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이애영,손은희,김태우 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1
Background: Cerebral white matter changes can be observed frequently in Alzheimer′s disease or healthy elderly as well as vascular dementia the clinical significance and injury mechanism of cerebral white matter changes have not been clarified Objectives: To evaluate the significance of cerebral white matter changes in elderly patients Methods: We assessed cognitive function and radiological features in patients with white matter changes to evaluate the effect of cerebral white matter changes and cortical central brain atrophy on cognition Grading of white matter changes was measured by the Scheltens scale The cortical atrophy was graded with visual inspection by two independent neurologists and the central atrophy was assessed with ventricular indices The cognitive status was evaluated with Mini-Mental state examination and the modified Mini-mental State examination Results: Identified risk factors for white matter changes were older age, hypertension, and female gender The degree of cerebral white matter changes was significantly associated with cognitive disturbances and their main effect on cognition was fluency and attention deficits There was no difference in the severity of cortical atrophy between the two groups Visual rating for cortical atrophy and measurement of ventricular indices showed good intra-and -observer reliability Conclusion: Our results support the hypothesis that cerebral white matter changes contribute to cognitive disturbances, especially frontal lobe dysfunctions in elderly irrespective of cortical brain atrophy.
이애영,노민수 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7
Abnormal pigmentation, particularly hyperpigmentation,is major issue of concern for people with coloredskin. Several hypopigmenting agents, which exert theiraction by inhibiting tyrosinase activity and/or transcription,have been used for treatment. However, results have beendiscouraging. To manage abnormal pigmentation properly,the mechanisms of melanogenesis should be understood. Endogenous and exogenous factors affect melanogenesis viaintracellular machineries.cAMP and PKC are critical factorsof important transduction pathways and cross-talk betweenthem could amplify the melanogenic effect. Here, factorsinvolved in melanogenesis regulation via cAMP and/or PKCpathways are reviewed with their action mechanisms.
이애영,이유신 대한천식알레르기학회 1989 천식 및 알레르기 Vol.9 No.3
Fixed drug eruption is characterized by the recurrence of the same lesions on the previously affected sites after exposure to the causative drugs. The hyperpigmentation of various degrees and durations is usually remained in the affected sites, therefore diagnosis of this disease is easy. The pathogenesis of fixed drug eruption has remained to be clear. However, there were several reports, which used patch test for the diagnosis of fixed drug eruption and detected to the causative drugs. The aim of this study was to know whether patch test was useful for the detection of causative drugs in fixed drug eruption. Patch test was applied to 10 patients of fixed drug eruption. The results were as follows. In patch tests, 6 cases showed erythema, infiltration, and subjective symptoms. One case reacted as erythema and itching, 3 cases as only subjective symptoms. These results of patch tests were confirmed by oral provocation tests in 7 patients.
서울신경심리검사-단축형의 지역사회 치매 관리 사업 인지평가도구로써 효용성
이애영,이주연,오응석,윤수진,윤보라,유성동 대한신경과학회 2019 대한신경과학회지 Vol.37 No.3
Background: The increasing number of dementia patients is increasing the importance of identifying them and also those at a high risk of dementia. The early diagnosis and management of dementia can slow the progression of the disease and reduce the socioeconomic burden. For these purposes, the Local Dementia Centers established in all regions of Korea are working on the early detection of dementia using neuropsychological batteries. This study investigated the utility of the Seoul Neuropsychological Screening Battery-Core (SNSB-C) in a dementia management project performed in the local community. Methods: This study was conducted in two parts. The first part used data from the Local Dementia Centers to investigate the accuracy of detecting cognitive impairment in SNSB-C compared with the Seoul Neuropsychological Screening Battery-Second Edition (SNSB-II). The second part of this study which data from hospital examined the accuracy of diagnosing dementia using SNSB-C. Results: Data were collected from 508 participants at the Local Dementia Centers in Daejeon and 50 participants at a hospital. SNSB-C had a high sensitivity and specificity for detecting cognitive impairment, and also a high sensitivity, high specificity, and positive predictive value for diagnosing dementia. Conclusions: The sensitivity in diagnosing dementia was as high for SNSB-C as for SNSB-II while taking less time. SNSB-C could therefore be a good diagnostic evaluation tool for use in local dementia centers.
치매환자에서 acetyl-L-carnitine (nicetile^�)의 임상적 효능 및 안전성에 관한 연구
이애영,김재문 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2
Background and Objectives : The increasing number of dementia patient in our society is a problematic due to the burden for families and social services. There is no cure for the degenerative dementia or vascular dementia resulting from stroke so far. Recently, Acetyl -L-carnitine (ALC) has been proved to improve learning and memory abilities in aging rats. To verify the clinical efficacy and safety of ALC for the patients with dementia, we evaluated 20 stroke-related dementia patients and 4 patients with the dementia of Alzheimer's type by using various neuropsychological assessments. Methods : All patients were assessed before taking the ALC with structured neuropsychological battery for determining their initial cognitive status. The drug was given orally with the dose of 500 mg b.i.d for longer than 6 months. Since then, clinical and neuropsychological re-evaluations were performed and checked out any side effects related with medication. Results : 1) The mean duration of medication was 246.8±61.4 days 2) The multi-infarct dementia was the most common type of vascular dementia 3) After six months of medication, 9 of 14 tests on the cognitive functions were improved in the patients with vascular dementia 4) There was no serious clinical or laboratory side effects related with ALC. Conclusion : ALC can be effective and safe agent for cognitive improvement in patients with vascular dementia via a cholinergic and oxidative brain metabolism.