형질전환돼지를 이용한 이종장기이식(xenotransplantation)과 돼지바이러스의 이종감염 잠재성 : A Review

채미경,김지영,김명철,박창식,김태용,전무형 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.1

Recent advances in xenotransplantation technology as a therapeutic approach have the potential to benefit human health. Despite the greater immunological barrier, pigs are favored over primates as a source of transplant tissue for a variety of practical, ethical and safety reasons. The pigs are easy to breed and economic to produce, and the physiology and the size of porcine organs are similar to those in humans. However, It is important to recognize that xenotransplantation may put the human community at risk. Transplantation of porcine organs to human will allow microorganism present in the donor organs to bypass the normal defense mechanism of the recipient. Through xenogeneic infection, an agent that is non-pathognic in its natural host may become pathogenic in the recipient. The present article reviews the current knowledge regarding porcine viruses and their potential for xenogeneic transmission in humans upon xenotransplantation.

부모의 학대 및 방임이 청소년의 학교생활적응에 미치는 영향: 자아정체감의 매개효과

채미경,김현숙 한국청소년학회 2018 청소년학연구 Vol.25 No.10

The purpose of this study was to investigate mediating effects of Ego-identity in relationship between parental abuse and neglect from parents and school adjustment. For this purpose, this study used third-year date from ‘Korean Children and Youth Panel Survey 2012(KCYPS)’, and analyzed 2,259 middle school students with third-grade. SPSS 22.0 was used for implementing a correlation and Multiple Regression Analysis. The results showed as follows: First, abused and neglect from parents and school adjustment showed a significant negative correlations, and same result to ego-identity. And ego-identity and school adjustment showed a significant positive correlation. Second, adolescents’ ego-identity had a partial mediating effect on the relation between abuse and neglect from parents and adolescents’ school adjustment. These results suggest that home, school, and local community need to make an effort to improve ego-identity of adolescents. Finally, suggestions for the limitations of this study and ideas for further research were discussed and proposed. 본 연구의 목적은 부모의 학대와 방임이 청소년의 학교생활적응에 미치는 영향에서 자아정체감의 매개효과가 어떠한 지를 알아보는 것이다. 이를 위해서‘한국아동청소년패널조사(KCYPS)’3차년도(2012) 데이터를 활용하여 중3 2,259명을 대상으로 분석하였다. 자료 분석을 위해 기술통계, Pearson 상관관계 및 위계적 회귀분석을 실시하였다. 연구 결과는 다음과 같다. 첫째, 부모의 학대와 방임은 학교생활적응, 자아정체감과 유의한 부적 상관을 보였고, 자아정체감과 학교생활적응은 유의한 정적 상관을 나타내어, 부모의 학대, 방임의 수준이 높을수록 자아정체감과 학교생활적응이 낮아지는 것을 알 수 있다. 둘째, 부모의 학대 및 방임, 학교생활적응 간의 관계에서 자아정체감의 매개효과의 검증 결과, 학대와 학교생활적응간의 관계에서 자아정체감은 부분매개효과를 가지며, 방임과 학교생활적응간의 관계에서도 부분매개효과를 갖는 것으로 나타났다. 이러한 결과는 청소년들의 학교생활적응을 향상시키기 위해서는 가정에서의 부모의 학대 및 방임 예방을 위한 적극적인 사회적 관심과 함께 청소년들의 자아정체성을 높이기 위한 노력이 필요함을 시사한다.

형질전환돼지를 이용한 이종장기이식(xenotransplantation)과 돼지바이러스의 이종감염 잠재성

채미경,김지영,김명철,박창식,김태용,전무형 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Recent advances in xenotransplantation technology as a therapeutic approach have the potential to benefit human health. Despite the greater immunological barrier,pigs are favored over primates as a source of transplant tissue for a variety of practical,ethical and safety reasons. The pigs are easy to breed and economic to produce,and the physiology and the size of porcine organs are similar to those in humans. However,It is important to recognize that xcnotransplantation may put the human community at risk. Transplantation of porcine organs to human will allow microorganism present in the donor organs to bypass the normal defense mechanism of the recipient. Through xenogeneic infection, an agent that is non cingohtap-in its natural host may become pathogenic in the recipient. The present article reviews the current knowledge regarding porcine viruses and their potential for xenogeneic transmission in humans upon xenotransplantation.

우리 나라 증권회사의 지식경영 실태 및 바람직한 모형에 관한 연구

지호준,채미경 안동대학교 경영연구소 1999 경영연구 Vol.3 No.1

우리 나라 증권회사들을 대상으로 지식경영의 실태를 다각도로 실증 분석해 본 결과 대체로 지식경영에 대한 인지도도 낮았으며, 지식관리시스템이 특히 부진한 것으로 나타났다. 또한 지식경영을 위한 제도적 뒷받침도 부족한 것으로 나타났다. 따라서 증권회사들이 바람직한 지식경영모형을 구축하기 위해서는 크게 하드웨어적인 시스템개선전략이 필요하며 소프트웨어적인 운영혁신전략도 필요한 것으로 나타났다.

Roxythromycin-tylosin-furaltadone 합제의 닭 유래 세균에 대한 시험관내 항균효과

김지영,채미경,윤효인,서상희,박배근,김현수,전무형 충남대학교 수의과대학 동물의과학연구소 2003 動物醫科學硏究誌 Vol.11 No.-

In vitro antimicrobial susceptibility of roxythromycin (Rx), tylosin (Tyl), erythromycin (EM) and furaltadone (Fur) was studied, either by the single type or the combinated type of Rx-Tyl-Fur (RTF) against E. co1i (30 strains), Staph. aureus (20 strains) and Mycoplasma gallisepticum (5 strains) that are the major pathogens in poultry farm. The paper disk diffusion and MIC tests were applied. In screening test by paper disk diffusion method, the single types of antibiotics showed the sensitivity against 55 strains of bacteria in order of Fur, EM, Rx and Tyl. The combinated RTF showed the higher rate of sensitivity (80∼83.3% at 64㎍/disk, 60-75% at 32㎍/disk) and wider range of growth inhibiting zone (19.6±3.7-24.8±4.7mm) than those of the single drugs. In MIC test, the sensitivity against the 55 strains appeared in order of Fur. EM, Rx and Tyl as similar to those of paper disk diffusion method. The MIC ranges of RTF were 0.125∼16㎍/ml for E. coli, 0.25∼16㎍/ml for Staph. aureus and 1-8㎍/ml for Myco. gallisepticum, showing evidently lower than those of the single types. The MIC_(50) and MIC_(90) of RTF were estimated l∼4㎍/ml and 8∼16㎍/ml, respectively, and remarkably lower than those of the single drugs.

원/달러 환율과 엔/달러 환율의 시차동조성

지호준,채미경 韓日經商學會 2001 韓日經商論集 Vol.22 No.-

This study is aimed to investigate lead-lag relation between won-dollar exchange rate and yen-dollar exchange rate. The result of Ljung-Box Q test on the cross-correlation analysis show that during the past the decade the nominal won-dollar exchange rate have 12 days time-lag cross correlation to the nominal yen-dollar exchange rate. But in the volatile period after IMF bailout package, there was no significant result. We performed the three kinds of causality test, Granger causality test, Sims' test of exogeneity and Geweke-Meese-Dent test, The evidence of the three causality tests suggests that the nominal change of yen-dollar exchange rate unidirectionally cause the nominal change won-dollar exchange rate for 12 days. In the volatile period after IMF bailout package, there was also no significant result in these tests. And in the real change of exchange rate, we have no significant cross-correlation except the stable period after IMF bailout package. Thus, the nominal change of yen-dollar exchange rate except the volatile period would contain any information exploitable in forecasting the nominal change of yen-dollar exchange rate and have the predictive value of leading indicators. Key words : lead-lag relation, won dollar exchange rate, yen dollar exchange rate, cross correlation, causality

Ciprofloxacin의 돼지 호흡기 감염증 및 설사증에 대한 치료효과

전무형,김지영,채미경,서상희,김명철,박창식,김태용,윤효인 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

To evaluate the clinical efficacy of ciprofloxacin (CFX) on treatment of the pigs with respiratory diseases or diarrhea. CFX at various dosages were administered intramuscularly to the diseased pigs selected from the pig farms located in Chungnam province. One hundreds and fourteen heads of pigs with respiratory diseases were divided into five groups and CFX at 0.25, 0.5, 1.0 (= 2.5mg CFX/Kg B.W.) and 2.0 doses were administered i.m. for 5 days. The recovery rates were found 31.8%, 73.9%, 91.3% and 92.0%, respectively, being higher than that of the untreated control group (19.0%). The mortality of the treated groups were 0%, that is lower than that of the control (9.5%). Seven kinds of bacteria were isolated from the respiratory organs of 86 pigs, and 34 (39.5%) of 86 pigs showed the complicated infection. In analyzing by the pigs infected with a single pathogen as P. multocida; A. pleuropneumonia. Staphyloccus spp. or Mymplasma spp., the recovery rates were 0∼66.6% at 0.25 dose, 66.6∼100% at 0.5 dose and 100% in all of 4 pathogens at 1.0 to 2.0 doses. At 0.25 dosage the pigs infected with A. pleuropneumonia showed the lowest recovery rate. One hundreds and twenty two heads of pigs with diarrhea were divided into five groups and CFX at 0.25, 0.5, 1.0 (= 2.5mg CFX/Kg B.W.) and 2.0 doses were administered i.m. for 5 days. The recovery rates were 29.1 %, 40.0%, 80.0% and 88.0%, respectively. The mortality of the treated groups were 0∼8.3%, being much lower than that of the control. Four kinds of bacteria were isolated from the fecal specimens of 94 pigs, and 84 (89.0%) of 94 pigs showed the complicated infection.

도축돈 장분변으로부터 Shiga Toxin-Producing Escherichia coli의 분리와 성상

송영환,김지영,채미경,박창식,김명철,전무형 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

Shiga toxin-producing Escherichia coli (STEC) causes various clinical signs in human and animals, and has been indicated as a global enteropathogen with zoonotic importance. In this study, the feces of healthy pigs were collected from the slaughtered pigs of Daejon abattoir during the period from December 2001 to October 2002. Of 326 specimens, 13 STEC were confirmed by culture, PCR and colony hybridization. The isolates were further studied for toxin types, pathogenic factors, plasmid profiles, and antimicrobial resistance to characterize the genetic and toxigenic properties. In PCR, all of 13 isolates were evident to have shiga toxin gene (stx). Of 13 isolates stx1 gene was detected in 4 and stx2 gene in 9. The genes of eaeA, hlyA and rfbE were not present in any isolates. In colony hybridization using shiga toxin common primer (STXc), 2 to 9 per 100 colonies subcultured from 13 isolates showed the positive reaction. In the examination for plasmid profiles of the isolates, one to eleven plasmids with varying sizes of 1.0 Kb to 100 Kb were detected, and the 13 STEC could be classified into four groups by the plasmid patterns. The antimicrobial resistance patterns of the isolates were comparably corresponded with the plasmid profile patterns.

Ciprofloxacin의 돼지 호흡기 감염증 및 설사증에 대한 치료효과

전무형,김지영,채미경,서상희,김명철,박창식,김태용,윤효인 충남대학교 수의과대학 동물의과학연구소 2003 動物醫科學硏究誌 Vol.11 No.-

To evaluate the clinical efficacy of ciprofloxacin (CFX) on treatment of the pigs with respiratory diseases or diarrhea, CFX at various dosages were administered intramuscularly to the diseased pigs selected from the pig farms located in Chungnam province. One hundreds and fourteen heads of pigs with respiratory diseases were divided into five groups and CFX at 0.25, 0.5, 1.0 ( = 2.5mg CFX/Kg B.W.) and 2.0 doses were administered i.m. for 5 days. The recovery rates were found 31.8%, 73.9%, 91.3% and 92.0%, respectively, being higher than that of the untreated control group (19.0%). The mortality of the treated groups were 0%, that is lower than that of the control (9.5%). Seven kinds of bacteria were isolated from the respiratory organs of 86 pigs, and 34 (39.5%) of 86 pigs showed the complicated infection. In analyzing by the pigs infected with a single pathogen as P. multocida, A. pleuropneumonia, Staphylclcoccus spp. or Mycoplasma spp., the recovery rates were 0∼66.6% at 0.25 dose. 66.6∼100% at 0.5 dose and 100% in all of 4 pathogens at 1.0 to 2.0 doses. At 0.25 dosage the pigs infected with A. pleuropneumonia showed the lowest recovery rate. One hundreds and twenty two heads of pigs with diarrhea were divided into five groups and CFX at 0.25, 0.5, 1.0 ( = 2.5mg CFX/Kg B.W.) and 2.0 doses were administered i.m. for 5 days. The recovery rates were 29.1%, 40.0%, 80.0% and 88.0%, respectively. The mortality of the treated groups were 0-8.3%, being much lower than that of the control. Four kinds of bacteria were isolated from the fecal specimens of 94 pigs, and 84 (89.0%) of 94 pigs showed the complicated infection.

도축돈 장분변으로부터 Shiga Toxin-Producing Escherchia coli의 분리 와 성상

송영환,김지영,채미경,박창식,김명철,전무형,Song, Young-hwan,Kim, Ji-young,Chae, Mi-kyung,Park, Chang-sik,Kim, Myung-chul,Jun, Moo-hyung 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.4

Shiga toxin-producing Escherichia coli (STEC) causes various clinical signs in human and animals, and has been indicated as a global enteropathogen with zoonotic importance. In this study, the feces of healthy pigs were collected from the slaughtered pigs of Daejon abattoir during the period from December 2001 to October 2002. Of 326 specimens, 13 STEC were confirmed by culture, PCR and colony hybridization. The isolates were further studied for toxin types, pathogenic factors, plasmid profiles, and antimicrobial resistance to characterize the genetic and toxigenic properties. In PCR, all of 13 isolates were evident to have shiga toxin gene (stx). Of 13 isolates stx1 gene was detected in 4 and stx2 gene in 9. The genes of eaeA, hlyA and rfbE were not present in any isolates. In colony hybridization using shiga toxin common primer (STXc), 2 to 9 per 100 colonies subcultured from 13 isolates showed the positive reaction. In the examination for plasmid profiles of the isolates, one to eleven plasmids with varying sizes of 1.0 Kb to 100 Kb were detected, and the 13 STEC could be classified into four groups by the plasmid patterns. The antimicrobial resistance patterns of the isolates were comparably corresponded with the plasmid profile patterns.