서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅰ) : 독성물질로 인한 파킨슨병 모델에서의 세포사 기전 연구 Study on the cell-death mechanisms of toxin-induced parkinsonism

강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

전주산업단지 및 주변지역 VOCs 및 악취물질 모니터링

김용문,박비오,고영삼,심재정,송병식,양고수 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

Important main odorous compounds and VOCs(volatile organic compounds) possibly emitted from the Jeon-Ju Industrial Sites were identified and measured in amount through making air sampling over Jeon-Ju Industrial Sites and analyzing them with the sate of the art analytical instrument. Sampling sites were chosen 8 points by considering the industrial characteristics for the 1,2 Industrial Sites and 2 points for the 3 Industrial. Site Sampling times were two times, the first one was March. 2002 - April. 2002, and the second was May. 2002 - July. 2002. Canister sampling units and polyester bags were used to collect 6 liters air samples during 1hour or 3minutes for VOCs and polyester bags were used to sample 10 - 50 liters of air for 3 minutes depending on analytic characteristics of odor compounds. The important main VOCs were measured as acetone, ethyl benzene, n-hexane, m,p-xylene, toluene, M.E.K.(methyl ethyl ketone), isopropanol, ethyl acetate, o-xylene, n-butyl acetate, ethanol, benzene as in order of average concentration for the Industrial Sites. The main odorous compounds were COS, H2S, CS2, MM(methyl mercaptan), form aldehyde, acetaldehyde for the 1,2 Industrial Sites and COS, H2S, form aldehyde, acetaldehyde were measured as main species for the 3 Industrial Site. NH3 was measured as below the detection limit of the instrument. The concentrations of sulfide compounds for the 1,2 Industrial Sites were relatively higher than ones for the 3 Industrial Site. Among aldehydes, form aldehyde, acetaldehyde were detected very highly as 0.1- 1ppm over all the Industrial Sites.

유치 및 초기 영구치아의 치수 신경분포

김영진,남순현,김현정,이재문,이인정 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

유치 및 초기 영구치의 치수신경분포 및 변화를 평가하기 위하여 교정치료를 위해 발치한 치근흡수가 비교적 적은 유치,정상 탈락기의 유치,맹출중인 교합하지 않은 제 1소구치,맹출이 완료되어 교합하고 있는 1소구치를 대상으로 neurofilament protein(NEP)을 이용한 면역조직화학적 방법으로 관찰하여 다음과 같은 결과를 얻었다. 치근흡수가 비교적 적은 유치에서도 영구치와 유사한 신경총의 존재와 신경분포 형태가 관찰되었으나,영구치에 비해 그 신경분포 밀도가 낮았으며 분지형성 또한 미약하게 나타났고,전상아질로 진입하는 섬유의 수가 적었다. 정상탈락기의 유치에서는 신경의 변성으로 소포(vesicle),단절(fragmentation)등이 관찰되었으며,그 신경분포가 현저히 감소되어 나타났고,총상의 형태도 소실되었다. 교합하지 않은 제 1소구치에서 치수내의 신경은 말단가지의 숫자가 적고,치수 조상아 세포 경계에 도달하였으며,비교적 가는 신경 섬유가 많았다. 교합하고 있는 제 1소구치에서 치수내의 신경은 말단이 조상아층으로 진출하고,어떤 신경섬유는 전상아질층까지 진입하였으며,비교적 굵은신경 섬유의 분포가 많아졌다. The purpose of this study was to investigate the distribution of nerves in the dental pulp of early extracted primary teeth,normal exfoliated teeth,partially-erupted,nonfunctional,premolars,and erupted,functional,premolars.Numbers of sample were 10 teeth in each group. The distribution of nerves in the dental pulp were investigated by means of immunohistochemistry for detection of neurofilament protein(NFP). The results were as follows: The early extracted primary teeth exhibited patterns of innervation similar to those observed for young permanent teeth.The plexiform arrangement of fibers was not evident in the primary teeth.Most nerves appear to terminate about the odontoblasts. As primary teeth began to undergo root resorption,degenerative changes such as vesicles and fragmentation appear in nerves.The quantity of neural tissue also decreased.In teeth in which the roots were almost completely resorbed only a small number of nerves remain. There was a decrease in the number of terminal branches in the pulp of the partiallyerupted,nonfunctional,premolars and those present reached the pulpo-odontoblastic border. The nerve terminals in the pulp of the erupted,functional,premolars were traced to the dentinal tubule and a few nerve fibers formed loops in the predentin.

Al/P-Si MIS型 太陽電池의 製作과 그 特性에 관한 硏究

金載文,安永奉,崔世崑 嶺南大學校 工業技術硏究所 1985 연구보고 Vol.13 No.1

The Al/P-Si MIS solar cells were fabricated by vacuum evaporation method. The interfacial oxide layer was grown by ramp heating for 5 minutes. Thin Aluminum film was deposited on the chemically etched (100) surface of a single sillcon crystal by vacuum evaporation. The solar cells showed good rectification properties which have the built-in potential of 0.76V and the quality factor of 1.6 under dark condition. The cells indicated that the open circuit voltage, short circuit photocurrent density, fill factor and energy conversion efficiency were 0.53V, 35mA/㎠, 0.62 and 12.4%, respectively, under 98mw/㎠ tungsten halogen lamp irradiation.

퍼지 제어기를 이용한 브러시리스 직류전동기의 속도 제어에 관한 연구

김선욱,김재문,김연충,이상석,원충연 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.2

This paper deals with the speed control of a BLDCM with rectangular back electromotive force using fuzzy logic controller. The fuzzy PI controllers make the many degrees of freedom in proportion to the number of the rule for input and its ability of adjustment for control input is excellent. Thus, the proper adjustment of the fuzzy rules can provide the good performance for the system. Above all, the advantage of the fuzzy controller has the characteristic of robustness for parameter variation, load change, noises. As a current controller, a hysterisis current controller is implemented, and in order to reduce torque ripple in low speed range, current controller detects the uncommutating mode current for every 60 electrical degree. The fuzzy speed controller is implemented by MCS80C196KC, a 16 bit one-chip microprocessor. The experimental results show that the performance of the fuzzy speed controller is superior to that of the conventional PI controller in terms of robustness for the change of load torque.

퍼지모델링을 이용한 저속비대선의 선미형상 주요치수 결정

김수영,김현철,정성재,하문근,안당,신수철 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

본 연구에서는 유전자 알고리즘을 적용한 퍼지모델링 기법을 이용하여 저속비대선에서 선미형상의 주요치수를 결정하고, 이를 실적선과 비교하였다. . This paper presents a method that determines the stern profile dimensions for full, slow-speed ship using fuzzy modeling, applied the genetic algorithm and compares with the database of ships

전압형 인버터에 의한 直流 스폿鎔接器의 定電力制御에 關한 硏究

김재문,김학성,박성수,원충연,김덕헌 成均館大學校 科學技術硏究所 1996 論文集 Vol.47 No.1

In recent years, there is increasing interests in spot welder with industrial growth of automobile. It makes autowelding and short-time welding possible. Conventional spot welders using AC source bring about the depreciation of welding products, because constant current control makes its workpiece spattered during welding process. In this paper, the constant power control strategy using PI controller is proposed to improve the quality of the welding products. PI controller is implemented by l6bit one chip 80C196KB microcontroller. Simulation and experimental results show that DC spot welder with single phase PWM inverter is effectively controlled by the constant power control method in very short-time.