호전이 있었다.(p<0.0001). 슬관절에 발생한 병변으로 수술적 치료를 시행 후 관절 운동 장애로 제약이 있던 환자는 2예(총 14예) 있었다. 결론: 최소 3년 이상의 추시 기간 동안 활막 전 절제술 및 전기 소작술을 통한 보강 치료로 호전된 임상 결과 및 낮은 재발율의 치료 효과를 얻을 수 있었다. 잦은 재발과 주요 관절에 발생하여 국소적 침투, 파괴로 기능 장애를 일으키는 미만형 색소 융모 결절성 활액막염에 치료에 있어 적절한 활막 전 절제술이 시행 될 경우 방사선 보강 치료는 제한 된 경우에만 필요할 것이다. Purpose: Pigmented villonodular synovitis (PVNS) is a rare soft tissue tumor, which usually arises in larger joints, such as the knee. It has a high recurrence rate after surgical treatment. The purpose of this study is to evaluate and analyze the clinical results of diffuse-type pigmented villonodular synovitis cases that were treated with open total synovectomy. Materials and Methods: Between 1994 and 2006, 21 patients who had diffuse-type pigmented villonodular synovitis were selectively reviewed. Among the 21 cases studied, 14 patients presented at the knee, 5 at the ankle, and 2 at the shoulder and elbow. The mean follow up period was 5.5 years (range, 36-157 months). The average age of the patients was 34 years consist of 7 men and 14 women. Clinical outcomes were analyzed retrospectively, including range of motion and complications. Results: Open total synovectomy and adjuvant electrocautrization were done in all cases except one. During the regular follow-up period after the surgery, two patients showed symptoms of recurrence. After re-operation, only one case was pathologically confirmed as a recurrence. The patient who had partial synovectomy and the other patient who had second operation due to recur rence received additional radiation therapy. Clinical outcome scores were improved in every aspect (p<0.0001). 2 out of 14 Patients who had pigmented villonodular synovitis at the knee developed stiff knee after the surgery. Conclusion: After the open total synovectomy with electrocautrization, a low recurrence rate and satisfactory clinical outcome was achieved, observed in a minimum of 3 years of follow-up.

지역 약사의 자발적 부작용 보고에 대한 인식 및 태도와 영향요인 조사: 설문조사 결과를 중심으로

이모세,최아형,장보현,김나영,이정민,신주영,전하림 한국임상약학회 2019 한국임상약학회지 Vol.29 No.2

Objective: To examine the perceptions and attitudes toward spontaneous adverse drug reaction (ADR) reporting system among community pharmacists and identify factors that influence reporting, by implementing a survey. Methods: A structured questionnaire was developed and distributed online. Request for the survey was posted on the website of pharmacy’s billing program, and the survey was conducted for 8 days. We collected the participants’ response on their work environment, experience of ADR reporting, and their perception and attitude on the reporting system. Multivariate logistic regression was used to evaluate factors influencing ADR reporting. Results: A total of 382 pharmacists participated in the survey. Significant contributing factors for reporting level were age (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.84-0.96), knowledge of reporting method (OR, 53.56; 95% CI, 9.10-315.41), installation of reporting program (OR, 31.92; 95% CI, 4.16-244.75), and encouragement from the Korean pharmaceutical association (OR, 4.13; 95% CI, 1.11-15.35). Regarding the attitude toward spontaneous ADR reporting system, ‘lack of time for reporting’ (OR, 0.29; 95% CI, 0.15-0.53) and ‘complexity of reporting procedure’ (OR, 0.51; 95% CI, 0.31-0.84), were associated with a low likelihood of reporting. Conclusion: Our results indicated that the knowledge of ADR reporting method, installation of the reporting program, and encouragement from the Korean Pharmaceutical Association contribute to active reporting. It is necessary to simplify the reporting method, make the ADR reporting program user-friendly, and provide educational interventions to increase participation in spontaneous reporting by the community pharmacists.

의약분업 논쟁의 역사적 고찰

이모세 약사공론 1993 대한약사회지 Vol.1993 No.4

지역약국에서 보고된 전문의약품과 일반의약품의 이상사례 보고현황 비교 분석

이모세,박소희,김나영,오인선,이정민,이의경,신주영 한국임상약학회 2018 한국임상약학회지 Vol.28 No.3

Objective: To compare adverse event reporting patterns between ethical-the-counter and over-the-counter drugs fromcommunity pharmacies and outpatient settings. Methods: We conducted a descriptive study using the adverse event reportingdatabase, wherein data were collected from the regional pharmacovigilance centers of the Korean Pharmaceutical Associationbetween January 1, 2016 and December 31, 2016. The reported drugs were classified into either ethical-the-counter or over-thecounterdrugs, and we compared the distribution of patient age and gender, frequent adverse events and medications, seriousadverse events, and causality assessment results, where causality assessments were performed according to the World HealthOrganization-The Uppsala Monitoring Centre’s system. Results: We included 17,570 reports (75,451 drug-adverse event pairs). Ethical-the-counter and over-the-counter drugs accounted for 81.4% and 18.6% of the total adverse event reports, respectively. The use of over-the-counter drugs was higher in females and patients aged <18 years, whereas the use of ethical-the-counterdrugs was higher in those aged >65 years. Alimentary tract and metabolism drugs, and respiratory system drugs were the mostfrequent ethical-the-counter and over-the-counter drugs, respectively. From causality assessment results, “possible” (75.4%) wasthe most commonly assigned category for ethical-the-counter drugs, while “possible” (44.0%) and “unlikely” (47.7%) were the mostcommon categories for over-the-counter drugs. The distribution of serious adverse events were similar for both ethical-thecounterand over-the-counter drugs. Conclusion: Differences were observed in age, gender, reported medications, and symptomsfor both ethical-the-counter and over-the-counter drugs. Further pharmacovigilance activities considering the adverse eventcharacteristics of over-the-counter drugs, which are comparable to ethical-the-counter drugs, should be performed.

의약분업 합의과정의 몇가지 특징과 병원약사회의 대응방안 : 1999년 5월 10일 합의안을 중심으로

이모세 한국병원약사회 1999 병원약사회지 Vol.16 No.1

Comparison of Efficiency of Self-renewal and Differentiation Potential in Tendon-derived Mesenchymal Stem Cells Isolated by Magnetic-activated Cell Sorting Method or Colony Picking Method

이모세,최유림,윤동석,이진우,윤길성,최우진,한승환,Lee, Moses,Choi, Yoorim,Yoon, Dong Suk,Lee, Jin Woo,Yoon, Gil Sung,Choi, Woo Jin,Han, Seung Hwan The Korean Foot and Ankle Society 2014 대한족부족관절학회지 Vol.18 No.3

Purpose: The purpose of this study is to evaluate the efficacy of mesenchymal stem cell (MSC) isolation by the magnetic-activated cell sorting (MACS) method in tendon tissue-derived cells compared to the colony picking method for isolation of MSCs by picking colony-forming cells. Materials and Methods: Human tendon-derived cells were isolated by enzyme digestion using normal tendon tissues from three donors. We used the magnetic kit and well-known MSC markers (CD90 or CD105) to isolate MSCs in tendon-derived cells using MACS. Cloning cylinders were used to isolate colony-forming cells having MSC characteristics in tendon-derived cells. Colony-forming unit-fibroblast (CFU-F) assay was used to evaluate the self-renewal capacity of cells isolated using the colony picking method or MACS. For comparison of differentiation potentials into osteogenic or adipogenic lineage between two groups, alizarin red S and oil red O staining were performed at 14 days after induction of differentiation in vitro. Results: Flow cytometry results showed that early passage tendon-derived cells expressed CD44 in 99.13%, CD90 in 56.51%, and CD105 in 86.19%. In the CFU-F assay, CD90+ or CD105+ cells isolated with MACS showed larger colony formation in size than cells isolated using the colony picking method. We also observed that CD90+ or CD105+ cells were constantly differentiated into both osteogenic and adipogenic lineages in cells from all donors, whereas cells isolated using the colony picking method were heterogeneous in differentiation potentials to the osteogenic and adipogenic lineages. Conclusion: CD90+ or CD105+ cells isolated using MACS showed superior MSC characteristics in the self-renewal and multi-differentiation capacities compared with cells isolated using the colony picking method.

Removal of a Broken Intramedullary Nail with a Narrow Hollow Using a Bulb-tipped Guide Wire and Kirschner Wire − A Case Report −

이모세,양규현 대한골절학회 2010 대한골절학회지 Vol.23 No.4

To report the unusual failure of proximal femoral nail antirotation (PFNA) at the level of lag screw hole and introduce a simple technique for removal of a broken intramedullary nail with a narrow hollow using a bulb-tipped guide wire and Kirschner wire.

우리나라 제약산업의 경쟁력 강화

양봉민,이모세 서울大學校 保健大學院 1998 보건학논집 Vol.35 No.1

With economic crisis in 1998, Korean pharmaceutical industry faces a new challenge for a change. The challenge began in 1987, when the IPR (intellectual property right) was enforced in the area of pharmaceutical products by the developed countries. Domestically, the challenge is related with the cost containment of pharmaceutical industry, analyzes problems that the industry is facing these days, and suggests future strategies for the industry to be competitive in the international market. Efforts to increase M&A among pharmaceutical firms are recommended as potential strategies.

物質特許導入前後 醫藥品市場의 構造變化에 관한 硏究

이모세,양봉민 서울大學校保健大學院 1995 國民保健硏究所硏究論叢 Vol.5 No.2

This study intended to investigate change in pharmaceutical market structure in relation to the introduction of product patent protection in Korea. The ultimate purpose of this study is to help the government seek the ways of improving pharmaceutical social benefit. The main results of this study is as follows; Concentration ratios decreased in total pharmaceutical market but has increased or decreased in therapeutic markets since the introduction of product patent protection in Korea. The share of multinational and cooperative enterprises had sharply increased 21.1% in 1989 to 29.7% in 1994 in hospital pharmaceutical market. On the contrary it had decreased a little in pharmacy pharmaceutical market, 10.9% in 1989 to 9.4% in 1994. Accordingly the introduction of product patent protection and its impact have resulted in change in pharmaceutical market structure of Korea. They have forced the total pharmaceutical market to be competitive. But it maybe force therapeutic market to be monopolic. The government policies on pharmaceutical products have to be directed to improve pharmaceutical socialbenefits with regard to these aspects.