다국소 망막전위도를 통한 특발성 망막전막제거술 전후의 황반 기능 평가

윤창기(Chang Ki Yoon),김태훈(Tae Hoon Kim),김현웅(Hyun Woong Kim) 대한검안학회 2016 Annals of optometry and contact lens Vol.15 No.1

Purpose: To assess macular function after vitrectomy and membrane removal in eyes with idiopathic epiretinal membrane by means of multifocal electroretinogram (mfERG). Methods: Visual acuity, macular thickness measured by optical coherence tomography, and mfERG recordings were achieved for 14 eyes of 14 patients who having idiopathic epiretinal membrane. All exams were performed before epiretinal membrane surgery and 1, 3, and 6 months after surgery. Results: Amplitude of mfERG were 139.18 ± 73.63 nV/deg2, 114.25 ± 29.16 nV/deg2 and 134.66 ± 69.64 nV/deg2 at before surgery, after 1 month and 3 months, respectively. Implicit time were 75.23 ± 31.34 nV/deg2, 66.20 ± 25.04 nV/deg2 and 74.79 ± 15.47 nV/deg2 at before surgery, after 1 month and 3 months, respectively. There were no significant changes in amplitude and implicit time measured by mfERG before and after the surgery (p>0.05). There were no significant correlations between the changes of amplitude and implicit time and visual acuity and macular thickness change. Conclusions: Changes in mfERG recordings were not concluded to be useful for predicting clinical prognosis after epiretinal membrane surgery in this study.

2016국민환경의식조사 연구

곽소윤 ( So-yoon Kwak ),이창훈 ( Chang-hoon Lee ),임용빈 ( Yong-bin Im ) 한국환경정책평가연구원 2016 한국환경정책평가연구원 기초연구보고서 Vol.2016 No.-

본 연구는 정기적으로 환경 전반에 대한 국민의 의식과 태도를 파악하기 위하여 기획되었으며, 매해 반복되는 기본부문과 당해 연도 정책이슈를 다루는 특별부문으로 구성된 2016년 국민 환경의식조사를 수행하고 환경에 대한 국민들의 인식을 살펴보았다. 2012년부터 시작된 국민환경의식조사의 기본 부문은 환경인식, 환경의식 및 태도, 환경 실천, 환경정책 수요, 삶의 질·지속가능성 부문으로 구성된다. 2016년 조사에서는 기후변화와 미세먼지가 특별 부문의 주제로 선정되었다. 본 설문조사는 전국의 만 19세 이상 69세 이하 성인 남녀 1,000명을 대상으로 조사전문기관의 방문면접조사를 통해 수행되었다. 환경 하면 떠오르는 이미지로 ‘기후 변화’라는 응답이 가장 높게 나왔고, 환경에 대한 만족도는 ‘자연 경관’에 대해 높게 나타났다. 국민의 과반수가 평소 환경문제에 대해 관심을 가지고 있는 것으로 나타났고, 환경보전이 개인에게 중요한 정도는 2015년에 비해 약간 감소하였으나 여전히 높은 수준을 보이며 국민의 대다수가 환경을 중요하게 생각하는 것으로 파악되었다. 생태주의적 세계관을 나타내는 점수는 2012년 조사 시작 이래 2015년까지 증가해오다 올해 조사 결과에서는 다소 감소하였다. 가장 우려하는 환경문제로는 ‘쓰레기 증가’를 꼽았고, 정보가 부족하다고 생각되는 환경문제로는 ‘자연자원의 고갈’을 응답하였다. 한편 환경오염 및 훼손에 대한 책임은 일반국민에게 있다고 생각하지만, 환경보전에 대한 책임은 주로 중앙정부에 있다고 생각하는 것으로 나타났다. 특별부문인 기후변화에서는 대부분의 응답자가 기후변화에 대해 인지하고 있는 것으로 나타났으며, 기후변화 하면 가장 먼저 떠오르는 이미지로 ‘평균 기온 상승’을 응답하였다. 대다수의 국민이 미세먼지에 관심을 가지고 있으나 우리나라의 미세먼지 수준에 대해서는 불만족스러워하는 것으로 나타났다. 또한 정부의 미세먼지 감축 노력에 대해서는 과반수의 국민이 부족하다고 느끼고 있는 것으로 파악되었다. 이와 같은 연속적인 국민환경의식조사 결과에 대한 정보를 통해 국민들의 인식 및 태도를 파악하고, 나아가 조사결과가 다양한 분석의 기초자료로 활용되어 정책의 활용도를 높이는 데에 일조하기를 기대한다. This study was planned to identify public awareness of and attitudes towards the environment on a regular basis. It conducted the 2016 survey of public attitudes towards the environment, which is consisting of the yearly repetitive basic parts and the special parts discussing issues of the year, and reviewed public awareness of the environment. The basic parts of the survey of public attitudes towards the environment that started from 2012 are composed of environmental perception, awareness of and attitudes towards the environment, environmental practice, demands for the environmental policies, and quality of life and sustainability. In the survey in 2016, climate change and particulate matter were selected as the subjects of the special parts. The survey was carried out on 1,000 men and women aged 19-69 years across the country through a face-to-face interview by a specialized survey agency. The image most associated with the environment was ‘climate change’, and the satisfaction for the environment was high with ‘natural landscape.’ It was identified that the majority of people were interested into the environmental issues in their everyday life. While the importance of environmental conservation to individuals slightly dropped from 2015, it was still high and most people was considering that the environment matters. The score of ecological world view had increased to 2015 from 2012 but slightly decreased this year. People chose ‘a rise in garbage’ as their most concerned environmental issue and ‘lacking natural resources’ as an environmental issue that they did not have enough information. On the other hand, people thought that the public was responsible for environmental pollution and damages but the central government should be held accountable for environmental conservation. In the special parts about climate change, most of the respondents were aware of climate change and answered that the image most associated with climate change was ‘average temperature rise’ It was figured out that most of the people were interested in particulate matter but dissatisfied with the level of particulate matter in South Korea. In addition, the majority of people thought that the government’s efforts to reducing particulate matter were not enough. It is expected to identify public awareness of and attitudes towards the environment based on the results of the annual survey of public attitudes towards the environment, and that the results can contribute to making policies as a fundamental data for various analyses.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

대구시 상업지역 지가의 분포패턴에 관한 연구

정현,윤창훈 한국부동산분석학회 2002 不動産學硏究 Vol.8 No.2

As a systematic complex, on internal space of a city is continuously changed through the separation and integration of various function, and is usually expressed as land price reflecting the status of social economics. The utility of land basically determines its price. And the change of land price not only causes functional integration and separation of the land but also affects the internal spatial structure of the city. Here, the change of the internal structure of city can be monitored through the investigation of the change of the land prices. Also, the change for the land utilization for the purpose can be detected through the analysis of the price of the land located in the specific region. Since the 1990's land area of Daegu City has been expanded and the spatial structure of the city begun to reorganize. Under these situations, proper distribution of the function is required through the investigation of the development pattern of Daegu City in terms of living area, development policy, and spatial arrangement of the city. This study aims to provide the basic information for the reorganization and development of the spatial structure of the city in the coming future throughout the evaluation of the distribution pattern of the land price in the commercial area of the city based on dong, gu, street, and direction, respectively.

중량물 들고 보행시 잡기유형의 차이에 대한 운동학적 분석

서국웅,윤양진,김용재,이훈식,정미라,이창민,이중숙 한국운동역학회 2000 한국운동역학회지 Vol.9 No.2

The purpose of this study was to examine the kinematic changes of the body according to various weight loads and the holding during carrying object. The experiments were conducted with utilizing image, analyses for five male and five female adults as subjects. The results were as followed. 1. Meaningful differences were shown partially in the angle changes of the subject's wrist joints, elbow joints and coxal articulations, but not in the angle changes of the subject's knee joints, according to the types of holding the objects while subjects carrying 5kg objects. So, carrying a light object of 5kg in workplaces or gyms doesn't have much influence on human joints and muscles. 2. Meaningful differences of angle changes were shown between right holding and vertical holding while subjects carrying 10kg objects. Female subjects had difficulties to hold the angles of their wrist joints and elbow joints, carrying 10kg objects, because the first loads were imposed on their wrists and female has weaker muscles than male. In right holding of 10kg objects, female subjects had backward body centers from their bodies, the angle of their coxal articulation became bigger and they had unstable behaviors. 3. Female subjects had wider angle of their wrist joints and elbow joints while carrying 15kg objects than male subjects. But male subjects had bigger angle of coxal articulation than female subjects. Because female has weaker muscles, female subjects couldn't maintain the angles of their wrist joints and elbow joints. 4. The 20kg objects influenced the angles of the wrist joints, the elbow joints and the coaxal articulations of both sex subjects in any type of holding during their carrying 20 kg objects, but didn't influence their knee joints. 5. in carrying 25kg objects, female subjects had wider angles of their wrist joints, elbow joints and knee joints in each holding type than male subjects and the significant difference were shown according to the holding type. But in the case of coxal articulation, male subjects had the bigger angles and meaningful differences. This comes from the weakness of female's muscle. N\Male subject's upper bodies were drawn back and the objects influenced their wrists more than their arms.

A Multicenter Analysis of Clinical Features and Long-Term Outcomes of POEMS Syndrome in Korea

Kook Hye Won,Jang Ji Eun,Min Chang-Ki,Yoon Dok Hyun,Kim Kihyun,Bang Soo-Mee,Park Yong,Lee Jae Hoon,Yoon Sung-Soo,Kim Jin Seok 대한의학회 2024 Journal of Korean medical science Vol.39 No.2

Background: POEMS syndrome is a rare form of plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins, and skin changes. Owing to its low incidence, there are few reports regarding this syndrome. This multicenter study included 84 patients diagnosed with POEMS syndrome in South Korea. Methods: We retrospectively evaluated 84 patients diagnosed with POEMS syndrome at 8 hospitals in South Korea between January 2000 and October 2022. The clinical characteristics and treatment outcomes were analyzed. Results: The median patient age was 53 years (range, 26–77 years), and 63.1% of the patients were male. All patients had peripheral neuropathy, and 81 (96.4%) had monoclonal plasma cell proliferation. Plasma vascular endothelial growth factor levels were available for 32 patients with a median of 821 pg/mL (range, 26–12,900 pg/mL). Other common features included skin changes (54.2%), volume overload (71.4%), and organomegaly (72.6%). Of the 84 patients, 75 received initial treatment (local radiotherapy, 6 [8.0%]; chemotherapy, 17 [22.7%]; both chemotherapy and local radiotherapy, 9 [12.0%]), upfront autologous stem cell transplantation (ASCT), 43 (57.3%; with induction chemotherapy, n = 12, 16.0%; without induction chemotherapy, n = 31, 41.3%). The median follow-up duration was 40.7 months. The 5-year overall survival (OS) was 78%, and the 5-year progression-free survival (PFS) was 55%. Patients who underwent upfront ASCT and were diagnosed after 2014 had a longer OS and PFS. Conclusion: The demographics of Korean patients with POEMS syndrome were similar to those reported previously. Because of the introduction of new treatment agents and the reduced rate of transplant-related mortality related to ASCT, the treatment outcomes of Korean patients with POEMS syndrome have improved in recent years.

αsi-I케이신과 타케이신成分과의 相互作用

尹彰焄 제주대학교 1984 논문집 Vol.19 No.-

αsi-I케이신과αsi-,β-,?? 케이신과의 相互作用을 檢討했다.αsi-I 케이신은β-,?? 케이신과 複合體를 形成했다. 따라서 αsi-케이신으로부터 αsi-I케이신으로 變換되어도 이들 케이신과의 結合사이튼느 保持되고 있다는 것이 確認되었다. 또αsi-I 케이신이αsi-,β- ,para ??케이신과 共存하는 系에서의 칼슘의 影響을 檢討했다. αsi-I케이신은 共存하는 他成分의 칼슘에의 한 沈殿性을 어느정도까지는 制御하는 能力을 가지고 있는 것으로 밝혀졌다. Interations of αsi-,β-and χ-casein were investigated using ultracentrifugation. The results showed a single peak having a ??value of 19.8 between αsi-,β-casein, and also a single peak having a ?? value of 11.7 between αsi-I casein and χ-casein in the absence of calcium. It is suggested that the associating site of αsi-I casein for complex formation remains when αsi- caseinis is converted to αsi-I casein. In addtion, the effect of αsi-I casein on the precipitation of αsi-,β-and para χ-casein in the presence of calcium was studied. It was revealed that αsi-I casein had a ability to stabilize these casein components in the presence of calcium at a certain degree.

서혜부 탈장으로 오인된 inguinal sparganosis 1례

장상훈,한병규,문기혁,송윤섭,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Sparoganosis is a parasitic infestation of human by a lavel form of an animal tapeworm, genus spirometra. ingestion of raw or undercooked flesh of numerous intermediate hosts results in human infection. Sparganum is usually found in the subcutaneous tissues of various parts of the body, but other sites, such as orbit, brain, and the abdominal viscera, have been recorded. we experienced a case of sparganosis it the spermatic cord.

αSI-1カゼイソのカルシウムによゐ 重合

尹彰焄 제주대학교 1984 논문집 Vol.18 No.-

Polymerizations of αs1-I casein by calcium ions were investigated by using electron microscope. The particles of αs1-I casein in the absence of calcium were spherical, but they polymerized into bent chains by the addition of calcium. The mean length of αs1-I casein increased slightly with the increase in calcium concentration. Based on these results, It was assumed that the smallest particle(polymerizing unit)has one(UI 1)or two(UI 2)binding sites and the probability to form i-mers of unit was calculated by using their parameters such as the ratio of UI 2 in all units and the association probabilities of UI1 and UI2. These results were compared with the frequency distributions abtained from electrom micrographs. It was suggested from the comparisons that αs1-I casein has one binding site over the range of calcium O-10 mM and it has two binding sites above 10mM calicum because of lacking of one binding site among three binding sites in αs1-casein.