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함동석,곽용태,서미경,박기정,나덕렬 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
A 65-year-old left-handed man. following a total left MCA infarction, showed right hemineglect, visuospatial dysfunction, ideomotor apraxia, and Gerstmann syndrome without aphasia These findings suggest that cognitive functions of this patient have been reversely lateralized except for the dominant parietal lobe. We report this case because this atypical lateralization of cognitive function is very rare This patient also showed unusual agraphia that consisted of well-formed but meaningless letters This writing pattern may help understand the contribution of non-dominant parietal lobe to Hangul writing process.
Ham, Dong Suk,Shin, Yong Kyoo,Lee, Chung Soo 중앙대학교 의과대학 의과학연구소 1994 中央醫大誌 Vol.19 No.2
5-Hydroxytryptamin과 5-hydroxytryptophan은 마이크로조움과 미토콘드리아의 비효소성 지질 과산화를 억제한다고 제시되고 있으나, 이들의 항산화 작용기전은 밝혀지고 있지 않다. 본 연구에서는 Fe_2+ 단독 또는 Cu^2+와 H_2O_2에 의한 간 마이크로조움의 산화성 손상에 나타내는 5-hydroxytryptamine(5-HT)과 tryptophan의 효괄르 관찰하였다. 이들의 효과를 지질 과산화와 반응성 산소대사물에 대한 제거 작용으로써 조사하였다. Fe^2+ 단독 또는 Cu^2+와 H_2O_2에 의한 마이크로조움의 지질 과산화는 5-HT에 의하여 용량에 따라 뚜렷하게 억제되었으며 tryptophan에 의하여 억제되었다. Fe^2+에 의한 지질 과산화는 SOD, DABCO와 DETAPAC에 의하여 억제되었고 catalase, DMSO와 sodium formate에 의하여 약간 억제되었다. Cu^2+와 H_2O_2의 과산화 작용은 catalase와 DABCO에 의하여 억제되었고 sodium formate에 의하여 약간 억제되었으나 DMSO는 유의한 효과를 나타내지 않았다. Ferricytochrome c는 Fe^2+첨가에 따라 환원되었으며 이러한 환원은 SOD와 tryptophan에 의하여 효과적으로 억제되었다. Fe^2+ 단독 또는 xanthine과 xanthine oxidase의 존재하에서 OHㆍ생성은 5-HT, tryptophan과 DMSO에 의하여 억제되었다. 자외선 조사에 따른 ^1O_2의 생성은 DABCO에 의하여 억제되었으나 5-HT와 tryptophan의 영향은 받지 않았다. 이상의 결과로부터 5-HT와 tryptophan은 O^-ㆍ_2와 OHㆍ 같은 반응성 산소대사물과 아마도 산소-금속이온 복합체에 대한 제거 작용으로써 H_2O_2가 있거나 없는 상태에서 금속이온에 의한 지질 과산화를 포함한 산화성 조직손상을 억제할 것으로 추정된다. 5-Hydroxytrytamine and 5-hydroxytryptophan have been shown to inhibit nonenzymically induced-lipid peroxidations of microsomes and mitochondria. However, the antioxidant action mechanism of them has not been elucidated. In this study, effects of 5-hydroxytryptamine and tryptophan on the oxidative injury of liver microsomes caused by either Fe^+ alone or Cu^2+ and H_2O_2 were investigated. Their effects were studied with respect to lipid peroxidation and scavenging effect on reactive oxygen intermediates. Lipid peroxidation of microsomes induced by either Fe^2+ alone or Cu^2+ and H_2O_2 was remarkably inhibited by 5-HT and was inhibited by tryptophan in a dose dependent fashion. Fe^2+ - induced lipid peroxidation was inhibited by SOD, DABCO, DETAPAC and was slightly inhibited by catalase, DMSO and sodium formate. The proxidative action of Cu^2+ and H_2O_2 was inhibited by catalase and DABCO and was slightly inhibited by sodium formate, whereas DMSO did not show any significant effect. Ferricytochrome c was reduced by the addition of Fe^2+ and the reduction was effectively inhibited by SOD and tryptophan. OHㆍ production in the presence of either Fe^2+ alone or xanthine and xanthine oxidase was inhibited by 5-HT, tryptophan and DMSO. Production of ^1O_2 by U.V. irradiation, which is inhibited by DABCO, was not affected 5-HT and tryptophan. These results suggest that 5-HT and tryptophan may inhibit the oxidative tissue injury including lipid peroxidation induced by metal ion with or without H_2O_2 though scavenging action on reactive oxygen species, such as O^-ㆍ_2 and OHㆍ and probably oxygen-metal ion complexes.