월강우량 회귀분석에 의한 농업용 저수지 저수율 모의

박창언 ( Chang Eon Park ) 한국농공학회 2016 한국농공학회 학술대회초록집 Vol.2016 No.-

농업용 저수지의 저수율을 모의하기 위하여는 저수지 유입량, 필요수량, 강우량 등의 물수지를 통하여 이루어지는 것이 일반적이다. 그러나, 물수지 분석을 위해서는 실제로 관개되어지는 관개량이 워낙 불확실하여 신뢰성있는 저수율 변화를 모의하기에는 한계가 있다. 더구나, 기후변화 영향평가 등을 비롯한 미래의 저수지 저수율 변화를 예측하기 위하여는 기존의 저수지 물관리 관행을 포함하는 수리, 수문특성이 적절히 반영되어진 저수율 모의방법이 필요하며, 이를 위하여 월강우량 자료를 이용한 회귀분석을 실시하여 월별 저수율을 모의할 수 있는 방법을 시도하였다. 과거 30년의 저수율 변화자료와 월강우량자료를 이용하여 월강우량과 월별 저수량 변화량에 대한 회귀분석을 실시하여 일정한 회귀방정식을 구성하고, 이를 활용하여 월별로 저수율 변화를 추적해 나가는 방법을 시도하였으며, 실제 저수율 변화를 적절히 재현할 수 있는 것으로 판단되었다. Water storage rate simulation In agricultural reservoirs was performed generally by water balance analysis with inflow discharge to reservoir, water demand in paddy field and precipitation, etc. In this simulation, we faced confidence limit with uncertain real irrigation discharge. So, we tried regression analysis using monthly precipitation in order to simulate monthly reservoir storage rate change. Regression analysis was perfromed with Monthly precipitation and monthly water storage rate change for 30 years, and monthly regression equations were drawn. Monthly water storage rate was simulated properly with these equations in agricultural reservoirs.

GT-POWER를 이용한 신형 로터리 엔진의 1D 해석 모델 개발

박영준(Youngjoon Park),박태준(Taejoon Park),이창언(Chang-Eon Lee) 한국연소학회 2020 KOSCOSYMPOSIUM논문집 Vol.2020 No.9

This study develops 1D CFD simulation models for a new rotary engine originated from a three-lobes Gerotor pump(GP3 RTE). The models consider unique characteristics of GP3 RTE such as effective-area variations. The models are compared to identify each parameter effect and validated by comparing to 3D CFD result. The most advanced model well predict the performance indexes. The model may allow as a convenient tool for getting basic informations on optimizing design parameters of GP3 RTE without time-consuming 3D design change.

상피성 암세포주에 대한 녹차 Catechin의 효과

박정현(Jeong Hyun Park),김대중(Dae Joong Kim),한장희(Jang Hee Hahn),김홍태(Hong Tae Kim),정용욱(Yong Wook Jung),성훈기(Hoon Ki Sung),김주영(Joo Young Kim),송인환(In Hwan Song),성언기(Eon Gi Sung),이융창(Yung Chang Lee) 대한해부학회 2001 Anatomy & Cell Biology Vol.34 No.5

Catechin은 녹차에서 추출되는 폴리페놀의 주요성분으로 고혈압 및 동맥경화의 예방효과, 당뇨억제효과, 항산화작용, 항암작용 등에 직접 관여하는 물질이다. 본 연구에서는 태평양에서 제공받은 녹차 catechin을 이용하여 상피성 암세포주인 A549 (폐암)와 EATC (복수암)세포에 투여한 후 처리농도와 시간에 따른 변화를 비교, 관찰함으로써 녹차의 효과와 작용기전을 밝혀내는데 목적이 있었다. 본실험은 A549 세포와 EATC 세포를 배양한 후 녹차 catechin을 1, 10, 100, 500 μg/ml의 농도로 48시간 동안 처리하였고, 광학현미경, 공초점현미경, 전자현미경 등을 이용하여 세포의 구조적 변화를 확인하였으며 MTT분석, 전기영동, 유세포분석기 등을 사용하여 세포 손상정도를 파악하였다. A549 세포에서는 catechin 1 μg/ml와 10 μg/ml 농도에서는 대조군에 비하여 큰 변화를 관찰할 수 없었다. 100 μg/ml catechin을 처리하였을 때 세포내의 검은 과립들의 수가 증가하였고 층판소체의 손상이 나타났다. 세포주기의 장애가 나타나 DNA 합성전기에 있는 세포들의 수가 급격히 증가하였다. 500 μg/ml 농도에서는 층판소체와 사립체의 파괴가 심하게 나타났으며 세포생존율이 감소하였고 세포주기의 장애도 관찰되었다. EATC 세포에서는 catechin의 농도가 A549 세포의 경우보다 낮은 농도에서도 세포증식 억제 및 세포손상 효과가 나타났다. 10 μg/ml 농도에서도 세포의 위축과 생존율의 감소가 일어났으며 전기영동상에 괴사되는 세포들이 파악되었다. 100μg/ml catechin을 처리하였을 때 자연사의 형태학적 관찰, 전기영동, 유세포분석 등에서 자연사 과정에 있는 세포들이 많이 나타났다. 결과적으로 녹차 catechin을 배양한 상피성 암세포에 투여함으로서 세포의 생존율과 증식이 억제되었고 그 과정에서 괴사, 자연사, 세포주기의 장애 등이 관여하는 것으로 생각된다. 그러나 일련의 세포손상과정을 유도하는 데 있어 세포의 종류, 처리 시간, 농도에 따라 다소 차이가 있음을 확인하였다. Catechin is main component of polyphenol extracts from green tea, it is associated with prevention of hypertension and atherosclerosis, anti-diabetic effect, antioxidant, antitumor. The purpose of this research is to investigate the effect and its mechanism of green tea catechin on epithelial cancer cell lines in various concentrations and durations. For this study, epithelial cancer cell lines, A549 (lung cancer), EATC (Ehrlich-Lettre ascites tumor cell) were used. Inverted, light, confocal and electron microscopes were applied to find morphological changes. MTT assay, flowcytometric analysis, gel electrophoresis were used to compare severity of cellular damages to control after exposure to 1, 10, 100 and 500 μg/ml catechin for 48 hours. In the A549 cells, after 1 μg/ml and 10 μg/ml catechin treatments, there was no notable changes. However, exposure to 100 μg/ml catechin induced increase of cytoplasmic granules, destruction of lamellar body, inhibition of cell cycle, especially G0/G1. In the early phase of 500 μg/ml catechin administration, decrease of cell population, severe destruction of lamellar bodies and mitochondria, derangement of cell cycle were shown. In the EATC, such as those effects occurred after exposure to lower concentration of catechin than in that of A549 cells. After exposure of 10 μg/ml catechin, rounded-up cells and necrotic cells were found. Whereas, most of cells were under apoptotic changes-cytoplasmic condensation, nuclear fragmentation, cellular shrinkage, ladder pattern in the electrophoresis, when administrated 100 μg/ml catechin. These results suggested that exposure of catechin induced severe cellular damage and growth inhibition in dose- and time-dependent manner. And we confirmed that these effects of catechin were involved with apoptosis, necrosis and cell cycle arrest and were quite different according to cancer type. Therefore, much more research would be demanded before clinical application of catechin to human cancer therapy and this study would be the basic source for further study of green tea.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

FEA와 다이나모메터를 이용한 자동차 디스크 브레이크의 열적 거동에 관한 연구

박범식,손영지,장성규,전언찬 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

While braking cars, a large amount of energy is taken into the brake system in a short period of time. This leads to some problems ; cracking of the disc, non-uniform wear of pad and disc, fade. Thus it is important to measure the contact thermal behaviour precisely between disc and pad. The measurements must be considered to design the brake system. The paper describes methods to analysis the problem of the thermal behavior on the ventilated disc with ANSYS-a program of FEA and a brake dynamometer. According to this way, the paper can present the error between the data by the dynamometer and the results of analysis by ANSYS.

검도 머리치기 유형에 따른 상지의 근전도 비교 분석

장언량,박영훈,염창홍,서국웅,노석규 한국운동역학회 2004 한국운동역학회지 Vol.14 No.3

E. R. JANG, Y. H. PARK, C. H. YOUM, K. W. SEO, S. J. NOH. Study of the forearm EMG activities during Kumdo head striking. Korean Journal of Sport Biomechanics, Vol. 14, No. 3, pp. 219-233, 2004. The purpose of this study was to compare the EMG activities of four-forearm muscles during Kumdo head striking. The four skilled and unskilled Kumdo club members were selected from D university in B city. Investigated muscles were left brachioradialis, right brachioradialis and left flexor carpi radialis, right flexor carpi radialis. Raw EMG data were collected during the head striking motions and the average EMG were calculated by the frame width of 0.05s, and then the average %MVC were calculated. The average %MVC values of each muscle in each group were compared. The results are as follows. 1) In each group, there were no significant statistical differences between every muscle over the all phases. 2) There were significant differences, however, between skilled group and unskilled group. The former got higher average %MVC at left flexor carpi radialis and the latter at right brachioradialis in the ready phase and in the impact phase.

검도 머리치기 유형에 따른 상지의 근전도 비교 분석

장언량,박영훈,염창홍,서국웅,이경순,강영택,양충모 釜山大學校 附設 體育科學硏究所 2004 體育科學硏究所 論文集 Vol.20 No.-

Of the fencing club members at D university in B city, the four skilled members and the 4 unskilled members were selected. The MVC of the left brachioradialis, right brachioradialis and left flexor carpi radialis, right flexor carpi radialis each was measured in each group according to the striking directions as they act 'striking left right head'......

스테레오 정합을 위한 간단한 구조 정보 추출 알고리즘

최환언,박창순,김두영 동아대학교 공과대학 부설 한국자원개발연구소 1991 硏究報告 Vol.15 No.1

In this paper, we present a simple algorithm to obtain three dimensional information of an object. In the preprocessing of the stereo matching, feature point informations of stereo image must be less sensitive to noise and well liked the correspondance problem. This paper described a simple technique of structure features extraction of 3-D object. The features such as corner point and its angle(convexity or concavity) are used for matching problem. The experimental results show that the described algorithm is a useful method for stereo correspondence problem.

니켈기 초내열합금 RENE 80 의 크리프시험중 결정입계 균열생성 및 전파

조창용,김학민,박용조,김승언,이상래 대한금속재료학회(대한금속학회) 1991 대한금속·재료학회지 Vol.29 No.11

Two kinds of specimens with different microstructure were prepared by changing casting variables in vacuum investment casting. The effect of microstructural difference on the creep behavior, creep crack initiation and creep crack propagation was studied in Ni base superalloy RENE 80. The specimen having fine grained and uniformly distributed carbide exhibited superior creep properties to the large grained specimen tested at 760℃. However above 870℃, two kinds of specimens showed similar creep behavior. At higher temperature creep, crack initiation was principally caused by the reaction between the grain boundary exposed at the surface and the test atmosphere rather than the internal microstructural changes. The crack initiated at the surface propagated to the internal area and this kind of crack propagation leads to fracture of material.

소모성 질환에 이환된 이유자돈에 대해 Porcine cytomegalovirus DNA Polymerase 유전자 검출과 분석

김지언,김지영,楚佳奇,채미경,장경수,김명철,박창식,전무형 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Porcine cytomegalovirus (PCMV) causes piglet deaths, runting, inclusion body rhinitis, respiratory and reproductive disorders in swine herd, resulting in the significant economic losses in the swine industry. Recently, in the field of pig-to-human xenotransplantation, PCMV has been indicated as a potential xenogeneic pathogen with the risk for infection transmitted from the xenograft donor to the recipient. In this study, PCMV DNA polymerase gene was detected in the sera and nasal swabs from 30 heads of the weaned piglets affected with various wasting diseases and 10 heads of normal healthy piglets using polymerase chain reaction (PCR), and the diagnostic efficacy of PCR was evaluated. The prevalence of the PCR-positive by specimens from the diseased piglets were 83.3% in sera and 33.3% in nasal swabs. In the normal healthy group, the PCR-positive rates of sera and nasal swabs were 40% and 30%, respectively. Ten piglets (25.0%) out of 40 showed the simultaneously positive results in both of sera and nasal swabs. According to this result, it was found that the serum specimen was the most appropriate sample for detection of PCMV by PCR. The nucleotide sequence homology of DNA polymerase gene of PCMV KS1 as compared with the reference strain of PCMV (GenBank accesson no.AF027217) was 99.0%.