녹농균의 연부조직 감염에 대한 녹농균 다가백신 효과에 관한 실험적 연구

임홍철,양문호 慶熙大學校 醫科大學 1987 慶熙 醫大 論文集 Vol.12 No.1

상어 간유 흡인에 의한 급성 지방성 폐렴 1예 : 증례보고

임성경,옥철호,김희규,장태원,정만홍 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

저자들은 상어 간유를 과량 복용하고 기침, 호흡곤란을 주소로 내원한 48세 여자 환자에서 방사선 소견과 기관지 폐포 세척액 검사를 통해 급성 지방성 폐렴으로 진단하고 스테로이드에 불응하는 경과를 취하자 우측 전폐 기관지 폐포 세척술을 시행하여 폐 병변과 증상의 호전을 보인 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute lipoid pneumonia is uncommon condition of the lungs that results from the aspiration of vegetable, animal, or mineral oils. Shark liver oil (so called Squalene) is taken as a traditional remedy in some Asian countries, and is used widely also in cosmetics. It results in foreign body type inflammatory reaction of the lung and can show various clinical presentations from asymptomatic incidental finding to severe pneumonia leading to acute respiratory failure. Although many cases have been reported, severe lipoid pneumonia requiring steroid or whole lung lavage for treatment is rare. We experienced a case of acute lipoid pneumonia of 48 year old female with dyspnea and cough caused by regular ingestion of large amount Shark liver oil, treated by whole lung lavage. We reported this case with a brief review of related literatures.

슬관절 내측부 인대 손상의 보존적 치료

임홍철,심재학,남혁우,왕준호,노영진 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Purpose : The medial collateral ligament injury is the most common injury of the knee. Recently Non-operative treatment has been preferred than operative treatment and most of patients have satisfactory clinical results after non-operative treatment. But a few patients have continuous instability after non-operative treatment, so the purpose of this study is to fine out the cause of persistent symptom. Methods and Materlals : We performed a retrospective study of one hundred thirty seven patients with medial collateral ligament injury treated non-operative from January 1990 to December 1997. W divided patients into two groups: isolated medial collateral ligament injury (groupⅠ): medial collateral ligament injury with concomitant anterior cruciate ligament injury (groupⅡ) and we analysed MRI finding, valgus instability, and Lysholm knee score. Result : At the follow up, three of group Ⅰ, five of group Ⅱ had persistent grade Ⅲ valgus instability. In group Ⅰ, we could find two case of rupture of the proper of medial collateral ligament with inward inversion and one case of concomitant posteromedial compartment injury. We could find the proper rupture of medial collateral ligament with inversion inward in two patients, the injury of posteromedial compartment in one patient. Two patients of group Ⅱ with grade Ⅲ valgus instability had anterior instability with laxity of grafted tendon after anterior cruciate ligament reconstruction. Conclusion : Most of isolated injury of the medial collateral ligament heals wthout operative intervention. But in case of rupture of the proper portion of medial collateral ligament with inversion inward or concomitant injury of posteromedial compartment, we should consider the operative treatment of medial collateral ligament. In case of medial collateral ligament injury with anterior cruciate ligament, it would better to consider the delicate reconstruction of anterior cruciate ligament.

칼슘길항제와 혐수성 산소 라디칼 제거물질이 백서 피부판 생존에 미치는 영향

양정열,임홍철,이명주,서재홍 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Regulation of Ca^++ channels across cell menbranes can be dramatically altered by ischemic states, and such agents relates to cytotoxic effect. The genration of free radicals in ischemic tssue is detrimental to survive of that tissue. If intracellular calcium increasement and free radical production can be blocked or scavenged, tissue damage should be minimized. In the concept of above theory, the author studied the effect of nifedipine. α-tocopherol known as a calcium channel blocker and hydrohobic scavenger on the random pattern skin flap survical of white rats . Sprague-Dawley rats(N-60) were divided into four groups of control(no medication) , nifedipine(10㎎/ ㎏ /day, I.M.), α-tocopherol(20㎎/㎏/day, I.M.). nifedipine plus α-tocopherol. All of medications were given for 11days from 4days before flap elevation and contnued for 7days after flap elevation. When flap survival rates were measured. Flap tissue was obsered by gross, light microscooc and electron microscopic levels. The results were obtained as follows. 1. Groups treated with nifedipine. α-tocopherol. nifedipine +α-tocopherol showed significant increase of the area of flap survival compared with that of the control group.(P<0.001 in nifedipine group and α-tocopherol, and P<0.01 in nifedipine plus α-tocopherol group.) 2. The flap survival was best improved in the α-tocopherol group. (P>0.05). 3. Skin including dermis after 3 days of Nifedipine plus α-tocopherol group disclosed marked proliferation and dilatations of vessels in the deeper part. 4. Electron micrograph of endothelial cells after 3 and 5 days of Nifedipine and α-tocopherol groups disclosed intact basement membrane, swelling of endoplasmic reticulum and mitochondria. Following the above results. It is suggested that calcium channel blocker and α-tocopherol seem to play a important role which incerase survival of the skin flap.

사람 성상세포종 세포주에서 사이토카인에 의한 Fas 및 FasL mRNA의 발현 조절

김옥준,임정희,최철희,최인홍,이병인,최일생 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

직업과 생활 습관, 그리고 CYP1A1, GSTM1, GSTT1 유전자 다형성이 요중 1-hydroxypyrene과 2-naphthol 농도에 미치는 영향

김헌,강종원,임현술,이호익,김용대,남홍매,이철호 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : This study was performed to describe the distribution patterns of urinary 1-hydroxypyrene (1-OHP) and 2-naphthol concentration in coke oven workers and workers not occupationally exposed to polycyclic aromatic hydrocarbons (PAH), and to determine the effects of occupation, life style, and genetic polymorphism of cytochrome P450 1A1(CYP1A1), glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) on urinary 1-OHP and 2-naphthol concentration. Methods : The study subjects were 19 coke oven workers and 156 shipyard workers. A questionnaire was used to obtain data about detailed smoking and food intake history. Urinary 1-OHP and 2-naphthol concentration and genetic polymorphism of CYP1A1, GSTM1, and GSTT1 were analyzed. Results : The urinary 1-OHP and 2-naphthol concentration was higher in the coke oven workers and in smokers. Urinary 1-OHP concentration was significantly correlated with time after last intake of roasted in non-smoking coke oven workers, whereas urinary 2-naphthol concentration was with amount of cigarette smoking at the sampling day in smoking shipyard workers. Urinary 1-OHP, but not 2-naphthol, concentration of the shipyard workers with Ile/Ile type of CYP1A1 was significantly lower than that of the shipyard workers with other CYP1A1 genotype. Conclusions : Urinary 1-OHP would be a better marker for occupational exposure to PAH in coke oven workers, and urinary 2-naphthol might be better for non-occupational inhalation exposure to PAH. CYP1A1 would not play an important role in the metabolism of naphthalene but in the metabolism of pyrene.

자연정화공법에 의한 인공습지 하수처리장에서 최적 수생식물의 선정

서동철,장병일,조인성,임석천,이홍재,조주식,김홍출,허종수 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

후두 및 하인두 편평세포암종에서 E-cadherin의 면역조직화학적 발현

도남용,나한조,이도용,허준,최지윤,이홍영,임성철 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background and Objectives : The cell-cell adhesion molecule E-cadherin is necessary for the maintenance of the epithelial cellular structure. We were designed to confirm the significance of E-cadherin as a marker for differentiation and invasiveness of squamous cell carcinoma of the larynx and hypopharynx. Materials and Methods : Our study was investigated for the immunohistochemical expression of the epithelium-specific cell adhesion molecule E-cadherin in formalin fixed paraffin embedded tissue specimen of 32 cases of squamous cell carcinoma of larynx and hypopharynx. Results : The positive expression of E-cadherin was 56.3%(18 cases) in squamous cell carcinoma of the larynx and hypopharynx. Decreased E-cadherin expression was a stastistically significant correlation with a increased grade of lymph node stage and clinical stage. Reduced expression was seen in the large tumor size and poorly differentiated tumors, but these result was not statistically significant. Conclusion : The expression of E-cadherin may be related with progression of squamous cell carcinoma of the larynx and hypopharynx. But these correlation were not sufficient for the prognostic indicators in squamous cell carcinomas of the larynx and hypopharynx.

좌심방 석회화와 관련된 반복된 좌심방 혈전 1예

김성훈,우성용,오유경,정우백,임철현,신재원,박철수,윤호중,정욱성,홍순조 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.