정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

PKI를 이용한 교육망에서의 리포트 인증 처리

한재균,김영진,한승조 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

The coding technology using Public Key Cryptosystem has developed the public key infrastructure to be able to do the services of Access-control, Authentication, Confidentiality, Integrity, and Non-repudiation with internet. In this study, making use of this PKI(Public Key Infrastructure) and the coding algorithm, I tried to make clear the problems on the way of submiting the notes of the remote educating institute of the cyber university. Thus, the students may hand out their notes with the certificate using the PKI(Public Key Infrastructure) without visiting the school, and also the dispute could be settled on whether they handed out their notes or not etc. In addition, I tried to get steadiness in processing the scores by improving way of submitting notes with the internet and the certificate using the PKI and enable taking advantage of the way on other fields as well as the graduate report by offering the convenience to the students

느타리버섯의 갈반병 원인균에 대한 길항세균 선발에 관한 연구

조재선,이은관,유승오,전억한 경희대학교 생명자원과학연구원 1997 硏究論文集 Vol.18 No.-

갈반병이 이병된 느타리 버섯과 버섯 재배장 주변 토양으로부터 채집한 균주로부터 갈반병 원인 균주 4개와 갈반병 길항 균주 3개를 선발 하였다. 선발된 균주를 API 20E kit에 의해 동정한 결과 갈반병 원인 균주 P-24, P-28은 P. putida로 P-27, P-33은 lane 1: PCR marker lane 2: P.fluorescens P. tolaasii로 동정 되었으며, 길항 균주중 A-11, A-20은 P. fluorescence로 A-29는 Pseudomonas sp.로 동정 되었으나, RAPD PCR 방법에 의한 유전적 유사성은 모든 균주가 다른 양상을 보였다(Fig. 5). 이는 생화학적 방법에 의한 Pseudomonas 계통의 균주 동정의 기술이 확립되지 않은 점도 있으며, 유전적 유사성은 달라도 같은 속의 균주가 많은 것으로 사료 된다. 길항성은 갈반병 원인 균주 대 길항 균주가 1:1의 농도로 길항성이 양호하여 Nair등(1972)의 보고 보다 우수한 길항성을 보였다. Screening experiments were carried out in order to select bacteria causing brown blotch disease on the mushroom. especially, Pleurotus ostreatus. Four brown blotch disease causing bacteria were isolated from the Pleurotus ostreatus and the soil around mushroom farm. Three other strains, A-11, A-20, A-29 showing antagonism against four brown blotch causing bacteria through pitting test and cross checking and found to be identified as Pseudomonas fluorescence for A-11 and A-20, and Pseudomonas sp. for A-29, respectively. Colony morphology test also showed that A-11 and A-29 were appeared as transparent gel with green color and A-20 colony showed opaque gel with light green color.

광선각화증, 각화극세포종과 Bowen's병에서 p53과 p21의 표출 양상

조명구,조현득,양승하,김의한 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background The function of the p53 protein was known to regulate cell proliferation by inhibiting cells entering Sphase. So DNA damaged cell proliferation was inhibited by apoptosis. P21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought go mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 were expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis were important. The authors analyzed immunohistochemical expression of mutant p53 and p21 protein in some skin tumors. Method Thirteen cases of actinic keratosis, 7 cases of keratoacanthoma and 8 cases of Bowen's disease were immunohistochemically stained with p53 and p21 monoclonal antibodies. Results; 1. In cases of positive p53 protein and negative p21 protein, the expressed p53 protein was suggested as mutant form. 2. Positive expression of p53 protein and p21 protein in prickle cell layer of actinic keratosis and Bowen's disease was suggesded that the composing cells of prickle cell layer were transformed into the proliferated cell. The p21 protein expression was suggested to be induced by the p53 independent pathway. 3. Negative expression of p53 protein and p21 protein in prickle cell layer of keratoacanthoma was suggested that the composing cells of prickle cell layer were completely mature cells, so the keratoacanthoma had good prognosis.

암호알고리즘을 이용한 프로그램 복제방지 시스템 개발

한승조,조금배,이준 조선대학교 전자정보통신연구소 2000 電子情報通信硏究所論文誌 Vol.3 No.1

The software market in the world is almost hundreds of thousands of trillion dollars and the copy protect measures have been researched in diversified ways The cost for copy protect amounts to 10% of the cost for purchasing the software and then if the copy protect is unsatisfactory, it will cause the loss over double the investment costs of copy protect The illegal copy is not confined merely to the executable program, but is made to the data of the field which general users have concerns by means of internet Especially, since there is no program for the minor in internet which has been distributed rapidly, the measures to protect children from illegal approach at communication networks in many countries including U S A as of 1997 has been researched Therefore, the copy protect lock requires more flexible application capacity than the rate of copy protect close to the perfection in cheaper price Accordingly the final results of this paper is to supply the program copy protect, high speed encryption of data and encryption communication functions using encryption algorithm built-in chip

상악골에 발생한 Monostotic 섬유성 이형성증의 1례

이승학,김경일,김완수,나한조 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

고추의 品種別 光合成速度와 葉의 形質間의 相關關係

安承烈,趙三增,李文煥,金鎭漢 충북대학교 농업과학기술연구소 1992 農業科學硏究 Vol.10 No.1

This study was carried out to study on the relationships between phetosynthetic rate and leaf characters in red pepper varieties. Leaf thickness, chlorophyll content, number of stomata, photosynthetic rate, length and width of palisade cell, and surface area and volume of palisade cell were measured, and inorganic elements were analyzed, and their relationships were studied. The results were summarized as follows: 1. Photosynthetic rate was higher in HongIlpumgochu, Hansolgochu, and lower in OngJogochu, TaeAnJaeRae and CheongYanggochu. 2. Chlorophyll content was higher in HanSolgochu, GiHogochu, and PalBanggochu and lower in TaeArJaeRae and CheongYanggochu. 3. Leaves were thicker in BokKyeongochu and PalBanggochu than in Cheongranggochu and Mankanggochu. 4. Number of stomata was higher in CO 1581, BokKyeongochu, and JinSolgochu than in TaeAnJaeRae and PalBangochu. 5. Palisade cell was longer in GiHogochu and HwaChungochu than in CheongYanggochu, OngJogochu, and HanSolgochu. 6. Palisade cell was wider in KwaRiPutgochu and Putgochu than in ShinHonggocu, TaeAnJaeRae, and SaeRoNaGungochu. 7. Surface area of palisade cell was greater in Gihogochu and HanSolgochu than in OnJogochu and TaeAnJaeRae. 8. Volume of palisade cell was greater in Putgochu and BokKyeongochu than in OngJogochu and ShinHonggochu. 9. Photosynthetic rate was positively and significantly correlated with chlorophyll content, number of stomata, length, thickness, surface area of palisade cell, and volume of palisade cell.

전자상거래 시스템에 적용 가능한 이동 에이전트 보안 메커님즘의 설계

나승현,한승조,정일용 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.1

This paper suggests the table for a mobile agent path which performs on transfer a mobile agent in security and based on which introduced the transfer protocol of a mobile agent. As the last prodceure of this, shows that how to write the closing time of a mobile transferring by using a Time stamp and keep not only preparing for the stop and attack for a receiving host but also the record of the transfer for a mobile agent. Later this paper will analyzes the security for an attack of a receiving host, a transmitting host and the third part host based on proposed system.

상악동에 발생한 거대한 Cholesterol 육아종 1례

김승찬,박형욱,김용기,나한조,도남용 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The cholesterol granuloma is not a specific clinical or pathologic entity but merely a term used to describe a tissue response to cholesterol crystal. The cholesterol granuloma in paranasal sinuses is rare disease. Recently the authors had experienced a case of huge cholesterol granuloma, which involved the right maxillary sinus. The cholesterol granuloma was removed successfully by mean of enucleation through the Caldwell-Luc approach. So, we report a case with brief review of the literature.