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신은경,김동운,김유은,나건,이기영 全南大學校 觸媒硏究所 1998 觸媒硏究 論文集 Vol.20 No.-
In this study, we prepared biodegradable polysaccharide films with pullulan, κ-carrageenan, curdlan and chitosan and measured physical properties and antibacterial activity All of polysaccharide films showed the high biodegradability but antibacterial activity on bacteria was only observed at chitosan film. The permeability of the gas(O₂and C0₂) of polysaccharide films besides chitosan film showed 50∼100 times lower than polyethylene(PE) film. Therefore, we prepared two film types to give low gas permeability and antibacterial property at polysaccharide film : one type was the physically mixed film(k-carrageenan +chitosan) and other type was the chitosan coated κ-carrageenan film. Chitosan coated κ-carrageenan film showed low gas permeability and antibacterial activity.
송효경,신유주 가톨릭대학교 자연과학연구소 2003 자연과학논문집 Vol.24 No.-
새로운 비양론적 페로브스카이트(perovskite) 전이금속 산화물 Li_(0.33)Sr_(0.34+x)Sc_(x)Nb_(1-x)O₃, Li_(0.33)Sr_(0.34+x-y)Sc_(x)La_(y)Ta_(1-x)O₃을 고체 합성법으로 고온합성 하였다. 이들은 모두 정방형 구조를 갖고 있으며, 조성에 따라 단위세포와 A-자리 공극의 농도 및 공유결합성의 변화를 보여준다. 이들의 이온전도도는 300-770K 영역에서 AC-impedence 측정법으로 측정되었다. 이들이 상온 전도도는 10^(-5)Scm^(-1)정도를 나타내었고, 온도가 증가하면서 10^(-2)Scm^(-1)정도까지 증가하였다. 이러한 전도도의 변화는 화학결합 특성, 공극율 및 단위세포의 크기와 연관지어 이해할 수 있었다. New non-stoichiomtric perovskite oxides Li_(0.33)Sr_(0.34+x)Sc_(x)Nb(1-x)O₃ and Li_(0.33)Sr_(0.34+x-y)Sc_(x)La_(y)-Ta(1-x)O₃ were directly prepared by solid-state thermal reaction. As prepared samples show the simple cubic structure and a small variation of lattice parameter, the vacancy concentraticn and bond character with the composition. The ionic conductivity were determined around 10^(-5) Scm^(-1) near room temperature but increased up to 10^(-2) Scm^(-1) with temperature. The conductivity behavior has been discussed in relation with the variation of chemical bonding, the vacancy concentration and the effective volume of unit-cell of the lattice.
산발성 장형 위선암 환자의 Microsatellite Instability와 병리학적 양상
조창희,홍유찬,안지현,최경현,이상호,신영명,윤기영,정민정,장희경 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
Background : Through many researches, microsatellite is expected to be a good diagnositic and prognostic factor in colorectal cancer, endometrial cancer, gastric cancer, and the others. The prevalence of microsatellite instability (MSI) in gastric carcinoma has reported variously, 13~44%. Purpose : We aimed to determine the prevalence of MSI-high and the relationship between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma of stomach. Material and Methods : We analyzed 106 sporadic intestinal type adenocarcinoma specimens excised from patients who were over thirty-five years old to determine the statue of microsatellite by DNA sequencing. The tissues were formalin-fixed and paraffin embedded. DNA were extracted and amplified by polymerase chain reaction (PCR). MSI was determined using five markers recommended by National Cancer Institute (NCI). Specimens were also studied with five patholical factors-differenciation of tumor cells, depth of invasion, lymph node metastasis, vessel invasion, and perineural invasion- to determine pathological state. Result : The microsatellite statue was determined as MSI-High in 5 cases (4.7%), no MSI-low, and MSS (microsatellite stable) in 101 cases (95.3%). Within the frequency, there was no large gap in the distinction of gender in MSI cases, but in MSS cases, there was three-times more cases in male. MSI cases had moderate-to-poor differenciation and trend to invade toward serosa. All MSI cases showed no perineural invasion. But we could not find any statistical significance between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma. Conclusion : Results suggest that MSI can not make any certain pathological significance in sporadic intestinal type adenocarcinoma. Even though less than 5% of sporadic intestinal type adenocarcinoma patients showed MSI, it can be used as a influential prediagnostic factor of gastric cancer. Further study with large scale of cases will be followed to verify these results.
녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험
장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3
목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.
최윤정;박유신;장유경 한양대학교 2004 韓國 生活 科學 硏究 Vol.- No.24
This study was carried out to investigated the growth development and nutritional health of poorly-fed children in Seoul Welfare Center. All subjects underwent a structured interview for general characteristics, anthropometric measurement and nutritional status. The results are as follows : The subjects were 30(male : 14, female : 16), among 7 to 12 years old. In higher grade boy, physical growth and development were decreased. Among the subjects, 37.7% were skipped the breakfast. In food group frequencies, subjects had animal protein such as meats(82.1%), fish(58.6%), and vegetable protein such as legumes(73.3%) 2 times and less a week. The average intakes of energy, vitamin B2, calcium were below 75% of the recommended dietary allowance. More than half of the subjects were under-nutrition (deficient of RDA, below 75%) in energy, vitamin A, vitamin B2, niacin, calcium and iron. Consequently, for balanced growth and development, it is necessary for school or community based nutritional support to supply dairy products that are major source of vitamin B2 and calcium for poorly-fed children.