정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

단일기간 재고품목의 생산/분배계획 문제를 위한 Evolutionary Ant Colony Optimization

홍성철,박양병 한국경영과학회 2003 한국경영과학회 학술대회논문집 Vol.- No.2

일정한 시간이 지나면 제품으로서의 가치가 사라지게 되는 단일기간 재고품목들은 생산된 직후 전량 각 고객들에게 주어진 납기에 맞추어 효율적인 분배가 요구된다. 본 연구에서는 고객들은 다수 종류의 제품을 주문할 수 있으며 제품종류별 분리배송을 허용하는 상황에서 생산비, 수송비, 납기위반비, 차량고정비를 최소화하기 위한 생산순서 및 차량경로를 수립함을 목적으로 한다. 이에 대한 해법으로써 진화개미해법을 개발하였다. 개발된 해법의 성능평가를 위해 각 고개의 위치, 주문 제품 종류, 주문량들을 다르게 하여 구축한 실험문제에 대하여 유전알고리듬해법과 비교실험을 수행하였다

大學校 敎職員의 健康實態에 관한 基礎的 調査硏究

양점홍,황철문,남태호,백영호,윤양진,황영성 부산대학교 사범대학 1993 교사교육연구 Vol.26 No.-

The purpose of this study was to analyze the staffs' health of P. University through survey research. Also, the staffs's health problem was analyzed by the regular health test's result and their lifestyle. The results were as following: 1. The analysis of lifestyle (1) A habit of smoking 1. It was presented the male smokers(55.9%) and females smokers(0.6%) of P. university staffs were found in this study. 2. It was presented the male smokers smoked average 18.2 pieces a day. Also, they began to smoke cigarette 21.5 years old. 3. The persistent smokers were 24.6% and 52.2% of smokers be going to quit smoking cigarette someday in the future. (2) A habit of drinking 1. It was presented 85.7% of males and 59.1% of females subject drinking normally. 2. It was presented 3.7% of male subjects were drinking alcohol almost everyday in a week. 3. The most frequent kind of alcohol is as following order a beer(males 67.6% & females 79.6%) and a soju(males 28.3% & females 4.3%). Males drunken average amount of beer was 2 bottles(640ml) and females drunken average amount of beer was 0.8 bottles in a week. (3) A habit of exercise 1. It was presented males (29.0%) and females (15.1%) were exercising regularly, but males (23.3%) and females (38.6%) of staffs were not exercise at all. 2. It was found males' regular kind of exercise was as following order mountain-climbing, tennis, and jogging and females' regular kind of exercise was as order swimming, free handing exercise, and mountain-climbing. 3. It was presented 25.1% of staffs exercised 6 times a week regularly. And each times of exercise, 37.3% of staffs spent less than 30 minutes. 4. It was presented staffs exercised for health (72.4%) and 48.4% of staffs could not exercise as following reasons of not enough times, home work, research.... 5. Male staffs prefer as following order kind of sport tennis, swimming, and golf and female staffs prefer as following order kind of sport swimming, tennis, and bowling in the future. (4) A habit of eating 1. It was presented 5.5% of males and 16.6% of females did not have a breakfast regularly. 2. Concerning balance of food content: do not concerning food (males 34.7% & females 23.8%) and subjects like vegetables 9males 25.7% & females 32.7%) were found. 3. It was presented 8.5% of males and 5.4% of females took the vitamin regularly. (5) Health condition 1. In present evaluation for subject's health condition, very healthy (males 7.5% & females 6.0%) and poor health (males 2.0% & females 1.8%) were found in this study. 2. In present evaluation criterion for subject's health condition, the ability of adaptation on fatigue was appeared the most (males 35.9% & females 40.7%). 3. It was presented subjects have a digestive trouble (males 23.5% & females 33.1%) which were the best health problem in subjects. 2. A analysis of result of regular health test (1) Physique test 1. It was presented height (males 169.5cm & females 158.6cm) and body weight (males 65.9kg & females 53.1kg) were found in this study. 2. According to this study, obesity (males 11.2% & females 5.6%) and low body weight (males 8.8% & females 14.8%) were found in this study. 3. A high blood pressure subject (males 8.7% & females 2.5%) over than a contraction blood pressure 140mmHg and A high blood pressure subject (males 8.5% & females 1.9%) over than a expansion blood pressure 90mmHg were found in this study. (2) A blood test 1. Normal hemoglobin of subject (males 99.8% & females 62.3%) and 37.7% of females less than normal hemoglobin were found in this study. 2. 5.3% of males and 2.5% of females have greater than a concentration of glucose 140mg/dl, but there was anyone less than a concentration of glucose 50mg/dl. 3. The greater than 251mg/dl staff''s T.C.(males 7.1% & females 4.9%) and the less than 130mg/dl staffs' T.C.(males 2.0% & females 3.7%) were found in this study. 4. It was found males 5.3%, 11.6% & females 1.9%, 4.3% were presented greater than GOT and GPT 341U/L. (3) Hepatitis, Urinary Sugar, and Urinary Protein test 1. According to this study result, positive hepatitis was presented males (6.5%) and female(4.3%). 2. Urinary sugar is greater than +- males (1.8%) and females (2.4%) were found in this study. 3. Urinary protein is greater than +- males (1.6%) and females (1.8%) were found in this study. (4) Chest X-ray test 1. It was found male (1.6%) suffered from tuberculosis of the lungs. (5) Dental test 1. It was presented 77.3% of males and 88.9% of females was not existed the upper caries. Also, 75.7% of males and 90.7% of females was not existed the bottom caries. 2. It was presented 96.8% of males and 99.4% of females had the non-deficit of teeth in the upper part of teeth. Also, 93.9% of males and 98.1% of females had the non-deficit of teeth in the bottom part of teeth. 3. It was presented 19% of males and 3.7% of females have the periodontal disease. (6) General report and judgment 1. In general report, it was found 75.3% of males and 91.4% of females were the normal health condition. It was presented 9.1% of males and 4.9% of females were the liver disease, 4.9% of males and 1.2% of females were the sugar diabetes, 4.9% of males and 0.6% of females were the high blood pressure, and 1.4% of males and 1.9% of females were high arrest of bleeding. 2. In general judgment, it was presented 75.5% of males and 91.4% of females were the normal health condition. However, it was presented 17.8% of males and 7.4% of females were required high observation, 6.7% of males and 1.2% of females were required simple observation. As presented P. University staffs' lifestyle, it was found still many staffs have not right living habit. It is necessary to be wellness of lifestyle and satisfaction of life through correction of self responsibility and management in their life. Therefore, it is possible to live with healthy in better quality of life which is high quality of life and new concept of health were offered. Also, researcher expected the regular health examination be more practical contents than informal contents. Researcher recommended that it is necessary to support the university administration to be more flexibility of the regular health examination day than set the certain day of regular health examination and it required to create a way of using the P. university hospital.

심실 중격 결손에 의한 감염성 심내막염 환자의 치과치료

양정현,현홍근,김영재,김정욱,장기택,이상훈,한세현,김종철 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.3

Pyridine 촉매하의 Cyclohexene의 Ozonolysis

홍원표,양현수,장자순,김철규 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.2

Terminally functionalized molecules are essential building block for the formation of polymers by polycondensation reactions. It is the major goal of this research to establish new routes for the preparation of such molecules by selective oxidation reaction of cyclohexene, using ozone as an oxydizing agent. To this purpose, it has been explored, whether the usual course of the ozonolysis of olefins can be modified with the help of specific catalyst in order to introduce the desired functional groups. In particular, the ozonolysis of cyclohexene in hydrocarbon solvents and in the presence of pyridine has been tested with the goal of preparing molecules containing one aldehyde and one carboxylic acid group. Ozonolysis of cyclohexene in hydrocarbon solvents such as methylene chloride and pentane can be guided by catalysis with pyridine, such that the reactions afford desired molecules. In this manner, pyridine catalized ozone oxidation converted cyclohexene into the corresponding 6-oxohexanoic acid(45.87%), adipaldehyde(14.68%), and polymeric ozonide(39.45%), via the ω-formyl carbonyl oxides in CH₂Cl₂at 0℃.

칼슘길항제와 혐수성 산소 라디칼 제거물질이 백서 피부판 생존에 미치는 영향

양정열,임홍철,이명주,서재홍 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Regulation of Ca^++ channels across cell menbranes can be dramatically altered by ischemic states, and such agents relates to cytotoxic effect. The genration of free radicals in ischemic tssue is detrimental to survive of that tissue. If intracellular calcium increasement and free radical production can be blocked or scavenged, tissue damage should be minimized. In the concept of above theory, the author studied the effect of nifedipine. α-tocopherol known as a calcium channel blocker and hydrohobic scavenger on the random pattern skin flap survical of white rats . Sprague-Dawley rats(N-60) were divided into four groups of control(no medication) , nifedipine(10㎎/ ㎏ /day, I.M.), α-tocopherol(20㎎/㎏/day, I.M.). nifedipine plus α-tocopherol. All of medications were given for 11days from 4days before flap elevation and contnued for 7days after flap elevation. When flap survival rates were measured. Flap tissue was obsered by gross, light microscooc and electron microscopic levels. The results were obtained as follows. 1. Groups treated with nifedipine. α-tocopherol. nifedipine +α-tocopherol showed significant increase of the area of flap survival compared with that of the control group.(P<0.001 in nifedipine group and α-tocopherol, and P<0.01 in nifedipine plus α-tocopherol group.) 2. The flap survival was best improved in the α-tocopherol group. (P>0.05). 3. Skin including dermis after 3 days of Nifedipine plus α-tocopherol group disclosed marked proliferation and dilatations of vessels in the deeper part. 4. Electron micrograph of endothelial cells after 3 and 5 days of Nifedipine and α-tocopherol groups disclosed intact basement membrane, swelling of endoplasmic reticulum and mitochondria. Following the above results. It is suggested that calcium channel blocker and α-tocopherol seem to play a important role which incerase survival of the skin flap.

우묵사스레피(Eurya emarginata)의 플라보노이드 화합물의 분리 및 동정

양홍철,박수영,강희경,이남호 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-

The extracts of Eurya emarginata showed inhibitory effect on the growth of HL-60 leukemia cells. So, 80% methanol(MeOH) extract of its leaves was partitioned to hexane, ethyl acetate, n-butanol and residual water fractions. The ethyl acetate fraction, which showed desirable activities, was further purified using SiO2 column chromatography(CC) followed by reverse phase silica gel CC, then another normal CC to give fraction 4-1-8 as a pure compound. The compound 4-1-8 was analyzed by NMR spectrometry using 1H, 13C, DEPT, HMQC and HMBC spectra, and finally proved to be well-known flavono glycoside, Quercitrin.

일간지 생산-배송계획 문제를 위한 혼성유전알고리듬 해법

박양병,홍성철 한국경영과학회 2003 한국경영과학회 학술대회논문집 Vol.- No.1(1)

많은 기업들은 그들의 생산과 배송 기능을 분리하여 각각의 최적화를 꾀하고 있는데, 이러한 접근방법에 의해 이룰 수 있는 절약은 제한적일 수밖에 없다. 최근의 공급사슬경영(SCM)에서는 이들 두 기능의 관련 비용을 총체적 관점에서 잘 조절하면서 동시에 통합 분석하는 것이 더 중요하다고 인식되고 있다. 본 논문에서는 일간지의 생산-배송계획 문제를 다룬다. 일간지는 재고로 유지될 수 없으며, 고객이 정한 시간보다 늦게 배송되면 큰 손실을 야기하는 일종의 단일기간 재고품목이다. 저자들은 일간지 생산-배송의 통합계획을 위한 혼성유전알고리듬 해법을 개발하고 예제를 이용하여 Hurter and Buer의 순차적 분리계획 해법과 성능을 비교한다. 계산실험 결과, 개발된 해법의 성능은 효과적인 것으로 나타난다.

Paraquat 투여 백서에서 Cyclophosphamide와 Dexamethasone의 치료 효과

신정철,신양수,유병전,임현성,정태흥,박찬국,오금탁,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

Paraquat (N,N'-dimethy 1-4,4'bipyrydinium : Gramoxone^(R), a widely used herbicide, is extremely toxic to all green plants and many eukaryotic organisms. In human, paraquat intoxication leads to multiple organ failure, it preferentially damages the lung, kidney and liver and may result in death. The participation of superoxide in initiating tissue damage by administration of paraquat is well known in which one electron reduction of paraquat leads to the formation of radical species which react with molecular oxygen to give superoxide. This process initiates immunological changes with the activation of neutrophilic leukocytes, which is related to further production of superoxide. In this experiment, therapeutic effects of cyclophosphamide and dexamethasone on blood cell count, malondialdehyde as a indicator of lipid peroxidation, and antioxidant enzymes levels in the lung, liver and kidney of paraquat intoxicated rats were inbestigated. The WBC count were significantly decreased by combined treatment of cyclophosphamide and dexamethasone in paraquat intoxicated rats at 3 and 5 days but RBC count were not changed. The contents of malondialdehyde were significantly decreased in the lung and Kidney by combined treatment at 10 days after paraquat intoxication. The catalase acitvities were markedly increased in the lung and liver of rats at 10 days after paraquat intoxication, and superoxide dismutase activities showed minimal changes in the lung, liver and kidney of rats by combined treatment. These results suggest that paraquat induced tissue damage in rats can be redeced by combined administration of cyclophosphamide and dexamethasone.

녹농균의 연부조직 감염에 대한 녹농균 다가백신 효과에 관한 실험적 연구

임홍철,양문호 慶熙大學校 醫科大學 1987 慶熙 醫大 論文集 Vol.12 No.1