정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

지리산 면양목장 조성에 관한 연구 : Ⅰ보. 면양목장 조성 및 면양사육 단지화 조성을 위한 기초조사 Ⅰ. Fundamental Survey of Resources for the Development of Sheep Range and Sheep Farm Grouping

정현승,강봉태 진주산업대학교 1970 論文集 Vol.4 No.-

This survey reports the availability of the various resources such as geography, meteology, traffic condition, soil property, labor resource, pasture distribution and water resource, for the development of sheep range and sheep-farm group, on the first step to the three-year plan in an area around the Forestry Experiment Station of Chinju Agricultural and Forestry Junior Teachnical College in Mt. Chiri. 1. The geographical conditions of the region found to be fit for the establishment of sheep range were as follows; longitude:127˚44'east,latitude:35˚22'north,elevation:600-900m above marine surface level, slope:5-25˚, total area: 280 ha, and administrative district: from high level flats to Yeo-gok and Dusuk village, Yupyung-ri, Samjang-myun, Sanchungkun, Kyung Sang Nam Do, Korea. Especially, eighty seven farm households and Karangip primary school distriduted around this region were found to be the reasonable resources for the development of sheep farm group in this region. 2. The soil of the area was composed of most of sand-loam with PH 5.3∼5.8, 2-5% of grit and 13.3% of humus (4.6-19.3%) among 30∼50㎝ depth of surface soil. These fertile soil properties were found to be fit for the development of pasture. 3. The meteological records of this region were found as follows: frosty period: from October 16 to April 22, yearly mean air temperature: 9.2℃ , ranging from 26.6℃ in August to (-)12 in January, annual rainfall: 2,346mm, yearly mean wind velocity: 6.2m/sec, direction of the wind: north-west in winter and south-east in summer. According to the above results from only one-year observation, the meteological conditions of this region were similar to those of Dae-Kwan Ryung area and were estimated to be favorable for sheep raising. 4. In this region 35 species of wild grasses were prosperous. The green yield of the grasses averaged 1,584㎏ per 10a and 0.87a was required for grazing a sheep. Therefore, it was estimated that about 3,000 heads of sheep would be well raised in this region. The fact that about 30 percent of Mt. Chiri area is available for sheep pasture suggested that 400,000㎏ of wool, or 250,000,000 won in price(equivalent to 1/10 of the total wool imported in 1967)could be gained from grazing about 100,000 heads of sheep in the whole area of Mt. Chiri, 54,000 ha. 5. Sufficient water resources, conclusive of mooring by the farmers around this region, irrigation water, underground water and especially the pond situated in high level flats were found to be available and the quality of water was satisfactory for watering sheep. 6. Concerning the traffic situation of this region, the construction of 1.5㎞ of road to Dusuk village (with 200m of bridge) and three 2㎞ range path from Dusuk village were required. However, such traffic problems are not serious because the sheep farming requires the road only for disposal of wool produced once a year. 7. From the managment survey for 87 farms around this area, it was found that each farm had 1,019.6 hours of unemployed labour per year, which was sufficient for raising 60 heads of sheep. So it could be estimated. that potential labour enough for raising 5,200 heads of sheep was reserved in this area. Moreover, the Karangip primary school boys are available as a good resource of labour for sheep grazing. The great deal of by-products of sericulture and potato-farming, which were the major industries in this region, was available for sheep raising.

탈회동결건조골에 혼합한 형질 변형 성장인자(TGF-β1)가 골조직 재생에 미치는 효과

정성민,이만섭,박준봉 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.1

The purpose of ss this study was to observe the effect of TGF-Rl on the regeneration of bone in guided bore regeneration. Four adult dogs aged 12 to 24 months were used in this study. Experimental bone defects were created surgically with surgical bur and chisel on the 3th. premolars. In experimental group; bone defect were grafted with DFDB and TGF-R1. In control groups, bone defects were grafted with only Dl-.DB. At 1, 2, 3 and 4 weeks, dogs were serially sacrificed and specimens were prepared with Hematoxylin-Eosin stain and Goldner`s stain for light microscopic evaluation. The results of this study were as follows 1. The infiltration of inflammatory cells was prominent in control groups at 1, 2 and 3 weeks. 2. The lining of osteoblast was observed at 2 weeks in control group, but at 1 week in experimental group. 3. In both groups, osteoid was formed at 2 weeks. In control groups, osteoid was fromed on only bone surface. but in experimental groups, osteoid were formed on both bone & DFDB surfaces. 4. In only experimental groups, The fusion of new bone & DFDB was only observed at 3 weeks. and the fusion of new bone & DFDG was more prominent at 4 weeks. But in control groups, No fusion of new bone & DFDB was oberved at 3 and 4weeks From the above result, the TGF-01 was effective in bone formation and increased inductive effect of DFDB guided bone regeneration technique. Inductive effect of DFDB was increased with TGF-131.

실과 교육과정 평가의 기본 모형과 평가 영역에 관한 연구

정성봉,김종우 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.2

The purpose of this study was to suggest evaluation basic model and evaluation area of the Practical Arts curriculum evaluation. The study was carried out through review of literature on curriculum, curriculum development and curriculum evaluation. The curriculum evaluation basic model for Practical Arts were established three demensions; aspects of curriculum, levels of curriculum and evaluation methods of the curriculum. The aspects of curriculum include three major areas of curriculum--development, implementation and outcomes. The levels of curriculum include three layers of curriculum in Korea--national, regional and school curriculum. The third dimension represents evaluation methods by which the values of the curriculum are determined. The two evaluation methods include quantitative approach. The curriculum evaluation areas for Practical Arts were established three categories; curriculum development, implementation and outcomes.

자연 치유된 원발성 피부 Alternariosis 2예

정예리,장성남,한승경,조흔정,서순봉,이광훈 대한의진균학회 1999 대한의진균학회지 Vol.4 No.2

The treatment of cutaneous altemariosis consists of surgical excision and systemic antifungal agent. However, only reduction or cessation of corticosteroids and immunosuppressive therapy, if it is possible, can be sufficient to treat the lesion in some cases. We present two cases of spontaneously healed primary cutaneous altemariosis. Case 1 was a 73-year-old female patient with diabetes mellitus, heart failure, chronic renal failure and chronic hepatitis. Case 2 was a 64-year-old male patient with iatrogenic Cushing's syndrome and diabetes mellitus. The correction of the underlying diseases resulted in improvement of the primary cutaneous altemariosis. [Kor J Med Mycol 4(2): 137-142]

智異山 면양목장 조성에 관한 연구 : Ⅷ報. 智異山 山野草가 緬羊의 繁殖率에 미치는 영향과 羊毛의 加工利用方法, 販路方案, 貯藏法 및 緬羊團地造成時의 經濟性 分析 Ⅷ. Effect of the native herbages in Mt. Chiri on the breeding percentage of sheep and the processing method, way of marketing and storage of wool and economical analysis in the collective feeding of sheep

鄭鉉丞,姜奉泰,李炳五 진주산업대학교 1972 論文集 Vol.9 No.-

This is the report for 1971 of the third year project among the three years plan on the development of sheep range in Mt. Chiri. To investigate the effect of native grasses in Mt. Chiri on the breeding percentage of sheep this experiment was carried out from March 22, 1971 to March 21, 1972. Numbers of experimental animal used in this experiment were 12. Furthermore, the processing method of wool, marketing, economical analysis in the collective feeding and storage were investigated in cooperation with this experiment. The results obtained here were as follows; 1. For the processing method of wool, there are two ways; one of the processing method of wool is the self-processing method which follows the easy method of wool processing and another of the processing method of wool exchange with the good of wool texture company which follows the charge processing method of wool. 2. For the marketing route of wool, because the wool texture company can buy limitlessly wool, there are two ways to sell wool. The one of the way is the direct sell method of wool to the wool texture company and the other of the way is the sell method of wool via the route of circulation mechanism. 3. In the case of economical analysis for the collective feeding of sheep, if farms could raise 3,000 of sheep in the method of collective feeding it could get net income of 150,000 to 300,000 won for 52 days per farm per year. 4. For the storage of wool, to attach of wool fat must be needed and in the case of short period storage, wool must be placed in the arid place and in the case of long period storage, wool should be prevented from the attack of insect and rat, attachment of spurious article such as dust, decrease of weight and denaturation of wool fat. 5. The breeding percentage of sheep fed only native herbages plant was 60%.

젤여과법을 이용한 토끼 심근 미오신의 분리 및 부분정제

정성탁,김대중,김호덕,라봉진 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.2

Myosin, the major protein required for the production of force and shortening in muscle, is a hexamer consisting two heavy chains (molecular mass∼200kDa) and pairs of light chains (molecular mass∼16 and 20kDa). Myosin and other contractile apparates from the left ventricular myocardium of rabbit were extracted using pyrophospate buffer system and was purified by using the gel filtration. And partially purified each protein component was confirmed by the electrophoresis in non-dissociation and dissociating conditions respectively. On Disc-PAGE of the crude extract, 4 bands clearly appeared and 3 protein components were separated by chromatography in the 5 fractions. In dissociating electrophoresis, each bands were separated into subunit in the pyrophosphate buffer. The first fraction contained the heavy chain of myosin, tropomyosin and myosin light chain 1 and 2. The second and third fraction were composed of tropomyosin and actin and the proteins that had molecular mass smaller than 15kDa were in the fourth and fifith fractions.

유리 전박골피판을 이용한 음경 재건술

정성광,변진석,백봉수,김법완 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

Reconstruction of the penis is indicated in a traumatic or surgical amputation, congenital penile absence, micropenis, male pseudohermaproditism, or transsexualism. Initially, penile reconstruction has been performed using a local flap, but often failed because of the multiple procedures, fistula or stricture of the urethra, and no sensation of the phallus. Ideally, penile reconstruction should be a one-stage procedure, creating a phallus with both tactile and aerogenous sensibility, water-tight neourethra allowing for voiding while standing, enough bulk with stiffness, and aesthetically acceptable appearance. Since August 1989 we have constructed a penis in 4 patients. We selected the radial forearm flap as a donor site because it offers a reliable artery, veins, nerves, and stiffner. It also offers thin, malleable skin with adequate width and length. We have followed these patients from 5 months to 10 months. All operations were successful except for one fistula formation.

수확후 채소류에 발생하는 진균독소의 탐색과 방제(Ⅱ) 이병된 양념 채소류(양파, 마늘, 고추)에서 주요 진균독소 검출

정일민,주호종,심성철,백수봉,유승헌 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

수확후 Alternaria, Penicillium 및 Fusarium에 이병된 고추, 양파, 마늘을 HPLC로 주요독소들을 검정한 결과 고추에서 Alternaria 독소의 AOH(alternariol)는 소량∼440㎍/g 및 ALT(altenuene)는 소량∼103㎍/g, TeA(tenuagonic acid)는 249∼342㎍/g 및 AME(alternariol monomethyl ether)는 206∼294㎍/g이 검출되었고 양파, 마늘에서 Penicillium 독소의 citrinin이 2.8∼18.4㎍/g, penicillin-G는 0∼439.0㎍/g, penicillic acid는 0∼10.2㎍/g 및 patulin은 0∼7.0㎍/g 검출되었다. 그리고 양파, 마늘에서 Fusarium 독소로는 fusaric acid가 0∼553.6㎍/g 검출되었을 뿐 deoxynivalenol과 nivalenol은 검출되지 않았다. The major mycotoxins were detected from peppers, onions and garlics infected postharvest pathogens, Alternaria, Penicillium and Fusarium. Analyses of the major mycotoxins were conducted using HPLC. Detected Alternaria mycotoxins per gram of infected postharvest peppers were alternariol (AOH) with amount ranged from small quantity to 440 ㎍/g, altenuene (ALT) with amount ranged from small quantity to 103 ㎍/g, tenuagonic acid (TeA) with amount ranged from 249 to 342 ㎍/g and alternariol monomethyl ether (AME) with amount ranged from 206 to 294 ㎍/g. Penicillium toxins per gram of infected postharvest onions and garlics were citrinin with amount ranged from 2.8 to 18.4 ㎍/g, penicillun-G with amount ranged from no detection to 439.0 ㎍/g, penicillic acid with amount ranged from no detection to small quantity and patulin with amount ranged from no detection to small quantity. Fusarium toxins per gram of infected postharvest onions and garlics were fusaric acid with amount ranged from no detection to 553.6 ㎍/g. However, deoxyrivalenol and nivalenol were not detected from onins and garlics infected by Fusarium.

벨마비 환자의 예후와 신경생리 검사소견의 관련성

백봉수,박성파,서정규 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5