Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

ATM망 트래픽 제어 알고리즘 연구

유진호,손준영,안재환,박성우,김명수,장혁수 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

ATM(Asynchronous Transfer Mode) is a transmission technique for the B-lSDN(Broadband Integrated Service Digital Network). Congestion problems are unavoidable in the ATM networks, since various traffic typos coexist in the networks. The preventive congestion control algorithm is widely used for the real time traffics such as voice and video. The reactive congestion control algorithm works well for the non-real time traffic within a short distance. A mixed traffic control algorithm is proposed, which works either preventively or reactively based on traffic types. The proposed algorithm sets a high and low threshold value at the output buffers and modifies the EPRCA(Enhanced Proportion Rate Control Algorithm) to control loss-sensitive cells. Delay-sensitive cells are handled by the priority control and the UPC(Usage Parameter Control) algorithm. The performance analysis shows that the proposed traffic control algorithm works well for both the VBR(Variab1e Bit Rate) and ABR(Available Bit Rate) traffic with small buffers

본태성 고혈압환자의 순응도에 관한 연구 IV : 의사개입과 제도개선의 합동효과 Effect of Combined Strategies Provided by Physician and Insurance

유원상,김용균,김준희,최석구,전영빈 인제대학교 1991 仁濟醫學 Vol.12 No.1

본태성 고혈압환자의 순응도 제고를 위하여 채택한 방책중 의사의 단독개입만으로는 13%의 통원탈락율의 개선, 보험급여 제도의 일부개선만으로는 3%의 악화에 비하여 양자 합동으로는 17%의 개선효과를 보았다. 따라서 진료의사의 좀 더 적극적인 개입과 보험급여의 진료일수제한 철폐가 요망된다. One hundred patients with essential hypertension, consecutively and newly diagnosed, were followed up at hypertension clinic of Paik Hospital to evaluate their compliance for 12 months with combination strategies provided by physician's intervention and extended insurance coverage. Rate of drop-out from reserved visit to clinic were 23% at the end of 3 months, 52% at the end of 12 month, which showed decrease, compared with 26%, and 63% respectively of ordinary management. In conclusion, in order to improve patient's compliance, a positive intervention by physician as well as lifting of insurance limitation should be intensified drastically.

주상골 골절에서 Herbert/Whipple 나사못의 바람직한 위치 : 모형연구 A Model Study

유재두,김종오,윤여헌,고영도,배서영,이정준 대한골절학회 2002 대한골절학회지 Vol.15 No.4

목 적 : 주상골 골절 치료에 사용하는 Herbert/Whipple 나사못의 바람직한 삽입 위치를 알아보고자 하였다. 대상 및 방법 : 4개의 사체에서 분리한 주상골을 이용하여 각 주상골마다 12개씩 주물 모형을 제작하여 대상으로 하였다. 각 모형에서 핀 삽입 안내 장치(jig, Zimmer??)를 이용하여 안내핀(guide wire)을 원위부에서 근위부를 향해 삽입하되 원위부에 A, B, C, D의 4개 근위부에 0, 5, 10의 3개의 지점을 설정하여 총 12가지 방법으로 삽입하였다. 각 모형은 주상골의 장축에 직각인 방향으로 근위부, 요부, 원위부의 세 단면을 만들고 핀 삽입의 흔적과 가장 가까운 피질골 표면과의 거리를 측정하여 이 거리가 대적으로 길 때 안전한 것으로 평가 하였다. 결 과 : 핀 삽입의 흔적과 가장 가까운 표면과의 거리가 근위부에서는 D5, 원위부에서는 C10이 유의하게 길었다. 원위 삽입 위치를 기준으로 하였을 때 근위부에서 C가 유의하게 거리가 길었고 요부, 원위부, 그리고 근위 목표 지점을 기준으로 하였을 때의 측정된 거리는 유의한 차이가 없었다. 결 론 : Herbert/Whipple 나사못의 삽입 위치는 근위부 골절에서는 D5군, 원위부 골절에서는 C5군이 가장 바람직한 위치라고 할 수 있엇고 요부 골절에서는 A0군과 D0군을 제외하면 별 다른 차이 없이 비교적 안전하다고 할 수 있다. 바람직한 위치 선정을 위해서는 근위부의 목표지점보다 원위부의 지점을 정확히 하는 것이 중요하다고 사료된다. Purpose : To evaluate optimal placement of the Herbert/Whipple screw in scaphoid fracture Materials and Methods: Forty eight model molded from four cadaver scaphoids were used for this study. Using the Herbert/Whipple jig, the guide wire was placed distal to proximal into each scaphoid with twelve method which were four entry points and three target points. Guide wire placement was then evaluated with three planes in the proximal, middle, distal planes and distance from the nearest cortex. Results : The most concentric position in the proximal plane was D5, in the middle plane C10. As distal entry point, the most concentric position in proximal plane was C. There were no statistical concentric, as middle, distal plane, and proximal entry point, Conclusion : The most ideal placement were D5 in proximal fractures of the scaphoid, C5 in distal fractures. In waist fractures of the scaphoid, there were relatively safe, except A0 and D0. The position of entry points was more important than that of target points for ideal screw placement.

응급 의료 센터내 사망 환자의 분석

유인술,김준식,진재우,이철주,민영기,조준필 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

We need the constitute of Emergency medical system that connect prehospital care of inhospital care effectively for optimal treatment of emergency patient. The analysis of actual condition of our emergency medical system, through study of mortality case in emergency medical center will be a aid to the constitute. The authors performed a review on the records of 60 cases who died in Ajou university Emergency medical center during management, since June 1994 to september 1995. Among the 60 patient, 72% were male and 28% were female. In nontrauma patient, 6th decade was many, in trauma patients, 3rd and 5th decade was many. Among the 60 patient, 33% were traumatic cases, 66% were nontraumatic cases. Among the traumatic patients, more than half of the cases were due to motor vehicle accidents. The most frequent time interval from onset of emergent situation to arreving at emergency center was more than 2 hours. The most common transfer method was by 119 ambulance. In most cases, prehospital treatments were not taken. In most cases, initial mental status was comatose, and systolic blood pressure was less than 60 mmHg. Most cardiovascular resuscitation was done in 30 min. to an hour. In cases as traffic accident of ischemic heart disease, where rapid transportation of the patient is critical for the patient's survival, however, in most cases it took more than two hours to bring such patients to hospital, and first aid treatment before arrival to hospital was rare. No prehospital treatment was done to nearly all patient. In many cases the patient was already in under coma or shock state. The inhospital care at emergency center was made relatively quickly and adequately. The mean duration of cardiopulmonary resustation was 30min to one hour. From this study, we could notice the poor quality of prehospital care in the region ,near Ajou university hospital, and we came to know that the improvement of quality of prehospital care was the most important factor to reduce the motality of emergency department patient. that is, in the treatment of emergency patients, weak points has been revealed in the pre-hospital treatment, the improvement of which is important factor for the survival of emergency patients.

임신 입덧에 의해 발증한 베르니케뇌증 환자에서 스테로이드 다량요법과 FLAIR MR기법

한영민,유도성,김영주,허필우,조경석,김달수,강준기 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.12

재조합효모 배양에서 비이온성 계면활성제가 외래 Glucoamylase 생산 및 분비에 미치는 영향

차형준,유영제 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.6

비이온성 계면활성제인 Triton X-100과 Tween 80의 재조합효모 배양에서의 외래 glucoamylase 생산과 분비에 대한 영향에 대하여 조사하였다. Tween 80을 첨가한 경우 분비에의 증대 역할은 수행하지 못하였다. Triton X-100 첨가의 경우에는 세포성장에 저해가 있는 반면에 분비효율의 증대가 있어났다. Triton X-100의 세포성장 저해 효과를 방지하기 위하여 배양 1일 후에 첨가한 결과 세포성장은 저해를 받지 않았으며 분비가 증가하여 배양액으로 분비된 glucoamylase 활성이 약 12% 증가하였다. The effects of nonionic surfactants (Triton X-100 and Tween 80) on cloned glucoamylase production and secretion in recombinant Saccharomyces cerevisiae culture were studied. Even though the extracellular glucoamylase activity was increased by addition of Tween 80 due to the increase of the cell mass, Tween 80 did not play a role in the increase of glucoamylase secretion. On the addition of Triton X-100 addition, the secretion efficiency was increased while the cell growth was inhibited. Triton X-100 was added to the culture broth after 24 hr of culture to minimize the inhibition of the cell growth, and consequently the glucoamylase activity in the culture broth was increased by 12%

세라믹-세라믹 관절면의 Bicontact^(�)형 인공 고관절 전치환술의 단기 추시 결과

김영민,김상림,유기형,김재광,유정준,김희중 대한고관절학회 2001 Hip and Pelvis Vol.13 No.1

중추성 요붕증으로 발현된 랑거한스세포 조직구증식증 1례

김준성,윤원상,김근모,최영권,박기원,김병희,유용상 대한소아내분비학회 2004 Annals of Pediatirc Endocrinology & Metabolism Vol.9 No.1

혈액 질환 진단용 화상 정보 시스템의 개발

이영준,박상권,이유경,박성섭,조한익 대한임상병리학회 1996 대한임상병리학회지 Vol.16 No.5