Characterization of the European type of maternal lineage evident in extant Jeju native pigs

Byeong‐Woo Kim,In‐Cheol Cho,Moon‐Sung Park,Tao Zhong,임현태,Sung‐Soo Lee,Hee‐Bok Park,Moon‐Suck Ko,Jun‐Heon Lee,Jin‐Tae Jeon 한국유전학회 2011 Genes & Genomics Vol.33 No.2

Using a partial D‐loop sequence of mtDNA, an intensive analysis was conducted of the maternal lineages of Jeju native pigs (JNPs) from Korea. In total, 100 mtDNA sequences were obtained from Asian wild boars (AWBs), European wild boars (EWBs), Asian domestic pigs (ADPs), European domestic pigs (EDPs), and JNPs and were used for phylogeny and network analyses. Two distinct JNP groups - one (JNPA) in the Asian cluster and the other (JNPE) in the European cluster - were identified in the estimated phylogenetic tree and network. The maternal lineage of JNPE was the closest to that of EWB and a clear haplogroup was identified that shared an identical haplotype (hap04) among 15 individuals of JNPE and 2 individuals of EWB. A Landrace and an EWB shared hap03with a JNPE. EWB, Landrace, Large White, and Duroc formed two clear haplogroups with JNPE in a parsimonious medianjoining network analysis, suggesting that an obvious maternal contribution of EDP has occurred in JNPE in recent years. A pair‐wise mismatch analysis also indicated that JNPE may have experienced a sudden population expansion, suggesting a more recent establishment compared with the gradual population expansion of JNPA. The JNPE group therefore should be further evaluated in order to decide whether this group should be culled or accepted into further programs for maintenance of the JNP population as a pure breed.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Possible Involvement of Photoperiodic Regulation in Reproductive Endocrine System of Female Olive Flounder Paralichthys olivaceus

Hyun Chul Kim,Chi Hoon Lee,Sung Pyu Hur,Byeong Hoon Kim,Jun Young Park,Young Don Lee 한국발생생물학회 2015 발생과 생식 Vol.19 No.1

This study investigated possible involvement of photoperiodic regulation in reproductive endocrine system of female olive flounder. To investigate the influence on brain-pituitary axis in endocrine system by regulating photoperiod, compared expression level of Kisspeptin and sbGnRH mRNA in brain and FSH-β, LH-β and GH mRNA in pituitary before and after spawning. Photoperiod was treated natural photoperiod and long photoperiod (15L:9D) conditions from Aug. 2013 to Jun. 2014. Continuous long photoperiod treatment from Aug. (post-spawning phase) was inhibited gonadal development of female olive flounder. In natural photoperiod group, the Kiss2 expression level a significant declined in Mar. (spawning period). And also, FSH-β, LH-β and GH mRNA expression levels were increasing at this period. However, in long photoperiod group, hypothalamic Kiss2, FSH-β, LH-β and GH mRNA expression levels did not show any significant fluctuation. These results suggest that expression of hypothalamic Kiss2, GtH and GH in the pituitary would change in response to photoperiod and their possible involvement of photoperiodic regulation in reproductive endocrine system of the BPG axis.

지구성 운동이 자연발생 고혈압 흰쥐의 혈압에 미치는 영향

이규승,전병화,김일곤,전종귀 忠南大學校體育科學硏究所 1996 體育科學硏究誌 Vol.14 No.1

The purpose of this study is to investigate the effects of indurance exercise on BP of SHR Experimental animals were SHR(180) and SD(90) and they were divided into three groups ; a experimental group1( practice group), a experiment group2(non practice group), and a comparative group (normal group). The experimental group 1 was practicing on a treadmill at 15m/min exercise intensity for 30 minutes a day four times per week for eight weeks. While raising experimental animals, We measured BP for each group once a week, and took the weight of the heart after killing a rat. and then we examined the concentration of ?? and ??, compared, and analyzed them. we have reached the following results. 1. As time passed, BP in the experimental group 1 was almost equal to BP eight weeks ago. BP in the experimental group 2 continued to rise and then showed typical hypertension. 2. The three groups were inclined to increase the weight of their hearts as time passed. However, the experimental group 2 presented the weight of hearts increasing compared with the experimental group1 after eight weeks. 3. In the experimental group 1, and experimental group 2 groups, ?? concentration was but ?? concentration increased as time passed. However, the experimental group1 showed fewer changes than the experimental group 2. 4. The weight of all three groups were inclined to increase as time passed, but it didn't present any noteworthy differences. According to the analysed result of the above experiment, endurannsce exercise becomes an important factor in preventing the raising of BP of SHR, and the hypertrophy of hearts. Key Words : Spontaneously Hypertension Rats, Blood Pressure, Endurance Ecercise

간세포암에 대한 간동맥 화학색전술의 치료효과

이헌영,김병호,정현용,김영건,조준식 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Hepatocellular carcinoma(HCC) is the second most common cause of cancer death in Korea. Generally, HCC was unresectable due to the frequently associated cirrhosis and advanced stage of tumor. As a palliative therapy of HCC, transcatheter arterial chemoembolization(TACE) was a proven effective mean of treating inoperable HCC. We have analyzed the effectiveness of TACE in inoperable HCC. TACE was performed in 20 patients from January in 1990 to May in 1993 at Chung Nam National University Hospital with the infusion of mixture of Lipiodol and Adriamycin. We analyzed the survival rates of the TACE group and the control group who received no specific treatment. The results were follows ; 1) The survival rate was significantly higher in TACE group than control group(p<0.01). The survival rate at the end sixth months and one year were 62.8% and 40.0% in TACE group, 26.6% and 0% in control group, respectively. 2) A declining level of AFP(Alph-fetoprotein) was shown in 8 among 10 cases who underwent TACE/and was higher than 500 ng/ml in pre-TACE level(p<0.01) and also tumor size was decreased in 7 among 20 cases who underwent TACE. 3) Side effects were fever(80.0%), and upper abdominal pain(75.0%) in TACE group but improved within 7 days after TACE and impairment of liver function was developed in most patients(TACE group) but improved within 2 weeks after TACE. As a palliative therapy of HCC, TACE is an effective and useful modality in treating and prolonging the survival time of patients with unresectable hepatocellular carcinoma.

12주간 축구훈련이 정신지체아의 심박수에 미치는 영향

이창규,김병완,현광석,조병준 대전대학교 기초과학연구소 1997 自然科學 Vol.8 No.1

12주간의 축구훈련이 정신지체아의 심박수에 미치는 영향을 알아보기 위하여 훈련되지않은 14명의 정신지체 남자 중학생들을 각 7명씩 축구훈련군과 비교군으로 나누었다. 훈련군은 최대심박수의 62.7%의 강도로 1일에 30분씩의 축구훈련을 1주에 3일의 빈도로 12주 동안 실시하였다. 트레드밀에서의 런닝 중에 나타나는 심박수의 반응을 12주간의 훈련 준후에 각각 측정하였다 12주간의 축구훈련 후에 트레드밀 런닝의 각 단계에서 정신지체 남자 중학생의 심박수가 유의하게 감소했으며 특히 트레드밀에서의 런닝 5분 경과시에는 훈련 전 152bpm에서 훈련 후에는 129.8bpm으로 현격한 감소를 나타냈다. 최대심박수의 50-70% 정도의 강도로 훈련을 실시하는 것이 정신지체 남자중학생들에게는 안전하고 효율적인 것으로 나타났다. The purpose of this study was to identify the effects of 12 weeks of soccer training. on heart rate in mentally retarded children. Fourteen untrained middle school boys were randomly selected and divided into 2 groups, exercise group(N=7) and non-exercise group(N=7). The exercise group had 30 minute-soccer training 3 days a week with intensity of 62.7% of HR? for 12 weeks. The heart rate responses to treadmill running were measured before and after 12 weeks of soccer training. The data were tested(p<.05) with paired t-test and independent t-test. The heart rate responses were improved significantly when mentally retarded boys were subjected to 12 weeks of soccer training. It is recommended to use exercise intensity within moderated range (50%-70% HR?) for mentally retarded boys.

K^+통로개방제 Pinacidil이 종양이식 생쥐에서 Tl-201의 체내분포에 미치는 영향

이재태,천경아,이상우,강도영,안병철,전수한,이규보,하정희 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1

Purpose: Thallium behaves similarly to potassium in vivo. Potassium channel opener (K-opener) opens ATP-sensitive K+ -channel located at cell membrane, resulting in potassium efflux from cytosol. We have previously reported that K-opener can alter biokinetics of T1-201 in cultured cells and in vivo. Malignant tumor cells have high Na-K ATPase activity due to increased metabolic activities and dedifferentiation, and differential delineation of malignant tumor can be possible with T1-201 imaging K-opener may affect tumoral uptake of T1-201 in vivo. To investigate the effects of pinacidil (one of the potent K-openers) on the localization of the tumor with T1-201 chloride, we evaluated the changes in biodistribution of T1-201 with pinacidil treatment in tumor-bearing mice. Materials and Methods: Balb/c mice received subcuta-neous implantation of murine breast cancer cells in the thigh and were used for biodistribution study 3 weeks later. 100㎍ of pinacidil dissolved in 200 □ DMSO/PBS solution was injected intravenously via tail vein at 10 min after 185 KBq (5 □Ci) T1-201 injection, Percentage organ uptake and whole body retention ratio of T1-201 were measured at various periods after injection, and values were compared between control and pinacidil-treated mice. Results: Pinacidil treatment resulted in mild decrease in blood levels of T1-201, but renal uptakes were markedly decreased at 30-min, 1- and 2-hour, compared to control group. Hepatic, intestinal and muscular uptake were not different. Absolute percentage uptake and tumor to blood ratios of T1-201 were lower in pinacidil treated mice than in the control group at all time points measured. Whole body retention ratio of T1-201 was lower in pinacidil treated mice (58±4%), than in the control group (67±3%) at 24 hours after with injection of 100 □g pinacidil. Conclusion: K-opener did not enhance, but rather decreased absolute tumoral uptake and tumor-to-blood ratios of T1-201 Decreased whole body retention ratio and renal uptake were observed with pinacidil treatment in tumor-bearing mice. (Korean J Nucl Med 2000;34:303-11)

Siriraj Stroke Score 따른 뇌졸중 환자 감별의 적합성

유병대,이명갑,서영조,조준,박찬상,이동필 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The differentiation between hemorrhagic(HS) and norhemorrhagic(NHS) stroke is the most important first step in the management of acute stroke because clinical management of the two disorders differs substantially. Neuroimaging studies are useful in diagnosing and distinctioning between HS and NHS. The use of clinical variables, such as Siriraj stroke scores(SSS), has led to good sensitivity, specificity and predictive values. The aim of our study was to evaluate the use of the SSS in the Korean population and assess whether it could aid to expedite treatment decisions. Methods: We reviewed 111 cases of stroke patients admitted to our hospital via the emergency department over a 6 months period from July to December 1998. Levels of consciousness, vomiting, headache, and atheroma markers used in the SSS were applied to these patients who met the criteria for a stroke. Results: Of the 111 patients, the SSS classified 83 with sensitivities of 81.1%(NHS) and 73.3%(HS) and positive predictive values of 84.3% and 68.8%, respectively. The overall accuracy rate was 78.3%. Conclusion: Our results suggest that the SSS is not reliable in distinguishing stroke types in the Korean population. Definite neuroimaging studies are needed prior to thrombolytic therapy.

P2P 기반 Mobile System 구현

황인선,이호현,전병균,김형균 광주보건대학 2004 論文集 Vol.29 No.-

P2P network environments provide mobile users with direct data transmission and sharingfacilities and those environments can be classified into hybrid P2P network environments and pure P2P network environments according to the arbitration mechanism among the peers in the network. In pure P2P network environments, however, each peer directly connects to another peer and gets services without server intervention, and so, network isolation can occur when the mediating peer fails to work. In this paper, we propose a scheme for each peer to keep connection to other peers continuously by maintaining IP addresses of its neighbor peers and connecting to the peers when the mediating peer fails to work. Although the P2P application that uses our proposed framework should obtain one or more IP addresses of the neighbor peers manually, after instantiation, the application can do its job while maintaining connection to the network continuously and automatically. In order to improve these weaknesses, we introduce LBS(Location Based Service) and mobile P2P(Peer to Peer)service into the existing systems, then design and implement the enhanced system for mobile SFA using them. Through this improvement, our system makes it possible for customers or sales agents to quickly share various information and increases the efficiency of sales activity by facilitating the competition and cooperation among sales agents and reducing time-cost.

키 프레임을 이용한 동영상 검색에 관한 연구

김희수,김형균,전병균,이호현 광주보건대학 2004 論文集 Vol.29 No.-

The primary goal of video parsing is to accurately detect fast/gradual scene changes to index the video data so that future retrieval may be performed efficiently. Due to the sheer volume of the video data, however, the goal of accurate detection must be met by some real-time (fast) automatic (or at least semi-automatic) video parsing mechanism. For this purpose, I have developed a fast algorithm to detect gradual scene change and also detect camera motions to reduce false positives (falsely declaring a scene-change). In this dissertation, we propose a new approach that detects the change of scene which contains fast motion, zooming, dissolve in AVI video sequence. The proposed scheme adopts the feature matching technique which ALH(Average of Luminance Histogram) in each frame with those in the previous frame. Experimental results show that the proposed method performs better in detection scene changes than other conventional methods.