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이석호,조재원,이규택,강인구,최규완,백승운,이종균,고광철,이종철,박철근,이준혁,오영륜 대한소화기학회 1998 대한소화기학회지 Vol.32 No.1
Fibrolamellar hepatocellular carcinoma (FLHCC) is a distinct variant of ordinary hepatocellular carcinoma (HCC) and is very rare in the Orient. Contrary to ordinary HCC, the FLHCC has very good prognosis and usually occurs in adolescents and young adults without sexual preference. In addition, it is rarely associated with liver cirrhosis and hepatitis B virus. The FLHCC presents a high resectability rate. Most cases of FLHCC have been reported in the Western countries and only nine cases have been reported in the Orient. We present here a case of FLHCC observed in a 48 year old man. The patient had no subjective symptoms when the tumor was revealed by ultrasonography. The patient had many ch'arateristics of FLHCC (i.e,, no association with HBV or HCV, normal range of alphafetoprotein, no evidence of cirrhosis). However, he was older than average-aged patient with FLHCC. The tumor was removed by right antero-inferior segmententomy of the liver and diagnosed as FLHCC. To our knowledge, this report is the fast case in Korea.
Lee, Chang Hyeok,Lim, Hyo Jin,Park, Jae Hyoung,Kim, Jung Hyun,Kim, Jung Soo,Jeong, Min Joon,Song, Min Kyung,Kim, Si Hwan,Hwang, Su Min,Eom, Tae Kang,Lee, Min Jung,Lee, Yang,Ryu, Sung Ju The Kangwon-Kyungki Mathematical Society 2013 한국수학논문집 Vol.21 No.3
We continue the study of power-Armendariz rings over IFP rings, introducing $k$-power Armendariz rings as a generalization of power-Armendariz rings. Han et al. showed that IFP rings are 1-power Armendariz. We prove that IFP rings are 2-power Armendariz. We moreover study a relationship between IFP rings and $k$-power Armendariz rings under a condition related to nilpotency of coefficients.
Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancer
Lee, Hyun Hee,Son, Young Joon,Lee, Won Hyeok,Park, Young Woo,Chae, Seoung Wan,Cho, Wha Ja,Kim, Young Min,Choi, Hye‐,Jeong,Choi, Dae Hwa,Jung, Seok Won,Min, Young Joo,Park, Soon Eun,Lee, Byung Ju Wiley Subscription Services, Inc., A Wiley Company 2010 International journal of cancer: Journal internati Vol.126 No.8
<P><B>Abstract</B></P><P>Tristetraprolin (TTP) is an AU‐rich element‐binding protein that regulates mRNA stability. Here, we report that TTP suppress the growth of human colon cancer cells both <I>in vivo</I> and <I>in vitro</I> by regulating of the expression of vascular endothelial growth factor (VEGF). TTP protein expression in human colonic tissues was markedly decreased in colonic adenocarcinoma compared with in normal mucosa and adenoma. VEGF expression was higher in colonic adenocarcinoma than in normal mucosa and adenoma. Specific inhibition of TTP expression by RNA‐interference increased the expression of VEGF in cultured human colon cancer cells, and TTP overexpression markedly decreased it. In addition, elevated expression of TTP decreased the expression level of luciferase linked to a 3′ terminal AU‐rich element (ARE) of VEGF mRNA. Colo320/TTP cells overexpressing TTP grew slowly <I>in vitro</I> and became tumors small in size when xenografted <I>s.c</I> into nude mice. These findings demonstrate that TTP acts as a negative regulator of VEGF gene expression in colon cancer cells, suggesting that it can be used as novel therapeutic agent to treat colon cancer.</P>
이석호,최윤호,손희정,류광현,이규택,김재준,김용일,최규완,최성호,백승운,이종균,고광철,이풍렬,이종철,노재형,이준혁,심상군 대한소화기학회 1999 대한소화기학회지 Vol.34 No.1
Background/Aims: We aimed to clarify clinical factors which suggest the possibility of neoplastic polyps of gallbladder. Methods: Ninety-five resected gallbladders with polyps were included. Size and number of the polyps were obtained by preoperative ultrasonography. Histollogically, the polyps were classified into non-neoplastic (cholesterol and inflammatory or hyperplastic polyp) and neoplastic lesions (adenoma and adenocarcinoma). Clinical features, maximum diameter and number of the polyps were compared between the two groups. Results: Of 95 patients, non-neoplastic polyps were observed in 65.3% and neoplastic polyps were observed in 34.7%. We found cholesterol polyp in 47.4%, inflammatory or hyperplastic polyp in 17.9%, adenoma in 25.2% and adenocarcinoma in 9.5%. Two groups showed no difference in age, sex, body mass index, cholesterol, triglyceride, glucose, ALT, HBsAg carriage and the number of polyps. Among the patients with non-neoplastic polyps, 70.2% was under 60 years, while 72.7% of the patients with neoplastic polyps was over 60 years (p$lt;0.05). The size of polyps was under 10 mm in 88.9% of non-neoplastic polyps, and between 10 and 15 mm in 40% of neoplastic leisions. Moreover, 68.4% of neoplastic polyps exceeds 15 mm in diameter (p$lt;0.05). Conclusions: The size of polyp (≥10 mm) and patient's age (≥60 years) could be indicators for neoplastic polyps.
이규택,김재준,백승운,이종균,고광철,이종철,이준혁,오영륜,안홍준,이풍렬 대한소화기학회 1998 대한소화기학회지 Vol.31 No.5
Primary hepatic leiomyosarcoma of the liver is a rare tumor, with fewer than 70 previously reported cases. There was only one case reported in Korea. We present the case of a 54-year-old man who presented with a mass in the right hepatic lobe on CT scan. Percutaneous biopsy was consistent with leiomyosarcoma. The patient was treated successfully by right lobectomy, and has been disease free for 19 months. We report the case of primary leiomyosarcoma of the liver with review of relevant literatures.
NMR Study of the pH Effect on the DNA Binding Affinity of Human RPA
Lee, Min-Woo,Choi, Ju-Hyeok,Choi, Jae-Gyu,Lee, Ae-Ree,Lee, Joon-Hwa 한국자기공명학회 2016 Journal of the Korean Magnetic Resonance Society Vol.20 No.3
The replication protein A (RPA) plays a crucial role in DNA replication, recombination, and repair. RPA consists of 70, 32 and 14 kDa subunits and has high single-stranded DNA (ssDNA) binding affinity. The largest subunit, RPA70, mainly contributes to bind to ssDNA as well as interact with many cellular and viral proteins. In this study, we performed nuclear magnetic resonance experiments on the complex of the DNA binding domain A of human RPA70 (RPA70A) with ssDNA, d(CCCCC), at various pH, to understand the effect of pH on the ssDNA binding of RPA70A. The chemical shift perturbations of binding residues were most significant at pH 6.5 and they reduced with pH increment. This study provides valuable insights into the molecular mechanism of the ssDNA binding of human RPA.
Efficient adsorption of sulfide gas using porous zeolite powder
Lee Sang-hwa,Jeon Young Pyo,Lee Young Jun,La Yunju,Song Jun Yong,Park Yong Yeol,Lee Eun Jung,Jeon Ok Sung,Park Sang Yoon,Yoo Young Joon,Yang Keun-Hyeok 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.12
We prepared zeolite 13× beads and 10% zeolite 13× bead-embedded water-permeable blocks using porous zeolite powder. The difference in the surface state and pore structure of the zeolite powder and bead was analyzed through scanning electron microscopy and Brunauer–Emmett–Teller measurements. The process for making zeolite beads partially damaged their surface. Furthermore, the pore structure of the zeolite beads changed from micropores to a mixture of micro- and mesopores. The sulfur oxide ( SOx) adsorption efficiency of zeolite powder, beads, and blocks was evaluated. The initial SOx adsorption efficiency of zeolite beads decreased after washing ten times, but the increase in SOx concentration after initial adsorption was very small. The SOx adsorption efficiency of the block was very high even after washing ten times. These results indicate that the block is promising for applications requiring the adsorption of harmful gases such as SOx and NOx.
Lee, Seungmin,Moon, Byung Joon,Lee, Hyun Jung,Bae, Sukang,Kim, Tae-Wook,Jung, Yong Chae,Park, Jong Hyeok,Lee, Sang Hyun American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.20
<P>In this study, we developed reduced graphene oxide (rGO)-incorporated porous agarose (Ar-rGO) composites that were prepared via a “one-pot” sol-gel method involving a mixing and vacuum freeze-drying process. These composites represent an easy-to-use adsorbent for organic contaminant removal. Ar-rGOs can efficiently adsorb organic molecules, especially aromatic organic compounds from wastewater, because of the synergistic effect between the agarose bundles, which function as a water absorption site, and the rGO sheets, which function as active sites for pollutant binding. The pore structures and morphology of the Ar-rGO composites varied according to the added rGO, resulting in effective water infiltration into the composites. The main adsorption mechanism of the aromatic organic compounds onto Ar-rGOs involved π-π interactions with the rGO sheets. The surface interaction was more effective for adsorbing/desorbing the aromatic pollutants than the electrostatic interaction via the O-containing functional groups. In addition, we confirmed that Ar-rGO is highly stable over the entire pH range (1-13) because of the presence of the rGO sheets.</P> [FIG OMISSION]</BR>
이종철,이석호,이규택,김재준,이종균,고광철,이풍렬,최규완,이준혁,오영륜,박근칠 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.3
Pseudomyxoma peritonei is a benign mucin producing tumor of the peritoneum which is usually diagnosed using a laparotomy. It is uncommon to find a case of pseudomyxoma peritonei which has been diagnosed using a peritoneoscopy in Korea; there are only two cases reported in the literature. We recently experienced a case of pseudomyxoma peritonei in a 61 year old woman who manifested a typical case using a peritoneoscopy. Thick, jelly-like materials were adherent to polypoid nodular masses of the parietal peritoneum, which originated from the mucinous cystadenocarcinoma of an ovary. In this report we discuss the case with relevant review of the literature.