정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

CT 유도하의 경피적 폐생검 : 임상적 의의 및 합병증에 관한 연구 A Study of Clinical Significance and Complication

박재성,백상현,차장규,홍현숙,김대호,박성진,조준희,임한혁,이혜경 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose : To determine the diagnostic accuracy and predicting factor of pneumothorax on CT-guided percutaneous transthoracic needle biopsy. Materials and Methods : Using automated biopsy devices, 107 CT-guided percutaneous needle biopsies of pulmonary lesions were performed. Final diagnosis was made with operation or other methods. We retrospectively analyzed the frequency of complications and diagnostic yields of 107 biopsies. The clinical features, treatment, and courses of complications were reviewed, and risk factors of pneumothorax such as depth and size of lesion, CT emphysema score of whole lung and pathway of needle, and the result of pulmonary function test were analyzed. Result : 96 biopsies(89.7%) yielded sufficient tissue for pathologic evaluation. For cases of malignant and benign disease, sensitivity was 91.5% and 87.5% respectively; the corresponding figures for diagnostic accuracy were 88.1% and 77.1%. So, sensitivity and diagnostic accuracy of percutaneous transthoracic needle biopsy was 89.7% and 83.2%. Eighteen(16.8%) of 107 patients developed pneumothorax and 3 of these required application of chest tube or percutaneous catheter drainage. In the group with pneumonthorax, the lesion was significantly smaller(p=0.029) and higher CT emphysema score of pathway of needle(p=0.032). But there were no significant difference between two groups(with or without pneumothorax) for depth of lesion, pulmonary function test(% predictive value of FEV1 and FEV1/FVC) and CT emphysema score of whole lung. Conclusion : CT-guided transthoracic needle biopsy of the pulmonary lesions is safe and easy method of obtaining specimens of good quality and quantity. It may be an useful procedure in the diagnosis of localized pulmonary lesions. For the prediction of pneumothorax, size of lesion and CT emphysema score of pathway of a needle are significant risk factors.

사과의 溫水處理와 그 果汁抽出에 關한 硏究

朴埈熙 慶北專門大學 (영주경상전문대학) 1979 慶北專門大學 論文集 Vol.2 No.-

사과를 75°C의 溫水中에 약 1시간 浸漬하고 8조각으로 잘라서 서서히 압착하면 당 등의 저분자 성분을 물과 함께 細胞膜璧을 通過해서 배출되어 지고 醒素및 蛋白質 등의 고분자 성분은 그데로 남는다. 따라서 이 방법 으로 얻어진 사과果汁은 最初부터 透明度가 높고 또 방치 하여도 褐變化 되지 않았으며 더욱이 향기가 특히 좋았다. When a whole apple was steeped in hot water at 75˚C for one hour, it was capable to discharge effectively the transparent juice under a moderate pressure and also the juice was prevented from browning reactions. The facts seemed to come from such reasons as those found in sweet potato, previously reported; that is, some parts of bound water in the cells were librated and also the membrane systems were altered in their permeability. Accordingly, by squeezing, low molecular components were excluded with water passing through the membrane systems, but high molecular ones such as enzymes related to browning reaction were apt to remain in the pressed cakes.

5세 남아의 Influenza 종격동기종 및 대엽성 폐렴 1례

오희성,한유진,연은경,선동신,송준환,박경배,박준수,김영통,남해선,최영진,김용배 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3S

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바이러스 프로그램에 대한 백신의 치료기법에 관한 연구

박준호,채선희 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(C)

인터넷의 급속한 확산과 네트워크 상에 접속된 대량의 컴퓨터 프로그램개발 보급이 확대되면서 바이러스의 감염이 빈번하고 그 대응책인 백신에 대한 필요성이 절실하다. 본 논문에서는 여러 가지 바이러스 영역에서 메모리 상주 바이러스 종류와 특징, 동작방식 및 증상을 분석하였고 백신 프로그램이 바이러스를 치료하는 기법을 고찰하였다.

한국무용 참가동기와 생활만족의 구조방정식 모형 분석

박준희,정혜선 朝鮮大學校 스포츠科學硏究所 2005 스포츠科學硏究 Vol.16 No.-

This study was to analyze the life satisfaction by korean dance participation's motivation. Specifically. this study was to test relationship among, participation motivation, active satisfaction and life satisfaction. The subjects(N=191) were selected in highschool and university located at Kwangju province by convenience random sampling. This study organized a self-administration reporting questionaire which was named<The survey on the life satisfaction by korean dance participation's motivation>. The result of reliability about questionaire was Chronbach' a=.758-902. The reliability analysis and SEM were used as statistic analysis techniques. On the basis of the results, the conclusions were drawn as follows; First. There was a signfticant influence between outer participating motivation and active satisfaction. Second, There was a significant influence between active satisfaction and life satisfaction. Third, the model which was generally coincided on X^(2) = 145.701 (P=.000), RMSEA = .073, TLI = .939, NFI = .910, CFI = .952, explained adequate relationship among korean dance participation's motivation, active satisfaction and life satisfaction.

대학의 교수학습 개발에 대한 요구분석 연구 : 동국대학교 교수집단을 중심으로 focusing on Faculties of the Dongguk University

박명희,김성훈,박명숙,이중권,박종호,이성림 동국대학교 교육연구원 2005 교육문제연구 Vol.16 No.-

본 연구의 목적은 동국대학교의 교수들이 수행하고 있는 교수학습 방식을 파악하고 각 방법들의 효과성을 교수들이 어떻게 인식하고 있는지를 알아 보고자 하였으며 창의적 교수학습방법개발에 대한 교수들의 요구를 파악하여 교수학습개발센터의 프로그램개발을 위한 기초자료로 삼고자 하였다. 수업방식에 있어서 전공, 교양을 막론하고 대부분이 강의식 수업방식이 높았으며(80.9%, 86%), 발표식, 토론식이 (14%, 18.6%) 실험실습 등이 그 다음으로 나타났다. 교수들은 전공과목보다는 교양수업에서 학생들의 요구에 맞는 수업 수업방식을 고려하고 있는 반면 수업방식의 효과에 대해 53%만이 효과적이라고 보고하고 있다. 교수들도 효과적인 강의방법 등 교수법에 대해 체계적으로 학습할 필요성을 느끼고 있었다. 강의 기술(교수방법)과 토론 중심 수업 방법에 대한 워크샵에 대한 요구가 가장 높게 나타났고 발표수업과 프로젝트수업 방법 등 강의식 수업 이외의 다른 수업방식에 대한 워크샵 요구도가 높았다. 그 외에 학교의 지원에 대해서는 첨단 수업 기자재 활용을 위한 보조자(조교)에 대한 요구도가 가장 높고 강의 운영을 위한 보조금, 개인별 상담 지원 순으로 요구도가 높게 나타났다. The purpose of this study was to comprehend the methods of teaching and learning carried out by the teachers of Dongguk University, and to find out how the professors found those methods effective. This research was also used to serve as a basis for the development of a more creative teaching-learning system to enhance better programs for the Professor Teaching-Learning Development Center. In teaching methods, regardless of classes for majors or for cultural enrichment, most of the courses were in the form of lectures (80.9%, 86%) followed by research and discussion (14%, 18.6%), with experiment and practical training coming in third. Although professors tend to choose a more student-oriented class method in distribution courses more than in major courses, it was reported that only 53% of the faculty claimed this class method to be effective. The faculty felt the need for professors to have more constructive learning in incorporating more effective teaching methods. The demand for professor workshops on teaching skills (teaching methods) and discussion oriented classes proved to be high, as well as the need for workshops on teaching methods other than lectures, such as research courses and project oriented class methods. Regarding other demands for university support, the demand for an assistant (assistant teacher) to help with the new technology equipment was the highest, followed by subsidies for course management and support in individual counseling.

韓國과 日本에 있어서의 學校外敎育에 關한 比較敎育人類學的 考察

朴俊熙 이화여자대학교 한국문화연구원 1982 韓國文化硏究院 論叢 Vol.40 No.-

Out-of-school education(Kwaaekongbu) has, for many years, provoked serious and concentrative efforts among teachers, educational administrators, parents, and community leaders. as one of the serious social problems of Korea and Japan, However, past efforts have been hampered by lack of "attractive devices;" hence, it has been studied from the standpoint of "normal educational development." It is, therefore, an area of study that should be deeply examined from the standpoint of comparative and educational anthropology from which "devices" can be proposed. Actually, there are many similar phenomena concerning out-of-school educational activities in Korea and Japan. The similarities in terms of national character and the attitudes toward the western influence between Korea and Japan are the reason why such phenomena would be occurred in relation to their out-of-school educational activities. As we understand, there are no so serious social problem surrounding out-of-school educational activities, in the developed countries, especially regarding entrance to uppergrade school. It is point that there lies a significant difference of the comparative educational activities between the "developed countries" and Japan and Korea. This is the reason why deeper investigation must be made to understand more fully, the anthropological and comparative factors of "out-of school" education. The results from this study took into account the deeply rooted cultural traditions, ways of thinking, and the national character which is based upon the confuscioustic patterns of life. However, there numerous "devices" from the standpoint of short term plans but few "devices" from a long term point of view. In Korea there have been a number of discussions and studies addressing this problem from the standpoint of the national policy of education. However, these discussions were genualy short term, phenomenological, and were not from a cultural, historical and anthropological point of view. Comparatively, Korea has addressed this problem in greater detail than in Japan. Moreover, Korea has taken positive steps toward rectifying the problem; however, Japan still lacks a genual policy. Moveover, both activities have experienced great difficulties to solve this problem because fundamental considerations were not introduced. However, it can be expected that the problem can be solved from the standpoint of educational anthropology. In otherwords, it is not an administrative and political problem but a greater problem of eduoational anthropology.

조기위암의 임상적 연구

박태준,양은수,류종철,박태군,이희승,신원창,이진호,김관엽 인제대학교 1994 仁濟醫學 Vol.15 No.1

1989년 9월부터 1993년 7월까지 인제대학교 의과대학 상계백병원에서 실시한 위내시경 소견이 조기위암이며 내시경 직시하 생검결과 선암으로 판명되어, 근치적 위절제술을 시행받은 23명의 환자에서 임상적 특징을 알아보고, 문헌고찰과 함께 보고하는 바이다. The incidence and mortality rate of stomach cancer ranks well ahead of all malignancies in Korea. The prognosis is excellent in early gastric cancer of which the overall 5 years survival rate of 85∼95% is comparative with that of advanced gastric cancer of 15∼49%. So early detection with very sensitive mordality of gastroscope and surgery is the only premise to decrease the mortality rate of gastric cancer. This report deals with the clinical aspects of 23 cases of early gastric cancer, which were confirmed with histopathologic examination of resected stomach during the 4 years from September 1989 to July 1993 at Sanggye Paik hospital, Seoul, Korea. Out of 23 cases of early gastric cancer, 14 cases were male, 9 cases were female, and the male to female ratio was 1.6 : 1. The most common type of early gastric cancer was talc type(43.5%), IIc and its combined type comprised most of them(87.0%). The most prevalent sloe of lesion was gastric angle(43.5%) and the most common direction was lesser curvature(73.9%) 19 cases of 23(78.3%) were between 1∼3cm in size, and there was no statistical significance between the size of the lesion and lymph node metastasis. Of the 9 cases with mucosal lesion, there were 2 cases with lymph node metastasis(22.2%), but 7cases(50.0% ) of 14 cases with submucosal lesion presented lymph node metastasis. Diagnostic accuracy of endoscopy on detection of early gastric cancer was 17 cases(73.9%) of total 23 cases in our study. As with other report, histopathulogic examination of resected stomach revealed adenocarcinoma, tubular type as the most common type. Frequent complaint of patients with early gastric cancer was epigastric pain(65.2%), and duration of the symptom was less than 12 months in 17 cases(73.1%) of 23 patients with early gastric cancer.

아동 무용활동이 생활성취도에 미치는 영향

박준희 韓國舞踊敎育學會 1998 韓國舞踊敎育學會誌 Vol.9 No.1

The aim of this study is to find influence of children's participation in dance on their life achievement including character property and life in school. The study is of three groups, experimental group 60, control group 60 and observer group(60 parents of the students) and they responded to my questionnaire on 2 parts including 7 scales. The results of the study are as follows. 1. The experimental group. 1) Their increased mean scores for character property are as follows : stability 2.16, positiveness 1.74, sociality 2.51, responsibiltity 1.24, and self-confidence 2.68. This results show that children's participation in sports have positive effects, especially for self confidence sociality, stability and positiveness. 2) Their increased mean scores for life in school are as follows : adaptation to life in school, 1.60, satisfaction with study in school, 0.49. This results show that children's participation in dance have positive effects to adaptation to life in school, but their is little effect in satisfaction with study in school. 2. The observer group. Their increased mean scores are as follows" Character property part(stability 2.52, positiveness, 1.96, sociality, 1.98, responsibility, 0.92, and self-confidence, 1.75.) Life in school part(adaptation to life in school 1.51, satisfaction with study in school 1.09). The result show that children's participation in dance have good effect to character property and life in school.