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최영권,황지혜,이희대,우영태,김영길,김동엽 대한재활의학회 2004 Annals of Rehabilitation Medicine Vol.28 No.2
Objective: To determine the most effective type of rigid rocker bottom for prevention of diabetic foot complications according to the different rocker angles and axes of diabetic shoes. Method: Thirteen healthy volunteers participated in this study and the plantar peak pressure and pressure time integrals were measured by insole plantar pressure system for subjects either barefoot and wearing rigid rocker shoes with 12 kinds of different rocking angles and rocking points (15, 20, 25, 30o and 60, 65, 70% of shoe length). Evaluation was analyzed at M1 (hindfoot), M2 (midfoot), M3 (medial forefoot area), M4 (central forefoot area), M5 (lateral forefoot area), M6 (1st toe area), M7 (lesser toes area) zones respectively. Results: Reduced pressure was observed in all kinds of rockers at central-metatarsal area (p<0.05). But pressure was not significantly changed at lateral metatarsal area in almost all types of rocker. With rocking point at 65 and 70%, pressure was increased at first and lesser toe area in all rocking angles. With rocking point at 60 and 70%, pressure was increased at midfoot area. Conclusion: Most effectively reduced pressure was observed with shoe of rocking point at 65% and rocking angle 30o.
췌장암 환자에서 gemcitabine 사용에 의해 발생한 중증 폐합병증 1 예
최영권,전미정,신보미,최윤미,정영진,이성구,김규표 대한췌담도학회 2013 대한췌담도학회지 Vol.18 No.2
Gemcitabine은 진행성 췌장암에서 가장 좋은 치료성적을 보여주는 항암제로 최근들어 그 사용이 점차로 증가함에 따라 여러가지 폐합병증들이 보고되고 있다. 대부분의 경미한 폐합병증은 자연적으로 호전되는 경과를 보이지만, 드물게 치명적인 폐합병증이 발생하는 경우에는 빠른 진단과 스테로이드를 포함한 치료가 매우 중요하다. 저자들은 기저 폐질환이 없는 전이성 췌장암 환자에서 gemcitabine 항암치료로 인해 중증 폐합병증이 발병하여 약제 중단 및 스테로이드 치료를 통하여 후유증 없이 호전된 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Gemcitabine is a chemotherapeutic agent which showed most superior results in patients with advanced pancreatic cancer. Various pulmonary toxicities have been described with increasing usage of gemcitabine, and these are usually mild and self-limiting. Although Severe pulmonary toxicity is rare, symptoms tend to be rapid in onset and potentially lethal. Therefore, early diagnosis and timely intervention with steroids are necessary to manage this complication. In this report, we describe a case of gemcitabine induced severe pulmonary toxicity in a patient who had no underlying pulmonary disease. Her symptoms and signs were improved rapidly with steroid treatment.
Gel filtration chromatography와 propionic acid/urea polyacrylamide gel electrophoresis를 이용한 봉독 성분의 분리
최영권,최석호,권기록,Choi, Young-Chon,Choi, Suk-Ho,Kwon, Ki-Rok 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.2
Objectives : This study was conducted to carry out Purification of Melittin and other peptide components from Bee Venom using gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis Methods : Melittin and other peptide components were separated from bee venom by using gel filtration chromatography on Sephadex G-50 column in 0.05M ammonium acetate buffer. Results : Melittin and other peptide components were separated from bee venom by using gel filtration chromatography on Sephadex G-50 column in 0.05M ammonium acetate buffer. The fractions obtained from gel filtration chromatography was analyzed by using SDS-PAGE and propionic acid/urea polyacrylamide gel electrophoresis. The melittin obtained from the gel filtration contained residual amount of phospholipase $A_2$ and a protein with molecular weight of 6,000. The contaminating proteins were removed by the second gel filtration chromatography. Conclusion : Gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis are useful to separate peptide components including melittin from bee venom.