Micro-photoluminescence Mapping of Localized Luminescent Centers in Blue and Green InGaN/GaN Multiple Quantum Wells

임상엽,김준헌,정문석,박승한,이종민 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.6

The micro-photoluminescence (PL) of blue and green InGaN/GaN multiple quantum wells (MQWs) grown on sapphire substrates was measured by using laser scanning confocal microscopy (LSCM). In particular, peak energy and linewidth mappings were performed on the MQWs in order to evaluate the influence of the In mole fraction. Double scale potentials were clearly resolved in both MQWs, though nanoscopic potential fluctuations became more significant in the green InGaN/GaN MQWs, which was confirmed via correlations between the PL peak energy and linewidth.

Percutaneous Coronary Intervention for Acute Myocardial Infarction in Elderly Patients with Renal Dysfunction: Results from the Korea Acute Myocardial Infarction Registry

임상엽,배은희,최준석,김창성,마성권,안영근,정명호,김원,우종신,김영조,조명찬,김종진,김수완,구본권 대한의학회 2013 Journal of Korean medical science Vol.28 No.7

This study aimed to evaluate the effects of percutaneous coronary intervention (PCI) on short- and long-term major adverse cardiac events (MACE) in elderly ( > 75 yr old) acute myocardial infarction (AMI) patients with renal dysfunction. As part of Korea AMI Registry (KAMIR), elderly patients with AMI and renal dysfunction (GFR < 60 mL/min) received either medical (n = 439) or PCI (n = 1,019) therapy. Primary end point was in-hospital death. Secondary end point was MACE during a 1 month and 1 yr follow-up. PCI group showed a significantly lower incidence of in-hospital death (20.0% vs 14.3%, P = 0.006). Short-term and long-term MACE rates were higher in medical therapy group (31.9% vs 19.0%; 57.7% vs 31.3%, P < 0.001), and this difference was mainly attributed to cardiac death (29.3% vs 17.6%; 51.9% vs 25.0%, P < 0.001). MACE-free survival time after adjustment was also higher in PCI group on short-term (hazard ratio, 0.67; confidence interval, 0.45-0.98; P = 0.037) and long-term follow-up (hazard ratio, 0.61, confidence interval, 0.45-0.83; P = 0.002). In elderly AMI patients with renal dysfunction, PCI therapy yields favorable in-hospital and short-term and long-term MACE-free survival.

Role of Statins in Coronary Artery Disease

임상엽 전남대학교 의과학연구소 2013 전남의대학술지 Vol.49 No.1

Statins have been known to significantly reduce cardiovascular events in patients with cardiovascular disease. This review was undertaken to examine the current evidence for the effect of statins in patients with coronary artery disease. Further research is needed to clarify questions concerning the optimal timing, dosage, and type of statin therapy as well as the problems associated with adverse effects.

급성 심근경색증 환자에서 관상동맥 중재술 중 발생한 No-reflow 현상에 대한 관상동맥 내 Adenosine 및 Nicorandil 병합 투여 효과

임상엽,배은희,정명호,김한균,임지현,박형욱,홍영준,박옥영,김주한,김원,안영근,조정관,박종춘,강정채 대한심장학회 2004 Korean Circulation Journal Vol.34 No.3

Background and Objectives:This study aimed to clarify the role of combined intracoronary administrationof adenosine and nicorandil in the no-reflow phenomenon. Subjects and Methods:Thirty four patients (66±10 years, 19 male) who developed no-reflow phenomenon during percutaneous coronary intervention (PCI)between January 2000 and December 2002 were examined as the subjects of the study. We classified the subjectsinto two groups:group Ⅰ (20 patients, 67±10 years, 10 male, nitrate alone) and group Ⅱ [14 patients,69±11 years, 9 male, combined intra-coronary administration of adenosine (24 μg/mL), nicorandil (2 mg/mL),and nitrate]. In-hospital and 6-month major adverse cardiac events (MACE) after PCI were compared betweenthe two groups. Results:Mean age, sex, and risk factors were similar in both groups. Left ventricularejection fraction was 49±7.4% in group Ⅰ and 49±13.6% in group Ⅱ (p=NS). The number of involved vessels,lesion type according to ACC/AHA classification, and TIMI flow rate were similar in both groups (p=NS).Incidence of dissection after balloon angioplasty, diameter and length of stent, and use of Reopro?? did notdiffer during PCI. TIMI 3 flow was obtained in 10 (50%) out of 20 patients in group Ⅰ and in 11 (78.6%) out of14 patients in group Ⅱ (p=0.033);blush score 3 was obtained in 8 (40%) patients in group Ⅰ and in 10 (71.4%)patients in group Ⅱ (p=0.01). In-hospital death did not occur in group Ⅱ, but occurred in 4 patients in group 배경 및 목적:경피적 관상동맥 중재술(perutanous coronary intervention:PCI) 시술 중에 일어나는 no-reflow 현상은 심실성 부정맥, 심실 파열, 초기 심부전 등 나쁜 예후와 연관되어 있다. 본 연구는 PCI 도중 no-reflow현상이 발생한 환자를 대상으로 관상동맥 내 adenosine과 nicorandil의 병합 투여의 단기 및 장기적 효과를알아보고자 하였다.방 법:2000년 1월부터 2002년 12월까지 급성 심근 경색증으로 PCI를 시술받던 중 no-reflow 현상이 발생하였던 34예(66±10세, 남:여=19:15)를 대상으로,관상동맥 nitrate만 투여한 군[I군:20예(남:여=10:10)]과 관상동맥 내 nitrate에 추가하여 adenosine 24μg/mL와 nicorandil 2 mg/mL의 병합 투여군[Ⅱ군:14예(남:여=9:5)]으로 나누어 단기 및 장기적 효과를 분석하였다 결 과: 양군 간에 관상동맥 질환의 위험인자 및 검사실 소견 은 유의한 차이를 보이지 않았으며, 좌심실 구혈율 또한 유의한 차이를 보이지 않았다(49.7±7.4% vs. 49.5± 13.6%, p=NS). 관상동맥 조영술에서 병변의 혈관의 수, 병변의 ACC/AHA 분류, 병변의 TIMI 혈류 등에서 유 의한 차이를 보이지 않았다. 시술 관련 요인으로는 풍 선 확장술 후 혈전 및 내막 박리의 발생 유무, 스텐트의 직경 및 길이, 혈소판 당단백 IIb/IIIa 억제제 사용 빈도 등에서 양군 간에 유의한 차이는 보이지 않았다. Ⅰ군 10예(50%), Ⅱ군 11예(78.6%)에서 재관류술 후 TIMI 3 혈류에 도달하였고(p=0.033), Ⅰ군 8예(40%), Ⅱ군 10예(71.4%)에서 재관류술 후 Blush score 3에 도달 하였다(p=0.01). 시술 후 Ⅰ군의 4예에서 병원 내 사 망하였으며, Ⅱ군에서는 병원 내 사망한 환자가 없었다 (p=0.041). 6개월 후 추적 검사에서 Ⅰ군의 1예에서 재경색증으로 재입원 하였고 1예에서 심장사 하였으며, Ⅰ군 6예(30%), Ⅱ군 3예(21.4%)에서 심부전이 발생 하였으나 양군 간에 유의한 차이는 보이지 않았다. 결 론: 급성 심근경색증 환자에서 PCI 도중에 일어나는 noreflow 현상에서 관상동맥 내 adenosine과 nicorandil 의 병합투여는 단기적으로 병원 내 사망률을 감소시키 는 효과가 있었다.

세상을 품은 아이들 `Youth Campus`

임상엽 한국사회복지행정학회 2016 한국사회복지행정학회 학술대회 자료집 Vol.2016 No.4

Poster : Comparison of Different Type of Drug-Eluting Stent Implantation in Patients With Diabetes Mellitus in the Korean Patients

임상엽,정명호,안영근,김영조,채성철,홍택종,성인환,채제건,김종진,조명찬,승기배,박승정 한국지질동맥경화학회(구 한국지질학회) 2009 한국지질동맥경화학회 추계학술발표논문집 Vol.2009 No.-

Fabrication of a Novel Nano-probe Slide for Near-field Optical Microscopy

임상엽,박승한,Eunhee Jeang,Jae-Hoon Lee,Kyuman Cho 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1

A novel probe structure, which can act as a planar nano-probe slide for near-field microscopy, was proposed and fabricated. Sub-wavelength apertures on a Si substrate are successfully produced by means of standard photolithography techniques with properly selected masks. In particular, the anisotropic etching characteristics of Si substrate and the hardness of the Si3N4 lm are utilized. Probe-to-probe scanning of the fabricated near-field nano-probe slide shows sub-wavelength confinement of light and comparable throughput to the conventional optical fiber probe. We also show that the nano-probe slide can serve as a supporting base and a sub-wavelength aperture to obtain the near-field photoluminescence spectra of a limited number of CdSe nanocrystals.

Zr-2.5%Nb 압력관 재료에서 수소 농도와 균질화 처리 온도에 따른 수소화물 석출 거동

임상엽,김성수,이경근 대한금속·재료학회 2019 대한금속·재료학회지 Vol.57 No.4

The precipitation characteristics of hydrides in Zr-2.5% Nb pressure tube material were investigated for various hydrogen concentrations and homogenization temperatures. A surface hydride was formed using the electrolytic method and homogenized at various temperatures up to at 550 oC. The homogenization treatment was carried out at 300-550 oC over 240 hours, and the hydrogen concentration in the Zr-2.5% Nb alloy varied from 28 to 144 ppm. Hydrides were observed by optical microscopy and the precipitation parameters of the hydrides were analyzed by MATLAB, quantitatively. This is the first achievement of quantitative analysis of hydrides in Zr-alloys. The length of hydrides increased linearly with hydrogen concentration when homogenized at or below 400 oC. The area fraction of hydrides increased linearly with the hydrogen concentration regardless of homogenization temperature. The length and the ratio (length/thickness) of the hydrides decreased with increasing homogenization temperature at 350-475 oC in 81-86 ppm hydrogen. The changes in the precipitation behavior of the hydrides with homogenization temperature are considered to be due to microstructure changes, both the decomposition of β-Zr and grain growth of α-Zr.

Acute Myocardial Infarction Induced by Thrombi within the CoronaryArtery Aneurysms of a Young Male SLE Patient

임상엽,정명호,이상록,홍서나,김계훈,손일석,박형욱,홍영준,김주한,김원,안영근,조정관,박종춘,강정채 대한심장학회 2006 Korean Circulation Journal Vol.36 No.1

We describe the case of a 30-year-old man with systemic lupus erythematosus (SLE) and he was struck with non-ST segment elevation myocardial infarction: this was due to the presence of multiple coronary artery aneurysmsthose were full of thrombi. A diagnostic coronary angiogram revealed huge dilatations in the proximal three coronaryarteries with multiple filling defects and a decreased flow rate, and these were suggestive of thrombi withinthe coronary artery aneurysms. An intravascular ultrasound (IVUS) examination revealed huge aneurysmal dilatationswith movable thrombi in three coronary arteries. He had an uneventful recovery without us having toperform any percutaneous coronary intervention. (Korean Circulation J 2006;36:72-75)

75세 이상 고령 급성 심근경색증 환자에서 일차적관상동맥 중재술 후 장기적 임상 경과

임상엽,정명호,양보라,김계훈,손일석,홍영준,박형욱,김주한,김원,안영근,조정관,박종춘,강정채 대한심장학회 2005 Korean Circulation Journal Vol.35 No.8

Background and Objectives:Primary percutaneous coronary intervention (PCI) has been found to be superior,in terms of hospital mortality and long-term follow-up, compared with thrombolytic therapy for acutemyocardial infarction (AMI). However, the clinical benefits of primary PCI have not been precisely evaluated inelderly patients. Subjects and Methods:Two hundred and twenty three patients (Group I: n=66, age≥75years, Group II: n=157, age<75 years), who underwent primary PCI for AMI at Chonnam National UniversityHospital, between 2000 and 2002, were analyzed according to their clinical, angiographic characteristics, inhospitaland one-year survival. Results:Group I had a higher percentage of women (45.5% vs. 19.1%, p=0.00), multi-vessel disease (42% vs. 28%, p=0.031), right coronary artery disease (52% vs. 33%, p=0.021), andmore frequent histories of diabetes mellitus (35% vs. 22%, p=0.039) and less smoking (38% vs. 60%, p=0.003) than Group II. Successful reperfusion by PCI was achieved in 97 and 96 %, respectively (p=NS). Therates of in-hospital mortality were similar in both groups (12.1% vs. 8.2%, p=NS). There were no significantdifferences in the major adverse cardiac events between the two groups during the one-year clinical follow-up(31.4 % vs. 36.9 %, p=NS). Conclusion:Primary PCI in AMI patients older than 75 years can be performedwith comparable procedural success rates and long-term clinical outcomes to those of younger patients. 배경 및 목적:일차적 관상동맥 중재술(PCI: percutaneous coronary in-tervention)을 시행 받은 환자가 혈전용해제 치료를 받은 환자들에 비해 심근경색의 재발이나 사망률이 낮은 것으로 알려져 있으나, 노인 환자들은 합병증 발생률이나 사망률이 높아서, 적극적인 재관류술이 젊은 환자에 비하여 비교적 적게 시행되고 있는 실정이다. 본 연구에서는 일차적 PCI를 시행 받은 75세 이상의 노인 환자들의 임상적 특성, 관상동맥 병변 및 중재술의 특징, 병원 내 및 1년 후 주요 심장 사건에대해 알아보고자 하였다. 방 법: 2000년 3월 1일부터 2002년 12월 30일까지 전남대학병원 심장센터에서 급성 심근경색증으로 진단받고 흉통 발생 12시간 이내 일차적 PCI를 시행받은 환자 223예를 대상으로 하였고, 나이에 따라 75세 이상의 I군(66예, 연령 78.3±3.5세, 남자 : 여자=36 : 30)과 75세 이하의 II군(157예, 연령57.3±9.5세, 남자 : 여자=127 : 30)으로 구분하였다. 결 과:성비는 여자가 I군 30예(46%), II군 30예(19%)로서 I군에서 여자의 비율이 높았다 (p<0.05). 심혈관질환의 위험인자는 당뇨병이 I군에서 더 높았고(35% vs. 22%, p=0.039), 흡연 력은 II군에서 더 많았다(38% vs. 60%, p=0.003). 관상동맥조영술에서 다혈관질환은 I군 28예(42%), II군 44예(28%) 로서 I군에서 다혈관질환이 많았다(p=0.031). 표적 병변은 I군에서는 우관동맥이 34예(52%), II군에서는 좌전하행지가 86예(55%)로서 유의하게 많았다(p=0.021). 스텐트 시술은 I군 56예(85%), II군 124예(79%)이었고, PCI 성공률은 I군 64예(97%), II군 151예(96%), 시술 후 합병증은 I군 5예(8%), II군 10예(6%)로서 양군 사이에 유의한 차이는 없었다. 병원내 주요 심장사건은 I군과 II군에서 각각 13예(19.6%), 32예 (20.3%)에서 발생하였고, 1년 후 주요 심장사건은 각각 16예 (31.4%), 51예(36.9%)로서 양군 간에 유의한 차이는 없었다.결 론:급성 심근경색증으로 내원하여 일차적 PCI를 시행한 75세 이상의 고령군은 젊은 환자군과 비교하여 성공률이나 합병증,주요 심장사건에서 차이를 보이지 않았다. 따라서 노인 환자에서도 일차적 PCI와 같은 적극적인 치료를 고려해야 할 것으로 생각된다.