방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술

채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

營業秘密侵害에 대한 刑事處罰의 可能性과 改善方案 : Possibility of Penal Sanctions and Suggestion on Reform

韓尙勳 國民大學校 法學硏究所 2002 법학논총 Vol.14 No.-

In modern society the importance of science and technology is enormously growing. Korean companies have developed high technology very rapidly in fields of memory semiconductors, computer, automobile, home appliances. This means that Korean companies are now not out of range of the global economic espionage. For example, in 1998 a ghost company founded by some former researchers took illegaly industrial secrets of Samsung and LG, and sold them to a Taiwanese company. In the aftermath of this case, the legislature has revised the Unfair Competition Prevention and Business Secret Protection Act, (Unfair Competition Act) and broadened the range of criminal responsibility in case of divulgence of trade secrets on techniques. The Act is effective since July 1, 1999. Nevertheless it is not to oversee that the revised Act does not provide enough criminal protection against economic espionage. In this paper I look into protection systems of other major countries, such as USA, Germany, Japan, Swiss, Austria, Italy. Through this comparative study we can found out what kind of problems the Korean protection system has and how to remedy them. The Unfair Competition Act penalizes some acts of misappropriation of trade secrets on techniques. Any officer or employee of an enterprise who, without any justifiable reason, uses in a foreign country any business secrets on techniques useful to the enterprise or, with knowledge that the secrets will be used in a foreign country, divulges them to a third party shall be punished by imprisonment for not more than seven years or by a fine not exceeding one hundred million won(Unfair Competition Act §18 Ⅰ 1). As same shall be punished any ex-officer or employee of an enterprise who, with intent to gain any unfair profit or to inflict any loss on the enterprise, uses in a foreign country any business secrets on techniques useful to such enterprise or, with knowledge that the secrets will be used in a foreign country, divulges them to a third party, in violation of the duties of observance of secrecy under a contract or any similar relation(Unfair Competition Act §18 Ⅰ 2). These provisions are intending to prevent disclosure of trade secrets in favor of foreign countries. Any officer or employee of an enterprise who divulges any business secrets on techniques useful to the enterprise to a third party, without any justifiable reasons shall be punished by imprisonment for not more than five years or by a fine not exceeding fifty million won(Unfair Competition Act §18 Ⅱ 1). Any ex-officer or employee of an enterprise who divulges any business secrets on techniques useful to such enterprise to a third party, with intent to gain any unfair profit or to inflict any loss on the enterprise, in violation of the duties of observance of secrecy under a contract or any similar relation shall be punished also by imprisonment not more than five years or by a fine not exceeding fifty million won(Unfair Competition Act §18 Ⅱ 2). The punishment of imprisonment and fine under Art. 18 Ⅰ and Ⅱ shall be concurrently imposed(§18 Ⅳ). A public action against the offense referred to in Art. 18 paragraphs (1) and (2) shall be instituted only on the aggrieved person's complaint: Provided, That the same shall not apply where it is deemed necessary for national security or material public interests(§18 Ⅴ). Other than the Unfair Competition Act some provisions of criminal code, such as breach of trust(Art. 355 Ⅱ), theft, etc can apply to the theft of trade secrets, but with limitations. In application of the Unfair Competition Act some problems can be pointed out: 1) the Act does not criminalize outside-actor, in that only officers or employees, whether present or former, fall under the criminal provisions. The application range of the criminal provisions should be widened. 2) The Act focus mainly on ‘divulge’ or disclose of trade secrets on techniques, and very limitedly on ‘use’ of trade secrets. We must say that a professional industrial spy could avoid the punishment by the Act, let aside other acts. So the Act should be revised so as to encompass the actions like ‘obtain, acquire, take away, steal, copy, photocopy’ of trade secrets. 3) Attempt, or conspiracy should be put under punishment in order to provide an enough protection of the trade secrets. 4) Some procedural measures are necessary to prevent disclosure of trade secrets in criminal trials.

地域社會發展에 關한 지역대학의 機能과 役割에 關한 연구

한상훈 영남대학교 지역발전연구소 2001 영남지역발전연구 Vol.28 No.-

Education and research are core functions of the university. However, in accordance with the rapidly changing social and economic conditions most universities are being asked to provide additional services to the community where they located. Since the universities usually have a bundle of buildings as well as huge playgrounds and have various high-tech research projects it is expected that the social and economic influence over the community might be great when the cooperation with the university and the community were successful for any purpose. Based on this thought this study examines the relationship between the university and the community through the previous studies related to the issue. Then the author suggests two different approaches for the further research direction for both the planners and local administrators to accomodate and enhance the potential success and growth of the community through the cooperation with local universities.

공공사업의 사업성평가 방법론에 관한 연구 : 새만금사업의 사업성 평가에 있어서 비용·편익항목 선정의 문제점을 중심으로 A Case Study of the Saemankum Project focused on the Selection of Evaluation Variables

한상훈 경주대학교 건설환경연구소 2004 建設環境論叢 Vol.- No.6

This study aims to examine the usefulness and limits of cost-benefit analysis in the evaluation of the feasibility of a certain public project. To accomplish this research objective two different examinations were proceeded in this study. One of which is the literature review of the cost-benefit analysis in terms of the role and function of the analysis in the feasibility study of a certain public project. The other is a case study of the Saemankum Project. This case study examines the selected variables for the cost-benefit analysis in order for conducting the feasibility study of the project. The results of these examinations show that cost-benefit analysis is very useful mean to examine the feasibility of a certain public project and its usefulness could be improved if the following conditions were satisfactorily considered in the analysis: (1) selection of the cost- and benefit-variables for analysis is proceeded under the same condition and time span, (2) the analysis should include a certain mediation process in advance to determine the final selection of the cost- and benefit-variables to secure the reliability of the results of the analyses.

폐흡충에 의한 무균성 노흉에 대한 돼지꼬리형 도관(pig-tail catheter)을 이용한 치료의 효과

한경택,권세훈,김형호,하재화,선길홍,권용은,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Pulmonary paragonimiasis is caused by consumption of raw or improperlycooked crustacea infected with the laval stage (metacercaria) of Paragonimus westermani. The most characteristic symptoms were rust-colored sputum and cough. Paragonimiasis causes pleural thickening or effusion in 48% of the patients. Pleuro-pulmonary paragonimiasis can be easily overlooked by physicians who do not suspect this disease in the differential diagnosis. Method: We compared the outcomes of 11 patients with paragonimus empyema managed either through thoracotomy or pig-tail catheter drain. These patients were confirmed by food history, clinical and radiological findings, and laboratory data. Results: The male and female ratio was 1.75 : 1, and mean age was 40.0 ± 13.5 years. AII patients had pulmonary symptoms such as cough or chest pain. Serum-ELISA for paragonimiasis were all positive (mean titer was 0.57). AII patients had pleural effusion in radiological findings( 2 patients had bilateral pleural effusion). All patients received praziquantel (75 ㎎/㎏/day for 3days). Two patients were treated with thoracotomy and nine patients were treated with pig-tail drain. Hospital stay were 14.5 days in thoracotomy group and 5.6 days in pig-tail group respectively, Conclusion: Compared to the conventional thoracotomy grouP, the patients with paragonimus empyema who received pig-tail catheters had a significantly-decreased period of drain in situ, were clinically improved earlier, and were discharged earlier.

철근콘크리트 보에 대한 CFRP의 정착길이

한상훈,최만용,조홍동,박중열,황선일 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.1

A failure mode in the beam strengthened with a high modulus plate appears as a interface debonding failure or ripping-off failure. This failure mode means that plate is separated from adhesive or concrete before displaying its own ability. Therefore, as a method for controlling a premature failure, it is need to use a general anchorage implement. We conducted bending tests for reinforced concrete beams strengthened with CFRP. The experimental variables were a concrete strength, reinforcement ratio, cover thickness of concrete and length ratio of CFRP for a pure span. A failure load, failure mode, load-deflection curve and strain response at different distances from a cut-off of CFRP and strain distribution curve were measured to determine the bond development length. Also, the bond development length was compared with Nguyen’s model and British Standard specification.

탄소섬유보강판의 홈삽입에 따른 철근콘크리트 보의 보강효과

한상훈,최만용,조홍동,박중열,황선일 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.1

This paper presents a feasibility study of an alternative strengthening method by slot-bonded CFRP plates for reinforced concrete beam. A total 14 reinforced concrete beam were constructed, tested and the response of the beams in terms of deflection, strains, failure load and failure mode were examined. Each specimen was initially loaded for 75% of ultimate load, cracked specimen were strengthened with CFRP plate and then tested until complete failure. Test variables included the strengthening method, steel ratio and strengthening length, and the effects according to each test variables are analysed. The experimental results show that proposed methods can increase the flexural strength and stiffness of the beam significantly. Also, the failure of the specimens strengthened by the proposed method are more ductile than externally bonded specimen.

Adamkiewicz 동맥의 폐색에 의한 척수경색 1례

이광훈,이종걸,이태연,신동익,이성현,이상수,한설희,차상훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

뇌혈관의 미만성 방추형 동맥류 : 1예 보고

한기석,신환식,박길선,김대영,김성진,차상훈 충북대학교 의과대학 충북대학교 의학연구소 1998 忠北醫大學術誌 Vol.8 No.2

저자들은 뇌동맥의 광범위한 확장을 보이는 희귀한 방추형 동맥류의 증례를 경험하였기에 전산화단층촬영영상과 자기공명영상 소견을 중심으로 보고하고자 한다. 49세 남자환자로 20 년전 고혈압으로 진단 받고 치료받던 환자로 현기증과 언어장애로 내원하였다. 내원 후 시행한 조영증강후 뇌 전산화 단층촬영에서 뇌저동맥, 중뇌동맥, 후뇌동맥 등이 확장되어 있고 구불구불하였으며, 확장된 뇌저동맥은 뇌교를 압박하고 있었다. 삼차원 구성기법을 이용한 전산화단층촬영 혈관조영술에서 뇌동맥이 광범위한 확장을 쉽게 이해할 수 있었다. 자기공명영상 T2강조영상에서 확장된 뇌동맥이 신호소실로 보였으며, 뇌저동맥이 뇌교를 오른쪽으로 압박하고 뇌교의 중앙부분에 뇌경색이나 허혈로 보이는 높은 신호강도를 보이는 부분이 있었다. 미만성 방추형 동맥류에 있어 전산화 단층촬영, 자기공명영상은 동맥확장의 범위와 정도를 평가하는데 도움을 주며, 혈전형성, 허혈, 주위 뇌조직의 압박 등의 소견을 잘 보여준다 Authors report a case of diffuse fusiform aneurysm of cerebral arteries, focusing findings of CT and MRI. A 49 year old male suffered by hypertension was presented by dysarthria, right hand tingling sensation and dizziness. Contrast media enhanced CT images showed markedly dilated and tortuous basilar artery and middle, posterior cerebral arteries. The location and extent of arterial dilatation was well depicted by CT angiogram. On T2 weighted MR image, dilated arteries were depicted as signal void and the compressed pons by dilated basilar artery and adjacent ischemic changes were also well depicted. CT and MRI are excellent imaging modality in the evaluation of extent and degree of diffuse fusiform aneurysm of cerebral arteries.