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Analysis of the Potent Prognostic Factors in Luminal-Type Breast Cancer
Han-Sung Kim,Inseok Park,Hyunjin Cho,Geumhee Gwak,Keun Ho Yang,배병노,김기환,Sehwan Han,Hong-Joo Kim,김영덕 한국유방암학회 2012 Journal of breast cancer Vol.15 No.4
Purpose: Luminal-type breast cancer has a good prognosis compared to other types, such as human epidermal growth factor receptor 2 and triple negative types. Luminal-type breast cancer is classified into luminal A and B, according to the proliferation index. We investigated the clinicopathological factors that affect the prognosis of the luminal-type subgroups. Methods: We reviewed the medical records and the pathologic reports of 159 luminal-type breast cancer patients who were treated between February 2005 and November 2007. We divided luminal-type breast cancer into luminal A and B, according to Ki-67 (cutoff value, 14%) and analyzed the clinicopathologic factors, such as age at diagnosis, intensity score of estrogen receptor and progesterone receptor, histologic grade, and Bcl-2. Moreover, we compared the disease-free survival (DFS) of each group. Results: In the univariate analysis, age (p=0.004), tumor size (p= 0.010), lymph node metastasis (p=0.001), and Bcl-2 (p=0.002) were statistically significant factors in luminal-type breast cancer. In the multivariate analysis, lymph node (p=0.049) and Bcl-2 (p= 0.034) were significant relevant factors in luminal-type breast cancer. In the subgroup analysis, the increased Bcl-2 (cutoff value, 33%) was related with a longer DFS in the luminal B group (p= 0.004). Conclusion: In our study, luminal A breast cancer showed a longer DFS than luminal B breast cancer, further, Bcl-2 may be a potent prognostic factor in luminal-type breast cancer
Han, Sehwan,Park, Kyeongmee,Shin, Eunah,Kim, Hyun-Jung,Kim, Jung Yeon,Kim, Ji Young,Gwak, Geumhee Spandidos Publications 2010 ONCOLOGY REPORTS Vol.24 No.1
<P>This study was performed to investigate whether the response to neoadjuvant chemotherapy in ductal-type breast cancer could be predicted by different genomic alterations. Array-based comparative genomic hybridization (aCGH) was performed on samples from 15 patients who underwent neoadjuvant chemotherapy with epirubicin plus docetaxel (ED). Frozen tissue bank samples were retrospectively selected from 8 patients who demonstrated complete pathologic response (pCR) and from 7 patients resistant to neoadjuvant chemotherapy. We performed aCGH with 4,277 human bacterial artificial chromosome (BAC) clones, scanning the genome for DNA copy number changes. In a cluster dendrogram of aCGH data, responders showed changes clustered in S940, S984, S44, S98, S130, S115, S478, and 1150T, whereas non-responder group changes clustered in S1029, S209, S219, S660, S133, S323, and S670. Compared to responders, non-responders showed more complicated genomic alterations; the most common gains were located at chromosome 8q (717%), 13q (71%), and 20q (57%), with the smallest regions of genomic gain at 8q24.3, 8q24.22, 8q24.21, 8q22.1, 8q22.2, 8q22.3, 13q21.1, 20q13.2, and 20q13.33. The most frequently deleted regions were observed on chromosome 8p (71%) and 17p (57%), with the smallest regions of deletion at 8p23.3, 8p23.2, 8p23.1, 8p21.3, 8p21.2, and 17p13.3. The results of the current study suggest that aberrations in chromosome 8 may contribute to the resistance to taxane-based neoadjuvant chemotherapy in ductal-type breast cancer. Results of our study indicate that candidate gene identification through aCGH should be validated by specific gene analysis since the sites of chromosomal aberration are quite different among studies.</P>
Interrelation of Cyclin D1, Cyclin E, and p27Kip1 Expression on Tissue Arrays of Breast Cancer
Sehwan Han,Young-Duck Kim,Hong-Yong Kim,Hong-Joo Kim,Kyeongmee Park,Byung-Noe Bae,Suk Yong Ryu,Ki Hwan Kim 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5
Purpose: To evaluate the clinical impact of the alteredexpression of cell cycle regulators in stage I and II breastcancers.Materials and Methods: The interaction between cyclinD1/E and p27Kip1 expressions were analyzed usingtissue microarray (TMA) technology in 133 breast cancers.Data from the immunohistochemical assays of 3molecules were merged, and analyzed, with a Ki67labeling index of the same tumors.Results: Cyclin D1 was expressed in 72 breast carcinomas(54.1%) and cyclin E in 60 (45.1%) out of the 133breast carcinomas. Expressions of cyclin D1 and cyclinE were inversely related to each other, and significantlyassociated with the estrogen receptor (ER) expressionand differentiation of the breast carcinoma. The expressionof cyclin E was significantly decreased in tumorsexpressing cyclin D1 (p=0.022). There was a trend forcyclin D1 expression to increase in tumors expressingp27Kip1 (p=0.053), but the expression of cyclin E didnot correlate with p27Kip1 expression. The Ki67 labelingindex was markedly increased in tumors expressing cyclinE, whereas it was significantly decreased in the cyclin D1or p27Kip1 expressing-tumors. From survival analysis,cyclin E expression was the only significant variable forthe prediction of poor survival.Conclusion: The abnormal expressions of cell cycleregulatory molecules are prevalent, and interrelated witheach other in breast cancer. Integration of TMA technologyallowed a high-throughput analysis for correlating molecularthe in situ findings, with the clinico-pathologicinformation. Among the three molecules studied, thecyclin E had a prognostic implication for stage I and IIbreast cancer. (Cancer Res Treat. 2002;34:388-393)
Transient Analysis of PT-IGBTs at High Temperature
Sehwan Ryu,Hokil Lee,Hyungkeun Ahn,Deuk-Young Han 전력전자학회 2001 ICPE(ISPE)논문집 Vol.2001 No.10
In this paper, excess minority carrier distribution in drift and buffer layers and accumulated charges for PT IGBT have been, for the first time, analytically expressed with different transient times, lifetimes and temperatures Furthermore those parameters are also expressed with temperature to predict the transient response which are critical to the real operation Active base region has been chosen to extract the temperature dependency of the device by including the buffer layer which is important but neglected due to the complexity up to now.<br/>
An Analytical Transient Model for NPT IGBT
SeHwan Ryu,HyungKeun Ahn,Deuk Young Han 전력전자학회 2001 ICPE(ISPE)논문집 Vol.2001 No.10
In this paper, transient characteristics of IGBT has been analytically solved to express the excess minority carrier distribution in active base region and the output voltage. Non-Punch Through(NPT) structure has been selected to prove the validity of the model. It is based on the equivalent circuit of MOSFET which supplies a low gain and a high level injection to the base of BJT None of the quasi static conditions have been assumed to trace the transient characteristics The basic elements of the model have been derived from the ambipolar transport theory.<br/> Theoretical predictions of the output voltages have been obtained with different lifetimes and compared with experimental and theoretical results available in the literature From the analytical approach, good agreement has been obtained to provide reliable and fast output of the device.
Thermal and structural analysis of a cryogenic conduction cooling system for a HTS _MR magnet
Sehwan In,Yong-Ju Hong,Han-Kil Yeom,Junseok Ko,Hyobong Kim,Seong-Je Park 한국초전도.저온공학회 2016 한국초전도저온공학회논문지 Vol.18 No.1
The superconducting NMR magnets have used cryogen such as liquid helium for their cooling. The conduction cooling methodusing cryocoolers, however, makes the cryogenic cooling system for NMR magnets more compact and user-friendly than thecryogen cooling method. This paper describes the thermal and structural analysis of a cryogenic conduction cooling system for a400 MHz HTS NMR magnet, focusing on the magnet assembly. The highly thermo-conductive cooling plates between HTS doublepancake coils are used to transfer the heat generated in coils, namely Joule heating at lap splice joints, to thermal link blocks andfinally the cryocooler. The conduction cooling structure of the HTS magnet assembly preliminarily designed is verified by thermaland structural analysis. The orthotropic thermal properties of the HTS coil, thermal contact resistance and radiation heat load areconsidered in the thermal analysis. The thermal analysis confirms the uniform temperature distribution for the present thermaldesign of the NMR magnet within 0.2 K. The mechanical stress and the displacement by the electromagnetic force and the thermalcontraction are checked to verify structural stability. The structural analysis indicates that the mechanical stress on each componentof the magnet is less than its material yield strength and the displacement is acceptable in comparison with the magnet dimension.