정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

백서 뇌에서 전기경련 충격에 의해 발현이 조절되는 새로운 유전자

정선주,박정은,강웅구,구영진,박주배,김용식 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 이 연구는 백서 뇌에서 전기경련 충격(Electroconvulsive shock, ECS)에 의해 발현이 조절되는 새로운 유전자를 검색하고, 발달단게 및 뇌 조직에 따른 발현양상을 관찰하기 위하여 시행되었다. 방법: 생후 7일, 21일된 어린 웅성 백서에 전기경련 충격을 가한 후 mRNS differential display-PCR(DD-PCR) 기법을 시행하여 발현의 차이를 나타내는 유전자를 검색한 후 서열분석을 실시하였다. 생후 7일 및 21일된 백서의 뇌와 성년 백서의 대뇌피질, 해마를 이용한 Northern blot 분석을 시행하여 검색된 유전자의 ECS 처치 후 시간경과에 따른 유전자 발현양상을 관찰하였다. 결과: ECS 처치군과 위충격군간에 발현의 차이를 나타낸 유전자 4개를 검색할 수 있었으며, 이중 ECS에 의해 발현이 증가되는 1개의 유전자를 선정하여 서열분석을 실시한 결과 EST 서열만이 보고된 새로운 유전자임이 밝혀졌다. 이 유전자는 생후 7일된 백서의 뇌에서는 ECS 처치 후 180분에 발현양의 증가가 최고치에 도달하였으나, 생후 21일된 백서의 뇌와 성년백서의 대뇌피질 및 해마에서는 360분 경과시까지 지속적으로 발현 양이 증가하였다. 결론: 이같은 결과는 ECS에 의해 생체 내에서 유전자 발현의 조절이 이루어짐을 시사하며, 향후 이러한 유전자의 세포 내 기능에 관한 연구를 시행함으로써, ECS에 의한 생체의 반응과 치료기전에 대한 이해를 넓힐 수 있을 것으로 기대된다. 중심단어:전기경련 충격·DD-PCR·유전자·백서 뇌. Objectives: This study was performed to identify genes regulated by electroconvulsive shock (ECS) and to observe the pattern of expression of genes according to different developmental stages and brain regions. Method: ECS(130V, 0.5 sec) was given to male Sprague-Dawley rats with age of postnatal day 7 and 21(P7, P21 respectively). After screening genes regulated by ECS with mRNA diffe-rential display-PCR(DD-PCR), we selected one clone among them and observed the induction of this gene after ECS by time-dependent Northern blot analysis of rat brain of P7, P21 and adult rat cortex and hippocampus. Results: By DD-PCR method, we have identified four clones whose expression was regulated by ECS. Among them, one(CP 10-2) was proved to be a new gene by sequencing and BLAST search. Its expression was increased after ECS in P7, P21, and adult rat brain. The expression of CP 10-2 reached peak level at 180 minutes after ECS in P7 rat brain, but was further increased until 360 minutes after ECS in P21 and adult rat brain. Conclusion: In this study, a new gene was identified in rat brain which showed up-regulated expression in response to ECS. Cloning and characterization of this new gene would be helpful to elucidate the effect of ECS in rat brain. KEY WORDS:Electroconvulsive shock·Differential display-PCR·Gene·Rat brain.

말쥐치 기름의 投與가 흰쥐의 血淸 및 肝臟의 콜레스테롤 濃度수준에 미치는 影響

鄭承鏞,黃淑子,姜晋順,朴畢淑 慶尙大學校 1985 論文集 Vol.24 No.2

Sprague Dawley계 숫 흰쥐에 eicosapentaenoic acid 및 docosahexaenoic acid둥 고도불포화지방산을 함유하고 있는 말쥐치커기름과 monoenoic acid를 많이 함유하고 있는 올리브기름을 각각 10% 씩 첨가하고 또한 vitamin E를 식이 100g당 5, 50, 100 I. U.로 첨가한 사료로서 2주간 사육한 후 혈청 및 간장 중의 cholesterol 농도, 과산화지질 및 α-tocopherol의 농도를 측정한 바 다음과 같은 결과를 얻었다. 1. 증체량 및 사료섭취량은 전 시험군 간에 있어 유의적인 차이는 없으나 말쥐치기름 투여군이 약간 낮은 경향이었다. 2. 혈청 중의 총 cholesterol 농도는 올리브기름 및 말쥐치기름 투여 군 모두 vitamin E의 첨가량을 증가시킴에 따라 낮아지는 경향이었으며, 말쥐치기름 투여군 은 올리브기름 투여군에 비해 유의적으로 그 농도가 낮았다 (P<0.05). 3. 혈청 중의 HDL-cholesterol 농도 및 총cholesterol 농도에 대한 HDL-cholesterol 농도의 비율은 말쥐치기름 투여군이 올리브기름 투여군에 비해 대체로 높은 경향이었다. 4. 간장 중의 총 cholesterol 농도는 말쥐치기름 투여군이 올리브기름 투여군에 비해 약간 낮은 경향이었다. 5. 혈청 및 간장 중의 과산화지질의 농도는 말쥐치기름 투여군이 유의 적으로 높았으며 (P<0.05) vitamin E의 첨가량을 증가시킴에 따라 감소되는 경향이었다. 6. 혈청 및 간장 중의 α-tocopherol 농도는 말쥐치기름 투여군이 유의적으로 낮았다 (F<0.05). The Sprague Dawley male rats were fed experimental diets containing 10% file fish oil or 10% olive oil, and three graded levels of vitamin E(5,50 and 100 I.U./l00g diet) were provided for each test oil group. After two weeks feeding, the concentration of cholesterol, lipid peroxide and a-tocopherol in serum and liver of rats were determined. The results were summarized as follows. 1. The amount of body weight gain and food intake of rats were not significantly different among all the experimental groups but tended to slightly be low in rats fed file fish oil diet. 2. Total cholesterol concentrations in serum tended to be decreased as vitamin E level increased all of the file fish oil and olive oil diet groups, serum total cholesterol concentrations of the file fish oil diet groups were significantly lower than those of the olive oil diet groups. 3. HDL-cholesterol concentrations and the ratio of HDL-cholesterol to total cholesterol in serum generally tended to be higher on the file fish oil diet groups than those of the olive oil diet groups. 4. Total cholesterol concentrations in liver tended to slightly be lower on the file fish oil diet groups than those of the olive oil diet groups. 5. Lipid peroxide values in serum and liver were significantly high on the file fish oil diet groups and tended to be decreased as vitamin E level increased. 6. The concentrations of α-tocopherol in serum and liver were significantly low on the file fish oil diet groups.

파종시기와 생육단계별 검정콩 종피의 안토시아닌 함량변이

정길웅,주용하,이동진 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.2

'검정콩1호'와 '진주1호'를 공시하여 검정콩 종피의 안토시아닌 색소들에 대한 파종시기(4월 15일, 5월 15일, 6월 15일)와 생육단계(R6, R7, R8)별 함량과 변화를 분석하여 기능성 검정콩의 품종육성 및 이용에 대한 기초 자료를 얻고자 실험 한 결과는 다음과 같다. 1. Delphinidin-3-glucoside, cyanidin-3-glucoside, petunidin-3-glucoside 및 total anthocyanin의 함량은 모두 6월 15일 파종에서 높았다. 2. 생육단계별 Delphinidin-3-glucoside, cyanidin-3-glucoside, petunidin-3-glucoside 및 total anthocyanin의 함량은 R6에서 R8으로 갈수록 증가하였다. 3. 안토시아닌의 Hunter's value인 L, a, b값 중 명도인 L값은 6월 15일 파종에서 가장 낮았으며, 적색도인 a값은 6월 15일 파종에서 가장 높았고, 황색도인 b값은 파종기간에 차이가 없었다. 4. 생육단계별로는 명도인 L값은 R6에서 R8으로 갈수록 낮았으며, 적색도인 a값과 황색도인 b값은 R6에서 R8으로 갈수록 높았다. 5. 안토시아닌 색소와 Hunter's value의 값들과의 상관관계는 delphinidin-3-glucoside, cyanidin-3-glucoside, petunidin-3-glucoside, total anthocyanin, a, b값은 모두 상호간에 고도의 정(+)의 상관관계를 나타냈으며, L값만이 D3G, C3G, Pt3G, TA, a, b값과 고도의 부(-)의 상관관계를 나타내었다. This experiment was conducted to investigate the content and color difference of anthocyanin with black soybean seedcoats as influenced by different planting dates and growth stages. Two varieties, Geomjeongkong #1 and Jinju #1 were tested. Planting date was on April 15, May 15, and June 15 and growth stage was measured three stages at R6 (full seed), R7 (physiological maturity), and R8 (harvest maturity). The content of delphinidin-3-glucoside (D3G), cyanidin-3-glucoside (C3G), petunidin-3-glucoside (Pt3G), and total anthocyanin (TA) were all higher on June 15 as planting date. The accumulation patterns of D3G, C3G, Pt3G, and TA from R6 (full seed) to R8 (harvest maturity) had all increased gradually from R6 to R8 as growth stage. In the L, a, and b of anthocyanin pigments according to planting dates, L as lightness was lowest on June 15 and a as redness was highest on June 15 but b as yellowness was not different among planting dates. In the L, a, and b of anthocyanin pigments according to growth stages, L had decreased from R6 to R8 whereas a and b had increased from R6 to R8. D3G, C3G, Pt3G, TA, a, and b showed reciprocally highly significant positive correlation. L only showed highly significant negative correlation with D3G, C3G, Pt3G, TA, a, and b.

La₂ O₃를 첨가한 Pb(Zr,Ti)0₃자기의 유전특성에 낟알 크기가 미치는 효과

金顯男,鄭相九,宋龍鎭 亞洲大學校 1986 論文集 Vol.9 No.-

Pb(Zr??Ti??)O₃ + lmol%La₂O₃ ceramics of which the mean grain sizes were 2.5, 2.8, 3.5μm respectively were prepared. The dielectric constant and the dissipation factor of them with evaporated gold electrodes were measured as a function of temperature. As the grain size decreases, the Curie temperature T?? increases slightly, the peak height of the dielectric constant curve decreases, and the peak width of the dielectric constant curve increases. The dielectric constant at room temperature remains constant regardless of the grain size. A model was followed which proposeds that each grain has a different phase transition temperature T?' and the distribution of T?' follows the Gaussian distribution. It was also assumed that each grain follows the Curie-Weiss law for T>T?' The relevant parameters were determined by the least square fit method by computer calculation. The above experimental results were explained by this model, and the variations of the parameters due to the variation of grain size were discussed. The dominant factor for the grain size e fects seems to be the inhomogeneity of the concentration of impurities.

흰쥐 적색핵에서의 Parvalbumin성 신경원의 분포상태와 미세구조

이문용,한동일,천명훈,정진웅 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

한국인 만성 간 질환 환자에서 G형 간염 바이러스 감염의 유병률에 대한 연구

이진호,이한주,윤정환,이효석,김정룡 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.31 No.3

한국 여성사 정립을 위한 인물 유형 연구 : from Ancient Times to Tae-han Che-guk(大韓帝國) 고대에서 대한제국 시대까지

정세화,최숙경,이배용,장필화,김영미,박진숙 이화여대 한국여성연구소 1988 여성학논집 Vol.5 No.-

This study is an attempt to analyse the types of women recorded in historical documents. The categories are broadly divided in three areas; political, social and familial spheres. In the political sphere, three queens in Shilla period, the only period in Korean history when a queen was the supreme ruler, and women who had a formal right to be involved in the determination of soverign successor, to assume regency, and who had various informal political influence. In the social sphere, women's economic and religeous activities were examined. Also women specialists such as medicine women, shamans and kisaeng (entertainers) are examined in this category. In the familial sphere, conjugal relationships of first (legitimate) wives and concubines, and women's status and activities are investigated. The gradual establishment of patriarchal system initiated by the state, and the conflict of women's interests in the process was analysed. As a result of this preliminary analyses, it became clear that the social position of women in Korean history was constricted with the growth of the power of the state. In the case of ancient Korea and Koryo period women's status in the family was comparatively higher and their personal activities were freer although their political and social activities were restricted. As time progressed, the establishment and reinforcement of partriarchal system of the state based on confucian ideology had crucial importance on the position of women in society. The system of family was restructured and carefully monitored, and the members of the family were closely controlled. The state sought the material and ideological bases of the power through these control. As a result, the status of women became more structurally subjugated to make heads of the family, especially after the mid Choson dynasty.