KI-180과 KI-188 칼슘조성물이 어린쥐의 성장발육에 미치는 영향

박승만(Seung-Man Park),성기승(Ki-Seung Seong),이종석(Jong-Seok Lee),이옥환(Ok-Hwan Lee),한찬규(Chan-Kyu Han) 한국식품과학회 2014 한국식품과학회지 Vol.46 No.3

본 연구에서는 KI-188 칼슘과 KI-180 조성물이 성장발육에 미치는 효과를 조사하였다. 시험기간중 KI-188 칼슘과 KI-180 식이군이 대조군 보다 성장률과 평균 식이섭취량은 증가하였다. 체장은 KI-188 칼슘과 KI-180 식이군이 대조군에 비해 평균 3.55 mm 더 길었고, 등뼈길이는 KI-180 식이군이 대조군 보다 통계적인 차이는 없었지만 0.5 mm 더 길었다. 대퇴골 무게는 KI-188 칼슘과 KI-180 식이군이 대조군에 비해 통계적으로 무거웠으며, 대퇴골길이는 대조군에 비해 각각 평균 0.89, 1.09 mm 더 길었다. 혈당, 총콜레스테롤 및 중성지방 농도는 차이가 없었고, 칼슘농도는 KI-188 칼슘과 KI-180 식이군 보다 대조군이 유의하게 높았다. 백혈구와 혈소판수는 차이가 없었고, 적혈구, 혈색소 및 헤마토크릿치는 대조군이 KI-188 칼슘과 KI-180 식이군 보다 통계적으로 높았다. ALP활성은 KI-180 식이군이 대조군 보다 통계적으로 높았고, osteocalcin농도는 KI-188 칼슘과 KI-180 식이군이 대조군에 비해 통계적으로 유의하게 높았다. 혈청 testosterone 농도는 KI-188 칼슘과 KI-180 식이군과 대조군 간에 차이가 없었다. IGF-1과 IGFBP-3 농도는 KI-180 조성물이 대조군 보다 각각 20%, 11% 정도 유의하게 더 높았다. 이상의 결과를 검토할 때 KI-188 칼슘과 KI-180 조성물은 어린쥐의 성장과 골격의 발달을 촉진시키고, 성장호르몬의 분비능을 양적으로 유도하여 전반적인 성장발육에 유효한 작용이 있는 것으로 사료된다. Herbs have active components that promote the growth rate of both animals and human. The KI-180 and KI-188 calcium food formulae contain Acanthopanacis cortex, Bombysis corpus and hoelen, seaweed calcium, chlorella extract, spirulina, colostrum powder, and other natural and functional components. We evaluated the growth-promoting effects of these formulae by analyzing the weight, femur and backbone, alkaline phosphatase, osteocalcin, testosterone, insulin-like growth factor (IGF)-1, and IGF binding protein-3 (IGFBP-3) of growing rats. Growing rats administered with KI-180 and KI-188 calcium showed the increase of body weight, body length, and femur weight and length of growing rats. In addition, administration of KI-180 and KI-188 calcium increased the alkaline phosphatase activity, the levels of osteocalcin and the growth hormones IGF-1 and IGFBP-3 of growing rats. The impact of KI-180 and KI-188 calcium on the physical development of growing rats suggests that the incorporation of these food formulae in the diets of growing children may promote the physical development.

Interrelation of Cyclin D1, Cyclin E, and p27Kip1 Expression on Tissue Arrays of Breast Cancer

Sehwan Han,Young-Duck Kim,Hong-Yong Kim,Hong-Joo Kim,Kyeongmee Park,Byung-Noe Bae,Suk Yong Ryu,Ki Hwan Kim 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5

Purpose: To evaluate the clinical impact of the alteredexpression of cell cycle regulators in stage I and II breastcancers.Materials and Methods: The interaction between cyclinD1/E and p27Kip1 expressions were analyzed usingtissue microarray (TMA) technology in 133 breast cancers.Data from the immunohistochemical assays of 3molecules were merged, and analyzed, with a Ki67labeling index of the same tumors.Results: Cyclin D1 was expressed in 72 breast carcinomas(54.1%) and cyclin E in 60 (45.1%) out of the 133breast carcinomas. Expressions of cyclin D1 and cyclinE were inversely related to each other, and significantlyassociated with the estrogen receptor (ER) expressionand differentiation of the breast carcinoma. The expressionof cyclin E was significantly decreased in tumorsexpressing cyclin D1 (p=0.022). There was a trend forcyclin D1 expression to increase in tumors expressingp27Kip1 (p=0.053), but the expression of cyclin E didnot correlate with p27Kip1 expression. The Ki67 labelingindex was markedly increased in tumors expressing cyclinE, whereas it was significantly decreased in the cyclin D1or p27Kip1 expressing-tumors. From survival analysis,cyclin E expression was the only significant variable forthe prediction of poor survival.Conclusion: The abnormal expressions of cell cycleregulatory molecules are prevalent, and interrelated witheach other in breast cancer. Integration of TMA technologyallowed a high-throughput analysis for correlating molecularthe in situ findings, with the clinico-pathologicinformation. Among the three molecules studied, thecyclin E had a prognostic implication for stage I and IIbreast cancer. (Cancer Res Treat. 2002;34:388-393)

Focal adhesion kinase and src expression in premalignant and malignant skin lesions

( Ju Yeon Choi ),( Jae Yun Lim ),( Han Saem Kim ),( Jung Min ),( Jung In Kim ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Chong Won Choi ),( Yoon Hwan Kim ),( Jin Hee Sohn ),( Hyunjoo Lee ),( Won Serk Ki 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Focal adhesion kinase (FAK) and Src are non-receptor tyrosine kinases. FAK and Src play a critical role in inducing malignant transformation in tumor cells. Objectives: We performed immunohistochemical staining for total and phosphorylated forms of FAK and Src, to evaluate the role of FAK and Src in the development of premalignant and malignant skin lesions. Methods: A total of 59 facial skin samples (30 actinic keratoses, 10 Bowen``s diseases, 13 squamous cell carcinomas and six perilesional skins) were immunohistochemically stained for Ki-67, total (t) and phosphorylated (p) form of FAK and Src. Methods: A total of 59 facial skin samples (30 actinic keratoses, 10 Bowen``s diseases, 13 squamous cell carcinomas and six perilesional skins) were immunohistochemically stained for Ki-67, total (t) and phosphorylated (p) form of FAK and Src. Results: Cells positive for t-Src, p-Src-y530, t-FAK and pFAK-s722 were detected in premalignant intra-epithelial lesions (PELs) and squamous cell carcinomas (SCCs), but not in the perilesional skin. There was a tendency towards high correlation between Ki-67 and t-FAK or pFAK-s722, suggestive of the active role of FAK in cell proliferation. Conclusion: Our findings of higher t-Src and p-Src-y530 positive cells in PELs, as compared to SCCs (with higher Ki-67 level), are suggestive of the other role of Src in tumor formation and progression, which requires further investigation.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

제주도 畜犬에 대한 Babesia 병 감염 조사 연구 : (특히 陽性犬의 血液學的 觀察) Hematological Observation infected dogs with Babesiasis

韓邦根,金麒煥 제주대학교 1972 논문집 Vol.4 No.-

I detected the babesiasis organisms in 11 among 395 house dogs of Jeju-Do, through the blood examination. After inoculation of natural infected dog's blood to the healthy or Splenectomized dogs, I examined their blood. The results of hematological observation are as follows : 1. In natural infected dogs, their hemoglobin contents, hematocrit value, and the number of drythrocytes decreased. And Polymorphonuclear leukocytosis appeared. 2. The color of the blood was pale and watery, and the erythrocytes were characterized their hypochromasia and Polychromasia, esp. anisocytosis. 3. Lymphocytosis appeared in natural infected dogs and in inoculated pups, too, in early stage. 4. The clinical symptoms of natural infected dogs were Paleness of visible mucous membrane, listletless, anorexia, Pyrexia, anemia, icterus and hemoglobin uria. And were same as in the splectomized pups, too. 5. In the natural infected dogs, the shape of babesiasis organisms was round, Polyangular, Pear-shaped, or vacuolated.

여자 중학생들의 슬관절 근육의 등속성 운동평가

한기훈,김환순 한국운동역학회 2003 한국운동역학회지 Vol.13 No.2

Han, K-H and Kim, H-S. Isokinetic Evaluation of Knee Muscles in Female Youth Group. Korean Journal of Biomechanics, vol. 13, No. 2, pp. 1-12. This study was performed to provide normative isokinetic strength of knee muscles of middle school non-athletic and athletic populations for rehabilitation and pre-season screening for injury prevention. Seven non-athletic subjects and 8 hockey players participated in this investigation. Each subject was tested at speeds of 60°/sec, and 300°/sec. The free weight of lower leg was measured at speed of 60°/sec to take gravity effect into consideration when peak torque of knee muscles occurred. The results showed that the relative peak torque production of knee flexors did not change but the relative peak torque of knee extensors decreased significantly. Hamstring/quadriceps rations increased mainly due to significant decreases in knee extensors torque production. No significant differences were found between groups. The hamstring/quadriceps rations for both groups were significantly lower when the gravity effect was not eliminated.

향상된 보안 시스템 모델에 관한 연구

韓昑希,全基煥 카톨릭대학교 성심교정 1996 論文集 Vol.3 No.-

현대 사회의 필수적 요소인 정보를 안전하게 보호하면서 다양한 서비스와 공유를 제공하기 위한 보안 시스템이 요구되어 다수의 보안 모델들이 제안 되어 있다. 본 논문에서는 이 중 정보흐름 모델인 기존의 수취-부여 보안 모델을 확장하여 보다 향상된 시스템을 제공하고자 하는 보안 모델을 제안 하였다. 수취-부여 모델은 정보의 흐름을 예측할수 있어 정보가 이동하는 경로를 그래프 형태로 파악하여 주체가 접근하고자 하는 객체를 파악할수 있고 사용자가 객체에 대한 참조를 획득할수 있는 조건을 알수 있다는 장점이 있다. 이러한 장점을 실제 시스템에 적용하고자 기존의 규칙들을 새로운 시스템 환경에 맞게 설정하여 본 논문에서 확장된 수취-부여 보안 모델을 제안 하였고 실제적인 목적 기계로는 Linux 시스템을 선정 하였다. Linux 시스템을 보다 안정된 시스템으로 재 설계하여 불법적인 파괴 및 훼손으로부터 정보를 안전하게 보존할수 있도록 하였다. 또한 이모델을 통해 보다 넓은 범위의 시스템이 적용 가능 할 수 있도록 하는 일반적인 이론을 제안하였다.

세 갈래로 가른 전두근판을 이용한 안검하수증의 교정

한기환,이경호 大韓成形外科學會 1988 Archives of Plastic Surgery Vol.15 No.1

The aim of blepharoptosis surgery is normal restoration of eyelid cosmetically and functionally. Methods of the correction of ptosis are many. While most of the operations can produce improved or even satisfactory results in mild ptosis, none is entirely satisfactory for the severe case. In 1982 Song reported a procedure using frontalis muscle which sutured to the anterior surface of the tarsus. Using his method, the authors have experienced arching of the upper eyelid margin. The authors divided distal portion of the frontalis muscle flap to 3 parts like a tripartite. The authors have used this tripartite frontalis muscle flap technique to severe and moderate cases with satisfactory results. The results were as follows: 1. In order to prevent an ectropion, the tunnel underneath the orbicularis oculi muscle is made so small that only the frontalis muscle flap can be passed through. 2. The height and curvature of the corrected lid margin is good and lasting. 3. Excision of excessive lid skin must be adequate in order to construct a complete and natural supratarsal fold. 4. Little or no ptosis was developed when looking forward and upward gazes. 5. The lagophthalmos during sleeping spontaneously disappeared about six month. 6. Recorrection is easy in the cases of over or undercorrection. 7. The wrinkles on the forehead disappeared by themselves.

실리콘판과 실리콘접착제로 만든 비삽입물

한기환 大韓成形外科學會 1988 Archives of Plastic Surgery Vol.15 No.1

Augmentation rhinoplasty now involves flat noses as well as saddle or deviated noses. Creation of an accurate nasal implant is critical for augmentation rhinoplasty in such cases. The author has devised a new method to create implants. First, an ideal nasal patters is made from a xeroradiogram of a profile of the face. A silicone sheet (0.06 inch in thickness) is then tailored to this pattern and mounted on a stone model of the patient's nasal impression. Silicone adhesive is squeezed onto both sides of the silicone sheet and cured. Finally a carving of the outer surface of the implant is done with a #11 blade. Consequently a nasal implant is composed of silicone sheet and silicone adhesive. The results of the clinical experience of augmentation rhinoplasty with this implant are as follows: 1. A shaping of the implant with the same angle and size of the preoperative design. 2. The undersurface of the implant has contact with the patient's nasal contour. 3. A smooth and natural curvature of the nose. 4. Easy carving because the implant is attached firmly to the stone model. 5. Preoperative discussion with the patient is possible. 6. A saving of operative time because the implant is perfectly shaped preoperatively 7. Less expense than other types of silicone implants. 8. The making of the implants is easier for inexperienced workers. 9. The disadvantages are that it is more time consuming and is a staged production

내시경을 이용한 관골궁골절 정복술

박대환,이재욱,장경수,송철홍,한동길,안기영 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.1

Although the zygomatic arch can be employed as a key landmark to the accurate alignment of a displaced zygoma fracture, it has been traditionally avoided because of the need for a bicoronal incision. Exposure of the zygomatic arch by means of the conventional bicoronal incision has several possible disadvantages, including an increased risk of blood loss, alopecia, loss of sensation posterior to the incision, and traction palsy of the facial nerve. Endoscopic-assisted exposure of a zygomatic arch can largely obviate the disadvantages of a bicoronal incision and yield this site accessible to reduction and internal fixation in the routine treatment of displaced zygoma fractures. 9 cases of endoscope-assisted open reduction of zygomatic arch fracture and 3 cases of internal fixation of a moderately displaced zygoma fracture are presented. To accomplish this technique, a rigid 4 mm, 30 degree down-angled endoscope, trocar and cannula, endoscopic forehead lift instrument were used. The postoperative courses were satisfactory with few complications. The use of endoscope in the treatment of zygoma reduction provided an expanded field of vision, direct manipulation of lesions, minimal postoperative scar. In particular, exposure and fixation of the zygomatic arch were performed without the need for a bicoronal incision.