재발성 류마티즘 환자에서 발작의 유발인자

주유철,이동민,양종태,신병철,임태영,서정균,정기영,최동헌,김원,조영신,고희관 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Palindromic rheumatism (PR) is known to be triggered without any obviously inciting events in most patients, although, in a few cases, attacks have been noted to relate to another events such as weather change, childbirth, ingestion of certain foods, or over-exercise. The aim of this study was to characterize the triggering factors on palindromic attacks. Materials and Methods : We evaluated sixty-four patients with PR for the presence of triggering factors and the relationship between attacks and triggering factors by interview of patients. We considered that there was an probable association between episodes and PR, if episodes within 24 hours prior to PR had triggered at least 50% of all attacks and a definite association between episodes and PR, if episodes within 24 hours prior to PR had triggered 100% of all attacks. Results : In 15 patients (35.9%), there was a possible association between episodes of PR and initiating events. In 8 patients (12.5%), there was a definite association between episodes of PR and initiating events. The triggering factors were physical over-activity including exercise (19/64: 29.7%), foods, such as rawfish, crab, and chicken, including alcohol (19/96: 19.8%). However, there were no difference between the groups with and without the triggering factor in sex ratio, duration and onset of PR, the positive rate of rheumatoid factor and involved sites. Conclusion : Our observations showed that PR was triggered by physical over-activity more than in previous reports and hypersensitivity to foods was a causative factor in some patients with PR. However, patients with triggering factors had a similiar clinical profile to patients without triggering factors.

다구찌 접근에 관한 통계적 의사결정 분석

柳志喆,裵榮柱 忠州大學校 1995 한국교통대학교 논문집 Vol.30 No.1

In this paper, we attempt to help alleviate this difficulty by pointing out that an encompassing perspective on Taquchi's Philosphy can be provided by statistical decision analysis. The subject deals with decision making in the face of partial or no imformation, and prescribes that an optimum decision is one that maximizes expected utility. The role of experimental design is to obtain partial information about the unknown quanties in an efficient manner. The objective of this paper was to argue that it is design by decision analysis rather than design by design that better encapsulates Taguchi's approach to offline quality control.

전류 비유 모델에 의한 초등학생의 전류 개념 변화 분석

유병길,강인석,김병철,남만희,박선희,소하연,윤희정,이영아,이하룡,전병문,정승호 부산교육대학교 과학교육연구소 2000 科學敎育硏究 Vol.25 No.-

There exists a major impediment to learning electricity which may illuminate why direct presentation of scientists' ideas is too aggressive a strategy. This impediment lies in thinking that electricity is used up and in envisaging the light bulb as a consumer. This view is based on a powerful idea which summarises much of our experience; it declares that 'things get used up', 'you cannot get something for nothing', and 'intuitive thinking'. To replace this view with scientific view, we made the analogy model. It is suggested that the analogy model is more effective in teaching electricity circuits than conventional teaching method.

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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강박장애 환자에서 Sertraline 치료반응의 예측인자에 관한 연구

유은정,우행원,김영철,연규월,김종원,임원정 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 1980년 중반부터 강박장애의 치료로 SSRIs가 널리 쓰이고 있으나 치료반응의 예측인자에 대한 연구는 미비한 실정이다. 본 연구에서는 sertraline 투여후 호전군과 비호전군의 인구학적 특성, 발병연령, 이환기간, 과거의 강방장애에 대한 투약경력, 정신과 질환의 가족력, 증상의 심각도, 임상양상 등의 변수들을 관찰하여 sertraline 치료반응과의 상관관계를 살펴보았으며 치료방응을 예측 할 수 있는 인자를 알아보았다. 방법: 연구 대상은 이대부속 동대문병원 정신과에 입원 또는 외래치료를 받은 환자들 중 정신과 진단 편람제 4판 진단 기준에 의거하여 강박장애로 진단 받은 31명(남자 10명, 여자 21명)이었다. 연구 방법은 sertraline을 하루 50mg씩 투약하면서 Y-BOCS, NIMHOCS, CGI로 강박증상의 변화를 평가하였고, HAM-A로 불안정도의 변화를 측정하여 투약 전 점수와 비교하였다. 결과: 1) Y-BOCS 점수 40%이상 감소와 함께 CGI 점수 2점 이상 감소를 보인 호전군은 대상환자 31명중 17명(54.8%)이었고, 비호전군은 14명이었다. 호전군이 비호전군에 비해 늦은 나이에 발병하는 경향을보였고(p<0.1), 이환기간이 짧았으며(p<0.05), 과거의 강박장애에 대한 투약경력은 적었다(p<0.05), 정신과 질환의 가족력은 두 집단간에 차이가 없었다. 2) 호전군에서 투약 전 Y-BOCS의 강박행동 점수가 유의하게 낮았으며(p<0.05), 기타 다른 평가척도에서는 두 집단간에 유의한 차이가 없었다. 3) 평균 Y-BOCS 점수는 투약 전에 비해 sertraline 투약 12주째 43.5%가 감소하였다. 투약 전과 비교하여 투약 2주째부터 불안을 평가하는 HAM-A 점수가 유의하게 감소하였고, 투약 4주째부터 Y-BOCS, NIMHOCS, CGI 점수가 유의하게 감소되기 시작하여 12주까지 지속되었다.(p<0.01). 4) 호전군에서 오염에 대한 강박사고와 씻음의 강박행동의 유의하게 많았으며(p<0.05), 셈의 강박행동은 없었다(p<0.05), 병적 의심은 비호전군에서 많은 경향을 보였다(p<0.1). 결론: 이상의 결과를 종합하면, 질병의 이환기간이 짧으며 과거의 강박장애에 대한 투약경력이 적고 투약 전강박행동이 심하지 않으며, 주된 임상양상이 오염에 대한 강박사고와 씻음의 강박행동인 경우 sertra-line에 좋은 치료반응을 보이지만, 셈의 강박행동이 있는 경우에는 치료반응이 좋지 않다고 예측할 수 있다. Objectives: The pharmacologic treatment of obsessive-compulsive disorder(OCD) with serotonergic antidepressant agents is well established in clinical psychiatry on the basis of serotonin hypothesis. Studies on predictive factors of treatment reponse to OCD are relatively scarce. The author compared the demographic factors, age of onset, length of illness, family history of mental illness, previous drug history for OCD, severity and type of symptoms between the drug reponders and non-responders to find out the predicitive factors that may be related to treatment response. Methods: The subjects were 31, both inpatients and outpatients who met the diagnostic criteria for OCD by DSM-IV and scored 20 or higher on the Yale-Brown Obsessive-Com-pulsive Scale(Y-BOCS) completed 12-week trial of sertraline. Y-BOCS, National Institute of Mental Health Obsessive-Compulsive Scale(NIMHOCS), Clinical Global Impression Scale(CGI) were scored to measure the changes of obsessive-compulsive symptoms, and Hamilto Anxiety Scale(HAM-A) was measured at each visit. Results: 1) The responders, defined as achieving at least a 40% decrease in the Y-BOCS total score and more than a 2 point decrease in CGI score, were 17(54.8%), and non-responders were 14(45.2%). Responders tended to show later onset(p<0.1), and shorter duration of illness(p<0.05), and less previous drug therapy for OCD(p<0.05) than non-responders. There were no significant differences in family history of mental illness between the two groups. 2) The basline Y-BOCS compulsive score was significantly lower in responders(p<0.05), although there was no significant difference in the basline severity of other measures. 3) The obsession of contamination and washing behaviors were more frequent, but compulsive counting was not shown, in responders(p<0.05). The pathological doubt tended to be more common in nonresponders(p<0.1). Conclusions: In summary, the patients with shorter duration of illness, less prior drug ther-apy for OCD, and less severe compulsive behaviors, and the obsession of contamination and washing behaviors are expected to be better outcome with sertraline, whereas compulsive counting are the predictor of poor response.

정신과 입원환자의 음주와 불안 및 우울성향과의 상관관계분석

유영식,나철,이길홍 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.1

In this study the author had attempted to establish a correlationship between alcohol use and anxious or depressive trends among psychiatric inpatient in various psychiatric institutions and private psychiatric clinics in Korea. The sampling were performed through three stage clustered random sampling method, and questionnaires were finally applied to a total of 428 psychiatric inpatients including 249 men and 179 women, during the period from February 20, 1988 to March 20, 1988. The data were processed by a SPSS program. Statistical methods employed in this study were a chi-square test, an analysis of variance, and a stepwise multiple regression analysis. The major findings were as follows: 1. In analysis of the results according to the persernal history of the alcohol user, the rate of alcohol dependence was higher in men: in older age group, in service and agricultural workers, and in lower educational level. 2. More significant 5 kinds of pathological alcohol use patterns to predict alcohol use disorder were "the inability to cut down or stop drinking (predictability = 59.6%)", "the continuation of drinking despite serious physical disorders (31.3%)", "an amnesic period for events occuring while intoxicated (30.9%)", "the need for daily use of alcohol for adequate functioning (28.3%)", and "the episodic consumption of alcohol lasting for one month (23.5%)". The significant alcohol related impairments were: "brief absense during driving (predictability - 20.1%)", "alcoholic pancreatitis (11.1%)", "alcoholic hepatitis (10.9%)", and, "alcoholic gastritis (7.4%)". 3. Alcohol use in psychiatric inpatients were significantly related with their anxious or depressive trends, and their relative strengths were higher with anxious trends compared to depressive trends. 4. Among anxious trneds, somatic equivalent symtoms of anxiety such as gastrointestinal and genitourinary systoms were more closely related with alcohol use in psychiatric inpatients. 5. Among depressive trends, physiological disturbane of depression such as rhythmic disturbance were more closely related with alcohol use in psychiatric inpatients. In conclusion, somato-physiological symtoms were more closely related with alcohol use than were psycological symtoms among anxious or depressive trends.

연속파형 Nd:YAG 레이저에 의한 인코넬 600의 용접 공정변수의 연구

배신철,유영태,송성욱,신호준,나기대 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.1

The laser welding process is one of the most advanced manufacturing technologies owing to its high speed and deep penetration. Welding characteristics of Inconel 600 Alloy using a continuous wave Nd:YAG laser are experimentally investigated. The major process parameters studied in the present laser welding experiment were position of focus, laser power, travel speed. The gap and offset maintained as small as possible. Optical microscope were used to investigate the microstructures of the welded zone. The follow conclusions can be drawn the laser power and travel speed have a pronounced effect the fusion zone size and shape.

Rent-a-Server를 이용한 웹서버의 동적 할당

沈永喆,劉信根 弘益大學校 科學技術硏究所 1999 科學技術硏究論文集 Vol.10 No.1

The response time to a web request depends upon the distance between the web client and the web server, the load of the web server, and the network traffic. Replicated web serves can reduce the response time of web requests requesting not only static documents but also dynamic documents such as CGI scripts. They also increase the availability of web servers. the number and locations of the replicated web servers should be determined considering both how much web requests are generated and where they are coming from. In this paper we proposed a method of dynamically replicating web servers. When the load of a certain web server becomes too high, a new web server is created on the Rent-a-Server which is close to the domain from which heavy requests are coming from. When the load of a web server on a certain Rent-a Server becomes very low, the web server is removed from that Rent-a Server. We also introduced a method which selects the web sever that will service a user's request considering both the proximity of the web server from the client and the web servers' load.

지역 사회 감염성 폐렴에서 Cefodizime의 효능 및 안전성을 Ceftriaxone과 비교한 연구

심영수,오명돈,한성구,최강원,정희순,김영환,유철규,최형석 대한감염학회 1994 감염 Vol.26 No.3

목적: Cefodizime은 새로운 주사용 제 3세대 항생제이다. 저자들은 감염성 폐렴 환자들에서 이 약물을 하루 1번 정맥주사하였을 때 관찰되는 임상적및 세균학적 효과와 안전성을 ceftriazone과 비교하기 위하여 본 연구를 시행하였다. 방법: 1992년 6월부터 1993년 11월까지 서울대학교 병원에 지역사회 감염성 폐렴으로 입원하였던 환자 32명을 무작위로 3군으로 나누고 제 1군 : Cefodizime 1g(n=11), 제2군 : Cefodizime 2g(n=10), 제3군 : Ceftrizxone 1g(n=11)을 각각 하루 1회 정맥주사로 투여하여 그 치료율및 안전성을 비교하였다. 결과: 1)Cefodizime은 제1군 100%, 제2군 80.0%의 임상적 반응율을 보였다. Ceftriaxone을 투여하였던 제 3군에서는 81.8%의 임상적 반응율을 보였다. 이러한 임상적 반응율의 결과는 세 군간에 통계적으로 유의한 차이를 보이지 않았다(p>0.05). 2)세균학적 반응율도 세 군간에 유의한 차이를 보이지 않았다. 3)Cefodizime의 안전성의 평가에서 제1군 및 제2군에서 구토 및 오심이 2예(9.5%)에서 관찰되었고 일시적인 간효소치의 상승이 1예(4.8%)에서 관찰되었다. 경미한 공복시 위통이 1예(4.8%)에서 관찰되었다. Ceftriaxone으로 치료한 군에서는 특별한 부작용은 관찰되지 않았다. 결론: 이상의 결과로 지역사회 감염성 폐렴의 치료에 있어서 cefodizime 1내지 2g을 정맥 주사로 하루 1회 치료할 경우 적어도 ceftriaxone과 유사하게 효과적이며 안전한 것으로 사료된다. Background:Cefodizime(Modivid) is a new parenteral form of cephalosporin showing the antibacterial specturm of the third generation. The clinical efficacy and safety of cefodizime have been well proven by some previous clinical studies performed in European countries and Japan. The objective of this study was to evaluate the clinical, radiological and antimicrobial efficacy of this drug in patients with community-acquired pneumonia compared to that of ceftriaxone. Methods: We performed an open, controlled, randomized study in 32 patients with community-acquired pneumonia at Seoul national University hospital from June 1992 to November 1993. In the first group(n=11) 1g of cefodizime, and in the second group(n=10) 2g of cefodizime were respectively administered intravenously once a day. and in the third group(n=11), 1g of ceftriaxone was administered intravenously. Results: The results were as follows. 1) Cefodizime showed the clinical response rate of 100% in group I, and 80.0% in group Ⅱ. The clinical response rate of ceftriaxone in group Ⅲ was 81.8%. There was no significant statistical difference(p>0.05). 2) The rates of bacteriological efficacy wee not statistically different among three groups. 3) In the cefodizime treatment group(group Ⅰ, group Ⅱ) nausea and vomiting were observed in 2 cases(9.5%) and transient elevations of hepatic transaminases in 1 case(4.8%). Mild abdominal pain occurred in 1 case(4.8%). No significant adverse reactions were observed in the ceftriaxone treatment group. Conclusion: We could conclude that once a day intravenous cefodizime therapy was as effective and well tolerated as ceftriaxone in the treatment of community-acquired pneumonia.

포항지역 이암풍화토의 전단특성에 관한 연구

김영수,유철호,문홍득 경북대학교 산업기술연구소 1996 産業技術硏究誌 Vol.24 No.-

A series of civil constructions and development near Pohang provinces have been activated recently. but the behaviour of weathered mudstone soils, consisting of most part pohang region have shown very different shear behaviour. And it has caused a lot of problems in constructing civil structures. Therefore It can be emphasized that we noticed the characteristic shear behaviour of weathered mudstone soils. Study of this soils is less reaserched comparing with the other soils. In this study, For the purpose of more careful and exact definitions of weathered mudstone soils even though the experiment was conducted only remoulded soil specimen, we applied constitutive equations to predict the shear strength of weathered mudstone soils. The constitutive equations being used in this study are the Cam-clay model and the Single-Hardening Stress-Strain model from Dr. Lade. The range of experiment have been restricted only Undrained shear strength, and we controlled the method of consolidation After all experiment, we have evaluated which constitutive equation was suitable for the weathered mudstone soils, and have tried to find out the shear characteristic of weathered mudstone soils around Pohang province.