정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

커튼월 단열 앵커링 유닛의 난방에너지 성능 및 경제성 평가

강승희,구보경,주선경,송승영 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

Curtain wall system has been widely applied to the residential unit of high-rise complex building which is the new trend in a recent construction market. It is very important to improve the insulation performance of curtain wall anchoring unit since it is composed of materials with high thermal conductivity, such as aluminium, steel and so on. Thus this study aims to evaluate the heating energy performance and economical efficiency of various alternatives which are different in position and material of insulation. As results, alternative of inserting the urethane washer & pad and coating the anchoring unit with urethane foam can improve the heating energy performance and L.C.C(Life Cycle Cost) by 6.33% and 0.95%, respectively, as compared with the existing case.

사고양식을 통한 대학생의 비판적 사고 성향의 구인 특성 이해

강승희,김대현 경북대학교 사범대학부속 중등교육연구소 2006 중등교육연구 Vol.54 No.3

Culex pipiens pallens 모기의 난성숙에 관한 연구

姜奭熙,이승훈 성균관대학교 기초과학연구소 1986 論文集 Vol.37 No.2

본 연구에서는 Culex pipiens 모기의 난성숙에 대한 Egg development neurosecretory hormone(EDNH)의 영향과 방출시기를 decapitation을 통한 in vitro fat body incubation과 rocket immunoelectrophoresis 방법에 의해 합성된 난황단백질의 정량과 follicle cell의 성숙정도를 측정하는 방법으로 조사하였다. C. pipiens를 흡혈 후 30분에 decapitation 하였을 때 follicle cell의 성숙은 25% 정도의 모기에서 일어났으며, 흡혈 후 1 시간에 decapitation한 모기에서는 90% 이상의 모기에서 난성숙이 일어났다. A. atropalpus 에서는 우화 후 6시간 이전에 decapitation하였을 때 follicle cell의 성숙이 일어나지 않았다. Decapitation후 in vitro fat body incubation에 의한 ^3H-protein과 ^3H-vitellogein의 정량결과에서도 C. pipiens는 흡혈 후 30분에 decapitation한 모기에서 난황단백질의 합성이 일어났다. 또한 흡혈 후 1시간에 decapitation한 모기에서는 12시간에 decapitation 한 모기와 비슷한 정도의 난황단백질의 합성이 일어났다. Decapitation 후 rocket immunoelectrophoresis 방법으로 난소내에 축적된 vitellin과 지방체내의 vitellogenin을 정량한 결과 흡혈 후 30분에 decapitation한 모기에서는 흡혈 후 18시간 지난 정상모기의 난소와 유사한 양의 vitellin이 축적되었으며, 흡혈 후 1시간에 decapitation한 모기에서는 흡혈 후 24시간 지난 정상모기의 난소와 유사한 양의 vitellin이 축적되었다. 또한 흡혈 후 30분에 decapitation한 모기의 지방체 내에서 10㎍ 이상의 vitellogenin이 합성된 것으로 관찰되었다. 이상의 결과는 흡혈 후, 또는 우화 후 6시간 이후부터 EDNH의 방출이 시작되는 것으로 알려진 A. atropalpus나 A. aegypti 모기와는 달리 C. pipiens 모기에 있어서는 흡혈 후 30분 정도만 되어도 뇌로부터 EDNH의 방출이 시작되어 난성숙에 필요한 난황단백질 합성의 시작을 자극하는 것으로 여겨진다. Synthesis of vitellogenin in the anautogenous mosquito, Culex pipiens pallens was examined by incubating the fat body in vitro. Vitellogenin synthesis began to occur at 6 hours after blood feeding, reached at maximum level by 24 hour, and was completed by 45 hours. Ovarian uptake of yolk was examined by measuring the amount of egg vitellin by rocket immunoelectrophoreisis. Ovarian vitellin level began to rise at 12 hour post blood meal and continued for up to 60 hours. Decapitation within 10 minutes after blood meal completely blocked vitellogenin synthesis by the fat body. When decapitation was performed at 1 hour post blood feeding, more than 90 percent o female produced mature eggs. These results are different from that of Aedes aegypti in which the critical period was found to be 6 hours post blood meal.

영아-어머니간 애착유형과 어머니의 민감성간의 관계 연구

강문희;김승경 서울여자대학교 1998 아동연구 Vol.3 No.-

[초록없음]

분자동력학법에 의한 LiMn₂O₄에서 Li ion 확산에 대한 연구

강은태,김희승 慶尙大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.15 No.-

As the information of the microscopic motion of particles such as atoms, molecular, and ions in the materials can be obtained through the molecular dynamics simulation, the molecular dynamics can be used to evaluate the properties of new materials. The molecular dynamics approach uses a fully ionic potential that accounts for electrostatic, repulsive, and dispersion interactions among all ions. In the simulation, initial configuration of the material was endowed and used NPT ensemble by statistical ensemble. The molecular dynamics simulation of the self-diffusion of lithium in lithium-manganese spinel materials upon lithium discharge process and various temperatures has been accomplished.

김치로부터 분리한 Pediococcus halophilus에 의한 α-Glucosidase의 생산

강국희,민해기,홍승표 成均館大學校 科學技術硏究所 1992 論文集 Vol.42 No.2

Six strains able to efficiently produce α-glucosidase were isolated from kimchi by enrichment culture in APT medium. Among them, Strain No.2 was found to have levels of α-glucosidase activity. The morphological, physiological and biochemical characteristics of the strain No.2 were studied according to the methods of Bergey's manual. Based on the results obtained in these experiments, Stain No.2 was identified to be a similar species to Pediococcus halophilus. The optima conditions for α-glucosidase production were cultured 0.5% starch, 0.4% yeast extract, 0.4% trypticase peptone, initial pH 7.5 at 37℃ and 24 hours cultivation.

Riblets을 이용한 난류 경계층의 표면 마찰항력 감소에 관한 연구

姜承熙,柳常新 한국항공대학교 1990 論文集 Vol.28 No.-

An experimental study on the skin friction drag reduction with riblets on the flat plate is presented. Riblets engraved on the flat plate modify the turbulent structure and the turbulent intensity of the wall region. The shapes and dimensions of riblets cross sections are reported as the major factors affecting the skin friction drag reduction in the turbulent boundary layer. Riblets of the circular and triangular cross sections are prepared for the experimental works. Reduction of the turbulent intensity of the triangular riblets is more pronounced than that of the circular riblets. Skin friction drag reduction about 9% is observed when a model of the triangular riblets is used. However, the drag reduction is almost not discernable when a model of circular riblets is tested.

레이저 박피술의 피부면적 감소효과와 레이저 punch out 병변의 치유에 대한 실험적 연구

강동희,윤을식,구상환,안덕선,박승하 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

An experimental study was designed to analyze the surface reduction effect of ultrapulse carbon dioxide laser on the skin of guinea pigs receiving laser resurfacing. Two squares of skin measuring 3x3 ㎠ were designed on each side of the abdomen of guinea pigs(n=10). Five animals received laser resurfacing on their abdomen at energy of 250mJ/5 watt, and five other animals received 500 mJ/5 watt. On each animal, the left side square was treated with one pass of a CO2 laser, and the right side q=square was treated with two passes using a C.P.G. scanner. The size of the resurfacing area was determined by celluloid overlays at 1,2,3,4 and 6 weeks. Immediately following laser resurfacing, the area was decreased to 69%(left side) and 56%(right side) of the designed area in the 250 mJ/5 watt group, and 59% and 40% in the 500mJ/5 watt group. After 6 weeks, the resurfaced area had been reduced to 70% and 56% of the designed area in the 250mJ/5 watt group, and 60% and 40% in the 500mJ/5 watt group. As a result, the effect of surface reduction by CO2 laser resurfacing increased at a higher power and when more passes of the ultrapulse carbon dioxide laser were applied. The laser treated skin continued to maintain its contracted dimensions. These findings suggest that ultrapulse carbon dioxide laser may be an effective treatment method for rhytides. Another experiment was performed on multiple punch-out lesions on guinea pig skin(n=2) with 1,2,3 mm collimated hand pieces for the purpose of determining a new laser treatment method. After 4 weeks, on gross and histological examination, there were no differences in the healing of multiple punch-out lesions and the healing of punch-out lesions was complete without any scarring. These findings suggest that the laser punch-out method can be used for the treatment of acne scars.

중공유리구에 고정화된 광촉매를 이용한 남조류의 증식억제

강민수,정익상,우승희,김성우,이동근 경상대학교 환경보전연구소 2001 環境保全硏究所報 Vol.9 No.-

Photocatalytic inactivation of Microcystisaeruginosa was carried out with the TiO₂-coated pyrex hollow glass beads under the illumination of UV light(370㎚ wavelength). After being irradiated with UV light in the presence of the TiO₂-coated pyrex glass beads, Microcystis aeruginosa, known as typical cyanobacteria, lost their photosynthetic activity, and the colonies of Microcystis cells were completely separated into individual spherical one. Complete photocatalytic inactivation of Microcystis aeruginosa was obtained in about 30min. Photosynthesis activity of the cyanobacteria could be inhibited effectively after being reacted photocatalytically with TiO₂ immobilized hollow glass ball.