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박중열,유성주,이은중,이대호,김지영,이상훈 한국바이오칩학회 2010 BioChip Journal Vol.4 No.3
We monitored the viability and morphology of mouse fibroblast cells cultured on PDMS sub strates with different degrees of polymer stiffness. The stiffness was controlled by varying the ratio between base and crosslinker agent during mixing. Although the standard PDMS mixing ratio is 10 : 1 (base to crosslinker; Young’s modulus, E=580 kPa), we found that a PDMS substrate with a high stiffness (mixing ratio of 5 : 1, E=1,000 kPa) was more favora ble as a substrate for fibroblast cell growth. It is important to note that an extracellular matrix coating was not applied to the PDMS so that the effect of stiffness on cell growth could be studied in isolation. A stiffness reduction of 40% (from a mixing ratio of 5 : 1 to 10 : 1)produced a significant reduction in survival rate (viability was reduced by 15%), and viability worsened (was reduced by 45%) for a substrate stiffness of 280 kPa (a mixing ratio of 20 : 1). The rate of spreading for the cells was measured to show that stiffer materials promoted more prolific fibroblast growth. These results provide PDMS stiffness guidelines for cell culture substrates.
Effective Methods to Improve the Biocompatibility of Poly(dimethylsiloxane)
박중열,황창모,이상훈 한국바이오칩학회 2008 BioChip Journal Vol.2 No.1
Poly (dimethylsiloxane) (PDMS) has become one of the popular materials in the field of bio-related microfluidic systems, and has been used for various biological assays. While the material is known to be biocompatible in general, it also has been reported that the attachment and survival rate of cells are limited on a PDMS substrate. In this paper, a simple and relevant method to improve heiocompatibilityof PDMS is proposed; the effects of various treatments using ethanol, water, and boiling-water were evaluated. The results show that the boiling-water treatment is the most appropriate, time saving, and simple method to improve the biocompatibility of PDMS.
탄소섬유판으로 휨보강된 철근콘크리트 보의 거동예측을 위한 해석적 연구
박중열,조홍동,한상훈 충북대학교 건설기술연구소 2003 建設技術論文集 Vol.22 No.2
Composite materials which have superior mechanical, chemical properties in comparison with conventional materials are used to strengthen RC structures and related studies are actively performed. Especially, the studies on behavior prediction of RC beam strengthened with CFRP plate are peformed recently. RC beams strengthened with CFRP plate appear material non-linearity, occurrence of cracks, geometric non-linearity, so behavior prediction based on linear-elastic theory may differ from experimental results. Therefore, in this study, to predict the behavior of RC beam flexurl strengthened with CFRP plate, analytical program considering material non-linearity is developed. To analyze, strain compatibility and force equilibrium are applied and internal forces of constitutive material are calculated using non-linear stress-strain relationship. To certainty the reliability of analytical program, deflection, strain of CFRP plate, change of neutral axis on cross section and crack distribution at failure are compared with those of experiment, and each results is almost coincident.
박중열 대한기계학회 2021 기술과 교육 Vol.9 No.1
코로나19는 전 세계적으로 사회적, 경제적, 심리적 그리고 다른 모든 면에서 현재 진행형으로 크고 작은 영향을 미치고 있으며 당연히 대학의 교육에도 큰 영향을 가져왔다. 대표적인 것은 전통적인 대면 교육을 포기하고 대체 방안인 비대면 온라인 교육으로 전환한 것이다. 이에 온라인 교육의 특징과 학생들의 반응을 알아보았다. 코로나19의 범세계적 유행이 지나간 후에는 대학 교육에 대한 인식 변화는 필연적일 것이다. 특히, 교·강사와 학생들 모두가 온라인 교육의 본질에 대한 이해가 강화되고 깊어 지고 있다. 이것은 온라인 교육을 보다 바람직한 방향으로 발전시킬 수 있는 원동력이 될 것이다. 미래에 전통적 대면 교육과 온라인 교육이 조화롭게 융합되어 새롭고 더 우수한 교육 형태로 거듭나기를 기대한다. COVID-19 is now affecting society, economics, psychology, and all other aspects globally, and has also had a major impact on university education. Most notable is the transition from traditional face-to-face training to non-faceto-face online training. Therefore, the characteristics of online education and the report on students' responses are introduced. After the pandemic of COVID-19 has passed, a change in perception of university education will be inevitable. In particular, both teachers and students are strengthening and deepening their understanding of the nature of online education. This will be the driving force to advance online education in a more desirable direction. In the future, it is hoped that traditional face-to-face education and online education will be harmoniously integrated and reborn as a new and superior form of education.
박중열,이병두,김웅,이홍규,고창순,민헌기,오승근,이진용,홍기석 대한내분비학회 1987 Endocrinology and metabolism Vol.2 No.2
About 10% of pheochromocytoma occurs in familial pattern and familial pheochromocytoma has a autosomal dominant mode of inheritance with varing degree of penetrance. It has been well known that the diagnosis before delivery and adequate management of pheochromocytoma during pregnancy markedaly reduce both maternal and fetal mortality. We report two cases of pheochromocytoma in two systers. One of which was bilateral, multiple adrenal tumors and the other was developed during pregnancy. The latter was diagnosed at antepantum and treated with alpha-and selective beta_1-adrenergic receptor blockades till delivery and then with successful simultaneous cesarean section and excision of tumors under thipental, nitrous oxide-oxygen-ethrane general anesthesia at 37 weeks of gestation. In conclusion, it is suggested that the family history and the life long follow-up of the patient with pheochromocytoma are very imporant to detect the familial pheochromocytoma and the multiple endocrine neoplasia. Hypertensive patient during pregnancy must be differentiated from a pheochromocytoma and the correct antepartum diagnosis and proper management may menkedly reduce maternal and fetal mortality.
사육 수온이 강도다리(Platichthys stellatus)와 교잡종(P. stellatus♀× Kareius bicoloratus♂) 3배체의 성장에 미치는 영향
박중열,이효빈,윤지혜,조윤수,이일영,임한규 한국수산과학회 2022 한국수산과학회지 Vol.55 No.6
Triploid fish have attracted the attention of fish farmers owing to of their larger cell size compared to that of diploid fish and their ability to utilize the energy required for sexual maturation for growth instead. However, the effect of increased growth in triploid fish has shown varying results. Therefore, this study aimed to compare growth between diploid and triploid starry flounders and diploid and triploid hybrid juveniles (starry flounder, Platichthys stellatus ♀×stone flounder, Kareius bicoloratus ♂) based on breeding water temperature to investigate the effect of increased growth in triploid fishes. The experiment was performed by categorizing the water temperature as high temperature (EXP. 1, 14.5–23.5°C) and low temperature (EXP. 2, 6.4–13.3°C) based on the optimal water temperature for starry flounder breeding. In EXP. 1, the growth of starry flounder triploids and hybrid triploids was significantly higher than that of diploids. However, in EXP. 2 the weight gain and specific growth rate of the starry flounder triploid were higher, and the growth of starry flounder was higher than that of the hybrids.