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서울신경심리검사-단축형의 지역사회 치매 관리 사업 인지평가도구로써 효용성
이애영,이주연,오응석,윤수진,윤보라,유성동 대한신경과학회 2019 대한신경과학회지 Vol.37 No.3
Background: The increasing number of dementia patients is increasing the importance of identifying them and also those at a high risk of dementia. The early diagnosis and management of dementia can slow the progression of the disease and reduce the socioeconomic burden. For these purposes, the Local Dementia Centers established in all regions of Korea are working on the early detection of dementia using neuropsychological batteries. This study investigated the utility of the Seoul Neuropsychological Screening Battery-Core (SNSB-C) in a dementia management project performed in the local community. Methods: This study was conducted in two parts. The first part used data from the Local Dementia Centers to investigate the accuracy of detecting cognitive impairment in SNSB-C compared with the Seoul Neuropsychological Screening Battery-Second Edition (SNSB-II). The second part of this study which data from hospital examined the accuracy of diagnosing dementia using SNSB-C. Results: Data were collected from 508 participants at the Local Dementia Centers in Daejeon and 50 participants at a hospital. SNSB-C had a high sensitivity and specificity for detecting cognitive impairment, and also a high sensitivity, high specificity, and positive predictive value for diagnosing dementia. Conclusions: The sensitivity in diagnosing dementia was as high for SNSB-C as for SNSB-II while taking less time. SNSB-C could therefore be a good diagnostic evaluation tool for use in local dementia centers.
이애영 대한신경과학회 2011 대한신경과학회지 Vol.29 No.3
The essential components of metabolic syndrome are insulin resistance, obesity, hypertension, and dyslipidemia. It is difficult to estimate its prevalence because several definitions of metabolic syndrome are in use. Although the exact cause-effect relation between metabolic syndrome and dementia is still controversial, the incidence of dementia and Alzheimer disease is relatively higher in individuals with metabolic syndrome than in those without it, regardless of mechanism. The pathophysiology of hyperinsulinemia and insulin resistance is responsible for causing cognitive decline or dementia in the elderly people, and It seems to be attributable to cerebral hypoperfusion and excessive Aβ deposition in the brain by insulin. Therefore, therapeutic intervention by modulating Aβ deposition and cerebral perfusion might be helpful to prevent patients with metabolic syndrome from getting cognitive dysfunction or dementia.
객체지향 데이타베이스 스키마의 구조적 일관성 유지를 위한 스키마 진화 모델
이애영,이동하,이전영(Ae-Yeong Lee),Dong-Ha Lee,Jeon-Young Lee 한국정보과학회 1996 정보과학회논문지(B) Vol.23 No.10
본 논문에서는 객체지향 데이타베이스의 스키마 변동 연산시 발생하는 스키마의 구조적인 문제들을 총체적으로 해결하기 위한 기본 틀을 제안한다. 객체지향 스키마에 대한 정확한 이해가 부족한 상태에서의 스키마 변동연산은 데이타베이스의 상태에 문제점을 야기할 수 있다. 스키마 변동시에 상하위 클래스간에 IS-A 관계를 유지하는 것은 정확한 질의 모델을 정의하기 위해 매우 중요한 문제이지만 기존의 모델에서는 유지하지 못하는 경우가 있는 것이 일례이다. 본 논문에서는 클래스간의 서브타입 관계를 재정의하고 속성간의 연관성을 파악하기 위해 속성간의 의미적 연관성을 정의한다. 속성간의 의미적 연관성은 속성의 도메인과 이름 그리고 근원 관계를 이용하여 정의된다. 이를 바탕으로 상위클래스에 정의된 속성을 하위클래스에서 상세화해서 계승받을 때, 이들 속성간의 연관성을 유지시켜주는 근원 속성, 파생 속성, 속성 파생 계층(ADH: Attribute Derivation Hierarchy)등을 정의한다. 이러한 개념들을 종합하여 스키마의 구조적 일관성을 정의하였고, 이를 이용하여 스키마의 구조적 일관성을 유지하는 스키마 변동 연산을 정의하였다. It proposes the basic framework for structural problems of schema when schema changes in object-oriented database. Without concrete knowledge of object-oriented database schema, schema change may result in undesirable status of database. Although maintaining IS-A relationship between super-class and sub-class is very important for defining concrete query model but there are a few models support it. In this article, it defines the subtype relation between classes and defines a semantic relation between attributes. The semantic relation between attributes is defined by using attributes domains and their origins. The origin attributes, inherited attributes and attribute derivation hierarchy(ADH) are defined based upon the semantic relations and they are used to maintain the relationship between the inherited attributes and the origin attributes. On the view of synthesizing these concepts, it defines structural consistency of schema and the schema change operations to guarantee structural consistency in schema evolution.
Night Shift Work and Risk of Depression: Meta-analysis of Observational Studies
이애영,명승권,조정진,정유진,윤종률,김미영 대한의학회 2017 Journal of Korean medical science Vol.32 No.7
This study aimed to assess whether night shift work is associated with the risk of depression by using a meta-analysis of observational studies. We searched PubMed and EMBASE in August, 2016 to locate eligible studies and investigated the association between night shift work and the risk of depression, reporting outcome measures with adjusted odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CIs). In the meta-analysis of a total of 11 observational studies with 9 cross-sectional study, 1 longitudinal study, and 1 cohort study, night shift work was significantly associated with an increased risk of depression (OR/RR, 1.43; 95% CI, 1.24–1.64; I2 = 78.0%). Also, subgroup meta-analyses by gender, night shift work duration, type of occupation, continent, and type of publication showed that night shift work was consistently associated with the increased risk of depression. The current meta-analysis suggests that night shift work is associated with the increased risk of depression. However, further large prospective cohort studies are needed to confirm this association.