Effect of Dietary Habits on Alzheimer’s Disease Progression

최성혜,민양기,안소현,정지향,박경원,김은주,윤수진,윤보라,장재원 연세대학교의과대학 2024 Yonsei medical journal Vol.65 No.4

Purpose: Research on the relationship between diet and dementia among Koreans are lacking. This study investigated the asso ciation between dietary habits and dementia progression over 3 years in patients with Alzheimer’s disease dementia (ADD). Materials and Methods: This study included 705 patients with mild-to-moderate ADD. Dietary habits were assessed using the Mini Dietary Assessment Index, comprising 10 questions. Outcome measures included the Clinical Dementia Rating scale-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living, Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), and neuropsychological test battery (NTB) z-scores, which were evaluated annually over 3 years. Results: In Q10 (eat all food evenly without being picky), the 3-year mean differences in CDR-SB (increases in scores represent worsening) compared to the “rarely” group were -1.86 [95% confidence interval (CI)=-3.64 – -0.09, p=0.039] for the “usually” group and -2.23 (95% CI=-4.40 – -0.06, p=0.044) for the “always” group. In Q7 (add salt or soy sauce to food when eating), the 3-year mean differences in CDR-SB compared to the “always” group were -2.47 (95% CI=-4.70 – -0.24, p=0.030) for the “usually” group and -3.16 (95% CI=-5.36 – -0.96, p=0.005) for the “rarely” group. The “rarely” and “usually” groups in Q7 showed significantly less decline in NTB z-score and CGA-NPI compared to the “always” group. Conclusion: Eating a balanced diet and reducing salt intake were associated with a slower decline in dementia severity, cogni tion, and behavioral alterations in patients with ADD.

단축형 Samsung Dementia Questionnaire (S-SDQ)의 개발과 타당도 평가

최성혜,나덕렬,오경미,박병주 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

혈관성 치매에서의 간단한 인지기능 평가 방법

최성혜 대한뇌졸중학회 2000 Journal of stroke Vol.2 No.2

혈관성치매에는 여러 아유형(subtype)이 있다. 그 중의 하나로서 Multi-infarct dementia는 territory infarction이 반복되어 발생하는 혈관성 치매이다[1]. 따라서 territory infarction의 위치에 따라 다양하게 나타나고‘patch’한 임상 양상을 보인다[2]. 연구자들은 단일 뇌경색으로도 치매가 발생할 수 있음을 보고하였고 이를 Single strategic infarct dementia라 명명하였다[3]. Single strategic infarct dementia도 뇌손상 부위에 따른 각기 독특한 임상 양상을 보인다[2]. 이에 비해 subcortical vascular dementia (VaD)는 기전, 뇌손상의 부위, 그리고 임상양상에 비교적 동질성을 보인다. Small vessel disease로 인하여 lacunar infarcts (lacunar state)과 ischemic white matter lesions (Binswanger type)이 발생하여 신경심리학적으로 집행기능(executive function)의 이상과 기억력 저하를 가져온다[4]. 일본에서 연구된 자료를 보면 혈관 성치매 환자 중 subcortical VaD가 5 2 %로 가장 흔한 아유형이었다[5]. 우리 나라에서 혈관성치매의 아유형별로 분포가 조사된 역학 자료는 없지만 일본과 유사하리라 판단된다. 따라서 본 글에서는 혈관성 치매의 한 아유형인 subcortical VaD에 초점을 맞추려 한다. Korean Journal of Stroke 2000;2(2): 126~130

소형무장헬기 탑재 표적획득추적장비의 표적좌표 성능개선

최성혜,윤시영,김미정,김병훈 한국항공우주학회 2013 한국항공우주학회 학술발표회 논문집 Vol.2013 No.4

소형무장헬기와 같은 공격형헬기의 표적획득 추적장비는 공대공 또는 공대지 공격을 위해 목표물의 정밀한 좌표를 제공하는 것이 중요하다. 본 논문에서는 기존의 전자광학장비가 적용했던 체계 GPS/INS로 헬기자세를 보상하여 표적시선을 측정하는 방법과 최신장비에 적용되고 있는 내부김발에 IMU를 장착하여 표적시선을 직접 측정하는 방법의 오차모델을 비교하여 표적좌표 정확도의 개선정도를 확인하였다. The TADS(Target Aquisition and Designation System) mounted on the Light Armed Helicopter have to provide precise target locations to the Command & Control System. The existing EO/IR system calculated the target location using the target LOS(line of sight) that is obtained by gimbal angles for body axis and helicopter attitudes received from the platform GPS/INS. In the latest system, the target LOS directly is measured by on-gimbal IMU. In this paper, we analysis the target location error models of these systems and compare their performances.

ICAI에서 구조화된 퍼지 학습 모델

최성혜,김강 한국컴퓨터정보학회 1998 韓國컴퓨터情報學會論文誌 Vol.3 No.3

치매환자들의 운전실태: 노인성치매임상연구센터 연구

최성혜,이지욱,김수정,최준용,권지원,윤병남,김종헌,윤보라,양영순,김상윤,정지향 대한치매학회 2014 Dementia and Neurocognitive Disorders Vol.13 No.4

Background: There are few studies about driving and dementia in Korea. The purpose of this study is to investigate the real condition of automobile driving in patients with dementia and the characteristics of those who continue to drive after diagnosis of dementia. Methods: A total of 4,377 patients including 3,792 with Alzheimer’s disease and 585 with vascular dementia were recruited from multiple nationwide hospitals. Clinical evaluations and neuropsychological tests were done in them according to the protocol of the Clinical Research Center for Dementia of South Korea study. Caregivers replied which patients drove an automobile, gave up driving, or has never driven. The same evaluations of them were followed after one year. Results: There were 272 (6.2%) drivers, 321 (7.3%) ex-drivers, and 3,784 (86.5%) non-drivers with dementia. Drivers with dementia were younger and had higher Korean Mini-Mental State Examination (K-MMSE) (21.5±4.3 vs 19.8±5.1 vs 17.4±5.2, p<0.001) and lower Clinical Dementia Rating scale-Sum of Boxes (CDR-SB) scores (4.08±2.15 vs 5.80±3.41 vs 5.83±3.39, p<0.001) compared with ex-drivers and non-drivers with dementia. The drivers and ex-drivers with dementia had higher educational level and a higher proportion of male compared with non-drivers with dementia (77.6% vs 80.1% vs 23.3%, p<0.001). About 54.6% of the drivers with dementia continued to drive at one year after diagnosis of dementia. They had higher K-MMSE (23.2±3.6 vs 20.8±4.5, p=0.003) and lower CDR-SB scores (3.30±1.47 vs 4.40±1.85, p=0.001) at baseline compared with those who quitted driving after baseline. Conclusions: Male patients who were relatively young and had high educational level and mild dementia had a tendency to drive an automobile at that time of diagnosis of dementia. About half of them continued to drive after diagnosis of dementia.

운동신경원성 질환을 동반한 전측두엽 치매 1례

최성혜,나덕렬,김병준,이정일,서연림,김상은 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

Samsung Dementia Questionnaire의 타당도와 신뢰도 평가

최성혜,나덕렬,강연욱,이원용,박병주 대한신경과학회 1998 대한신경과학회지 Vol.16 No.3

한국판 Global Deterioration Scale의 타당도

최성혜,나덕렬,이병화,함동석,정지향,정용,구은정,하충건,안성신 대한신경과학회 2002 대한신경과학회지 Vol.20 No.6

뷰티교육종사자의 전문성인식이 직무만족도 및 직무열의에 미치는 영향

최성혜,박성연,황혜주 한국인체미용예술학회 2020 한국인체미용예술학회지 Vol.21 No.4

This study attempted to investigate the effects of perception of professionalism on job satisfaction and job engagement against cosmetology instructors. The goal is to enhance the efficiency of human resources management by increasing job satisfaction and job engagement. For this, an online questionnaire survey was performed against cosmetology instructors from across the country from May 1 to Jun 4, 2020 (33 days), and a total of 424 copies were used for final analysis. The collected data were analyzed by frequency analysis, factor analysis, correlation analysis and multiple regression analysis, using SPSS 23.0, and the results found the followings: First, according to analysis of correlations among perception of professionalism, job satisfaction and job engagement, all sub-factors of the perception of professionalism revealed a statistically significant correlation with job satisfaction and job engagement factors. In addition, job satisfaction and job engagement factors were correlated to each other with statistical significance. Second, in terms of the influence of perception of professionalism on job satisfaction, all sub-factors of perception of professionalism had an effect on teaching profession consciousness and development. Third, regarding the influence of perception of professionalism on job engagement, ‘social status and competence’, ‘social service’, ‘systematic instruction’ and ‘code of ethics’ affected all sub-factors of job engagement. Fourth, concerning the effects of job satisfaction on job engagement, ‘innovation’, ‘autonomy’ and ‘teaching profession consciousness’ had an influence on ‘devotion’ and ‘commitment’. All sub-factors of job satisfaction affected ‘vitality’. It is anticipated that the study results would help cosmetology instructors build self-confidence through perception of professionalism and provide basic data for high-quality educational services by enhancing job satisfaction and engagement.