암유전자와 암억제 유전자(총설)

박주배 한국과학기술원 유전공학연구소 1996 생명공학동향 Vol.4 No.1

위암의 암유전자

박주배 한국과학기술원 유전공학연구소 1996 생명공학동향 Vol.4 No.1

위암 발암 관련 암유전자와 암억제유전자

박주배 주식회사 녹십자 1998 녹십자의보 Vol.26 No.3

분말사출성형 충진공정의 유한요소해석 ( Finite Element Analysis of Powder Injection Molding Filling Process )

박주배,권태헌 대한기계학회 1992 대한기계학회 춘추학술대회 Vol.- No.-

항복응력과 미끄럼현상을 고려한 분말사출성형 충전공정의 유한요소해석

박주배,권태헌 대한기계학회 1993 대한기계학회논문집 Vol.17 No.6

본 연구에서는 분말혼합체의 특성인 항복응력을 포함한 Generalized Newtonian Fluid의 구성 방정식을 도입하고 미끄럼현상을 고려한 신소재의 사출성형 충전과정 해석용 CAE(computer aided engineering)시스템을 개발하였다. 수치모사를 위한 수치해석방법으로는, 유한요소법(finite element method)과 유한차분법(finite difference method)을 함께 사용하였다. 유한요소법과 검사체적법(control volume technique) 을 병용하여 유동의 진행을 수치모사 하였으며, 유한차분법을 사용하여 온도분포를 계산하였다. Powder Injection Molding(PM) is an advanced and complicated technology for manufacturing ceramic or metal products making use of a conventional injection molding process, which is generally used for plastic products. Among many technologies involved in the successful PIM, injection molding process is one of the key steps to form a desired shape out of powder/binder mixtures. Thus, it is of great importance to have a numerical tool to predict the powder injection molding filling process. In this regard, a finite element analysis system has been developed for numerical simulations of filling process of powder injection molding. Powder/polymer mixtures during the filling pro cess of injection molding can be rheologically characterized as Non-Newtonian fluids with a so called yield phenomena and have a peculiar feature of apparent slip phenomena on the wall boundaries surrounding mold cavity. Therefore, in the present study, a physical modeling of the filling process of powder/polymer mixtures was developed to take into account both the yield stress and slip phenomena and a finite element formulation was developed accordingly. The numerical analysis scheme for filling simulation is accomplished by combining a finite element method with control volume technique to simulate the movement of flow front and a finite difference method to calculate the temperature distribution. The present study presents the modeling, numerical scheme and some numerical analysis results showing the effect of the yield stress and slip phenomena.

SV40 large T gene에 의해 불멸화된 사람 태아 간세포주의 확립

박주배,김정룡,이주영,이효석,박중원 대한소화기학회 1992 대한소화기학회지 Vol.24 No.6

정신분열병 환자의 혈청과 뇌척수액의 동 및 아연농도에 관한 예비적 연구

김용식,장안기,박주배 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.4

27명의 정신분열환자 대상군과 10명의 대조군을 두어 atomic absorption spectrotometry를 사용하여 혈청과 뇌척수액의 동과 아연농도를 측정하여 이를 비교하고, 항정신약물의 미치는 영향을 연구하여 다음과 같을 결론을 얻었다. 첫째, 혈청과 뇌척수액의 구리농도는 대조군과 대상군 사이에 유의한 차이가 없으며 항정신약물은 뇌척수액이나 혈청의 동농도에 영향을 주지 않았다. 둘째, 혈청이나 뇌척수액의 아연농도는 전체대상군과 대조군은 유의한 차이가 없었다. 그러나 대조군과 3주간 위약군의 뇌척수액 아연농도는 유의한 차이가 있었다. 셋째, 항정신약물은 뇌척수액 아연농도에 영향을 주지 않으나 혈청에서는 투약후 아연농도가 유의하게 낮았다. 넷째, 혈청의 동농도와 뇌척수액의 동농도 및 혈청아연농도와 뇌척수액 아연농도 사이에는 상관관계는 없었다. (본 연구에 많은 도움을 주신 서울의대 생화학교실원 오석배 용인정신병원장님을 비롯한 용인정신병원직원 여러분께 감사드립니다.) To investigate copper and zinc concentrations in schizophrenia, we have measured copper and zinc concentrations in the serum and CSF of 27 male schizophrenia (mean age 30.2±5.6) and 10 male controls (mean age 42.7±10.6) with atomic absorption spectrophotometry. The results were as follows. 1. There were no significant differences in serum and CSF copper concentrations between groups of controls, unmedicated schizophrenic patients, and schizophrenic patients taking neuroleptics. Neuroleptics did not significantly alter mean copper concentrations in serum and CSF of schizophrenic patients. 2. There were no significant differences in serum and CSF zinc concentrations between groups of controls, and schizophrenic patients. But mean CSF zinc concentrations was lower in a group of 3-week-drug- free schizophrenic patients. 3. Neuroleptics did not significantly alter mean CSF zinc concentrations of schizophrenic patients, but serum zinc concentrations were influenced by neuroleptics. 4. There were no significant correlations between CSF copper (or zinc) concentrations and serum copper (or zinc) concentrations in schizophrenic patients or controls.

Chlorpromazine이 백서 해마에서 전기경련 충격에 의한 MAPK 타이로신 인산화에 미치는 영향

주연호,정성훈,전송희,강웅구,김용식,김상욱,박주배 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.2

Object : In order to examine the interaction mechanisms of electroconvulsive shock(ECS) and antipsychotic drug at the level of molecular biology, we observed the effect of chlorpromazine pre-treatment on the activation of mitogen activated protein kinase(MAPK) induced by electroconvulsive shock(ECS) in rat hippocampus Method : Male Sprague-Dawley rats were divided into 2 groups. To the experimental group chlorpromazine(20㎎/㎏) was given intraperitoneally, and to the control distilled water was given instead. Thirty minutes later, ECS was given and the hippocampus was dissected out 2 minutes thereafter. Immunoblotting with antiphosphotyrosine antibody was carried out, and the signal intensity at 42kDa band was quantitized using densitometer. The obtained result was compared by student t-test between the experimental and the control group. The absolute amount of MAPK was measured by immunoblotting with anti-MAPK antibody. Result : The tyrosine phosphorylation of MAPK reached peak at 2 minutes after ECS. However, in the chlorpromazine pre-treated group, the peak level of MAPK tyrosine phosphorylation was significantly attenuated(t=-3.12, df=14, p=0.008) compared to the control. In contrast to this, the absolute amount of MAPK did not differ between the pretreated and the control group. Conclusion : Chlorpromazine attenuated the tyrosine phosphorylation of MAPK by ECS. This finding seems to be related to the fact that chlorpromazine pre-treatment changed the cfos expression by ECS in rat brain. Antipsychotic drug and ECS might interact at the level of MAPK signal transduction system, and this might explained the observed synergistic effect of two treatment modality.

여성성기결핵의 임상적 관찰

박주배(JB Park),주창남(CN Joo),윤석한(SH Yoon),박인수(IS Park) 대한산부인과학회 1975 Obstetrics & Gynecology Science Vol.18 No.10

A study has been made for 64 cases of genital tuberculosis in women who have been treated during 11 years from January 1, 1963 to December 31, 1973 Among 64 cases 25 cases were histologically proved with biopsy and 39 cases were histologically proved with surgical specimens at laparotomy. Among 25 cases which were diagnosed with biopsy, 2 cases of tuberculosis of vagina and 6 cases of tuberculosis of cervix were included. Five hundred and eighty curettings were examined for the study of inferility and tuberculosis of endometrium was found in 3.4% genital tuberculosis occurred with greatest frequency between the ages of 21 and 30 years an incidence of 45.3%. The average age was 30 years at the first attendance the youngest patient being aged 16 years and the oldest 63. The most frequent site of tuberculous lesion in the surgical specimens was the fallopian tubes. Among the fallopian tubes of 27 patients, tuberculous involvement was noted in 23 among the ovaries of 25 patients the lesion was noted in 10 and among the uteri of 14 patients in 4. Three patients were unmarried among the remaining 61 cases 27, at least gave a history of previous pregnancy History of previous extragenital tuberculous were noted in 32 cases ; namely pulmonary tuberculous in 14, plurisy in 9, peritonitis in 8 and osseous tuberculous in 1.

電氣衝擊이 白鼠의 線條體內 도파민 受容體에 미치는 影響

박주배,김진수,이정균,김용식 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

For the purpose of examining the nature of certain psychiatric illnesses on which ECS has some beneficial affect authors observed the effect of ECS on striatal dopamine receptors of male albino Sprague-Dawley rats, divided into twelve groups according to three factors-treatment (ECS, sham-ECS and control), frequency (one time and seven times) and maturity (interval between decapitation and the last treatment). The result is: there was no significant difference between groups. Through the finding of no difference between sham-ECS and control groups we can exclued the possible relationship of nonspecific stress effects induced by sham-ECS with the ECS-induced effect. The finding that there was no significant difference between ECS and control groups was discussed carefully in view of inappropriateness of experimental model. Further well-controlled researches are needed to examine the delayed effect of ECS.