방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술

채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

원판형 진행파 초음파 모터의 동특성 해석

한상훈,김종선,변흠필 한국 항공대학교 항공산업기술연구소 1998 航空宇宙産業技術硏究所 硏究誌 Vol.8 No.-

본 연구에서는 압전작동기를 이용한 원판형 진행파 초음파 모터에 대한 동역학적 모델과 성능분석을 수행하였다. 초음파 모터는 거의 대부분이 모터가 사용될 용도에 따라 그 외경의 크기가 미리 정해지므로 이러한 기본 제원이 설정된 후 해석적 모델을 이용한 모터변수 선정 및 동특성 해석에 관한 수치적 예를 보였다. 고정자의 자유 진동해석과 압전작동기에 의해 가진된 강제진동해석, 고정자산의 모델, 고정자와 회전자와의 접촉특성모델들을 통해 고정자의 진동형상, 고유진동수, 고정자산의 배열, 회전속도, 전달토크, 응답특성등 모터의 동특성과 성능특성을 수치적으로 연구하였다. This paper deals with the dynamic analysis and the performance prediction of a piezoelectric annular traveling wave ultrasonic motor. The vibrational characteristics of the stator plate is studied based on the laminated plate theory and the rotor is modeled as a rigid plate. It is also studied some relations between the mechanism of friction, the pressure distribution and other driving factors using Hertzian contact theory. The transient and steady state characteristics of the motor such as natural frequencies mod shapes, speed characteristics, driving torque, etc, are studied and compared with the other research works through the numerical analysis.

공공사업의 사업성평가 방법론에 관한 연구 : 새만금사업의 사업성 평가에 있어서 비용·편익항목 선정의 문제점을 중심으로 A Case Study of the Saemankum Project focused on the Selection of Evaluation Variables

한상훈 경주대학교 건설환경연구소 2004 建設環境論叢 Vol.- No.6

This study aims to examine the usefulness and limits of cost-benefit analysis in the evaluation of the feasibility of a certain public project. To accomplish this research objective two different examinations were proceeded in this study. One of which is the literature review of the cost-benefit analysis in terms of the role and function of the analysis in the feasibility study of a certain public project. The other is a case study of the Saemankum Project. This case study examines the selected variables for the cost-benefit analysis in order for conducting the feasibility study of the project. The results of these examinations show that cost-benefit analysis is very useful mean to examine the feasibility of a certain public project and its usefulness could be improved if the following conditions were satisfactorily considered in the analysis: (1) selection of the cost- and benefit-variables for analysis is proceeded under the same condition and time span, (2) the analysis should include a certain mediation process in advance to determine the final selection of the cost- and benefit-variables to secure the reliability of the results of the analyses.

뇌혈관의 미만성 방추형 동맥류 : 1예 보고

한기석,신환식,박길선,김대영,김성진,차상훈 충북대학교 의과대학 충북대학교 의학연구소 1998 忠北醫大學術誌 Vol.8 No.2

저자들은 뇌동맥의 광범위한 확장을 보이는 희귀한 방추형 동맥류의 증례를 경험하였기에 전산화단층촬영영상과 자기공명영상 소견을 중심으로 보고하고자 한다. 49세 남자환자로 20 년전 고혈압으로 진단 받고 치료받던 환자로 현기증과 언어장애로 내원하였다. 내원 후 시행한 조영증강후 뇌 전산화 단층촬영에서 뇌저동맥, 중뇌동맥, 후뇌동맥 등이 확장되어 있고 구불구불하였으며, 확장된 뇌저동맥은 뇌교를 압박하고 있었다. 삼차원 구성기법을 이용한 전산화단층촬영 혈관조영술에서 뇌동맥이 광범위한 확장을 쉽게 이해할 수 있었다. 자기공명영상 T2강조영상에서 확장된 뇌동맥이 신호소실로 보였으며, 뇌저동맥이 뇌교를 오른쪽으로 압박하고 뇌교의 중앙부분에 뇌경색이나 허혈로 보이는 높은 신호강도를 보이는 부분이 있었다. 미만성 방추형 동맥류에 있어 전산화 단층촬영, 자기공명영상은 동맥확장의 범위와 정도를 평가하는데 도움을 주며, 혈전형성, 허혈, 주위 뇌조직의 압박 등의 소견을 잘 보여준다 Authors report a case of diffuse fusiform aneurysm of cerebral arteries, focusing findings of CT and MRI. A 49 year old male suffered by hypertension was presented by dysarthria, right hand tingling sensation and dizziness. Contrast media enhanced CT images showed markedly dilated and tortuous basilar artery and middle, posterior cerebral arteries. The location and extent of arterial dilatation was well depicted by CT angiogram. On T2 weighted MR image, dilated arteries were depicted as signal void and the compressed pons by dilated basilar artery and adjacent ischemic changes were also well depicted. CT and MRI are excellent imaging modality in the evaluation of extent and degree of diffuse fusiform aneurysm of cerebral arteries.

地域社會發展에 關한 지역대학의 機能과 役割에 關한 연구

한상훈 영남대학교 지역발전연구소 2001 영남지역발전연구 Vol.28 No.-

Education and research are core functions of the university. However, in accordance with the rapidly changing social and economic conditions most universities are being asked to provide additional services to the community where they located. Since the universities usually have a bundle of buildings as well as huge playgrounds and have various high-tech research projects it is expected that the social and economic influence over the community might be great when the cooperation with the university and the community were successful for any purpose. Based on this thought this study examines the relationship between the university and the community through the previous studies related to the issue. Then the author suggests two different approaches for the further research direction for both the planners and local administrators to accomodate and enhance the potential success and growth of the community through the cooperation with local universities.

무용전공 대학생의 스트레스 요인 분석

한태준,우태화,오상훈 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.1

Stressors which dance specialty university student have been suffered from during activity in dance were analyzed through open-questionnaire, the participants in this survey were 228 dance specialty university student, sort questions according to the affinity and similarity of them in the aspects of conception, questionnaire was summed up in six factors and twenty questions. Arranged twenty questions were determined by the fifth levels of Likert's type scale to be good for responses. As the result of analysis of responded contents, they were sorted as main six factors like that university professor, training, school, finance, individual, rest. As Jim Taylor told, dancers are apt to have disease and injuries when dancers are under the stress, and those who have abnormal increase of decrease in one's own weights can have more stress. The way of conducted a good performance by dance specialty university student is that dancers should have responsibility as worker and have pride as artist, many study and analysis will be necessary if there are any other in actual circumstances or not in actual circumstances.

CFRP와 콘크리트 계면에서의 부착특성

한상훈,조홍동,박중열,황선일,김형진 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.2

Externally bonding technique of CFRP(Carbon Fiber Reinforced Polymer Plate) is widely used in strengthening of concrete structures, and the improving effect of flexural strength and stiffness has been proven by early researchers. But, strengthened concrete structures present brittle failure mode accompanied with debonding of CFRP. That is, it means that the behavior of concrete structures strengthened with CFRP is mainly dependent on mechanical characteristics of CFRP and concrete interface. Therefore, double-lap shear test was performed to examine the bond characteristics on interface. The experimental variables are included with the strength of concrete, bond length and width. Test results showed that effective bond length of CFRP is approximately 30cm and maximum interfacial shear stress at specimen failure is 47 kgf/㎠.

Chlamydia psittaci strain fransis의 plasmid pCpA1과 C. psittaci strain 6BC의 plasmid의 염기서열 상동성 분석

한상훈,정규회,G. V. Stokes,윤병수 경기대학교 1999 論文集 Vol.43 No.2

In Chlamydia, there is not efficient transformation vector system. This defect makes hard to study of Chlamydia. As a first process for E. coli-to-chlamydia shuttle vector construction, we executed DNA sequencing analysis of Chlamydia psittaci 6BC plasmid whole origine and parts of ORFs. We compared them with already known Chlamydia psittaci francis pCpA1 whole origine and parts of ORFs sequences using Computer DNA sequence analysis program PCGENE and demonstrated that partially analyzed origins and ORFs on two plasmids matched perfectly each other.

설갑상선 : 1 예 보고 A Case Report

한기석,배일헌,차상훈,김성진,박길선 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

갑상선 조직 전체가 설기저부에 발생한 이소성 설갑상선 증례를 경험하였기에 그 방사선학적 소견을 문헌고찰과 함께 보고하고자 한다. 증례는 59세 여자 환자로 40 일전부터 발생한 음성 변화를 주소로 내원하였다. 이학적 검사에서 설 기지부 중앙에 회백색의 격막에 둘러 쌓인 3 cm 가량의 종괴가 있었으며, 종괴는 내장으로 돌출하여 구인두를 막고 있었다. 경부 전산화 단층촬영 측면 정찰 촬영에서, 설 기저부에 후방으로 돌출하여 구인두를 막고 있는 경계가 분명한 연부조직 종괴가 보였으며, 전산화 단층촬영 동맥기와 정맥기에 주변의 혈관과 비슷한 강하고 균일한 조영증강을 보이는 장경 2.5 cm의 원형 종괴가 있었다. 또한 갑상선이 있어야 할 경부 전방 공간에서 정상 갑상선 조직은 전혀 보이지 않았다. 설 기저부의 종괴에서 생검을 시행하였으며 병리 검사에서 갑상선 조직으로 진단되어 설갑상선으로 확진되었다. The authors report a case of ectopic thyroid that whole thyroid tissue was replaced by lingual thyroid. A 59-year-old female presented with dysphonia duration of 40 days. On physical examination, there was a 3 cm sized well encapsulated whitish mass protruding to oral cavity in milline of tongue to base. Computerized tomography of neck revealed homogeneously enhancing well marginated 2.5 cm sized round mass in the cecum of tongue base on arterial and venous phase. And there was no normal thyroid gland in lower anterior neck.