최초 임상증상으로 볼부위의 종괴로 나타난 전이성 신세포암 : 증례보고

박용일,유지형,성락희,노충희,김현정,정재용 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

신세포암의 골격근으로의 전이는 매우 드문경우로 현재까지 약 20편정도의 증예 보고만이 있을뿐이다. 우리는 이 증례보고에서 매우 드문 경우인 최초 임상증상으로 볼부위의 종괴를 주소로 내원후 전이성 신세포암으로 진단받은 65세 남자의 증례와 전이성 신세포암이 골격근으로 전이된 경우의 문헌들을 리뷰하였다. 환자는 내원 3개월전 왼쪽 볼부위에 무통성 종괴가 있는것을 처음 인지하였다. 절제된 종괴의 병리학적 소견은 전이성 신세포암으로 나타났으며 영상의학검사상 좌측신장에 6x5㎝ 크기의 종괴를 보였고 양측 폐에 다수의 작은 결절들을 보였다. 환자는 근치적 신절제술을 받았으며 이후 폐전이에 대해 5-fluorouracil, interferon-a과 interleukin-2을 이용한 변역요법을 시행하였다. 이후 폐 전산화단층촬영상 암이 진행된 것으로 나타나 Sutene^(?)을 이용한 경구 표적요법을 시행중이다.

Pollen Viability of Common Buckwheat (Fagopyrum esculentum Moench.) in in vitro Germination and its Application to Male Gametophyte Isolation

Woo, Sun-HeeㆍKeun-Yook ChungㆍHeung-Tae, KimㆍYong-Gu, ChoㆍHong-Sig, KimㆍBeom-Heon, Songㆍ Chul-Won, Lee and Seung-Keun Jong 忠北大學校 農業科學硏究所 2004 農業科學硏究 Vol.21 No.-

-본문참고-

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

sfs유전자의 malE유전자 발현 촉진

정수열,이희영,최용락 東亞大學校附設遺傳工學硏究所 1995 遺傳工學硏究 Vol.- No.2

CRP에 변이가 도입된 crp*¹ 유전자를 통하여 cloning된 sfs(sugar fermentation stimulation)유전자 중 nlp와 sfs4 유전자가 maltose 및 maltodextrin의 운반에 관여하는 유전자들 중에서 MalE 단백질을 증가시킴을 immunoblotling을 통하여 확인했다. 즉 MalE 단백질은 periplasmic에 존재하면서 cytoplasmic membrane에 존재하는 MalFGK 단백질과 반응하여 cytoplasm내로 maltose, maltodextrin을 운반하는 MBP(maltose binding protein)로 밝혀져 있다. Most crp* mutants isolated so far were capable of fermenting lactose despite the absence of cAMP, however, they could ferment other sugar such as maltose in the presence of cAMP. nlp and sfs4 genes, which stimulated the maltose metabolism in a crp*¹, cya::km(MK2001) host system. Especially, MalE protein(malE gene: MBP: maltose binding protein), that is transport protein with maltose and maltodextrin in periplasmic, were increased in the cloned with nlp and sfs4 genes.

교사들의 공통과학 실험 · 실습 선호도 조사 분석

정원우,이윤종,강용희,윤일희,이우붕,손종경,김중욱,강동진,권용주 慶北大學校 師範大學 科學敎育硏究所 1999 科學敎育硏究誌 Vol.23 No.-

The purpose of this study is to investigate the status of the experimental and practical education in high school general science. The present status and reasonable management of the experimental and practical education in high school general science were evaluated by the questionaires. To do this, 146 science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of general science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.

저신장 소아에서 성장호르몬 치료가 두개안면필 성장에 미치는 영향

정성호,김진욱,박용훈,황충주,이희경 대한치과교정학회 2010 대한치과교정학회지 Vol.40 No.4

Objective: The purpose of this study was to analyze the effect of growth hormone treatment (GHT) on craniofacial growth in children of short stature. Methods: Nineteen untreated children of short stature were referred from the Pediatric Department, Yeungnam University Hospital as a subject group. All subjects had lateral cephalograms taken before, after 1 year and after 2 years of growth hormone treatment. As a reference group, we selected 19 normal children with paired sampling who matched the subjects' age and sex, from the Department of Orthodontics, Kyungpook National University Hospital. Results: Before GHT, anterior cranial base length and upper posterior facial height, posterior total facial height, mandibular ramus length, and mandibular corpus length were significantly smaller in the reference group. In angular craniofacial measurements, saddle angle and mandibular plane angle were larger. SNA and SNB were smaller in the reference group. After two years of GHT, growth hormone accelerated growth in several craniofacial components. The posterior total facial height, the anterior, posterior cranial base length, and the mandibular ramus length were increased. And the difference in mandibular plane angle and ANB values compared with the reference group was decreased. Conclusions: GHT over 2 years leads to a craniofacial catch-up growth tendency, which is pronounced in interstitial cartilage and condylar cartilage. 저신장이란 같은 연령 및 성별 소아들의 표준 신장 평균치에서 -2.0 SD 이하인 경우를 말한다. 본 연구의 목적은 저신장 소아의 두개안면골격의 특성을 분석하고, 성장호르몬 치료가 신장을 성장시킴과 동시에 두개안면골격에 어떤 영향을 주는지 알아보고자 함이다. 영남대학교 의과대학 부속병원 소아청소년과에서 저신장으로 진단받은 소아를 대상으로 성장 호르몬 치료 전 그리고 치료 후 1년, 2년 후 총 3회 측모 두부 방사선 규격 사진의 촬영을 시행하였다. 대조군은 경북대학교 치의학전문대학원 교정과에 소장된 한국인 평균 신장의 2 표준오차 내의 아동들을 대상으로 측모 두부 방사선 규격사진을 2년마다 10년간 촬영한 자료를 이용하여 저신장 소아의 연령과 성별을 기준으로 짝진 표집(paired sampling)을 하였다. 성장 호르몬 치료 전 저신장 소아는 작고 후퇴된 하악골과 편평한 두개저를 가지는 것으로 나타났다. 성장 호르몬 치료 후 anterior, posterior cranial base length, upper posterior facial height, lower anterior facial height, posterior total facial height, mandibular ramus length, mandibular corpus length와 overall mandibular length 성장량이 정상군에서의 2년 성장량과 비교했을 때 유의하게 큰 것으로 나타났으며 각도 계측에서는 saddle angle, mandibular plane angle과 ANB변화량이 정상군에서의 2년 성장량과 비교했을 때 큰 변화를 보이며 정상군의 평균치를 따라잡는 경향을 보였다. 성장 호르몬 치료는 불균형적인 성장의 징후 없이 정상화를 향한 성장(따라잡기 성장)을 나타내었으며 이는 특히 하악과두의 성장과 후안면고경의 성장을 촉진시켜 저신장 소아의 convex 한 profile을 완화하는 것으로 판단된다.

中共의 政治性向

鄭然植,尹龍熙 慶北大學校 東洋文化硏究所 1978 東洋文化硏究 Vol.5 No.-

Since Chinese vice Premier Teng Hsiao-pin recovered his power there has been Much change in chinese political sphere such as domestic affairs, economics, military, culture and foreign relations as well. Therefore this paper aims at trying to figure out an inclination of recent Chinese politics and to examin how does inclination effect the relation-ship with the major powers surounding Korean peninsular. Untill the mid 1970's Mao's teaching had been a only dominant doctrine in the field of Chinese political ideology but recently it shows us some symptoms of reassessment of Mao's thought under the Hua ana Teng's leadership. Therefore the theoretical basis of Sino-Soviet dispute lanunched by Khrushchev's destalinization and peaceful coexistence will be gradually discolored by it's pragmatic professionalism which inclined to bring industrialization and modernization to china. In the economic aspect china has blaimed foreign investment as a comparador capital during more than two decades. Now they are willing to accept foreign investment and technical co-operation program from western countries including U.S. and Japan for the fulfilment of their recent modernization program While China defines Russia as a main enemy she is willing to maintain reliable relationship with U.S. and to have technical assistance of nuclear power and highly developed electronic equipment for modernization of their military. Thus Chinese political inclination has effected role of the major powers. In other words China needed to promote relation with U.S., Japan and Western European countries and U.S.-Sino relation stimulated Japan to normalize relation with China. During this process Russia has maid enormous efforts to hinder the normalization of Sino-Japan relation and Russia on the other hand presented favourable attitude to the Taiwan and South Korea. It means there has been a Keen competition among Major powers and China more likely to promote relations with U.S. Japan and western European countries in the near future.

발단 단계별로 분할한 생쥐 수정란에 Rat H-Y 항체 처리가 분할란의 발달에 미치는 영향

정장용,박희성,문승식,박성진 진주산업대학교 1993 論文集 Vol.32 No.-

This experiment was carried out to develop a new technique of identifying XX or XY-bearing bisected embryos prior to implantation by immunological method. H-Y antiserum prepared in inbred Wistar female rats by repeated immunization with spleen cells from males of the same strain. The reactivity of H-Y antibody was confirmed by culturing mouse embryos in the medium containing H-Y antiserum and complement obtained from the guinea pig. The optimal condition for the activity of H-Y antibody was also investigated by culturing embryos under the concentration or affected H-Y antibody and culture rate. The bisection rate of mouse embryo at 4-cell stage(64.6%) was significantly(P<0.05) low than 8-cell(76.0%), morula(81.2%) or blastocyst(81.3%). And not significantly(P<0.05) different from 4 to 8-cell and morula to blastocyst stage embryos. When the bisected embryos without any damage from microsurgery were cultured in vitro up to twin blastocyst or twin reformated blastocyst, the in vitro development of demi-embryos bisected at morula to blastocyst was 81.6 to 84.7%. However, the in vitro development of demi-embryos bisected at 4-cell(31.6%) to 8-cell(37.8%) stage was significantly(P<0.05) lower. The lysis-rate of bisected 4- to 8-cell and morula to blastocyst embryo was 42.7 and 58.6%. The morphology embryos of zona-free and intact embryos showed the embryos lysis rate of 48.5 and 42.7% respectively(P<0.05).

고등학교 지구과학 실험·실습 요목 비교 분석

정원우,이윤종,기우항,김영호,양승영,강용희,안병호,임성규,윤일희,김중욱,윤성효,강동진 경북대학교 과학교육연구소 1997 科學敎育硏究誌 Vol.21 No.-

The purpose of this study is to investigate the status of the experimental and practical education in high school earth. The present status and reasonable management of the experimental and practical education in high school earth science have been grasped from the questionaires. To do this, eighty eight earth science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of earth science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.

Stevia의 抗糖尿病效果에 關한 硏究

丁明鉉,金永洙,文永熙,李明烈 朝鮮大學校 1981 藥學硏究誌 Vol.4 No.1

This study was enforced to investigate the antidiabetic action of Stevia Ex. and stevioside on Alloxan diabetes. The blood sugar, blood urea nitrogen, glutamic oxaloacetic transaminase and cholesterol level were measured in this study. The results were as follows; 1) Stevia Ex. and stevioside increased the blood sugar levels' slightly in normal rat, but they were not significant except stevioside 300㎎ group. 2) Stevia Ex. and stevioside restrained the blood sugar levels in proportion to the sample amount in Alloxan diabetes. Especially stevioside 300㎎ group showed very excellent antidiabetic effects. 3) Stevia Ex. and stevioside decreased the serum G.O.T. levelsincreased by Alloxan. 4) Serum total cholesterol levels were convereted near to the normal value by Stevia Ex. and stevioside in Alloxan diabetes. 5) But B.U.N. levels were not influenced by Stevia Ex. and stoviosdie in Alloxan diabetes.