정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조각자나무의 部位 및 採取時期別 SAPONIN 含量 差異에 關한 硏究

朴涌基,康秉秀 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

On the whole, it has been known that the common effect by the part of the Gleditschia is the discharge of phlegm, the push of pus and the removal of tumor, the main component of which is the Gleditschia-saponin. It has been reported that the component consisted in the Lehume and the Semin and did not exist in the Thorn. This study was designed in the fact that the component will be contained in the Thorn which has been often used for the treatment of the push of pus and the removal of tumor, and in the fact that we could expect the good remedical value in the clinical treatment by comparing the content by its collection times, as the difference of the main component content by its collection times would differ in the remidical value. Comparative study was made through analyzing Gleditshcia-saponin content by the MeOH extract and by the water extract according to various part and collection times of Gleditschia. The result s were as follows: 1. As the result of the saponin confirmation reaction. both of the constant saopninfiable reaction and the Libermann-Burchard reaction proved positive. 2. The result confirmed of the Thin layer chromatograms showed that the sorts of the Gleditschia-saponin was eight and the Rf value of the Gleditschia-saponin by its part was the same. 3. As the result of measuring the Gleditschia-saponin content by MeOH extract, the Legume was highest by its part and the things gathered in December were highest by the collection times. 4. The result by the water extract showed that the Lehume was highest according to its part and the things gathered in December were highest by the collection times. 5. The content by the MeOH extract was higher than that by the water extract. From the above results. The Gleditschia-saponin was contained not only in the Legume and the Semen but also in the Thorn. The content of Gleditschia-saponin was highest in December by the collection times.

직업적 연폭로가 일부 신경행동학적 검사수행에 미치는 영향

안익수,안현철,김용배,리갑수,김화성,황규윤,최은,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to investigate that blood lead levels of lead exposed workers is associated with decreased performance in neurobehavioral tests in adults, we investigate 78 workers in a battery industry. Three items among neurobehavioral core test battery of World Health Organization, including digit span, Santa ana dexterity, digit symbol were administered to workers occupationally lead exposed workers by operational guide for the WHO neurobehavioral core test battery. Blood lead (PbB) and zinc protoporphyrin in whole blood (ZZP) were selected as an index of lead exposure. Detailed occupational history such as exposed agent, age, work duration, smoking and drinking habits, were recorded as confounding factors. After controlling age, the results of digit span and digit symbol among the neurobehavioral tests were significant contributed by PbB.

覆盆子類가 白鼠의 排卵과 卵巢에 미치는 影響

金捧秀,朴涌基,康秉秀 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1

Rubi Fructus is a well known remedy for female infertility, especially due to lack of kidney-yang or shenyangxu(???). An attempt was made to evaluate the influences of Rubi Fructus (mature Rubus crataegifolius BUNGE, mature Rubus coreanus MIQ and immature Rubus coreanum MIQ) on the morphological changes of the ovary. The experiment was performed to investigate the effects of the seeds of mature Rubus cratagifolius BUNGE (W1), the seeds of mature Rubus coreanus MIQ (W2) and the seeds of immature Rubus coreanus MIQ (W3) on the formation of follicles in rat ovary. The results are as follows: 1. Results using three herbs of mature seed of Rubus cratagifolius BUNGE (W1), mature seed of Rubus coreanus MIQ (W2)and immature seed of Rubus coreanus MIQ (W3) clearly showed the stimulating effects on the increasing number of follicles in rat ovary. Of them, W1 increased the follicle formation by 171% compared to normal control after 4 days of treatment. In cases of W2 and W3, the formed numbers of the follicle were increased to 228% and 285%, respectively. On the other hand, the follicle formations of W1, W2, and W3 were most effective, showing 208, 258 and 266%, respectively, after 8 days of treatment. These results showed that effect of immature Rubus coreanus MIQ was similar to that of the mature Rubus coreanus MIQ without any differences. 2. The size of the follicle stimulated by W2 was about 1.0 mm, although the size of the normal control was 0.3 mm. However, those of W1 and W2 were about 0.5 mm, indicating that the treatments of the herbal extracts are also effective for the follicle size. Therefore, it was concluded that all these herbs showed the effects on average of follicles in ovary. Especially, mature Rubus coreanus MIQ showed the highest effect among them. 3. Fractions of W1-B, W2-B and W3-B, when each extract were separated by analytical HPLC(high performance liquid chromatography), showed the activities of follicle number and size of follicles in ovary. These results suggest that the effect of Rubi Fructus is related to treatment of female infertility due to ovulation difficuty. Of them, mature Rubus coreanus MIQ is the most potent effector on the ovulation in Rats.

마우스 단핵 탐식 세포에서 Nitric oxide 생성의 조절 기전에 관한 연구

최병기,김수응 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.3

ADP-ribosylation may be involved in the process of macrophage activation. Nitric oxide (NO) has emerged as an important intracellular and intercellular regulatory molecule with function as diverse as vasodilation, neural communication or host defense. NO is derived from the oxidation of the terminal guanidino nitrogen atom of L-arginine by the NADPH-dependent enzyme, nitric oxide synthase (NOS) which is one of the three different isomers in mammalian tissues. Since NO can exert protective or regulatory functions in the cell at a low concentration while toxic effects at higher concentrations, its role may be tightly regulated in the cell. Therefore, this paper was focused on signal transduction pathway of NO synthesis, role of endogenous TGF-β in NO production, effect of NO on superoxide formation. Costimulation of murine peritoneal macrophageswith interferon-gamma (IFN-γ) and phorbol 12-myristate 13-acetate (PMA) increased both NO secretion and mRNA expression of inducible nitric oxide synthase (iNOS) when PMA abolished costimulation. Pretreatmnet of the cells with PMA abolished costimuation effects due to the depletion of protein kinase C (PKC) activities. The involvement of PKC in NO secretion could be further confirmed by PKC inhibitor, staurosporine, and phorbol ester derivative, phorbol 12,13-didecanoate. Addition of actinomycine D in IFN-γ plus PMA stimulated cells inhibited both NO secretion and mRNA expression of iNOS indication that PMA stabilizes mRNA of iNOS. Exogenous TGF-β reduced NO secretion in IFN-γ stimulated murine macrophages. However addition of antisense oligodeoxynucleotide (ODN) to TGF-β to this system recovered the ability of NO production and inhibited mRNA expression of TGF-β. ACAS interactive laser cytometry analysis showed that transportation of FITC-abeled antisense ODN complementary to TGF-β mRNA could be observed within 5 min and reached maximal intensity in 30 min in the murine macrophage cells. NO released by activated macrophages inhibits superoxide formation in the same cells. This inhibition may be related on NO-induced auto-adenosine diphosphate (ADP)-ribosylation. In addition, ADP-ribosylation may be involved in the process of macrophage activation.

Tulipa gesneriana의 組織培養에 關한 硏究 : Ⅰ. Callus 誘起에 미치는 2,4-D와 Kinetin의 效果 Ⅰ. Effects of 2,4-D and Kinetin on the callus induction

李炳基,朴鶴封,宋鎭水 全北大學校 1984 論文集 Vol.26 No.-

Effects of 2,4-dichlorophenoxyacetic acid(2,4-D) and kinetin on the induction and growth of calluses of Tulipa gesneriana cv. Golden Apeldoorn were investigated in vitro. Style tissues were cultured on Murashige and Skoog's media containing various levels of 2, 4-D and kinein. The calluses were induced vigorously from the medium supplemented with 1-2mg/ι 2,4-d and 0.5-lmg/ι kinetin, Espcially, the friable calluses like protuberance were formed from the medium containing 2mg/ι 2,4-D and 1mg/ι kinetin. The poor calluses were initiated from the medium supplemented with 1mg/ι 2,4-D or 1mg/ι kinetin only.

14세 여환에서 쇄골에 발생한 동맥류성 골 낭종 : 증례보고

김동수,김용민,최의성,손현철,박경진,조병기,홍경호 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1

동맥류성 골낭종(aneurysmal bone cyst)은 Jaffe와 Lichtenstein(1942)에 의해 처음 기술된 이래 많은 증례가 보고되었다. 동맥류성 골낭종은 주로 장관 골의 골간단과 척추에서 발생한다. 병인은 정확히 밝혀지지 않았으나, 반응성 현상으로 생각되며, 원발성 또는 다른 병변과 동반될 수 있다. 쇄골 등 기타 골에서 발생하는 경우는 매우 드물다. 저자들은 우측 쇄골에서 동맥류성 골낭종 1예를 경험하여 보고하는 바이다. 14세 여자환자가 우측 견갑부의 우연히 발견된 종괴를 주소로 내원하였다. 환자는 종괴에 대해 이학적 검사 및 혈액 검사상 측이한 소견을 보이지 않았다. 방사선 검사상, 쇄골 내측부에 골 용해성으로 팽윤된 병변이 관찰되었고, 동맥류성 골낭종, 단순 골낭종, 전이성 골종양 등의 의증 하에 절제술을 시행하였다. 절제된 종괴의 육안 소견상, 얇은피질 골로 쌓여 있으며, 노란색 액체로 차있는 4x5cm 종괴가 관찰되었고, 완전 절제술을 시행하였다. 광학현미경상, 혈액으로 차있는 다양한 크기의 낭성 구조가 보였고, 여러 개의 거대세포가 격막을 이루고 있었다. 조직학적 소견과 MRI소견, 임상 소견을 종합하였을 때, 쇄골에서 원발성으로 발생한 동맥류성 골낭종을 진단할 수 있었다. Many cases of aneurysmal bone cyst(ABC) have been reported since Jaffe and Lichtenstein(1942) first reported. Aneurysmal bone cyst mostly occurs in metaphysis of the long bones and vertebral column. The reason for this disease has not be clearly explained yet, but it is estimated as reactive change and can be accompanied with primary lesion or another lesion. It rarely occurs in clavicle or other bones. We report one case of ABC in right clavicle. 14-year-old female patient who accidentally found palpable mass on right shoulder visited hospital. We did not find any specifics regarding this patient's mass after physical exam and blood test. Radiologic exam showed a large expansile mass with osteolytic lesion, The differential diagnosis includes ABC, simple bone cyst, metastatic bone tumor, etc. Based on visual observation on excised 4×5 cm mass, it was covered by thin cortical bone and filled with yellow fluid, and complete excision was done. On histological examination, the mass consist of various size of cystic structures. and several giant cells comprised septae. Based on histological examination, MRI, clinical examination, we made a diagnosis that it was primary anuerysmal bone cyst in clavicle

Wolff-Parkinson-White증후군의 임상상 및 전기생리학적 소견

안신기,이문형,장양수,오동진,최인석,하종원,임세중,김병옥,정남식,심원흠,조승연,김성순 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

가토의 요추간반에 대하여 오존을 이용한 화학적 용해술

김영수,전병찬,권기영 The Korean Neurosurgical Society 2003 Journal of Korean neurosurgical society Vol.34 No.6

광섬유 Fabry-Perot 간섭형 전류 및 전압센서 시스템의 제작

박동수,김명규,김창원,이정희,손병기 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1

Although the conventional current transformers(CTs) and the potential transformers(PTs) have been used in the power system, new method is demanded which can measure with safty, EMI(electro-magnetic interference)-free. Over the last few years, variours kinds of optical measurement systems have been studied. The optical CTs and PTs systems, however, are very complicated and large, and hence the systems have a difficulty to maintain and repair. A new type fiber optic voltage and current transducers were fabricated by using fiber optic Fabry-Perot interferometer and PZT. A simple optical signal processing circuits and its PC interface circuits were also designed.