연 폭로시 성별에 따른 혈중 Zinc Protoporphyrin의 양-반응 관계

김용배,리갑수,황규윤,이성수,안규동,이병국,안현철,Kim, Yong-Bae,Lee, Gap-Soo,Hwang, Kyu-Yoon,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook,Ahn, Hyun-Cheol 대한예방의학회 1999 Journal of Preventive Medicine and Public Health Vol.32 No.4

Objectives : To evaluate whether a relation between blood lead and zinc proto porphyrin(ZPP) was modified by gender in Korean lead workers. Methods : A cross-sectional study was conducted with 1,304 male and 101 female subjects in 1997. The relation between blood lead and ZPP were evaluated with linear, exponential, and quadratic models. Then, the different effect of gender on the relation was examined by adding the interaction terms in the each model. Results : $Mean{\pm}SD$ of blood lead and ZPP level was different between male$(27.7{\pm}10{\mu}g/dl\;and\;51.3{\pm}23.4{\mu}g/dl)$ and female subjects$(22.5{\pm}9.2{\mu}g/dl\;and\;78.7{\pm}38.6{\mu}g/dl)$. After adjusting for possible confounders, the effect modification by gender was significant in linear$(\beta=1.119,\;p<0.001)$, exponential$(\beta=Exp(0.008),\;p<0.05)$, and quadratic model$(\beta=1.388,\;p<0.001)$. In separate analysis, a quadratic relation between blood lead and ZPP was shown in male lead workers$(\beta=0.036,\;p<0.001)$, but an exponential relation in female lead workers$(\beta=Exp(0.029), p<0.001)$. Conclusion : Our data showed that the increasing rate of ZPP in female were always higher than in male lead workers, suggesting that females were more susceptible to occupational lead exposure than males.

Crouzon씨 병에서 두개골 연장술을 이용한 두개골 조기유합증의 교정

김용배,박은수,정성균 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Crouzon's disease has three characteristics that are craniosynostosis, enophthalmos, and midfacial hypoplasia. Among these characteristics, craniosynostosis causes restriction of cranial and brain growth and variable morphologic deformities. An inadequate intracranial volume causes increased intracranial pressure(IICP) and functional impairment. Classic surgical decompression is frontal advancement with vault remodeling, but it may have drawbacks such as invasiveness, long operation time, difficulty of postoperative care, frequent complication and large amount of hemorrhage. We compared cranial distraction osteogenesis with classic surgical method in terms of their merits and drawbacks and reached to conclude that the cranial distraction osteogenesis is more effective than the classical surgical methods in Cronzon's disease. We treated a 12-month-old female with frog-like face, who had no IICP using cranial distraction osteogenesis, and gained a satisfactory result. In conclusion, the application of distraction osteogenesis in correcting bicoronal & sagittal craniosynostosis is very effective.

間按正犯에 關한 小考

金容培 청주대학교 법학연구소 1967 法學論考 Vol.7 No.-

효율적인 블록 FIR 디지털 필터의 구현 ( Efficient Block FIR Digital Filter Implementations )

김용배,김택성,김상민,정진균 대한전자공학회 1997 대한전자공학회 학술대회 Vol.1997 No.01

고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.

문진 방법에 따른 연관련 자각증상과 연노출 지표들과의 관련성

김용배,이병국 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Objectives: this study was carried out to investigate the relationship between lead related symptoms and lead exposure indices by self-administrered questionnaire and direct review questionnaire in lead workers. Method: The study design was cross-sectional and research subjects were 172 workers in storage battery industries as lead exposed group and 84 workers who were not exposed to lead as control group. Lead related symptoms(15 items) were obtained by self-administered questionnaire. After then investigator asked workers about each items and completed drect interview questionnaire. Blood lead(PbB), zinc protoporphyrin(ZPP), δ-aminolevulinic acid in urine(ALAU), hemoglobin(Hb) were selected as indicators of lead exposure. Results: There was significant correlation between lead related symptoms and lead exposure index(blood ZPP) in direct review questionnaire, whereas there was no significant correlation in self-administered questionnaire. Conclusions: Our results supported current self-administered questionnair should be reassessed sensitivity and specificity. Also, if necessary, direct review questionnaire was highly recommended for the effective health management of lead workers.

소화효소제의 제조에 관한 연구(제4보)

김용배,이병국,신현종,김완회 한국약제학회 1978 Journal of Pharmaceutical Investigation Vol.8 No.4

Since the active center of digestive enzymetic preparations, while under storage, lose their activity and potency by the exposure to moisture, colorization, solidifying and other physical changes. It is more important than beautiful package form that protected packaging form moisture to get a pharmaceutical safety preparations and to maintain a definite potency. Then, in order to get a desirable conditions of storage and packaging, we used shellac and AEA^ⓡ as a coating base, and blister package, foil and bottle container as a packaging material. Temperature were set on room temperature and 37℃, moisture was adjusted to 40% RH and 80% RH as a accelerated conditions. Accelerated test was carried out 6 times. The results are as follows: 1) The effect of packaging conditions give great influence on the maintenace of the stable potency. 2) Best result was produced with bottle container package. 3) AEA^ⓡ is more useful than shellac as a coating base of prevention from moisture. 4) Absorption of moisture gave considerable effects on potency and it has a limited point. 5) Difference in potency between optimal and worst condition is 472 u/2T, and difference in effective period is about 44 months.

절제 불가능한 췌장암의 동시항암화학방사선요법

김용배,성진실,송시영,박승우,서창옥,Kim, Yong-Bae,Seong, Jin-Sil,Song, Si-Young,Park, Seung-Woo,Suh, Chang-Ok 대한방사선종양학회 2002 Radiation Oncology Journal Vol.20 No.4

목적 : 절제 불가능한 췌장암은 예후가 불량하여 효과적인 치료법의 개발이 요망되고 있다. 본 연구에서는 Gemcitabine 또는 Paclitaxel과 5-Fluorouracil (5-FU)을 이용한 동시항암화학방사선요법을 시행하여 치료효과를 분석하고자 하였다. 대상 및 방법: 임상적으로 혹은 개복수술 소견 상 절제 불가능한 췌장암으로 진단받은 환자를 대상으로 Gemcitabine 또는 Paclitaxel과 5-FU을 이용한 동시항암화학방사선요법을 시행하였다. 방사선 치료는 원발병소와 주위 림프절을 포함하여 5주 동안 45 Gy를 조사하였다. 이 기간동안 Gemcitabine $1,000\;mg/m^2$ 또는 Paclitaxel $50\;mg/m^2$의 매주 1회 주사 및 5-FU의 매일 경구 투여를 시행하였다. 추적관찰기간은 6개월에서 36개월이었으며, 생존율은 Kaplan-Meier법을 이용하여 분석하였다. 결과 : 1999년 1월부터 2001년 11월까지 본 치료법이 시행된 경우는 54예였으며, 이중 계획된 치료를 종료한 42예를 분석하였다. 남녀 비는 30 : 12였고 중앙 연령은 60세였다. 총 54예 중 치료 중 원격전이나 암종증(carcinomatosis) 등으로의 진행 6명$(50\%)$, 시작시 불량한 전신수행 상태 4명$(33.3\%)$, 병변과 무관한 병발질환 1명$(8.3\%)$, 치료 거부 1명$(8.3\%)$ 등으로 총 12예에서 치료가 중단되었다. 42명의 환자 중 40예에서 반응 평가가 가능하였으며 완전 관해 1예, 부분 관해 24예로 관해율은 $59\%$로 나타났다. 중앙 생존값은 12개월, 1년 생존율은 $46.7\%$, 2년 생존율은 $17.0\%$였다. Grade III 이상의 치료독성으로는 혈액학적 독성이 8예$(19\%)$, 오심, 구토 등의 비혈액학적 독성이 9예$(20\%)$이었다. 이중 2명은 치료독성에 의한 상부 소화기 출혈로 사망하였다. 결론 : 절제 불가능한 췌장암에서 Gemcitabine 또는 Paclitaxel를 이용한 동시항암화학방사선요법은 관해율과 생존율에 있어서 효과적인 치료로 생각된다. 그러나 독성감소를 위한 연구가 또한 병행되어야 할 것으로 생각된다. Purpose : To analyze the treatment results of concurrent chemoradiation with oral 5-FU plus Gemcitabine or Paclitaxel for unresectable pancreatic cancer. Materials & Methods : The patients, who were diagnosed by imaging modalities or by explo-laparotomy, were treated with concurrent chemoradiation. Radiotherapy was delivered to primary tumor and regional lymph nodes, and the total dose was 45 Gy. Patients received Gemcitabine $1,000\;mg/m^2$ or Paclitaxel $50\;mg/m^2$ weekly and oral 5-FU daily The total number of cycles of chemotherapy ranged from 1 to 39 (median, 11 cycles). The follow-up period ranged from 6 to 36 months, Survival was analyzed using the Kaplan-Meier method. Results : Fifty-four patients between Jan. 1999 to Nov. 2001 were included in this study. Forty-two patients who completed the planned treatment were included in this analysis. The patients' age ranged from 37 to 73 years (median, 50 years) and the male to female ratio was 30:12. Treatment was interrupted for 12 patients due to: disease progression for 6 $(50\%)$, poor performance status for 4 $(33.3\%)$, intercurrent disease for 1 $(8.3\%)$, and refusal for 1 $(8.3\%)$. Response evaluation was possible for 40 patients. One patient gained complete remission and 24 patients gained partial remission, hence the response rate was $59\%$. The survival rates were $46.7\%\;and\;17.0\%$ at 1 year and 2 years, respectively with a median survival time of 12 months. Patients treated with Paclitaxel showed superior outcomes compared to those patients treated with Gemcitabine, in terms of both response rate and survival rate although this difference was not statistically significant. Grade III or IV hematologic toxicity was shown in 8 patients $(19\%)$, while grade III or IV non-hematologic toxicity was shown in 5 patients $(12\%)$. Conclusion : Concurrent chemoradiation with oral 5-FU and Gemcitabine or Paclitaxel improves both the response rate and survival rate in patients with unresectable pancreatic cancer. A prospective study should be investigated in order to improve both the patient selection and the treatment outcome as well as to reduce the toxicity.

소화효소제(消化酵素劑)의 제조(製造)에 관(關)한 연구(硏究) 제4보(第4報)

김용배,김완회,이병국,신현종,Kim, Yong-Bae,Kim, Whan-Hoe,Yi, Pyong-Kuk,Shin, Hyun-Jong 한국약제학회 1978 Journal of Pharmaceutical Investigation Vol.8 No.4

Since the active center of digestive enzymetic preparations, while under storage, lose their activity and potency by the exposure to moisture, colorization, solidifying and other physical changes. It is more important than beautiful package form that protected packaging form from moisture to get a pharmaceutical safety preparations and to maintain a definite potency. Then, in order to get a desirable conditions of storage and packaging, we used shellac and $AEA^{\circledR}$ as a coating base, and blister package, foil and bottle container as a packaging material. Temperature were set on room temperature and $37^{\circ}C$, moisture was adjusted to 40% RH and 80 % RH as a accelerated conditions. Accelerated test was carried out 6 times. The results are as follows: 1) The effect of packaging conditions give great influence on the maintenace of the stable potency. 2) Best result was produced with bottle container package. 3) $AEA^{\circledR}$ is more useful than shellac as a coating base of prevention from moisture. 4) Absorption of moisture gave considerable effects on potency and it has a limited point. 5) Difference in potency between optimal and worst condition is 472 u/2T, and difference in effective period is about 44 months.

액정재료와 액정디스플레이에 응용기술

김용배 한국공업화학회 2003 공업화학 Vol.14 No.4

다양한 액정화합물을 이용하여 컴퓨터 모니터, 사무자동화기기, 전화통신기기 및 군사용장비 등의 여러 가지 액정디스플레이 제품들이 개발되고있다. 아직까지는 정보를 표시하는 응답속도에 문제점이 있지만, 지난 10년간에 괄목할만한 성장을 계속하여 왔으며, 가까운 장래에 여러 가지 기술적 문제들이 해결될 것이다. 이 논문에서 액정디스플레이 제품에 이용되는 액정재료 기술들을 포괄적으로 설명하려고 한다. The various liquid crystal materials have allowed the development of a wide variety of LCD products in the computer monitor, office automation telecommunication and military devices. Although the newer LCDs showed sometimes limited response speed at which data can be displayed this area has enjoyed dramatic growth only during the past 10 years. Therefore many of the technical problems will be solved within the next few years. The aim of this work is to resent a comprehensive review of the technical aspects of the liquid crystal material technologies that will be used in the various LCD products.