정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

필라델피아 염색체 양성 급성골수성백혈병에서 Imatinib Mesylate로 분자학적 관해를 유도한 후 성공적인 자가 말초혈액 조혈모세포이식이 시행되었던 1예

김여경,이제중,이병환,변정래,조덕,이일권,정익주,양동욱,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1

저자들은 필라델피아 염색체 양성 급성골수성백혈병 환자에서 복합항암화학요법으로 혈액학적 완전관해를 유도하고, imatinib mesylate를 이용하여 분자학적 관해를 유도한 후, 성공적으로 자가 말초혈액조혈모세포이식을 시행하였던 1예를 경험하였기에 이를 보고하는 바이다. Philadelphia chromosome (Ph¹)-positive acute myeloid leukemia (AML) is very rare disease, comprising 3~4% of the AML, and is a clinically distinct entity with poor clinical outcome with conventional chemotherapy. We report a case of Ph¹-positive AML who underwent successful autologous peripheral blood stem cell transplantation after achieving a molecular remission with imatinib mesylate.

고온 접촉식 탐상용 초음파 탐촉자 개발 및 평가

김기복,김병극,이승석,윤남원,윤동진,안윤국 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

고온(500℃) 환경에서 접촉식 탐상이 가능한 초음파 탐촉자를 개발하고 평가하였다. 고온용 탐촉자는 Curie 온도가 600 ℃ 이상인 bismuth titanate 계열의 압전세라믹 소자, 텅스텐 분말과 inorganic binder를 혼합한 후면재, 알루미나 튜브, 전면재, 하우징 등으로 구성되었다. 기본 공진주파수가 각각 1.04 및 2.08 ㎒의 2 종류 탐촉자를 제작하였으며 각종 고온용 커플런트의 온도특성을 시험하였다. 개발된 고온용 탐촉자를 이용하여 강재 시편을 대상으로 시편에서의 초음파 반사신호를 측정한 결과 시편의 온도가 증가함에 따라 반사신호의 크기는 감소하였다. 고온에서 반복측정 실험결과 500℃에서 연속적인 접촉식 초음파 탐상이 가능한 것으로 나타났다. Piezoelectric ultrasonic transducers for high temperature contact measurement were developed. These high temperature ultrasonic transducers (HTUT) consisted of bismuth titanate piezoceramic element whose Curie temperature is higher than 600℃, a backing material of the mixture of tungsten powder and inorganic binder, an inner alumina tube, a wear plate and a housing. The operational frequencies of the HTUT were 1.04 and 2.08 ㎒, respectively. Various commercially available couplant for high temperature were evaluated and compared. As a couplant for high temperature ultrasonic testing between HTUT and test specimen, gold epoxy was selected. The peak amplitude of pulse-echo signals from steel test specimen decreased with increasing temperature. The operational temperature of the HTUT reached up to 500℃ at which the continuous contact measurement was possible.

승용차용 알루미늄 합금 휠의 진동특성에 관한 실험적 연구

金秉三,홍동표 全北大學校 1993 論文集 Vol.36 No.-

Vibration characteristics of a wheel play an important role to judge a ride comfortability and quality for a passenger car. In this study, the vibration characteristics of al-alloy and steel wheel for passenger car are studied. Natural frequency, damping and mode shape are determined experimentally by frequency response function. Results show that wheel material property, size and design are parameter for shift of natural frequency and damping.

調和 集中 荷重을 받고 回轉하는 타이어에서 音響 放射

김병삼,홍동표 全北大學校 1992 論文集 Vol.34 No.-

The Problem of sound radiation from rotational tire under the action of harmonic point forces is studied. The reaction on the vibratory response of the rotational tire is taken into account. The rotational tire is assumed to occupy the plane y = 0. The rotational tire material and the elastic foundation are assumed to be lossless and Bernoulli-Euler beam theory including a tension force (T), damping coefficient (C) and stiffness of foundation (k_s) will be employed. The non- dimensional sound power is derived through integration of the surface intensity distribution over the entire rotational tire. The expression for sound power is integrated numerically and the results examined as a function of wavenumber ratio (γ) and stiffness factor (ψ). Here, our purpose is to explain the response of sound power over a number of non-dimensional parameters describing tension, stiffness, damping and foundation stiffness.

수도권 지역 개신교인, 불교인, 천주교인의 종교적 내재성(immanence) 비교 : 종교정향과 종교의식의 실증적 분석을 중심으로 An Empirical Analysis on religious orientation and religious attitudes

金東基,高炳哲 韓國宗敎敎育學會 2004 宗敎敎育學硏究 Vol.19 No.-

이 연구는 수도권 지역의 개신교, 불교, 천주교 신자들 간의 내재성 차이를 검증하여 신앙인들을 이해하고, 종교 간의 의식차이를 연구하는 데 중요한 기초 자료를 제공하는 것이 목적이다. 첫째, 변인들의 주요 항목들 간의 상관관계 분석 결과에서 세 종교 전체에서 보면, 신앙중요도는 종교적 내재성의 수용성과 현재성에서 유의미하게 상관성이 있고, 경계성에서는 상관이 유의미하지 않았다. 둘째, 종교적 내재성 정도에 따른 종교 간 비교를 위한 t검증 결과에서는 개신교가 경계성과 수용성에서 다른 종교와 큰 차이를 보였다. 셋째, 종교적 내재성과 종교정향의 정도가 종교의식에 미치는 영향에 대한 변량분석 결과는 세 종교 전체에서, 내재성 세 척도(수용성, 경계성, 현재성)의 거의 모두에서 유의미한 상호작용이 일어났다. 종교별로는 유의미한 변량분석 결과가 천주교가 가장 많았고, 그 다음이 개신교, 불교의 순으로 나타났다. 내재성 하위 척도별로는 수용성, 현재성, 경계성의 순이다. 종교정향 하위 척도별로는 추구적 정향,외적 정향, 내적 정향의 순으로 나타났다. The purpose of this study was to examine the effects of immanence in the Protestant, the Buddhist and the Catholic believers in the Seoul Metropolitan Area, as analyzing their religious orientations and religious attitudes. First, the results revealed that relationships(r) were significant among believing attitude, acceptance, present-orientation by the participants in 3 religions. But the relationship was not significant between believing attitude and boundary-leveling. Second, the results of t-test were significant between boundary-leveling and acceptance of religious immanence by the Protestant then other religions. Third, the result of ANOVA showed that the interaction effect of immanence scales(acceptance, present-orientation, boundary-leveling) and religious orientations(external, internal, quest) were significant to religious attitudes by participants in 3 religions. The Catholic were the most significant interactional effect; the Protestant were the second weaker significant level and the Buddhist were the third significant level. Acceptance scales were the most significant interactional effect; the present-orientation was the second weaker significant level and the boundary-leveling was the third significant level. Quest scales were the most significant interactional effect; the external scales was the second significant level and the internal scales was the third significant level.

고정상태에서 경상용차용 타이어의 진동특성

김용우,최동수,김병삼 순천대학교 2000 순천대학교 자연과학논문집 Vol.19 No.1

To investigate differences between the dynamic characteristics of two kinds of light-duty truck tires, modal testings have been performed on radial tire and bias tire under constrained condition. Through the test, modal parameters, such as natural frequencies, modal decay rates and mode shapes, were obtained. The mode shapes in direction of circumference and of meridian are presented. The test results have shown that the modal frequencies of bias tire are much higher than the corresponding values of radial tire with a similar mode shape, which is in accordance with the fact that the radial rigidity of bias tire is higher than that of radial tire. Most of the modal decay rates of bias tire are larger than those of radial tire within the scope of this experiment. In the frequency domain range of test, the bias tire has extra mode which do not occur in the radial tire. This difference is based on the fact that the circumferential rigidity of the bias tire is quite low whereas that of radial tire is so high that the frequencies of the corresponding modes are out of the frequency range of test. As the inflation pressure increases, the natural frequencies are increased while most of the modal decay rates remain constant or are decreased slightly.

노인인구에서 ApoE 유전자형에 따른 머리둘레와 인지기능간의 연관성

김경란,오병훈,이준영,김은아,정해관,이동우,홍창형 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Objectives : The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community. Methods : A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype. Results : On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE ε4 allele, current smoking and alcohol drinking status (β=0.15, P=0.04). Only in the lowest qu-artile group, presence of ApoE ε4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alco-hol drinking and smoking status (β= -1.39, P= 0.008) Conclusion : These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE ε4 allele may be a medicating factor.

알코올 의존환자의 인격장애에 관한 연구

김동인,김병조,박유경 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 본 연구의 목적은 알코올 의존이 없는군과 입원한 알코올 의존군 사이의 인격장애의 유벼율을 알아보고, 여러가지의 축Ⅱ 장애의 범위와 중복을 알아보고자 하였다. 방 법 : 대상은 일반군에서 알코올 의존이 없는 87명과 정신병원에 입원된 알코올 의존환자 94명이었다. 알코올 의존은 DSM-IV에 의거하여 미시건 알코올 의존 선별검사로 진단하였고, 정상군과 환자군 모두 PDQ-4+를 시행하였다. 결 과 : 정상군은 52.3%가 적어도 1개 이상의 인격장애를 가지고 있었으며 한 사람당 평균 1.23개였다. 알코올 의존군은 88.3%가 적어도 1개 이상의 인격장애를 가지고 있었으며 한 환자당 평균 4.26개였다. 결 론 : 본 연구에서는 단일의 "알코올성 인격장애"는 없었다. Objectives : The purpose of this study was to examine the prevalence of personality disorders among non-alcoholics and hospitalized alcoholics and the extent and nature of the overlap between different axis Ⅱ disorders. Methods : Subjects were 87 non-alcoholics in the general population group and 94 alcoholics admitted to psychiatric hospital. Alcohol dependence was diagnosed according to DSM-IV by the MAST, and general group and patients were assessed with the PDQ-4+. Results : In the general population group, 52.3% of non-alcoholics had at least one personality disorder and the average number of personality disorders was 1.23 per person. In the alcohol group, 88.3% of the patients had at least on personality disorder and the average number of personality disorders was .426 per patient. Conclusion : In our study, there is no single "alcoholic personality" emerged.

주파수응답함수법에 의한 타이어 반경방향 고유진동수와 감쇠비 측정

김용우,김병삼,최동수 順天大學校 1999 論文集 Vol.18 No.1

In this paper, we have reported fundamental natural frequencies and damping ratios in the radial direction of various tires, from passenger car tires to truck-bus tires, under unconstrained condition. We have determined the radial directional modal parameters of tires, which are subjected to different levels of inflation pressure, by using frequency response function method. The results show that experimental conditions shift the natural frequency and damping ratio.