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      • KCI등재

        정신분열병에 대한 리스페리돈의 효과 및 안정성

        이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

        연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

      • KCI등재
      • KCI등재

        K 강선 및 긴장대 강선을 이용한 원위 쇄골 제 2형 골절의 치료

        정환용,이우석,전택수,김대환,김광균,임재우 대한골절학회 2003 대한골절학회지 Vol.16 No.2

        목 적: 쇄골 윈위부 제 Ⅱ형 골절의 치료에 있어 견봉 쇄골 관절을 통과하지 않고 직접 골편을 고정시키는 K 강선 및 긴장대 강선을 이용한 고정술로 치료한 환자에서 임상 결과를 후향적으로 분석하여 보고하고자 한다. 대상 및 방법: 2000년 5월부터 2001년 5월까지 쇄골 원위부 제 Ⅱ형 골절로 관혈적 정복술 및 K 강선 및 긴장대 강선을 이용한 고정술을 실시한 12례 중 최소 1년 이상 추시가 가능한 11례를 대상으로 하였다. 임상적 평가를 위해 최종 추시에서 변형된 견관절 기능 평가법을 사용하여 결과를 분석하였고 골유합 상태, 합병증, 견관절 운동범위를 측정하였다. 결 과: 전례에서 골유합을 얻었으며, 수술 후 골 유합까지의 기간은 평균 10주 (8~12주)였다. 최종 추시 상 견관절의 운동범위는 모두 정상 소견이었고, 변형된 견관절 기능 평가상 우수 9례, 양호 2례였다. 결 론: 쇄골 원위부 제 Ⅱ형 골절에서 K 강선 및 긴장대 강선을 이용한 고정술은 좋은 치료 방법 중 하나로 사료된다. Purpose: This is retrospective study to analyze the clinical results of the usefulness of K-wires and tension band wiring that fix the fracture fragment directly without passing the acromioclavicular joint in distal clacivle type Ⅱ fractures. Materials and Methods: From May 2000 to May 2001, eleven patients with distal clavicle type Ⅱ fracture were treated by open reduction and internal fixation with K-wires and tension band wiring. The clinical results were analyzed according to modified shoulder rating scale for distal clavicle freacture. Radiological union, complication, and range of motion of the shoulder were assessed. Results: All fractures were united at 10 weeks (8~12 weeks) in average. Finally, full range of motion of the shoulder joint was achieved in all patients. No complication was found and the modified shoulder rating scale for distal clavicle fracture were as follows: excellent 9 and good 2. Conclusion: K-wires and tension band wiring can be a good treatment method for distal clavicle type Ⅱ fractures.

      • KCI등재

        교사들의 공통과학 실험 · 실습 선호도 조사 분석

        정원우,이윤종,강용희,윤일희,이우붕,손종경,김중욱,강동진,권용주 慶北大學校 師範大學 科學敎育硏究所 1999 科學敎育硏究誌 Vol.23 No.-

        The purpose of this study is to investigate the status of the experimental and practical education in high school general science. The present status and reasonable management of the experimental and practical education in high school general science were evaluated by the questionaires. To do this, 146 science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of general science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.

      • 재활용재 혼입 콘크리트 패널의 진동감쇠성 평가실험

        정영수,조성호,최우성,박용구 中央大學校 建設環境硏究所 1998 環境科學硏究 Vol.9 No.1

        Vibration-controlled concrete has been developed by using various concrete mixtures, such as latex, rubber powders, plastic resins and polystyrene(styrofoam). As part of the recycling research of obsolete aged <tires and plastic> materials, vibration-reducing mixtures are used for 10 concrete panels above 200 ㎏/㎠ in uniaxial compressive strength. Laboratory test and open space test have been carried out for the analysis of the impact wave, of which data have been transferred by the FFT technique to comparatively investigate damping ratios of 10 concrete panels. According to wave propagation analysis on vibration- controlled concrete for this research, it can be concluded that Latex concrete has relatively larger damping ratios than those for noncontrolled normal concrete with similar compressive strength.

      • 어음의 善意取得에서 治癒되는 瑕疵의 範圍

        禹洪九,鄭容相 건국대학교 1996 學術誌 Vol.40 No.1

        In modern society the negotiability of a bill should be guaranteed in order to carry out its native function. There are defence, the institution of the good faith purchase of a bill, and the separate rule of a bill action for it. Because of these institutions, the negotiability of the transactions of a bill is promoted. It's important to protect both the negotiability of a bill and the debtor of a bill. The harmony of interests between the creditor of a bill and the debtor of a bill is guaranteed under the law of Bill. The institution of the good faith purchase of a bill is to harmonize between the creditor of a bill and the debtor of a bill. In Korea the institution of the good faith purrchase of a bio originated from the institution of the good faith purchase of chattel historically. But the good faith purchase of a bill is easier than that of chattel based on Civil law. The conditions of the good faith purchase of a bill are as follows. Firstly a bill should be obtained by the method of the law of a Bill. Secondly the indorsement of a bill should be continued. Thirdly a bill should be acquired by a rightless person. Fourthly the purchaser of a bill should have no bad faith and gross negligence. Fifthly there should be personal economic interests in association with the purchase of a bill. In this thesis a writer is inclined to examine whether a bill is obtained from a rightless person or the good faith purchase of a bill is recognized in case of defect of purchase of a bill(eg.assignor's disability, rightless agency, defect of manifestation of intention)with the exception that an assignor is a rightless person. In this connection there are serious conflicts of theories for it. A writer supports the position to recognize the good faith purchase of a bill restricted a rightless person on the basis of interpretation of the current Law of a Bill, general provision of private law and realization of legal stability The system of this thesis is as follows. 1.Introduction. 2.The controversies concerning scope of defect. A writer briefly introduces legislative examples concerning the good faith purchase of a bill, analyzes the controversies concerning the scope of defect in Korea, Japan and Germany through theories and cases. 3.Conclusion A writer analyzes the basic background of controversies concerning the scope of defect, presents a legal interpretation and legislative opinion.

      • KCI등재

        굽은 경골 교합성 골수강내 금속정 : 1예 보고 A Case Report

        정환용,이우석,김대환 대한골절학회 2003 대한골절학회지 Vol.16 No.1

        경골 골절에서 골수강내 금속정 치료 후 이차적인 수상으로 발생한 파손된 골수강내 금속정에 관한 보고는 간간히 있었으나, 굽은 골수강내 금속정에 대한 보고는 극히 드물었다. 저자들은 이전에 경골 골절로 골수강내 금속정으로 수술한 후 교통사고로 발생한 굽은 골수강내 금속정 환자 1예를 치험하였기에 보고하는 바이다. Broken tibial intramedullary nails caused by secondary trauma have been infrequently reported, but bent intramedullary tibial nail was extremely rare. We describe a rare case of a bent intramedullary tibial nail due to a traffic accident who had previously operated with intramedullary tibial nail

      • SCOPUSKCI등재
      • 마케팅환경변화와 통합커뮤니케이션 디자인(ICD)에 관한 연구

        정은주,이용우 동서대학교부설연구센터 2001 연구센터논문집 Vol.4 No.1

        This research is aimed to study the change in design environment caused by being digitalized, to define the new concept and sphere in digital design, to find out the direct or indirect on design by the social and cultural changes resulted in informational technology and internet, and to find out the change and response in design world being brought about it. Powerful digital forms a new world and market. Internet world, a symbol of the power, changes the area, method, and the process of design. The unity of interior decoration and appliance caused by the digitalization of living space brings about that of interior decoration and production design. On account of the change of the electronic products resulted in the informational technology, product design area has been changed from the outward appearance of the design to the software design and the interface design of users. Converted from electronic publication to multimedia design and homepage design area, virtual design also faces the same problem. This phenomenon will also change design area. Banner advertisement, as a representative of new media, appears newly. Electronic newspaper, news broadcasting, radio, and magazine through Internet unite the existing printing media and mass media such as radio, TV. As a result, their respective characteristics disappear and design areas seem to be changed into Internet broadcasting which has equivalent position and method. This change will be much faster on account of the rapid development of information technology. But impersonality and inhumanity caused by digitalization is the problem which digital society and designers should solve together.

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