정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

大邱地域住民의 生活體育 實態分析 : 早起運動參與度를 中心으로 Focusing on participation degree of populations exercising in the morning

蔡鴻遠,金柄斗,李敏炯,金基學,朴宇奎 慶北大學校 體育科學硏究所 1991 체육과학연구지 Vol.7 No.-

The purpose of this study is to get the source materials to activate mass sports of regional populations. At first, it was by sex, age, and occupations examined and analysed populations that would participate in physical activities from 5 to 8 Am at 28 pate-up mountains and 477 workplaces, schools, public facilities, and commercial facilities sontrolled by 7 district offices in Daegu. The mothod of investigation made a preliminary inquiry in advance and set in place 70 investigators in entrance of path-up mountains and sports facilities. Especially, the occupational classification was adopted from socilolgical job calssification model and every result value of analysis was dealed and compared with percentage by means of Daewoo Corona 286 PC. Accordiangly, the concrete conclusions are summarized as follows : 1) The total number of persons participating in mass sports in the morning is 18,045(men 10,850 : 59%, women 7,465 : 41%), and it is about 1% level by the rate of population and low participation rate in comparison with advanced nations. ① It is showed that the participation value in proportion to sex is 17.4% more in men's case taking 10,587 persons(58.7%) than 7,458 persons(41.3%) in women's case. ② Taking the dimensions of participation degree in proportion to age, it is taken the most value in fifties age with 5,092 persons (28%), showing in sixties, forties, thirties, twenties age in sequence. ③ Taking the dimensions of participation degree in proportion to occupation, it is taken the most value in housewife with 5,569 persons (31%), showing the unemployed, independent enterprise, technical expert, clerical work, deministrative position, student, technical work, manual labor, agriculture and forestry, and fishery in sequence. 2) Judging from the participation degree in proportion to district office, it is taken the most value in Mam-gu with 3,821 persons(21.2%) and Dalseo-gu with 3,776 persons(20.9%) and the least in Joong-gu with 1,612 persons(8.9) and Seo-gu with 1,589 persons(8.8%). It is assumed that low participation value in Joong-gu and Seo-gu should result from deficient facilities and close space of urban.

彈性抵抗 Tubex 運動이 腕回轉 파워에 미치는 效果

蔡鴻遠,金柄斗,李敏炯,林銖遠 慶北大學校 體育科學硏究所 1990 체육과학연구지 Vol.6 No.-

The purpose of this study is to analyze the effect of elastic recoil tubex exercise for development of shoulder rotation power, 9 male players were selected out of the volleyball players in kpu. The experiment was focused on full swing, half swing, chest full and pull down with tube(1 Tubex tension-1½ Tubex tension). The exercise duration was 8 weeks, and it's frequency was 4-5 times or 5-6 times a week, and they got tests twice : one at the begining of the experiment, and the other 8 weeks later. The test was measured at 60°/sec, 180°/sec and 240°/sec using cybex 340 system, the result of which are as follows : ① Peak torque The wrist showed significant (P<.01, P<.05) increases in the extension at 60°/sec, 180°/sec and 240°/sec, and only the flexion at 240°/sec (P<.05). In the elbow, only extension, was significant (P<.05) increase at 240°/sec. Also in the shoulder, only extension was significant (P<.01, P<.05) increase at 60°/sec, 180°/sec and 240°/sec. But in te shoulder, the adducation and abduction appears nonsignificant. ② Muscle endurance ratio The result of the test upon both the flexion and the extension in the wrist were statistically significant (P<.01) at 240°/sec. ③ Flexion / extension ratio The ratio of Flexion and extension apperar nonsignificant decrease after experiment. but there was only significant (P<.05) decrease in wrist at 180°/sec.

cDNA array 방법을 이용한 망간에 노출된 흰쥐 뇌기저핵의 유전자발현 분석

이채관,노성민,문덕환,,김정호,손병철,김대환,이창희,김휘동,김정원,김종은,안진홍,이채언 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study investigated the gene expression profile in basal ganglia of manganese-exposed rats based on cDNA array analysis. Methods: For cDNA array, 25 male Sprague-Dawley rats (250±25 g) were intraperitoneally injected with 25 ㎎/㎏ B. W./day of MnCl2 (0.3 ㎖) for 10 days. For dose-related gene expression analysis, rats were intraperitoneally injected with 0.2, 1.0, and 5.0 ㎎/㎏ B. W/day of MnCl2 for 10 days. Control rats were injected with an equal volume of saline. RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α^(32)P]-dATP. Membrane sets of the Atlas Rat 1.2 array Ⅱ and Toxicology array 1.2 kit (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. Northern blot hybridization method was employed to assess the dose-related gene expression. Results: Fifty-two genes showed significant changes in expression of more than two-fold. Twenty-eight were up-regulated and 24 were down-regulated in the manganese-exposed group compared to the control. Among the 52 genes, 28 genes including nuclear factor I-X1 (NF1-X1), neuroligin 2 and 3, mitochondrial stress-70 protein (MTHSP70), neurodegeneration-associated protein 1 (Neurodap 1), multidrug resistance protein (MDR), and endoplasmic reticulum stress protein 72 (ERP72), were reported for the first time related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia. According to the dose-related gene expression analyses, MTHSP70, Neurodap 1 and ERP72 genes were up-regulated compared to the control even in the group exposed to low manganese dose ( 0.2 ㎎/㎏ B.W./day). Conclusions: Twenty-eight genes detected for the first time in this study were closely related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia and further study of these genes can give some more useful information about the manganese metabolism.

社會體育振興을 위한 國民意識 再考方案

金柄斗,蔡鴻遠,安禹洪,李敏炯,申榮吉,金基學,鄭相澤,林銖遠 慶北大學校 體育科學硏究所 1987 체육과학연구지 Vol.3 No.-

The purpose of this paper is to investigate and analyze the nation's consciousness about the social physical education by regional groups(big cityes, middle cityes, farm village, fishing villge). And the researchers are to find a way to populize this movement. These subjects for this investigation were chosen at random among the citizens in four region. 4,450 sheets of questionnaire were given to the citizen. And 3,587(81%) sheets of them were received from male(2,582) and female(975) citizens. The results of this investigation are as follows: 1. The nation's consciousness has not been still modernized and the nation tend to depend on their doctors rather than on the new active leisure sports, which is a passive and conventional way, to keep their health. 2. Most people have spent their leisures on nonactive hobby such as reading, listening to music, and watching TV rather than sports. 3. Most residents pointed out lack of facilities, and needed professional directors and various programs they could participate. 4. The opening of citizen athletic field and the gymnasiums to citizens was needed to recruit the lack of facility, and the participation to commercial sport ws differed by economical status and leisure time, however, they usually participated such activities as table-tennis, swimning and tennis. 5. To activate social physical education, first of all, an expansion of the facilities such as athletic fields and gymnasium is needed under the active support of government. 6. The facilities for young men and the handicapped is insufficient, and to prevent juvenile delinquency and guide them into the right way, we should lead them out to participate sports activity. And the facility for the handicapped is needed too.

장중첩증을 동반한 맹장 지방종 1예

홍의실,나병규,김민옥,유일영,채지영,채희복,윤세진,이상전,송형근,박길선,정현용 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

대장 지방종은 주로 우측 결장에 호발하고 특히 회맹판 부위와 맹장 부위에 호발한다. 또한 50~60대에 빈도가 높고 증상이 있는 환자에서 장중첩증이 높게는 40~50%에서 보고되고 있어 성인 장중첩증의 원인으로 중요한 비중을 차지한다. 특히 성인 장중첩증 및 장폐쇄의 중요 원인인 악성 종양과 임상 양상이 유사하여 감별진단이 중요하다. 저자들은 반복적인 복통을 주소로 내원한 환자에서 맹장의 4×5㎝의 점막하 지방종이 말단 회장부위와 반복적인 장중첩중이 발생했던 1례를 부분 절제술로 치료하여 양호한 임상 경과를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Lipomas are one of the most common benign nonepithelial tumors of the colon which are often detected incidentally by radiologic investigation or on operation. These tumors are usually without specific symptoms. Colonic lipomas occur most often in the right colon, particularly in the ileocecal valve and the cecum. Most patients are asymptomatic. but tumors larger than 2 cm tend to produce a change in bowel habit. abdominal pain. rectorrhagia and complications including luminal obstruction or intestinal intussusception. Diagnosis can be made by colonoscopy abdominal CT. MRI, or barium enema. We report a case of lipoma of the cecum that originated in the submucosa and presented as a intussusception in a 50-year-old woman with a brief review of the literature.

초음파화학 공정에 의한 파라핀계 상전이물질의 에멀전 형성과 이로 부터 멜라민-포름알데히드 수지를 벽 재료로 사용한 마이크로캡슐의 제조

한창훈,채하늘,민병길,Han, Chang-Hoon,Chae, Haneul,Min, Byung Gil 한국섬유공학회 2021 한국섬유공학회지 Vol.58 No.4

An O/W emulsion of paraffinic phase change material (PCM) was prepared through a sonochemical process for microencapsulation using melamine-formaldehyde resin as the wall material. It was found that the octadecane micelles selected as PCM were successfully formed in water with a diameter of 1-3 ㎛ through ultrasonication for 5 min. Anionic surfactants were found to be more effective than non-ionic surfactants in the formation of emulsions consisting of PCM micelles through a sonochemical process. Spherical PCM microcapsules were obtained from the PCM emulsion and melamine-formaldehyde prepolymer, which was used as the wall material. The diameter of the PCM microcapsules increased with increasing microencapsulation time and the prepolymer to PCM weight ratio.

고농도 산소 공급이 노인의 인지 능력과 혈중 산소 포화도에 미치는 영향

김지혜(Ji-Hye Kim),신채호(Chae-Ho Shin),최윤정(Yoon-Jeong Choi),최미현(Mi-Hyun Choi),이수정(Su-Jeong Lee),양재웅(Jae-Woong Yang),민병찬(Byung-Chan Min),박세진(Se-Jin Park),정순철(Soon-Cheol Chung) 대한인간공학회 2010 대한인간공학회 학술대회논문집 Vol.2010 No.10

This study investigated changes in cognitive task performance and blood oxygen saturation (SpO2) of old people when the concentration and supply rate of oxygen administration were varied (21% (1L/min), 93% (1L/min), and 93% (5L/min)). It recruited totally 20 elderly subjects including 9 males (75.1±4.2 years) and 11 females (73.1±4.3 years). The experiment consisted of 1-back task performed under three conditions (21% (1L/min), 93% (1L/min), and 93% (5L/min)). Each run consisted of three phases: Adaptation of oxygen administration (3 min), Control (2 min), and 1-bak task (2 min). SpO2 [%] was measured during each phase. Higher concentration and supply rate of oxygen administration were associated with more pronounced increase in SpO2 and decrease in response time of 1-back task.

강섬유 보강 콘크리트 슬래브 휨강성의 실험적 평가

채병민(Chae, Byung Min),심우경(Shim, Woo Kyung),정승원(Jung, Seong Won),홍건호(Hong, Geon Ho) 한국콘크리트학회 2018 한국콘크리트학회 학술대회 논문집 Vol.30 No.2

트러스 데크플레이트를 이용한 강섬유 보강 콘크리트 슬래브의 구조 거동

채병민(Chae, Byung Min),홍건호(Hong, Geon Ho) 한국콘크리트학회 2018 한국콘크리트학회 학술대회 논문집 Vol.30 No.1