트레드밀 운동시 흡기근 테이핑이 폐활량에 미치는 영향

김민지,신수영,송월섭,조수진,최동락,황미진,황진규,박진현,김경,Dennis W. Fell 대구대학교 특수교육재활과학연구소 2011 再活科學硏究 Vol.29 No.1

이 연구는 트레드밀 운동과 키네시오 테이핑의 효과에 따른 폐활량의 변화를 알아보기 위해 26명의 비흡연자가 참가하였으며 키네시오 테이핑을 적용하지 않은 그룹과 키네시오 테이핑을 적용한 두 그룹으로 무작위로 배정하고 각 군들을 주 3회 6주간의 트레드밀 훈련을 실시하였다. 실험 전과 후, 스파이로미터를 사용하여 키네시오 테이핑의 적용 따른 폐활량 변화 효과를 측정하였다. 이 연구의 결과를 종합해보면 키네시오 테이핑을 적용 그룹에서 적용하지 않은 그룹에 비해 FVC, FEV1에서 유의한 증가를 보였다. 이러한 결과는 건강한 성인에서 키네시오 테이핑을 적용한 경우 키네시오 테이핑을 적용하지 않고 트레드밀 운동을 한 경우보다 폐활량의 향상에 효과적이라고 생각되어진다. The purpose of this study was to investigate the variation of vital capacity(VC) according to the effects of kinesio taping with treadmill exercise. Twenty-six non-smokers were participated in this research and these subjects were randomly assigned into two groups. To measure the VC variation effects of kinesio taping, spirometer was used. The collected data were analyzed statistically by using a paired Mauchly test and repeated measure ANOVA. The results of this study were as follows; A group: treadmill with kinesio taping B group: treadmill without kinesio taping. Between A and B, there were significant differences. In the case of A group, there was 11.66% increase of VC, during 3 weeks experiment(p<.01). In the case of B group, there were significant differences, 3.35% increase of VC, during 3 weeks taping intervention(p<.01). After 6 weeks experiment, the improvement of VC shown a significant difference with intergroup (p<.05). From this result, it was revealed that treadmill exercise with kinesio taping was effective to improve VC to healthy adult than treadmill exercise without kinesio taping.

중도장애인의 이전직장복귀 가능성에 관한 연구

김민섭,송치호 한국장애인고용촉진공단 고용개발원 2007 장애와 고용 Vol.17 No.2

본 연구는 중도장애인의 이전직장복귀 가능성에 영향을 미치는 요인을 인적자본이론과 차별이론을 중심으로 분석했다. 이를 위해 본 연구는 한국장애인고용촉진공단의‘2005년 장애인근로자 실태조사’데이터를 이용해 근로 중 장애가 발생한 중도장애인을 선별하고 이전직장복귀 여부에 대한 로지스틱 회귀분석을 실시했다. 분석 결과는 다음과 같다. 첫째, 인적자본이론은 중도장애인의 이전직장복귀 가능성을 설명하는 유효한 이론이라는 것이 확인되었다. 인적자본이론의 주요 변수인 교육정도의 경우, 교육기간이 1년 증가하면 이전직장복귀 확률은 평균적으로 0.7% 증가하고, 근속년수가 1년 증가하면 평균적으로 2.3%의 이전 직장복귀 확률이 높아지는 것으로 나타났다. 둘째, 여성장애인은 남성장애인에 비해 이전직장에 복귀할 확률이 평균적으로 6.5% 낮은 것으로 나타나, 중도장애인의 이전직장복귀에도 여성장애인에 대한 이중차별이 존재하는 것으로 분석됐다. 셋째, 장애유형 측면에서는 눈에 쉽게 보이는 신체외부장애인이 장애사실이 부각되지 않는 신체내부장애인보다 이전직장에 복귀할 확률이 낮은 것으로 분석되었다. 이는 장애 발생이후 복귀 여부 결정에 있어 장애에 대한 선입견과 낙인이 작용한다는 의미로서, 장애인의 이전직장복귀 여부를 설명하는 데 차별이론도 일정 정도의 설명력을 가지고 있음을 말해준다. This study analyzes factors determining job retention of the workers with acquired disabilities, focusing on human capital theory and discrimination theory. Using ‘2005 Survey of the Current Status of Workers with Disabilities’ collected by the Korea Employment Promotion Agency for the Disabled(KEPAD), we attempt logistic regression analysis. The model specification in this study has classified the factors that affect job retention probability into three categories; demographic, human capital, disability factor. Based on the pertinent results in the employment of the disabled workers, implications in theory and policy would be induced. The major findings are as follows. First, the human capital theory has been proved to be effective for explaining the job retention probability of the disabled workers. The educational factor, one of the factors based on that theory, has been influenced the job retention. Holding other things the same, as the educational year goes up by one unit, the job retention probability goes up by zero point seven percent on the average. Likewise, as the length of service increases by one unit, the probability increases by two point seven percent on the average, holding the other things constant. Second, holding the level of other things fixed, on average, women’s job retention probability is less than men’s by six point five percent. This result has been implied that the dual discrimination on the women disabled workers still exists in the job retention process of the disabled labor market. Third, one of the disability factors, the disabled type has effected on the job retention probability. Remaining other things the same, the externally corporeal handicapped workers’ job retention probability is lower than the internally corporeal handicapped’s, on the average. This result has suggested that the determinant of the job retention would be affected by the prejudice or stigmatization on the disabled. Consequently, the discrimination theory seems to be effective for elucidating the job retention probability of the disabled workers.

Identification of novel tumor suppressors in the DNA damage response pathway and functional validation of them in vivo.

Song, Min-Seop,Lee, Ho,Lee, Juhyun,Hong, Hyungyoung,Lee, Jinsuk,Shim, Yousun,Song, Sujeong,Lim, Dae-Sik 이화여자대학교 세포신호전달연구센터 2002 고사리 세포신호전달 심포지움 Vol. No.4

Maintenance of genomic integrity is of fundamental importance for the survival of all living organisms. This genomic integrity can be threatened during normal cell cycling as well as by external chromosomal insults, thus cell must sense the DNA damages and activate the DNA damage signal transduction pathways including cell cycle checkpoint control and DNA repair. The key players in DNA damage responses are the ATM(Ataxia telangiectasia-mutated), ATR(AT and rad3-related), Chk1 and Chk2 kinases in mammalian cells, which play an essential role in activating DNA damage responses via phosphorylation of many downstream targets following DNA damage. The final effectors are checkpoint controller(p53, Nbs1/Mre11/Rad50, Brcal) and DNA repair proteins(NBS1/Mre11/Rad50, Brcal). Significantly, many of genes involved in this pathway are implicated in human cancer prone diseases such as A-T(ATM-/-), Li-Farumeni Syndrome(LF; p53-/- or Chk2-/-); Familial Breast & Ovarian Cancer(Brca+/-), Nijimengen breakage syndrome(NBS1-/-), A-T like disorder(ATLD; Mre11-/-). Since most of proteins mediate their functions through protein-protein interactions, the DNA damage response pathway is a web of protein-protein interactions. Therefore, these genes responsible for developing human cancer prone diseases will provide us to identify more proteins which mutations cause of sporadic cancer development. Here, in order to discover the novel tumor suppressors and to map the protein-protein interactions between known proteins. we developed and used a high-throughput yeast two-hybrid system("reverse proteomics"), starting with 15 proteins involved in the DNA damage responses. First, we mated the prey libraries(4.5×10^(7)) to 15 baits, subsequently the 980 surviving diploid cells in selection media have been identified. Initially, we cloned more than 20 novel genes out of 100 positive clones, which might be involved in DNA damage responses and now continue to analyze the remaining protein-protein interactions. In addition, more than 13 new novel protein-protein interactions were mapped in DNA damage response pathways. We will discuss the partial protein networks and function of novel proteins in DNA damage responses.

Oncologic Comparison between Non-Radical Management Versus Total Mesorectal Excision in ycT0-1 After Chemoradiotherapy for Patients with Mid or Low Rectal Cancer

Kwang-Seop Song,Min-Hyun Kim,Jeong-Rae Cho,Sung Chan Park,Dae Kyung Sohn,Jae Hwan Oh,Min Jung Kim,Ji Won Park,Seung-Yong Jeong,Kyu Joo Park,Heung-Kwon Oh,Duck-Woo Kim,Sung-Bum Kang 대한외과학회 2018 대한외과학회 학술대회 초록집 Vol.2018 No.11

증예(症例) : 항결핵제 투여후 발생한 전격성 간염 1예

송민섭 ( Min Seop Song ),황민호 ( Min Ho Hwang ),윤찬호 ( Chan Ho Yun ),김용문 ( Yong Mun Kim ),김정화 ( Jeoung Hwa Kim ),조덕수 ( Deok Su Cho ),김귀완 ( Kwi Wan Kim ) 전북대학교 의과학연구소 2001 全北醫大論文集 Vol.25 No.1

항결핵제는 황달을 포함한 전격성 간염에 이르기까지 다양한 정도의 간기능 이상을 초래할 수 있는데 INH, PZA에서 비교적 흔하고 INH와 RFP을 동시에 투여할 때 간독성의 상승효과가 있다. 저자등은 바이러스성 및 자가면역성 간질환이 배제되었고, 다른 독성 물질에 노출된 적이 없었던 4제 병용 투여환자에서 발생한 전격성 간염 1 예를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다. Idiosyncratic drug reactions may cause fulminant hepatic failure. The most frequent culprits are anaesthetic agents, non-steroidal anti-inflammatory drugs and isoniazid given with rifampicin. In approximately 10 percent of adults treated with the antituberculous drug isoniazid, elevated serum aminotransferase levels develop during the first few weeks of therapy. We report a twenty six year-old male patient with fulminant hepatitis due to antituberculous drugs (isoniazid, rifampicin, ethambutol, pyrazinamide), He, previously having been well, typically develops non-specific symptoms-nausea, malaise and showed jaundice. He suffered from uncontrolled ascites and pleural effusion. Viral hepatitis and alcoholic hepatitis were excluded from his history and serological study data. After changing of antituberculous drugs and with conservative care, he was discharged with improved clinical condition.

소비자중재의 법제화에 관한 연구

송민수(Song, Min-Su),윤민섭(Yun, Min-Seop),나광식(Na, Kwang-sik) 한국소비자원 2013 정책연구보고서 Vol.- No.-

HT-29 대장암세포에서 Akt 활성 저해에 따른 셀레늄의 세포 증식억제 효과

Song Yi Park(박송이),In-Seop Kim(김인섭),Se Hee Lee(이세희),Sol Hwa Lee(이솔화),Da Woon Jung(정다운),Ock Jin Park(박옥진),Young Min Kim(김영민) 한국생명과학회 2012 생명과학회지 Vol.22 No.1

Akt는 세포의 증식과 분화에 관여하며 많은 암종에서 과발현되어 있다는 것이 보고되었다. 본 연구에서는 Akt의 조절을 통한 셀레늄의 HT-29 세포의 세포증식억제 시너지효과를 확인하였다. 셀레늄을 농도별과 시간별로 처리하였을 때 HT-29 세포의 증식이 억제되었고, apoptosis가 일어남을 확인하였다. 셀레늄을 농도별로 처리하여 Western blotting 및 immunofluorescence를 실시한 결과 Akt의 인산화가 저해되었고 COX-2의 발현도 저해되었다. 또한 Akt 저해제인 LY294002를 처리한 결과, HT-29 대장암세포의 증식이 억제되었으며, LY294002를 셀레늄과 병행처리하였을 때 셀레늄에 의한 세포증식억제 효과가 더 강하게 나타나는 것을 확인하였다. Akt siRNA에 의한 Akt의 불활성화는 non-transfected 세포에 비하여 HT-29 세포의 성장을 더 강하게 억제하였으며, Akt가 불활성화 되었을 때 COX-2의 발현 역시 non-transfected 세포에 비하여 감소된 것을 확인하였다. 따라서 HT-29 세포에서 셀레늄의 세포증식억제 효과는 Akt와 COX-2 신호분자의 조절을 통해 일어나며, Akt 의 저해는 셀레늄의 대장암세포증식 억제에 시너지 효과를 나타냄을 확인하였다. Akt is known to play an important role in cell proliferation and differentiation, and is also over-expressed in several types of cancer cells. In this study, we explored the anti-proliferative effects of selenium in HT-29 colon cancer cells, mediated through effects on Akt and COX-2. Selenium treatments at different concentrations and for different durations inhibited proliferation of HT-29 colon cancer cells and increased apoptotic cell death. Selenium treatment decreased Akt phosphorylation and COX-2 expression. Treatment with LY294002 (an Akt inhibitor) decreased proliferation of HT-29 cells, while a combined treatment with LY294002 and selenium resulted in even further decreases in cell proliferation. Inactivation of Akt by Akt siRNA treatment abolished these inhibitory effects on cell growth. COX-2 expression decreased in Akt transfected cells compared to non-transfected cells. These results suggest that selenium induced both anti-proliferative and apoptotic effects by inhibiting Akt phosphorylation and COX-2 expression. Selenium treatment also appeared to induce synergistic anti-proliferative effects by inhibition of Akt in HT-29 colon cancer cells.

First Record of Cleantioides planicauda (Crustacea: Isopoda: Holognathidae) from South Korea

Song, Ji-Hun,Kim, Min-Seop,Min, Gi-Sik The Korean Society of Systematic Zoology 2014 Animal Systematics, Evolution and Diversity Vol.30 No.1

Cleantioides planicauda (Benedict, 1899) has previously been recorded in China and Japan. In the present study, to our knowledge, we report for the first time the occurrence of this species in South Korea. Here, we provide detailed descriptions and illustrations of the diagnostic characteristics of C. planicauda. Further, for the first time, we determined the partial sequence of mitochondrial cytochrome c oxidase subunit 1 (CO1) gene of C. planicauda for molecular characteristic. Additionally, we provide a key to the Korean species and distribution of the genus Cleantioides. As a result of this study, four species of the genus Cleantioides, including C. planicauda, have now been recorded in South Korea.

The Prognostic Value of the Charlson's Comorbidity Index in Patients with Prolonged Acute Mechanical Ventilation: A Single Center Experience

Song, Seung Eon,Lee, Sang Hee,Jo, Eun-Jung,Eom, Jung Seop,Mok, Jeong Ha,Kim, Mi-Hyun,Kim, Ki Uk,Lee, Min Ki,Lee, Kwangha The Korean Academy of Tuberculosis and Respiratory 2016 Tuberculosis and Respiratory Diseases Vol.79 No.4

Background: The aim of our study was to evaluate the prognostic value of Charlson's weighted index of comorbidities (WIC) in patients with prolonged acute mechanical ventilation (PAMV, ventilator care ${\geq}96$ hours). Methods: We retrospectively enrolled 299 Korean PAMV patients who were admitted in a medical intensive care unit (ICU) of a university-affiliated tertiary care hospital between 2008 and 2013. Survivors were defined as patients who survived for 60 days after ICU admission. Results: The patients' mean age was $65.1{\pm}14.1$ years and 70.6% were male. The mean ICU and hospital length of stay was $21.9{\pm}19.7$ and $39.4{\pm}39.1$ days, respectively. In addition, the 60-day mortality rate after ICU admission was 35.5%. The mean WIC was $2.3{\pm}1.8$, with significant differences between nonsurvivors and survivors ($2.7{\pm}2.1$ vs. $2.1{\pm}1.7$, p<0.05). The area under the curve of receiver-operating-characteristics curve for WIC was 0.593 (95% confidence interval [CI], 0.523-0.661; p<0.05). Based on Kaplan-Meier curves of 60-day survival, WIC ${\geq}5$ had statistically lower survival than WIC <5 (logrank test, p<0.05). In a multivariate Cox proportional hazard model, WIC ${\geq}5$ was associated with poor prognosis (hazard ratio, 1.901; 95% CI, 1.140-3.171; p<0.05). The mortality rate of patients with WIC ${\geq}5$ was 54.2%. Conclusion: Our study showed a WIC score ${\geq}5$ might be helpful in predicting 60-day mortality in PAMV patients.

Integration of Menopausal Information into the Multiple Biomarker Diagnosis for Early Diagnosis of Ovarian Cancer

Min-Ki Jang,Yu-Seop Kim,Chan-Young Park,Hye-Jung Song,Jong-Dae Kim 보안공학연구지원센터 2013 International Journal of Bio-Science and Bio-Techn Vol.5 No.4