SMAS 거상술 및 Malar Fat Pad의 수지박리를 이용한 안면거상술

강연웅,유원민,김지명,박병윤 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.5

"한국판 학령전기 기질성격검사[K-psTCI]" 의 신뢰도 및 타당도 검사

박진균,김지웅,기선완,신의진 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : The purpose of this study was to evaluate the reliability and validity of the Korean version of Preschool Temperament and Character Inventory (K-psTCI), a questionnaire based on Cloninger's seven-factor model of personality. Methods : The psTCI was translated into Korean and administered to 266 children aged 2-6 years. α test-retest study of the K-psTCI was conducted across a 4-month interval, Internal consistency was calculated by Cronbach a. Test-retest and reliability was analyzed by Pearson correlation analysis. Factor analyses for the temperament and character dimensions were performed using principal component analysis, rotating factors by varimax. The psTCI scores of Korean and United States preschoolers were compared Results : Cronbach α values for the K-psTCI scales ranged from .62 to .78 for each dimensions. Test-retest correlations (r) ranged from .50 to .77 for each dimensions. Explorative factor analysis with the condition of eigenvalue greater than 2 produced four factors for the temperament items and three factors for the character items like the US original version of psTCI. Through factor analyses, five items in the K-psTCI were categorized differently from the US version of psTCI. Korean preschoolers had higher mean scores on Cooperativeness (CO) in males as compared to a sample of US preschoolers. Conclusion : The results of this study suggests that the Korean preschool TCI is satisfactory in reliability and validity.

Protein microarray를 이용한 Apin-단백질의 상호작용에 관한 연구

박주철,박선화,김흥중,박종태,윤성호,김지웅,이태연,손호현 대한치과보존학회 2007 Restorative Dentistry & Endodontics Vol.32 No.5

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

남녀별 음주율 현황과 음주와 관련된 요인분석

이지전,이상욱,송재석,박웅섭 關東大學校 醫科大學 醫科學硏究所 2003 關東醫大學術誌 Vol.7 No.1

In this study, drinking prevalence and the factors associated with drinking by gender were investigated. A cross-sectional study was conducted from 22 April to 3 May in 2002. 1000 subjects(301 females and 699 males) aged 13 to 59 were personally interviewed by trained interviewers. Data on socio-demographic characteristics, drinking related behaviors and health behaviors of subjects were collected. Among females, 191(63.5%) subjects were drinkers and preferred beverage was beer. Drinkers were likely to be 30-39 year-old, employed, religionless, smokers and metropolitan city residents. Among males, 579(82.8%) subjects were drinkers and preferred beverage was Soju. Drinkers were likely to be 19-29 year-old, religionless, jobless, smokers and county residents. After adjusting for various confounders, age, religion and smoking were statistically significantly related to drinking. Smoker(Odds ratio=2.68 females, 2.77 males) and catholic-buddhist(OR=1.51 female, 3.83 males) had higher drinking risk than non-smoker and protestant. County residents had borderline significantly lower drinking risks(OR=0.50) than metropolitan city residents among females.

정신분열증 환자에서 주관적 음성증상경험의 임상적 의의

김지웅,김찬형,구민성,손석한,박진철,최문종,이은철,윤도준,이홍식 대한신경정신의학회 1999 신경정신의학 Vol.38 No.1

연구목적 : 현재까지 정신분열증의 음성증상평가는 주로 객관적인 평가에만 의존해왔기 때문에, 환자들이 주관적으로 직접 경험하는 음성증상의 평가는 경시된 경향이 있었다. 그러나 실제 많은 정신분열증 환자들은 음성증상을 자가하고 있다. 특히, 개관적인 양성 및 음성증상이 관찰되지 않는 경우에도 환자 본인은 음성증상으로 괴로워한다는 이전의 연구보고들이 있었다. 따라서 저자들은 주관적인 음성증상경험과 개관적인 양성증상 및 음성 증상, 우울증상, 불안증상, 추세외로증상과의 상관성을 알아봄으로써 정신분열증의 정신병리에 있어 주관적 음성증상의 존재를 규명하고, 정신분열증 정신병리의 발생기전을 유추해보며 이차적 음성증상과의 관계를 규명하고자 하였으며. 이러한 연구가 정신분열증 정신병리를 이해하는데 도움을 줄 수 있을 뿐 아니라 환자를 공감적으로 이해하는데 도움을 줄 수 있을 것으로 생각되어 본 연구를 시행하였다. 방 법 : DSM-Ⅳ 진단기준의 정신분열증 진단기준에 해당하는 환자를 대상으로 하였다. 주관적인 음성증상의 평가를 위해서 Scale for the Subjective Experience of Negative Symptoms : Korean version(KSENS)을 이용하였고, 개관적인 정신분열증 정신병리의 평가는 Positive and Negative Syndrome Scale(PNASS)를 이용하였다. 우울증상, 불안증상, 추세외로증상의 평가를 위해서 각각 Hamilton Rating Scale for Depression(HAM-D), Hamilton Rating Scale for Anxiety(HAM-A), Extrapyramidal Symptoms Rating Scale(ESRS)을 이용하였다. 각 정신병리척도 점수간의 상관성은 Spearman 상관계수를 이용하여 분석하였다. 결 과 : K-SENS 24항목 중에서 환자가 이를 불편한 것으로 경험하고 있는 항목의 비율과 PANSS 양성척도점수 사이에는 유의한 상관점이 있었으며 (r=-0.40, p〈0.05), 양성증상 중에서도 특히 과대성(r=-0.46, p〈0.05), 의심/피해(r=-0.34, p〈0.05), 적개심(r=-0.52, p〈0.05) 등의 증상과 유의한 상관관계를 보였다. K-SENS 24 항목 중에서 환자가 이를 불편한 것으로 경험하고 있는 항목의 비율과 PANSS 전체점수(r=-0.25, p〉0.05), PANSS 음성척도점수(r=-0.20, p〉0.05), PANSS 일반정신병리척도(r=-0.08, p〉0.05),와는 각각 유의한 상관성이 없었다. K-SENS 24항목 중에서 환자가 이를 불편한 것으로 경험하고 있는 항목의 비율과 HAM-D 점수(r=-0.01, p〉0.05), HAM-A 점수(r=-0.11, p〉0.05), ESRS 총점(r=0.34, p〉0.05)은 각각 유의한 상관성이 없었다. 결 론 : 본 연구결과에서, 정신분열증 환자들이 불편한 것으로 경험하는 주관적 음성증상과 과대성, 의심/피해, 적개심 같은 양성증상은 역상관관계가 있었으며, 이러한 결과를 바탕으로 양성증상이 주관적으로 불편하게 느끼는 음성증상에 대한 가능성과, 혹은 양성증상이 심할 경우, 이에 압도되어 음성증상을 주관적으로 느끼지 못할 수 있다는 가능성이 시사되었으며, 향후 종적인 연구를 통해 이를 규명해 볼 필요성이 제시되었다. 주관적인 음성증상경험과 우울증상, 불안증상, 추세외로 증상과는 상관성이 없는 것으로 나타나서 이들 증상과는 독립적인 증상임을 시사한다. Objective : Since the evaluation of negative symptoms has depended on the clinician's objective observation, the patients subjective experience of negative symptoms has been neglected. However, in fact, a lot of patients are aware of their negative symptoms. There are several reported suggesting that patients suffer from the subjective experiences of their deficit symptoms, even though the objective positive and negative symptoms cannot be observed. Under these circumstances, we have attempted this study with the idea that it would be helpful in understanding the psychopathology of schizophrenia. Also it would help clarifying the relationship between subjective experience of negative symptoms and objectives positive and negative symptoms, depression anxiety symptoms, and extrapyramidal symptoms. Method : All the 37 patients satisfied the diagnostic criteria of DSM-Ⅵ for schizophrenia. The subjective experiences of negative symptoms were evaluated using Scale for the Subjective Experience of Negative Symptoms : Korean version(KSENS), and for the depression, anxiety, extrapyramidal symptoms, we used Hamilton Rating Scale for Depression(HAM-D), Hamilton Rating Scale for Anxiety(HAM-A), and Extrapyramidal Symptoms Rating Scale(ESRS). The correlation between each psychopathology was tested by calculating Spearman correlation coefficient. Results : There was a significant correlation between the ratio of items experienced as uncomfortable symptoms among 24 items of K-SENS, and the score of PANSS positive subscale(γ=-0.40, p〈0.05), Among the positive symptoms, grandiosity(γ=-0.46, p〈0.05), suspiciousnes/persecution(γ=-0.34, p〈0.05), and hostility(γ=-0.52, p〈0.05) showed a significant correlation with the ratio of items experienced as uncomfortable symptoms among 24 items of K-SENS. There was no significant correlation between the ratio of items experienced as uncomfortable symptoms among 24 items of K-SENS, and PANSS total score(γ=-0.25, p〉0.05), or negative subscale score(γ=-0.20, p〉0.05), or general psychology subscale score(γ=-0.08, p〉0.05), respectively. There was no significant correlation between ratio of items experienced as uncomfortable symptoms among 24 items of K-SENS, and HAM-D(γ=-0.01, p〉0.05), or HAM-A(γ=-0.11, p〉0.05), ESRS(γ=0.34, p〉0.05), respectively. Conclusion : These revealed that the negative correlation between the subjective negative symptoms experienced as an uncomfortable ones and the objective symptoms such as grandiosity, suspiciousness/persecution, and hostility. From these results, the possibility that positive symptoms are used as a defense to hide from the negative symptoms because they are overwhelmed by their positive symptoms, is suggested. These results also suggest that subjective experiences of negative symptoms are independent from depression, anxiety and extrapyramidal symptoms.

신경모세포종의 화학 및 방사선요법이 치아우식활성도에 미치는 영향

이지현,박기태,성기웅,김지연 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

소아암 환자의 치료 방법으로 주로 사용되는 항암화학요법이나 방사선요법이 구강 건강에 미치는 영향은 매우 크다. 구강 점막염, 타액 분비율의 변화, 구강내 감염을 야기할 수 있고, 부분무치증, 왜소치, 치근 발육이상, 저석회화증이 나타날 수 있다. 본 연구는 신경모세포종으로 치료 받은 환아들에 있어 항암치료가 치아우식증 발생 위험도에 어떠한 영향을 미치는지 알아보기 위해 실시되었다. 삼성서울병원 소아청소년과에 신경모세포종으로 내원하여 화학 및 방사선치료요법을 받은 환아들을 대상으로 Dentocult.. SM, Dentobuff.. Strip을 이용하여 항암치료 후의 타액 분비율, 타액 완충능, 타액 내의 Streptococcus mutans 수를 알아보고 정상 어린이들의 결과와 비교하였으며, 신경모세포종 환아에서 처음 치료를 시작한 나이, 치료 종결 후 경과 시간에 따라 치아우식활성도가 어떻게 달라지는지에 대해서도 알아보았다. 그 결과 타액 분비율은 환아가 대조군에 비해 유의성 있게 낮은 결과를 보인 반면(p<0.05), 타액 완충능과 Streptococcus mutans 수는 환아와 대조군 간에 유의성 있는 차이를 보이지 않았다. 환아에서 치료를 시작한 나이나 치료 종결 후 경과 시간에 따른 치아우식활성도에서도 통계적 유의차는 없었다. Chemotherapy or radiotherapy used for the treatment of pediatric cancer may have many adverse effects on the oral cavity. Oral mucositis, reduced salivary flow, oral infection, hypodontia, microdontia, arrested root development, and enamel hypoplasia are common oral complications. The aim of this study is to evaluate the effects of cancer therapy on dental caries activities. The children who had been treated for neuroblastoma in the department of pediatrics, Samsung Medical Center, were included and healthy children served as controls. The salivary flow rate, salivary buffering capacity, and Streptococcus mutans counts of both groups were evaluated using Dentocult SM and Dentobuff Strip. The dental caries activity related to the age at the start of treatment and the time elapsed since treatment completion were also evaluated. As a result, neuroblastoma patients had significantly lower salivary flow rate than the controls, while there were no significant differences between two groups as for salivary buffering capacity and Streptococcus mutans counts. The dental caries activities related to the age at the start of treatment and the time elapsed since treatment completion were not significantly different.

응급실내에서 발생한 폭력의 실태

최웅지,조남수,조수형,김성중,박광철,박진실 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background and Objectives: The objective of this study was to obtain circumstances about violence providers and cause of the violence in emergency room. Materials and Methods: Reports were provided to emergency department doctors, nurses and emergency medical technicians working in Chosun University Hospital Emergency Center during the sixty days from 26 May 2003 to 24 July 2003. Report form consisted of the degree of violence, the reason for the violence, dermographic information about violence providers, outbreak time of violence and response of emergency personnels. Results: SixtyUeight case of violence in the emergency department were reported. Almost all of the violence was due to the male gender and high incidence in third and fourth decade. The violence occured mostly in the night shift. 55.9% of violence was done by patient and 41.2% was done by patient's guardians. The leading cause of violence were alcohol drunken and delay of laboratory test and treatment. Verbal abuse and threats were the most concern form of violence, Conclusion: It is necessary to solve the problems faced in the emergency department not only administrative and financial aid but also regular preventive education and further study.

전이성 신세포암 환자에서의 IFN-α와 5-FU를 이용한 복합 면역 화학 요법

김세웅,이지열,장광식,박왕진,정호석,조용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 전이성 신세포암의 경우 일반적으로 항암 화학요법, 방사선 치료 그리고 호르몬 치료 등의 다양한 치료 방법에도 불구하고 그 치료 성적이 불량하며 최근 진행된 전이성 신세포암이 치료에 사용되고 있는 면역요법과 면역화학요법의 치료 효과에 대한 많은 논란이 있다. 이에 저자들은 전이성 신세포암 환자들을 대상으로 시행한 interferon-α와 5-fluorouracil의 병용투여에 대한 면역화학요법의 치료 성적, 추적관찰 결과 및 부작용의 발현정도를 확인하여 그 임상적 유용성을 알아보고자 하였다. 방법 : 1995년 3월부터 2000년 2월까지 가톨릭 대학 부속 성모 병원에서 치료를 받았던 진행성, 전이성 신세포암 환자들 중 interferon-α와 5-fluorourcail의 복합면역화학요법을 시행 받고 추적관찰이 가능했던 총 17명의 환자를 대상으로 하였다. 대상 환자들에 대해 28일을 주기로 5-fluorouracil 750㎎/㎡(Body surface area)을 5일간 지속성 정맥 주사로 투여한 후 주 3회 interferon-α 300만 unit를 4주간 피하 주사하였다. 이들에 대해 8주마다 전산화 단층촬영, 동위원소 골주사, 흉부단순 촬영 등의 영상 진단을 통한 정기적인 추적 관찰을 시행하고 이들의 치료 성적, 추적관찰 결과 및 부작용 등에 대해 알아보았다. 결과 : Interferon-α와 5-Fluorouracil의 복합면역화학요법을 이용한 전체 17명의 전이성 신세포 암 환자의 경우 반응율은 완전관해는 없었으나 부분관해를 보인 경우가 2명(11.8%), 안정상태 유지는 6명(35.3%)이었다. 폐전이의 경우 복합면역화학요법에 대해 비교적 좋은 반응을 기대할 수 있었으며 이들의 생존 기간의 중앙값은 13.8개월이었다. 거의 모든 환자에서 미열을 동반한 전신 증상과 전신 쇠약감을 관찰 할 수 있었고 그 밖에 오심, 구토 및 설사 등의 소화기 증상과 두통 등의 경미한 부작용을 일부 환자에서 관찰할 수 있었으나 백혈구 감소증, 혈소판 감소증과 간기능 이상 등의 심각한 부작용을 보인 경우는 극히 적었다. 결론 : 전이성 신세포암은 비교적 그 예후가 불량하며 동시에 효과적인 치료 방법이 명확히 알려지지 않은 상태이다. 이러한 전이성 신세포암의 치료에 대한 interferon-α와 5-fluorouracil의 복합면역화학요법은 다른 종양의 치료에 비해 비교적 낮은 반응률과 고비용이 문제점으로 생각되나 비교적 부작용이 적은 안전한 치료 방법이므로 전이상 신세포암 환자에 있어 시행해 볼 가치가 있는 치료 방법의 하나로 사료된다. Background : Renal cell carcinoma is relatively resistant to both chemotherapy and immunotherapy. In this study, we evaluated and verified the efficacy and toxicity of therapies using interferon-α plus 5-fluorouracil in patients with metastatic renal cell carcinoma. Methods : A total of 17 patients with metastatic renal cell carcinoma were treated with interferon-α (3 million units/day. 3 times/week) subcutaneously plus 5-fluorouracil (750㎎/㎡ /day for 5 days) intravenously every 28 days from March 1995 to February 2000. We studied the response rate and the side effects of this regimen. Results : Among 17 patients treated with interferon-a plus 5-fluorouracil, 2 patient with lung metastasis was achieved partial remission (11.8%) and 3 patient with lymph node metastasis, 2 patients with lung metastasis and I patient with lung and bone metastases were achieved stable disease (35.3%). I and 5 year survival rates and median survival duration were 55%, 7% and 13.8 months, respectively. There were only mild to moderate side effects. The most common side effects were flu-like symptom such as fever, chill and malaise followed by gastrointestinal symptom such as nausea, vomiting and diarrhea, headache. High grade toxicities such as severe neutropenia and thrombocytopenia were rare. Conclusion : Immunochemotherapy using interferon-α plus 5-fluorouracil were moderately effective with modest toxicity in metastatic renal cell carcinoma. The most favorable response can be expected in lung metastasis. Most of side effects were tolerable. The effective therapy in patients with metastatic renal cell carcinoma should be studied and evaluated by further large randomized trials.

인터넷 기반에서 자동화 복합 공정 제어 시스템 구현

한얼,박성무,허지웅,홍상은 순천향대학교 부설 산업기술연구소 2008 순천향 산업기술연구소논문집 Vol.14 No.1

Recent advances in information technology and internet based skills have an effect on the structure of production for a conventional industry, In the future, the concept of 'e-automation' will be used as a total solution for improving the competitiveness of company. This paper introduces the internet-based monitoring and control system as a new concept to improve productivity in industrial manufacturing. The major functions of the developed system are (1) integrating the different type of PLC(GL0FA-G3 and MELSBC-Q), (2) connecting the dual communication protocols (TCP/IP and RS-232C) and (3) supporting the MMKMan Machine Interface). The operating system is developed using LabVIEW Program and the system connects with internet for remote monitoring and control methods.