「『拙藁千百』 譯註」(7) : 권1「金文正公墓誌」의 분석을 중심으로

이진한(Lee, Jin-Han),김보광(Kim, Bo-Kwang),김규록(Kim, Kyu-Rok) 고려사학회 2014 한국사학보 Vol.- No.55

『졸고천백』은 2권으로 된 최해의 문집이다. 최해는 주로 고려에서 활동하다가 정치적으로 소외되어 크게 현달하지 못하고 40세 정도에 은퇴하였다. 그는 대신 이제현, 이곡, 최문도 등 당대 최고의 문인과 교유하였다. 이 논문에서는 『졸고천백』중 권1의 15번째 글인「김문정공의 묘지」라는 글의 특징을 살피고, 번역 및 주석의 작업을 하였다. 이 글은 고려후기의 인물인 김태현을 위한 묘지명이다. 1261년에 태어난 김태현은 1276년(충렬왕 2)에 과거 급제한 이래 1330년에 사망할때까지 거의 대부분의 시기를 관원으로 활동하였다. 이 시기에 고려는 충렬왕과 충선왕의 重祚, 충선왕의 활동 및 토번 유배, 입성책동 등 굵직굵직한 정치적 사건을 겪었다. 이러한 정치상황에 따라 그는 관직 경력 상의 부침을 겪었는데, 「김태현묘지명」에서 주목되는 몇 가지를 정리하면 아래와 같다. 1) 아버지인 김수에 대한 기록이 주목된다. 삼별초가 제주도로 들어가려 할 때 제주로 파견되어 이를 막으려다 전사하였다는 내용이 실려 있다. 2) 김태현이 1280년에 충렬왕이 직접 선발한 시험에 합격하여, ‘전시문생’이라 불리면서 충렬왕의 측근으로 활동했다. 3) 그래서 충선왕이 1298년에 즉위하였을 때 그가 면직되었다는 사실 등 여타 기록에서 찾을 수 없는 경력을 이 묘지명을 통해서 확인할 수 있었다. Cholgo Ch"onbaek is a two-volume anthology of Choi Hae. He mostly worked in Goryeo, then later became politically isolated and made an early retirement at around 40 without significant achievements. This study examined the characteristics of ‘the epitaph for Kim Tae-hyun,’ the 15th entry in the book, and translated and annotated the original text. Mr. Kim was born in 1261, passed the state examination in 1276, and served as a government official most of his life until his death in 1330. This was a politically turmoil period that saw the enthronement, dethronement, as well as reinstatement of King Chungryeol and King Chungseon, the exile of King Chungseon to the present-day Tibet (Tobun at the time), the Mongol intervention in the Goryeo territory. Amid these political unrest, Mr. Kim’s career fluctuated as well. Some of the events are recorded in the work, which cannot be found elsewhere: 1) His father Su Kim is mentioned, who was dispatched to Jeju Island and killed there while trying to keep Sambyeolcho(a special capital defense unit) from entering the island. 2) Mr. Kim passed a state test directly overseen by King Chungryeol in 1280, and worked as a close aide to the king with a title Jeonsi-munsaeng(king"s students). 3) He lost his post when King Chungseon was enthroned in 1298. 4) The record shows that in the early 1300s, the Yuan dynasty operated 11 stations between Gaepyung and Gamsukseong.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

개질 아스팔트 혼합물의 변형강도 측정 연구

김광우,도영수,이기호,조문진,최선주 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-

본 논문은 아스팔트 혼합물의 소성변형 저항성과 상관성이 높은 특성치를 찾고자 Kim test를 개발하여 현재 적용성 연구결과를 다루고 있다. 이 논문은 새로운 강도특성치인 변형강도(S_(D))를 개발하는 Kim, test 연구의 4단계 연구 결과이다. 13 mm 골재(편마암, 화강암)와 입도(밀입도, 갭입도) 5가지 폴리머로 제조한 8가지 바인더로 두 가지 입도에서 소성변형 저항성이 다른 32가지 혼합물을 만들었다. 슬래브(305㎜×305㎜×62㎜)공시체를 제조하여 한쪽은 Kim, test를 수행하기 위하여 18 cm정도로 잘라서 코어를 3개 채취하고 다른 한쪽은 12cm크기로 하여 반복주행시험을 실시하였다. Kim, test는 하중봉 3(0.75), 4(1.0)을 사용하였다. W/T시험으로부터 최종 침하 깊이와 동적안정도의 두 가지 소성변형 계수를 각 혼합물별로 구했다. 각 하중봉과 골재별, 입도별로 S_(D)와 소성변형 계수간의 통계적 상관관계 분석을 수행한 결과 S_(D)와 소성변형 계수와의 결정계수가 매우 높게 (R²>0.95) 나타났다. 하중봉 4(1.0)이 3(0.75)보다 다소 높은 상관성을 보였다. 향후 Kim test실험에서 하중봉 4(1.0)을 사용하고 4단계 방법을 이용한다면 소성변형 특성치인 침하깊이(DR)와 동적안정도(DS)와의 상관성이 매우 큰 시험법이 될 것이다. 또한 변형강도의 파괴 메커니즘은 콘크리트의 펀칭파괴와 유사하여 콘크리트의 전단강도 추정식을 근거로 아스팔트 콘크리트의 재료 특성에 적합한 추정식 계수 ◁ 원문 수식 참조 ▷ 를 얻었다. 이 식을 이용한다면 아스팔트 콘크리트가 견딜 수 있는 임계하중을 변형강도에 근거하여 추정할 수 있을 것이다. This study shows predictability of rut parameters of modified and unmodified asphalt concretes based on the deformation strength (S_(D)) which is calculated from the maximum load, deformation and size variables of loading head under simple static loading. This paper is the result of latest studies, phase 4 which is a part of Kim, Test studies for developing a new strength property for asphalt concrete. Two aggregates, gneiss and granite, two gradations, dense-graded, gap-graded, with maximum, size of 13mm and eight binders using different contents of five polymers (RLDPE, RHDPE, LDPE, SBS, SBR) were used to produce 32 different mixtures. A slab (305㎜×305㎜×62㎜) was cut into two pieces(18cm and 12cm width) and three 10cm cores were taken for S_(D) test from the larger piece and wheel tracking test was performed on the smaller piece. Kim test was performed using loading head 4(1.0), 3(0.75). Two rut parameters, depth of rut and dynamic stability, from the rut depth-cycle curve from a WT test were obtained for each mixture. Statistical analysis were performed for each loading head, aggregate, and gradation to find out correlation between S_(D) values and each rut parameter. The analysis results showed that S_(D) had high R² (over 0.95) on the average with rut parameters. The loading head 4(1.0) showed R² better than 3(0.75). It is concluded that S_(D) is the property that has excellent predictability for rut parameter of asphalt concretes. An equation, ◁ 원문 수식 참조 ▷ was obtained based on the equation of concrete shear load creating punching failure and current test data, because the failure mechanism of S_(D) is similar to punching failure of concrete. In the equation, P is shearing force creating punching effect, b is length of perimeter of punching area and d is depth of specimen. If this formula is used, a critical load for deformation failure will be predicted based on the S_(D).

북한경제의 달러화의 김정일 '궁정경제'

김광진 연세대학교 통일연구원 2007 통일연구 Vol.11 No.2

Dollarization and dependence on hard currency for Kim Jong Il, north korean economy and the people is more than serious now. The world already experienced Kim Jong Il's 'pertinacity' to getting back frozen 25mi11ion dollars at BDA, Macau., even not hesitating to show up with failed atomic bomb test. With a new government in South Korea, the south-north relationship is passing through temporary adjustment period and hundreds of thousands of food aid is stopped for a few months, but the rumor is at rampant that a massive starvation is about to break out in North Korea. This is only a case showing North Korea's dependence on outside, It makes quite anxious to know how the present economic situation and rehabilitation ability is for them and why they can not survive even several months without outside help. For correct diagnosis of this, it's needed to look into economic structure, foreign dependence and serious dollarization. The main focus of discussion here is on dollarization. There are 2 kinds in dollarization of economy; one is by government's active involvement through foreign exchange, monetary and foreign economic policy and the other is natural process by market itself as a result of economic downfall, steep devaluation of national currency, increased outside dependence and expanding black market economy. The situation in Peru in mid 90's is for former case. As for North Korea, it was propelled by 'Royal Court Economy' which was set up and expanded by Kim Jong Il and this case is not exactly by government policy. The devastated people's economy run by cabinet, its increased outside dependence, deepening reliance of formal economy and citizens on market by its expansion, rapidly growing 2nd economy and steep fall of 'WON' is another reason. Kim Jong Il himself and market affected both in a mixed way. Independence of munitions industry in 1972 from cabinet by setting up 'Committee of Economy No. 2' and growing up economic sector at party with a start of 'Bureau 39' in 1974 formed up 'Royal Court Economy' which is military-industrial complex. It became the direct source of Kim Jong Il's ruling finance and began to serve solely for munitions industry and system's safeguard. Structured mainly for foreign trade and hard currency earning, it has eaten out people's economy, becoming a group or conglomerate and now occupy 40~60% of the total national economy. Its expansion and running by Dollar kicked up more serious dollarization of economy. Now almost all the nation's hard currency income is made and overtaken by this economic sector. Its current asset is 248 times more than people's economy. This is the main obstacle to rehabilitation of people's economy. The economic sector run by cabinet extracted to 45% scale in late 90's, the peak of hardship, as compared with the level of late 80's when steep fall began. This brought increased outside dependence, growing market and exploding 2nd economy. For survival, citizens were forced into the market rather than relying on state distribution. At the same time, value of 'WON' fell 20 times for 5-6 years since it was devalued to market level in 2002 which was called 7.1 measure.' All these accelerated objection of national currency, increased possession of dollar and black market transactions which makes dollarization extreme. Now it is not too much to say that north korean economy is 'dollar economy,' or 'hard currency economy'. Inflow of outside assistance and dollar at present economic structure means direct inflow into 'Royal Court Economy,' the military-industrial complex. The rehabilitation of north korean economy is only possible when people's economy, the key industries revive. At the moment, the monopoly of hard currency by 'Royal Court Economy' and its priority in resource distribution blocks this way. This is the main reason why North Korea can not stand on itself even though a vast amount of aid was input into the state for past 10 years. Of course, food, fertilizer and heavy oil aid for consuming purpose might be another reason but this is only an excuse. Some say that on a condition one can not change the present system from outside, it can be a pretty smart way to make use of 'Royal Court Economy' sector as motivating force in changing North Korea by letting them taste market economy, which has freer access to outside world. It is sure that the employees in this sector has better ability and skill, and in future they will play the major role in leading change, for they have more frequent contact with outside, better information and understanding of market mechanism. This imposes us another difficult task of choosing how to look at 'Royal Court Economy' and how to handle them.

HDPE 폐비닐 개질 아스팔트 혼합물의 강도 및 공용 특성 연구

김광우 ( Kim Kwang Woo ),이기호 ( Lee Gi Ho ),권오선 ( Kwon Oh Sun ),조문진 ( Cho Mun Jin ) 한국농공학회 2004 한국농공학회 학술대회초록집 Vol.2004 No.-

본 연구는 폐비닐 펠렛을 도로포장재료로 재활용하여 자원절약 및 아스팔트 혼합물의 품질향상을 위한 연구이다. 이를 위하여 폐비닐의 첨가량별 배합설계를 수행하여 적정 폐비닐 첨가량과 최적 아스팔트 함량으로 편마암과 화강암 2가지 골재와 폐비닐인 RHDPE의 함량을 4가지로 혼합물을 제작하여 8종류의 개질 혼합물과 2종류의 무개질 혼합물을 제작하였다. 그리고 이 공시체에 대하여 마살안정도, 간접인장강도 및 Kim test와 반복주행시험 등 실내시험을 통하여 혼합물의 특성을 분석하였다. 폐비닐 첨가량은 RHDPE가 8%일 때 안정도와 간접인장강도 모두 가장 우수한 것으로 나타났고 취성도 나타나지 않았다. RHDPE를 첨가한 혼합물에 대하여 Kim test를 수행한 결과 DR과 DS 모두 높은 상관성을 보였다. 그리고 반복주행시험에서는 RHDPE를 첨가한 혼합물이 일반 혼합물보다 우수하였다. 향후 많은 실험을 통해 RHDPE의 우수성을 입증한다면 소성변형 저항성에 우수한 재료로 이용될 수 있을 것이다. This study is a fundamental research for recycled high-density polyethylene (RHDPE) in asphalt mixture for improving roadway pavement. Mix design was conducted by RHDPE content and optimum asphalt content (OAC) was determined for dense-graded surface course mixture. Marshall stability test, indirect tensile strength (ITS) test, wheel tracking test and Kim-test were carried out to measure the characteristics of RHDPE-added asphalt concretes. From the results of this study, RHDPE in asphalt mixture is possible. It could be considered that adding too much RHDPE in asphalt mixture is not proper. The optimum content of RHDPE was appeared to be 8%. In Kim-test, Statistical analysis were performed for each loading head and aggregate to find out correlation between SD values and each rut parameter. The analysis result showed that SD had very high coefficient of determination on the average with rut parameters.

Risperidone 조기 중단군 및 장기 유지군의 임상적 특성 비교

김광수,박원명,전태연,배치운,김대진,백인호,이철,김정수,한상익,최보문,장계호,고효진 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : Risperidone 투여후 조기 중단한 환자들과 장기적으로 계속 risperidone을 복용하고 있는 환자의 임상적 특성을 평가하고 나아가 risperidone장기 유지와 조기 중단의 요인을 분석하고 정신병리가 약물 투여에 미치는 영향을 조사하고자 하였다. 방 법 : 연구 대상자는 1996년 1월부터 1996년 12월까지 가톨릭대학교 의과대학 부속 8개 병원 정신과에서 risperidone을 투여 시작한 환자 580명중 DSM-IV기준에 의해 정신분열병으로 진단받고 투여 기간이 6개월 미만(조기 중단군)이거나 2년 이상(장기 유지군)을 경과하였으며 의무기록의 누락이 없는 210명을 선정하였다. 두 군간 임상적 특성을 조사하기 위하여 인구학적 변인, 정신병리학적 변인, 약물 투여기록 및 부작용 등을 과거 의무기록을 근거로 평가하였다. 결 과 : 대상환자 210명 중 조기 중단군이 67명(31.9%)이었고 장기 유지군은 143명(68.1%)이었으며 두 군간 인구학적 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 최대 용량은 유의한 차이가 없었으나 유지용량은 조기 중단군에서 4.49(±1.44)mg,장기 유지군에서 3.67(±1.50)mg으로 유의한 차이가 있었다(t=3.698, p<0.05). 또한, 이전 항정신병약물의 사용 기왕력 변인에서 조기 중단군은 기왕력이 없는 환자가 39명(58.2%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 27명(40.3%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 1명(1.5%)이었고, 장기 유지군은 기왕력이 없는 환자가 58명(40.6%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 77명(53.8%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 8명(5.6%)으로 유의한 차이가 있었다.(x²=6.559, df-=2, p<0.05). 결 론 : 본 연구결과에 의하면 가급적 환자 상태에 따라 낮은 최적 치료 용량을 투여하는 것이 장기잔의 투여를 바람직한 것으로 생각된다. 본 연구와 같은 대규모의 후향적 자연적 연구는 일반 실제 진료에서 risperidone의 효과 및 기타 다른 측면에서의 유용한 정보를 얻을 것으로 기대된다. Objective : This retrospective naturalistic study was designed to compare the clinical characteristics including psychopathology of two groups of patients, long-term maintenance group and short-term drop-out group, who were taking risperidone. Method : Datas were collected for 210 schizophrenic patients with complete medical records among 580 patients who were enrolled with risperidone administration from January 1996 to December 1996 in 8 affiliated hospital of the Catholic University. The short-term drop-out patients group were assigned to whom treatment period was less than 6 month, and the long-term maintained patients group, treatment period was more than 2 years. We assessed demographics, psychopathology, and other variables related with medication based on past medical records. Results : Among subjects of 210, short-term drop-out patients group were 67(31.9%) and long-term maintained patients group were 143(68.1%). Demographics and psychopathology were not significantly different between two groups. The stating and maximal dosage of risperidone was not significantly different between two groups but the maintenance dosage of risperidone was lower in long-term medicated patients group than short-term drop-out patients group(t=3.698, p<0.05). Additionally, the result of this study showed differences in experiences of past antipsychotic use as following. The number of no previous use of antipsychotic was 39(58.2%), the number of high potency amtipsychotic use was 27(40.3%), and the number of no previous use of antipsychotic was 58(40.6%), the number of high potency ntipsychotic use was 77(53.8%), the number of low potency antipsychotic use was8(5.6%) in long-term maintained group.(x²=6.559, df-=2, p<0.05). Conclusions : According to these results, administration of low therapeutic dosage should be recommended for long-term maintenance as if possible. Multi-center based retrospective naturalistic study like this would be useful for getting informations about efficacy and some other aspects of antipsychotic administration in practial field.

정상과 갑상선 종양조직에서 사람 IGF-I 유전자의 발현

김성운,장현하,박상미,김덕윤,우정택,양인명,김진우,김영설,김광원,고석환,홍성화,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

Many of the growth-promoting properties of growth hormone(GH) are mediated by insulin-like growth factor-I(IGF-I), a highly conserved circulating 70-amino acid peptide. Recent studies have shown that multiple mechanisms influence IGF-I gene expression, including transcription from two promoters, alternative RNA splicing, and variable polyadenylation. In thyroid tissue, thyroid stimulating hormone(TSH) and IGF-I are the most possible candidates for follicular cell proliferation and hypertrophy. Actually IGF-I had autocrine and paracrine effect for tissue growing. We prepared thyroid tumor tissue mRNAs using single step method for detecting IGF-I levels according to different tissues, i.e., thyroid adenoma or papillary thyroid carcinoma. We used Northern blot analysis for IGF-I mRNA and RNase protection assay (RPA) for IGF-I transcription start sites. For Northern blot, we used whole human IGF-I cDNA as a DNA probe and for RPA, we used IGF-I exon 1 containing noncoding promoter 1 as a riboprobe. We got good RNA bands from Northern blot analysis around 1 kb (IGF-IA) and 7.5 kb (IGF-IB) region. To clarify the amount of both IGF-IA and IB mRNAs, we measured autoradiographied signal of IGF-I mRNAs bands using densitometer. In IGF-IA signals, there's no change among liver and thyroid tissues, but in case of IGF-IB mRNA bands, the signal was markedly increased in thyroid carcinoma tissues than that of normal thyroid tissue (85% vs 14%). In the study of RPA, all thyroid tissues used the same transcription start sites as those of liver's. We concluded that that this different regulation of IGF-I mRNA was originated from tissue specificity. That meant some tissue specific transcription factor/s were related to tissue IGF-I expression.

Azithromycin으로 치료한 임신 중 쓰쓰가무시병 1예

김광석,최진욱,서호종,김기훈,박성호,서광섭,고성만,김순혜,김호정 대한감염학회 2001 감염 Vol.33 No.5

We report a case of tsutsugamushi disease in a 26 year-old pregnant woman who was treated with azithromycin. Her gestation period was 27 weeks and she admitted with fever, rash, and eschar on the right shoulder. Currently recommended medications for the treatment of scrub typhus are doxycycline or chloramphenicol. But, these drugs are class D drugs according to the U.S. Food and Drug Administration (FDA) Fetal Risk Summary, so they couldn't be used to treat pregnant women. Recently, a few case reports suggested that azithromycin, a relatively new macrolide antibiotic, was effective and safe for the treatment of scrub typhus in pregnant women. And, there is no evidence that azithromycin causes harmful effects to the developing fetus or to children. On the basis of current in vivo test that confirms the effectiveness of azithromycin, it may be the drug of choice for the treatment of scrub typhus in pregnant women and children. (Korean J Infect Dis 33:380-382, 2001)

첨가제를 첨가한 TMA-포접화합물의 상변화에 관한 실험적 연구

김진흥,정낙규,김창오,박호진,강승현,김광일 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.2

The purpose of this study is to investigate the propriety of TMA clathrate as a cold storage medium. Particularly, this is to examine the extent of subcooling improvement when the surfactants are added to the TMA clathrate, because water used cold storage material has low phase change temperature and subcooling. this study has been analysed and compared with TMA 30wt% clathrate how phase change temperature, subcooling and specific heat in the various concentrations are changed. This results view to be improved phase change temperature and subcooling of TMA30wt% as a cold storage medium, when it had some surfactant. Additionally, it is that surfactant must be controlled under available solution limit and study for new additive must be lasted to know its effect.

주폐자충 폐렴으로 발현된 Felty 증후군 1예

김성호,남대근,문재현,김지홍,김보석,안진광,문태건,안병재,김성일 全南大醫大 2001 전남의대학술지 Vol.37 No.3