과학교육 개선을 위한 실험모델 제작에 관한 연구(Ⅰ)

이기종,이광호,이종철,김자홍 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1

A curriculum for teaching materials in Science Education was studied as a model for modified xperiment on fundamental courses. Coscious effort can be made to desingn experiments that require minimum apparatus, that require low-cost equipment that can be made to from cheap locally available materials. Computer-aided instruction programs at high school, freshman course level have been developed. The software package was consist of five programs: The program contains explanation and problems for the calculation of resonance energy, molecular structure, mole concept, Rutherford's experiment, thermodynamic processes. Special course equipment package explanation mole concept, Rutheford's experiment, thermo dynamic processes. Special course were designed in Science Education with the understanding that to a certain extent science values would be covered in all of the modified experiments and program models.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Adamkiewicz 동맥의 폐색에 의한 척수경색 1례

이광훈,이종걸,이태연,신동익,이성현,이상수,한설희,차상훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구

전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.

최단시간 경로 검색을 위한 지능형 지리 정보 시스템

이종연,남광우 충북대학교 컴퓨터정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.2

이 논문은 여행자로부터 시작점과 종점, 여행기간, 도로 상태, 교통량, 계절, 날씨, 비용, 여행자의 수, 호텔 시설, 방문을 원하는 관광지 등의 여행정보를 반영하여 최단시간 여행경로를 검색할 수 있는 지능형 지리정보 시스템을 제안한다. 주요 연구 내용으로는 기본 개념 정의, 설계시 고려 사항, 규칙 베이스와 지식처리 시스템, 그리고 기존의 지리정보 시스템과 지식처리 시스템과의 정보교환 방법 등을 기술한다. 또한 최단시간 여행경로 검색을 위한 지식처리 알고리즘을 기술하고, 공간질의 예를 통해 질의 수행 과정을 평가한다. 끝으로, 제안한 지능형 지리정보 시스템은 여행자에게 여행 조건을 반영할 수 있는 최단시간 여행경로를 탐색하는 고부가 지리정보 서비스의 제공이 기대된다. In this paper, we propose an architecture of an intelligent geographic information system(IGIS) which can retrieve the shortest-time path for tourist guide from a starting point to a target point. reflecting traveling period, road status, traffic volume, season, weather, cost, members for a travel, and hotel facilities, in addition to famous places which tourists want to visit. It defines basic concepts, design considerations, rule bases for its knowledge processing system, and the communication method of between a GIS software and the knowledge processing system. An algorithm of knowledge processing to retrieve the shortest-time path for travelers will be also described and then evaluated a query process of the system by an example of spatial query. Finally, we expect that the proposed system which is based on a conventional GIS software should provide the tourist with an advanced geographic information services to fine the shortest-time path depending on traveling conditions.

화상환자에서 혈청중 가용성 Interleukin-2 Receptor의 변동

이희성,이유진,이종량,백광진,하재성,전건수 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

Cell-mediated immunity frequently becomes severely impaired after burn. However, the cause of postburn immune dysfunction is unclear and controversy exists over both pathophysiology and clinical relevance of these abnormalities. This study was undertaken to invstigate the immune responses in vivo of patients with burn. Levels of soluble IL-2R, a sensitive marker of T-cell activation, were measured in 26 patients with burn. Serum soluble IL-2R levels in patients with burn were significantly higher than those of normal controls. Serum soluble IL-2R levels were correlated closely with the severity of the burn. The burn patients were classified according to the outcome. Patients with fatal outcom always showd a higher soluble IL-2R levels than survivors. Postburn sera significantly suppressed mitogen-indeced lymphocyte proliferation. These data indicate that soluble IL-2R might be useful parameters for monitoring of the clinical course in burn patients.

Finite Element Analysis of Stress Distribution with Load Transfer Characteristics of the Implant/bone Interface

이종우,이청희,조광헌 대한치과이식학회 2003 대한치과이식학회지 Vol.22 No.1

영주지방에 있어서 봉군의 실내월동 시험

이동률,이종원,이석건,최광수 慶北大學校農業科學技術硏究所 2001 慶北大農學誌 Vol.19 No.-

The studies was conducted to establish the indoor overwintering methods for productive honeybee colonies in the wintering chamber which provides satisfactory inside temperature ranging 2∼9。C and ventilation for the wintering honeybee colonies in Korea. Mortality of the indoor wintered honeybee colonies was 6.3∼7.1% during the winter season of 1997-1998 and 5∼10% during the winter season 1998∼1999. The decreased rates of colony weights during the wintering season were 10.6∼10.7% in the strong colonies and 10.2∼11.7% in the weak colonies. The increased rates of colony population overwintered in the chamber were 136.1∼142.3% in the strong colonies and 128∼136.5% in the weak colonies.

保健事業 實態에 關한 調査硏究 : 忠南 瑞山郡 雲山面, 海美面 一部 Seu San Gun, Choong Chung Nam Do

李貞子,金顯光,洪鍾寬 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.4

능동 규칙 시스템의 구성요소 설계

이연식,김광종 群山大學校 情報通信技術硏究所 1999 情報通信技術硏究論文集 Vol.3 No.-

Conventional database systems are passive, but recent trends in database technology have focused on extending conventional database systems to enhance their functionality and to accommodate novel and more advanced applications. One important enhancement is transforming database systems to be active. Active database system performs certain operations automatically in response to certain events occurring or certain conditions being satisfied. Active rule system is the most important component in an active database system. Mainly, the active rule system have several elements of event detector, condition evaluator, action executor and rule manager, etc. In this paper, we propose the design of components of active rule system which can support the active capabilities and review and evaluate the most prominent research projects in active database systems. And also, we describe the guideline for implementation of rule systems to be supported the various concepts of rules and the efficient rule processing for active database systems.