정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

결핵성 수막염 환자에서 결핵균 30 kDa 및 32 kDa 단백항원에 대한 항체반응의 비교

백태현,김선영,이건수,김화중,김성호,조은경,박정규 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The 30 and 32 kDa antigens from Mycobacterium tuberculosis H37Rv culture filtrates, identified as biologically important proteins in the immune responses against mycobacterial infection, were purified and used in enzyme linked ummunosorbent assay (ELISA) for the determination in specific IgG and IgM levels in cerebrospinal fluids of 15 patients with tuberculous meningitis and 17 controls with nontuberculous diseases. High reactivity to both antigens was observed in tuberculous meningitis. Mean IgG and IgM antibody levels differed significantly (P < 0.001) between patients and con trols. Mean IgG antibody levels were also higher than IgM levels in tuberculous meningitis. A comparison of the antibody levels against the 30 and 32 kDa antigen within the tuberculous meningitis patients showed higher IgG reactivity to the 30 kDa than to the 32 kDa antigen, suggesting that the antibody response of these patients is directed predominantly against the 30 kDa protein. However, the patterns of reactivity to 30/32 kDa, 30 kDa and 32 kDa antigen in individual subjects were similar. By the cut-off value adding 2 stsndard deviation to the mean absorbance of controls, the sensitivity and specificity of the IgG antibody to the 30 kDa antigen were 100% and 94.4%, respectively. These values were higher than those obtained by 30/ 32 kDa and 32 kDa antigen. From the above results, it is suggested that the 30 kDa antigen may be dominant antigen and more valuable in the diagnosis of tuberculous meningitis than 32 kDa antigen.

우리나라 일부 석면사업장의 석면폐 유병률

백도명,백남원,최정근,손미아,임정기,이원진,문영한,박정선,최병순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Asbestos industry has been in operation over 60 years in Korea. However, the prevalence of asbestosis has not been yet reported. With rapid turn-over of workers, previous cross-sectional studies of current workers on the job could not find cases with exposures long enough for the development of asbestosis. This study was done to evaluate asbestosis prevalence of those worksites with operation history of more than 20 years. In total, 139 workers from 5 worksites were examined. Asbestos industries covered in the study include 2 asbestos textile, 1 brake lining, and 2 ship repairing worksites. Chest x-ray was taken from all workers and read by two experts familiar with pneumoconiosis classification according to 1980 ILO guidelines. Those with findings compatible with asbestosis were further ckecked with high resolution computerized tomography (HRCT). Pulmonary function tests were done according to ATS guidelines, and occupational and previous medical history was taken through a standardized interview. Air-borne asbestos was measured according to NIOSH method 7400. The air-borne asbestos concentrations ranged from 0.2-1.3 f/cc for asbestos textile, from 0.7-1.0 f/cc for brake lining, and from 6.3-7.8 f/cc during asbestos removal at ship repairing worksite. Of the 139 workers 25 had abnormal chest radiographic findings, and 10 of them had findings compatible with pneumoconiosis. When work history and current asbestos measurements were accounted, 9 workers who had more than 10 years of asbestos exposure history showed chest radiographic findings of pneumoconiosis with Finally, 4 workers showed finding of pulmonary fibrosis and/or pleural thickening at HRCT, and 2 of them had restrictive lung function changes. The study results showed that, among 139 subjects, there were 4(3%) definite asbestosis cases confirmed with HRCT. The prevalence of probable asbestosis was 7% for 10-14 years of exposure, 13% for 15-19 years of exposure, and 23% for 20 or more years of exposure. The prevalence of compensable asbestosis with abnormal lung function was 4-6% for those with 15 or more years of exposure.

현대 헤어스타일에 나타난 아르누보 양식 연구

김주섭,백선영,이종민 한국패션뷰티학회 2008 한국패션뷰티학회지 Vol.6 No.2

This study is to understand how fluidity and natural features of Art Nouveau style are reflected in hair style of Art Nouveau age and Modern age and be a help to the trend analysis of hair style in the future. The study is conducted with the research on Art Nouveau expression in hair style and analysis of hair-show, trend presentation, documents related with hair style, TV drama, theses, journals and internet etc through advance research for Art Nouveau and Hair. The result of the analysis on Art Nouveau pattern in hair design is presented as below. First, it shows rounded, winding, flowing and thick-waved style of Art Nouveau pattern in modern long and short hair style. It also shows the beauty of long, bending and flexible lines, waving liveness and thin and slim lines and this is the Art Nouveau pattern that is also applied to other fields. In terms of decoration, it does not use tree vines, leaves and petals that are expressed in paintings of Art Nouveau age. Second, it shows natural up-style by lifting hair up with waved long hair that is one pattern of Art Nouveau and expresses hair style with feathers of birds, tree vines, leaves and petals etc for more decoration in animal pattern to make cute, romantic and elegant style in hair style.

현대 헤어스타일에 나타난 Art Deco적 특성

김민정,안성관,백선영 한국패션뷰티학회 2008 한국패션뷰티학회지 Vol.6 No.1

The purpose of this study was to observe the Art-Deco style art and hair-style. Art-deco design, which was popular in the 20th century, especially in the 1920s and 1930s, actively absorbed new forms, materials, and aesthetic values that come from technological developments and bridged the tradition to new pupblic culture. Art-Deco style art showed abstract and geometrical decoration tendency to meet modern concept and sense. The over all study on back grounds of Art-Deco style and its art works made possible to figure out the summary on formative characteristics of the style such as simplicity, exoticism, vivid colors, and functionalism. These findings suggest that hair styles borrow its characteristics or image from the past style to create new styles. It was found in the development of new hair styles that patterns or geometric motive appearing the Art-De´eco style are the source of rich design.

전국 단위 감시체계의 현황과 전망

강성규,안연순,지영구,김형옥,하미나,권호장,백남종,김성아,홍윤철,김재용,강대희,정혜선,하은희 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

Prevention and Control of Antimicrobial Resistance and Zoonoses : Characterization of SCCmec in methicil1in-resistant Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitic milk in Korea

( Young Hwan Paik ),( So Hyun Kim ),( Sun Young Hwang ),( Hye Cheong Koo ),( Sook Shin ),( Jin San Moon ),( Woo Kyung Jung ),( Jun Man Kim ),( Jung Won Kang ),( Young Kyung Park ),( Sun Young Park ),( 대한인수공통전염병학회 2007 창립총회 및 학술대회 초록집 Vol.2007 No.1

Prevention and Control of Antimicrobial Resistance and Zoonoses : Genetic comparison of the methicillin resistant Staphylococcus aureus (MRSA) and methicillin susceptible S. aureus (MSSA) isolated from bovine milk in Korea

( Sun Young Hwang ),( So Hyun Kim ),( Nam Hoon Kwon ),( Young Kyung Park ),( Hye Cheong Koo ),( Woo Kyung Jung ),( Jun Man Kim ),( Young Hwan Paik ),( Sun Young Park ),( Yong Ho Park ) 대한인수공통전염병학회 2007 창립총회 및 학술대회 초록집 Vol.2007 No.1

Comparison of Methods to Estimate Liver Function in Newly- Diagnosed Hepatocellular Carcinoma Patients with Ascites

( Young Sun Ko ),( Dong Hyun Sinn ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Liver function is a key element in determining outcome of patients with hepatocellular carcinoma (HCC). For HCC with ascites, estimation of liver function is particularly important, as they already have decreased liver function. We aimed to find out best method to predict outcome of HCC patients with ascites. Methods: A total of 437 newly-diagnosed HCC patients with ascites (mean age = 56.0 y, male = 74.8%, hepatitis B virus = 73.2%) were analyzed. We compared Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, MELD-Na score, and the Albumin-bilirubin (ALBI) grade for overall survival. Results: During a median 9.0 months of follow-up (range; 0.1 ~ 154.0), mortality was observed in 373 (85.4%) patients. MELD-Na showed highest time-dependent area under receiver-operating characteristics curves (AUROCs) at 1 year (0.672) that was significantly higher than ALBI grade (0.605), MELD score (0.580), and Child-Pugh score (0.580). The median survival was significantly lower for those with MELD-Na ≥ 12 than MELD-Na < 12 (median: 13.6 vs. 3.7 months, p < 0.001). Overall, 350 patients received treatment, and most commonly used modality was transarterial chemoembolization (62.3%), followed by radiofrequency ablation (15.7%) and resection (13.4%). Overall survival was significantly different for those who received treatment than those who did not (median survival: 13.3 vs. 2.4 months, p < 0.001). When patients were further stratified by mUICC stage and MELD-Na score, treatment was not associated with better outcome for mUICC stage IV patients with MELD-Na ≥ 12 (median survival: 2.2 vs. 1.8 months for treatment vs. best supportive care, p = 0.15), while treatment was associated with better outcome in other subgroups. Conclusions: In HCC patients with ascites, treatment was associated with better survival, except for subgroup with advanced tumor with decreased liver function, indicating that ascites per se is not absolute contraindication for HCC treatment. For these patients, MELD-Na showed better performance than MELD, Child-Pugh score and ALBI score for predicting overall survival.

Selective-Delay Garbage Collection Mechanism for Read Operations in Multichannel Flash-Based Storage Devices

Paik, Joon-Young,Cho, Eun-Sun,Jin, Rize,Chung, Tae-Sun IEEE 2018 IEEE TRANSACTIONS ON CONSUMER ELECTRONICS - Vol.64 No.1

<P>Flash memory has been a dominant storage medium in consumer electronics. Its wide deployment results from the remarkable progress in garbage collection mechanism which resolves the inherent limitation, not-in-place-update property, of flash memory. In this paper, we propose a new garbage collection management scheme, called selective-delay garbage collection, which can be used to optimize read operations. In our proposal, garbage collections are allowed to proceed only if they do not block the execution of incoming read operations. For this, the proposed scheme cooperates with an event queue in storage devices of consumer electronics. When read operations in the event queue are likely to collide with a garbage collection request, the read operations are processed preferentially by delaying garbage collection. This reduces the average read latency by avoiding time-consuming garbage collections. The experimental results with realistic workloads show that average read latency decreases by up to 13.53%, and the time elapsed by garbage collections is reduced by up to 78.37%, whereas the increase in write latency is limited to 0.83%.</P>