스웨징(swagging) 작업자에서 수지진동증후군 및 신경전도장애

김성아,김상우,정상재,이채용,김규상,정보우,박상규 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.2

목 적 : 스웨징작업자들에서 발생한 수지진동증후군 사례를 실제 진동수준 평가와 함께 보고하고, 진단시 신경전도검사의 소견에 대한 해석을 검토하고자 하였다. 방 법 : 2001년 4월과 5월에 구미소재 스웨징작업 종사자 8인을 대상으로 병력문진, 자각증상평가, 이학적 검사를 실시하고 수지진동증후군의심자 4인에대해 냉각부하검사와 신경전도검사를 실시하였다. 작업장조사는 진동측정장비들을 이용하여 실제 작업환경에서 측정후 국제표준화기구에 따라 평가하였으며, 수근관증후군의 동시 가능성을 알아보고자 인간 공학적 요인에 대해 조사평가 하였다. 6개월후인 12월에는 이들 4인에 대해 진동각검사와 싱경전도검사를 추적검사하였다. 결 과 : 진동수준은 주파수가중가속도값이 단일작업은 0.99∼10.79 m/sec^2, 2개의 복합작업은 3.03 ∼12.98 m/sec^2로서 ISO의 권고치를 초과하고 있었다. 1차 대상근로자 8인의 근무기간은 평균 8.7년(범위 0.8∼15)이었고, 1인은 당뇨병자이었다. 스톡홀름 분류에 의한 증상평가, 손톱압박검사, 진동각검사에서 비교적 진동노출수준과 비려하여 임상소견을 나타내었고, 2차 평가대상자 4인의 경우 신경전도검사에서 1인은 정상, 2인은 수근관증후군, 1인은 말초신경병증으로 해석되었다. 그러나, 문헌 고찰을 통해 수근관증후군으로 나온 신경전도검사결과는 오히려 진동으로 인한 다병소 신경장해로 판단하였다. 6개월후 추적 신경전도검사에서 4인 모두 진동으로 인한 다병소 신경자해를 확인하였다. 그러나, 1인에서는 수근관증후군의 동시존재 가능성을 고려하였다. 결 론 : 고정된 진동공구인 스웨징사용자들에서 수지진동증후군발생을 확인하고, 진동노출수준을 실제로 측정하여 그 양-반응관계를 동시에 평가하였다. 신경전도검사의 해석과 관련하여 수지진동증후군에서 종종 동시 존재하는 수근관증후군과의 연관성 및 감별점을 실례로써 제시함으로써 향후 진동장해를 평가하는데 도움을 주고자 하였다. Objectives : To investigate the hand-arm vibration syndrome (HAVS) among symptomatic swagging workers exposed to hand-arm vibration, using medical evaluation and measurement of workplace vibration. Furthermore, to evaluate the neurophysiological findings. Methods : Four workers showing symptoms relevant to HAVS were evaluated. Medical evaluation consisted of medical interview, questionnaire, nail-bed compression test, and sensory perception tests for vibration and pain. Some other diseases were excluded by a medical interview, hematological assessment, and urinalysis. Cold provocation test was used to assess the peripheral vascular changes, and a nerve conduction velocity (NCV) test was implemented to ascertain the peripheral neural changes. Pegboard, hole plate, and tapping board tests were performed to assess motor nerve function. The hand-arm vibration acceleration levels of the swagging machines were measured. Six months later, follow-up NCV tests were performed. Results : The actual exposure time to vibration was not longer than 15 minutes per day. The hand-arm vibration acceleration levels of the swagging machines, according to actual exposure time, were from 3.63 to 12.98 m/sec^2, by ISO 5349. The vibratory perception thresholds and the recovery time of a nail color following finger cooling were significantly increased in all four workers. The perception of pain was mildly increased. The nerve conduction studies at first diagnosis and follow-up showed multifocal neural impairment caused by vibration. However, we could not rule out the concomitant presence of the carpal tunnel syndrome in one worker. Conclusions : These results show that HAVS can be caused by hand-arm vibration in swagging workers. Interestingly, the NCV results suggested that vibration-induced neural conduction impairments could vary, and need to be interpreted cautiously.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

Clomipramine을 투여하여 치료된 강박장애 2례

김보연,이규환,채영래,이철,백인호 최신의학사 1990 最新醫學 Vol.33 No.1

운동강도 수준과 특수기능성 섬유 착용이 성장기 운동선수의 수면 중 뇌파 및 성장 호르몬 분비에 미치는 영향

김용규,이채산 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

The purpose of this study was to investigate the effect of exercise intensity level and multi-functional fabric on changes of EEG and growth hormone(GH) during sleep and quality of sleep of the 8 young female athletes. The subjects participated in separated experimental procedure; sleeping with group worn multi-functional fabric(experimental group) and worn cotton(control group) for 450min. During the night (22:00-05:30), we recorded the changes of nocturnal polysomnographic sleep recording and GH were measured among 23:00, 24:00, 02:00, and 04:00. The results of this study were follows: First, The results show that there are significant differences in percentage of stage 1, 2 and slow wave sleep(SWS) between multi-functional Fabric worn and non in moderate exercise level(F1, 28=91.293, p=.000). The SWS percentage of worn multi-functional Fabric group was 1.8 times higher than non worn multi-functional Fabric group in moderate exercise level. The SWS percentage of group worn multi-functional fabric was 1.5 times higher than group non worn multi-functional fabric in excessive exercise level. Second, The changes of GH secretion varied depending by two experimental procedure. The peak GH secretion in experimental group was more than controls by 1.3time in moderate exercise level. And The peak GH secretion in experimental group was more than controls by 2.1time in excessive exercise.

農家所得을 위한 감의 효율적 이용을 위한 젖산발효

김순동,서정식,상채규,구경희 효성여자대학교 새마을연구소 1984 새마을硏究論文集 Vol.4 No.-

This study was carried out to improve the utility of persimmon fruit by lactic acid fermentation and drying. A strain of Streptococcus lactis was used in the fermentation. The changes in acidity, pH, number of microorganism, and the content of sugar, lycopene and tannin were determined during fermentation. Color of the fermented persimmon was checked by using a colorimeter, while quality of persimmon was evaluated by sensory test. The optimum temperature for lactate fermentation was at 25℃ showing on acidity of 50mg lactate per 100g fresh weight, when 10^7 cells per ml(1% inoclum)of Streptococcus lactis was added as the starter. By sterilization at 1kg/cm^2 for 15 minutes, the fruit was coagulated and colored reddish. The loss of brix degree was 2.3%. The content of fructose was increased while sucrose and glucose 23%, respectively. The rate of tannin and lycopene loss were 32% and 23%, respectively. Tannin slightly inhibited growth of the microorganism. Optimum temperature for drying of fermented fruit was at 60℃ with little variation in color. The fermented and dried persimmon was better in texture and taste than the raisin. From above results, it was clear that quality of persimmon fruit such as texture, and storage characteristics can be improved by lactate fermentation and drying.

X-대역 SiGe HBT MMIC 이중 평형형 상향 주파수 혼합기 개발

채규성,서정욱,김창우 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

SiGe HBT를 이용하여 X-band에 적용할 수 있는 두가지 형태의 상향 주파수 혼합기를 설계 및 제작하였다. 상향 주파수 혼합기는 Gilbert-cell 구조를 이용하여 LO 및 IF balun을 포함한 이중 평형형 형태로 설계하였으며, 일반적인 Gilbert-cell 구조와 선형성 향상을 위한 degeneration resistor를 삽입한 두가지 형태의 IC를 설계 및 제작하였다. 제작된 이중 평형형 상향 주파수 혼합기는 degeneration resistor를 삽입한 경우,0 to RF 변환 특성 측정 결과, 8.0 GHz의 -5 dBm LO 신호 및 100 MHz IG 신호 입력시, 10.5 dB의 IF to RF 선형 변환 이득과 -10.5 dBm의 Pl-dB RF 출력 전력을 나타내었다. 또한 일반적인 Gilbert-cell 구조를 이용한 상향 주파수 혼합기는, IF to RF 변환 특성 측정 결과, 8.0 GHz의 -5 dBm LO 신호 및 100 MHz IF 신호 입력시, 15.8 dB의 IF to RF 선형 변환 이득과 -14.5 dHm의 P_(1-dB) RF 출력 전력을 나타내었다. 따라서, degeneration resistor를 이용한 이중 평형형 상향 주파수 혼합기가 약 4 dBm의 선형성 개선 효과를 나타내었다.

개에서 심실 조율부위 및 조율주기에 따른 혈역학적 변화

김희열,김재형,노태호,김종진,진승원,유기동,이만영,채장성,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

관동맥 우회로술 중 경식도 심초음파도로 관찰한 도부타민 투여후와 우회로술후의 좌심실 국소벽운동

김희열,김종진,윤호중,유기동,박지원,이길환,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8